• Journal of Life Science
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• v.33 no.3
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• pp.268-276
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• 2023

This study was conducted to optimize the formulation conditions of the immediate-release layer of carvedilol in the development of a two-layer tablet formulation for carvedilol and ivabradine. Using a 2⁴+3 full-factorial design of experiments, excipients (microcrystalline cellulose, citric acid, and crospovidone) of the carvedilol immediate-release layer (wet granulation part) and process parameters for the tablet compression process (main compression) were optimized, and seven types of each dependent variable (assay, content uniformity, hardness, friability, disintegration, and dissolution [pH 1.2 and 6.8]) were evaluated using design expert software. The analysis of variance results confirmed that the main compression has a significant effect on hardness, friability, and disintegration time and that microcrystalline cellulose has a major effect on friability and dissolution. In addition, it was confirmed that citric acid has a significant effect on friability. Crospovidone affects friability and dissolution. According to the design space from the design of the experiment results, the optimized range is microcrystalline cellulose (~18.0-32.0 mg), citric acid (~0.5-12 mg), and main compression (~615-837 kgf). Consequently, this study confirmed the availability of manufacturing the carvedilol immediate-release layer in which all risk factors evaluated in the initial risk assessment are removed.

• Proceedings of the KSME Conference
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• 2007.05b
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• pp.2775-2780
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• 2007

The ballistic range has long been employed in a variety of engineering fields such as high-speed impact engineering, projectile aerodynamics and aeroballistics, since it can create very high-pressure states in a short time. Since the operation of the ballistic range includes many complicated processes, each should be studied in detail for the best operation of the device. One of the main processes which have a major influence in its operation is the compression of the driver gas. Most of the studies available in this field hardly discuss this process in detail and thus lack a proper understanding of its effect. In the present study, a computational analysis has been made to investigate the compression process in the pump tube of a ballistic range. The results obtained are validated with some experimental data. It is seen that the pump tube parameters and the piston mass significantly affect the compression process and the time to build up the required diaphragm rupture pressure.

• Journal of Korea Foundry Society
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• v.3 no.3
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• pp.181-187
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• 1983

Effects of retained compression strength on the collapsibility of $CO_2$ mold sand using sodium silicate were studied. The results obtained from the experiment are summurized as follows; 1) The sand mixtures increased their compression strength and retained compression strength when content of sodium silicate is high or mole ratio of sodium silicate is high. 2) Increase of retained strength has a maximum value at temperatures about $200^{\circ}C$. When the sample reached $800^{\circ}C$, the binder bridge are homogeneous. The retained strength is increased. 3) Decrease of retained strength at temperatures over $200^{\circ}C$ is caused by pore formation and additives of seacoal markedly accelerated pore formations.

• Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
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• 2002.10b
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• pp.333-334
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• 2002

Injection-compression molding parts are many cases with complicated boundary condition which is difficult to analysis of mold characteristics precisely. In this study, the effects of various process parameters such as multi-point gate location, initial charge volume, injection time and pressure have been investigated using finite element method to fomulate the melt front advancement during the mold filling process. A general governing equation for tracking the filling process during injection-compression molding is applied to volume of fluid method. To verify the results of present analysis, they are compared with those of the other paper. The results show a strong effect of processing conditions as a result of variations in the three-dimensional complex geometry model.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.22 no.6
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• pp.823-831
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• 1998

In order to investigate the impulsive noise at the exit of high-speed railway tunnel and the pressure transients inside the tunnel, numerical calculations using a Total Variation Dimishing difference scheme were applied to axisymmetric unsteady compressible flow field. Some compression wave forms were assumed to model the compression wave produced in real high-speed railway tunnel. The numerical data were extensively explored to analyze the peak over-pressure and maximum pressure gradient in the pressure wavefront. The effect of the distance and cross-sectional area ratio between two-continuous ducts on the characteristics of the pressure waves were investigated. The peak over-pressure inside the second duct decreases for the distance and cross-sectional area ratio between two tunnels to increase. The peak over-pressure and maximum pressure gradient of the pressure wavefront inside the second duct increase as the maximum pressure gradient of initial compression wave increases. The present results were qualitatively well agreed with the results of the previous shock tube experiment.

• Proceedings of the Korean Society For Composite Materials Conference
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• 2002.05a
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• pp.184-187
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• 2002

Compression molding was specifically developed for replacement of metal components with composites. As the mechanical properties of the products are dependent on the separation and orientation, it is important to research the fiber mat structure and molding conditions. In this study, the effects of the fiber mat structure(NP: 5, 10, 25punches/$\textrm{cm}^2$) and the mold closure speed($\dot{\textrm{h}}$=0.1, 1, 10mm/min) on the viscosity of composites were discussed. The composites is treated as a Non-Newtonian power-law fluid. The parallel-plate plastometer is used and the viscosity is obtained from the relationship between the compression load and the thickness of the specimen.

• Proceedings of the Korean Society For Composite Materials Conference
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• 2001.10a
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• pp.33-38
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• 2001

This study aims to systematically research the various phenomena which arise from compression molding of fiber reinforced plastic composites. Long fiber reinforced plastic composites are rib type compression molded in order to measure the orientation in products, and the specimens are photographed with soft X-ray. The intensity of the photograph is applied by an image scanner, and the fiber orientation distribution of products is measured by using an image processing technique.

• Textile Coloration and Finishing
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• v.8 no.6
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• pp.55-64
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• 1996

The compression properties of the 2 folded yams such as compression linearity, compression resilience, and compression work with various wool/polyester blend ratios and with single and 2-folded yarn twists under various degrees of twisting were studied for analyzing twist characteristics, inter and intra frictional effects. A variation of single and 2-folded yarn twists was analysed in their twist structure. This structural analysis was discussed with various wool/polyester blend ratios and various single and 2-folded yarn twists.

• 한국가스학회:학술대회논문집
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• 1998.09a
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• pp.255-260
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• 1998

This study describes the results of Coefficient Of Performance(COP) analysis by cycle simulation for two types of absorption-compression hybride cycle using the water/Lithium Bromide solution pair, These types are basic hybride systems introducing a mechanical compression process into the refrigerant vapor phase of the single effect absorption cycle. In absorption-compression hybrid cycles, coefficient of performance is improved compared with absorption cycle. Hybride cycle Type ll is considered as a key technology to support energy utilization system, given its capability of utilizing waste heat to drive system with a high level of efficiency.

• Journal of Korean Medicine Rehabilitation
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• v.27 no.4
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• pp.147-154
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• 2017

The purpose of this study is to report the effectiveness of Fire needling therapy in patients with a vertebral compression fracture. Three patients with a acute vertebral compression fracture were treated using Fire needling therapy. To evaluate the effectiveness of Fire needling therapy, we checked Numerical rating scale on a daily and Oswestry disability index on admission and discharge. Numerical rating scale decreased as the number of Fire needling therapy increased. Oswestry disability index on discharge improved compared to admission. The limitation of this study is the insufficient number of cases and outcome measurements. Further studies are needed to prove effect and safety.