• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.2291-2295
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• 2016

Small molecule tyrosine kinase inhibitors targeting HER 2 receptors have emerged as an important therapeutic approach in inhibition of downstream proliferation and survival signals for the treatment of breast cancers. Recent drug discovery efforts have demonstrated that naturally occurring polyphenolic compounds like delphinidin have potential to inhibit proliferation and promote apoptosis of breast cancer cells by targeting HER2 receptors. While delphinidin may thus reduce tumour size, it is associated with serious side effects like dysphonia. Owing to the narrow therapeutic window of delphinidin, the present study aimed to identify high affinity compounds targeting HER2 with safer pharmacological profiles than delphinidin through virtual screening approaches. Delphinidin served as the query parent for identification of structurally similar compounds by Tanimoto-based similarity searching with a threshold of 95% against the PubChem database. The compounds retrieved were further subjected to Lipinski and Verber's filters to obtain drug like agents, then further filtered by diversity based screens with a cut off of 0.6. The compound with Pubchem ID: 91596862 was identified to have higher affinity than its parent. In addition it also proved to be non-toxic with a better ADMET profile and higher kinase activity. The compound identified in the study can be put to further in vitro drug testing to complement the present study.

• 대한조선학회논문집
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• 제46권6호
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• pp.587-594
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• 2009

In the paper the effect of a stern-plate attached to a ship was taken into account. The relationship between the trim angle of a ship and the wave-resistance coefficient induced by the a stern-plate was studied using the potential flow analysis method. Numerical algorithm was described using the panel method and the vortex lattice method(VLM) to simulate the flow phenomena around a ship. The non-linearity of the free surface boundary conditions were considered using the iterative method and the IGE-GMRES(Incomplete Gaussian Elimination-The Generalized Minimal RESidual) algorithm was adopted to solve the linear equation at each iterative step. Numerical calculations were carried out to investigate the validity of the adopted algorithm using KCS(KRISO 3600 TEU Container) hull. Possible cases for attachment of the plate were checked. The results showed that the numerical algorithm could be physically appropriate.

• 정보교육학회논문지
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• 제20권6호
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• pp.543-552
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• 2016

최근들어 사회연결망분석을 이용한 연구가 사회과학 영역뿐 아니라 자연과학 영역에 이르기까지 여러분야에서 다양하게 연구되고 있다. 이에 본 논문에서는 정보교육분야 논문의 흐름을 분석하기 위해 R을 사용하여 정보교육학회 논문 빅데이터를 수집하고 텍스트분석과 사회연결망 분석을 실시하였다. 분석 결과, 논문 데이터에서 자주 언급되는 단어들은 IT 기술발전과 정보교육과정의 변화에 맞게 기간1에서는 CAI, 코스웨어 단어가, 기간2에서는 ICT 단어가, 기간3에서는 스마트, 스크래치 단어가, 기간4에서는 컴퓨팅 사고력, 코딩 단어가 처음으로 등장하였다. 또한, 추출된 단어들의 사회연결망 분석을 실시한 결과, 기간1에서는 단조로운 연결망 형태를 보이다가 기간3부터 중심성이 높은 단어가 다양해짐을 볼 수 있어 연구주제가 복잡하고 구체화됨을 알 수 있었다.

• The Journal of Advanced Prosthodontics
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• 제8권3호
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• pp.207-213
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• 2016

PURPOSE. A recently introduced direct drill-guiding implant surgery system features minimal tolerance of surgical instruments in the metal sleeve by using shank-modified drills and a sleeve-incorporated stereolithographic guide template. The purpose of this study was to evaluate the accuracy of this new guided surgery system in partially edentulous patients using geometric analyses. MATERIALS AND METHODS. For the study, 21 implants were placed in 11 consecutive patients using the direct drill-guiding implant surgery system. The stereolithographic surgical guide was fabricated using cone-beam computed tomography, digital scanning, computer-aided design and computer-assisted manufacturing, and additive manufacturing processes. After surgery, the positional and angular deviations between planned and placed implants were measured at the abutment level using implant-planning software. The Kruskal-Wallis test and Mann-Whitney U test were used to compare the deviations (${\alpha}=.05$). RESULTS. The mean horizontal deviations were 0.593 mm (SD 0.238) mesiodistally and 0.691 mm (SD 0.344) buccolingually. The mean vertical deviation was 0.925 mm (SD 0.376) occlusogingivally. The vertical deviation was significantly larger than the horizontal deviation (P=.018). The mean angular deviation was 2.024 degrees (SD 0.942) mesiodistally and 2.390 degrees (SD 1.142) buccolingually. CONCLUSION. The direct drill-guiding implant surgery system demonstrates high accuracy in placing implants. Use of the drill shank as the guiding component is an effective way for reducing tolerance.

• 항공우주산업기술동향
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• 제7권2호
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• pp.59-67
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• 2009

항공우주산업과 관련된 항공기, 인공위성, 발사체 등의 구조체 개발을 위해서는 설계단계에서부터 해석 및 제작에 이르기까지 다양한 전산기술(CAD/CAE/CAM)이 널리 적용되고 있다. 이 중 구조해석을 위해서는 NASTRAN, ABAQUS, ANSYS와 같은 유한요소법에 기반을 둔 CAE 소프트웨어가 개발되어 산업현장에 널리 보급되어 있으며, 정적해석, 동적해석, 진동해석, 충돌해석 등 해석목적에 맞게 모듈화가 되어있다. 최근에는 해 석알고리즘 및 컴퓨터성능의 발달에 힘입어 다중물리해석, 최적설계와 같은 난해하며 높은 계산량을 요구하는 문제의 적용과 및 다자유도문제의 해결이 진행되고 있는 추세이다. 본 논문에서는 항공우주산업분야에 주로 사용되는 구조해석 소프트웨어의 최신기술동향을 살펴본다.

• 한국정밀공학회지
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• 제16권12호
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• pp.230-238
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• 1999

This paper describes a research work of developing computer-aided design of lead frame, semiconductor, with blanking operation which is very precise for progressive working. Approach to the system is based on the knowledge-based rules. Knowledge for the system is formulated from plasticity theories, experimental results and the empirical knowledge of field experts. This system has been written in AutoLISP on the AutoCAD using a personal computer and in I-DEAS Drafting Programming Language on the I-DEAS Master Series Drafting with Workstation, HP9000/715(64) and tool kit on the ESPRIT. Transference of data among AutoCAD, I-DEAS Master Series Drafting, and ESPRIT is accomplished by DXF(drawing exchange format) and IGES(initial graphics exchange specification) methods. This system is composed of six modules, which are input and shape treatment, production feasibility check, strip-layout, die-layout, modelling, and post-processor modules. The system can design process planning and Die design considering several factors and generate NC data automatically according to drawings of die-layout module. As forming process of high precision product and die design system using 2-D geometry recognition are integrated with technology of process planning, die design, and CAE analysis, standardization of die part in die design and process planning of high pression product for semiconductor lead frame is possible to set. Results carried out in each module will provide efficiencies to the designer and the manufacturer of lead frame, semiconductor.

• 정보과학회 논문지
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• 제41권10호
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• pp.838-846
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• 2014

터치기반 스마트 기기의 발달에 따라, 사용자가 펜/손가락을 이용하여 그린 스케치를 기반으로 다양한 멀티미디어 검색 기술은 컴퓨터 비전, 컴퓨터 그래픽스, 패턴인식, HCI 분야에서 많은 각광을 받고 있다. 하지만, 기존의 텍스트 정보를 기반으로 한 검색 시스템은 사용자가 원하는 멀티미디어 데이터를 정확히 검색하는데 한계가 있다. 따라서, 멀티미디어 자체가 가지고 있는 정보를 이용하여 검색할 수 있는 내용 기반 멀티미디어 검색에 관한 연구가 필요하게 되었다. 본 논문에서는 Hybrid Edge Descriptor(HED)를 사용한 웹 환경에서의 사용자가 스케치로부터 3차원 모델을 검색할 수 있는 시스템을 제안한다. 3차원 모델로부터 다양한 방향으로 투영된 suggestive contour 영상 및 사용자가 그린 스케치 영상으로부터 전역/지역 히스토그램 분석을 이용한 HED 검색자를 통해 회전 및 이동에 강인한 3차원 모델 검색 시스템을 제안한다.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2000년도 추계학술대회 논문집
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• pp.591-594
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• 2000

This paper describes a research work of developing a computer-aided design of product with bending and piercing for progressive working. An approach to the system for progressive working is based on the knowledge-based rules. Knowledge for the system is formulated from plasticity theories, experimental results and the empirical knowledge of field experts. The system has been written in AutoLISP on the AutoCAD with a personal computer and is composed of four main modules, which are input and shape treatment, flat pattern layout, strip layout and die layout module. Based on knowledge-based rules, the system is designed by considering several factors such as radius and angle of bend, material and thickness of product, complexities of blank geometry and punch profile, bending sequence, and availability of press. Strip layout drawing generated by the piercing processes with punch profiles divided into for external area is simulated in 3-D graphic forms, including bending sequences for the product with piercing and bending. Results obtained using the modules enable the manufacturer for progressive working of electronic products to be more efficient in this field.

• 한국실천공학교육학회논문지
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• 제4권1호
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• pp.72-79
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• 2012

컴퓨터 관련 산업의 발전과 함께 컴퓨터를 이용한 교육의 향상도 같이 이루어지고 있으며, 그 중에서 가상 훈련(Virtual Training, VT)은 가장 주목 받고 있는 미래형 교육 매체 중 하나이다. 이러한 추세에 따라 많은 양의 가상 훈련용 3D 모델들이 개발되고 있으나, 이들을 통합적으로 관리하여 재사용을 편리하게 하는 시스템에 대한 연구는 부족하다. 본 논문에서는 3D 모델들을 통합적으로 관리할 수 있는 시스템을 제안한다. 컨텐츠 저작도구들에서 편리하게 이용할 수 있는 모델 형식에 대해 조사하며, 중앙 서버에 저장하는 방법에 대해 연구한다. 3D 모델을 저장하기에 알맞은 DB 구조를 설계하고, 모델을 검색하고 인출하기 편한 방법에 대해 제안한다. 본 논문에서 개발된 관리 시스템 소프트웨어를 통해 3D 모델의 재사용이 촉진될 것이 기대된다.

• 한국정밀공학회지
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• 제15권2호
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• pp.124-133
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• 1998

This paper describes a research work of developing a computer-aided design of blanking and piercing for irregular-shaped sheet metal products. An approach to the development of compact and practical CAB system is based on the knowledge-based rules. Knowledge for the CAD system is formulated from plasticity theories, experimental results and the empirical knowledge of field experts. The system has been written in AutoLISP on the AutoCAD with a personal computer. Based on knowledge-based rules, the system, STRT-DES, is designed by considering several factors, such as complexities of blank geometry and punch profile, availability of press equipment and standard parts, utilization ratio which minimizes the scrap in a single or a pairwise operation, bridge width, grain orientation and design requirements which maximize the strength of the part when subsequent bending is involved. This system checks a forming feasibility with both internal and external features, a dimension of blanked hole, and a corner and a fillet radius for irregualrly shaped sheet metal products. Therefore this system can carry out a die design for each process which is obtained from results of an automated blank layout drawing with a best utilization ratio for irregular shape of product that was successful in production feasibility check module and those of an automated strip layout drawing and generate part drawings and the assembly drawing of die set in graphic forms.