Once the foundation displacement of the transmission tower occurs, additional stress will be generated on the tower members, which will affect the seismic response of transmission tower-line systems (TTLSs). Furthermore, existing research has shown that the reciprocating slippage of joints needs to be considered in the seismic analysis. The hysteretic behavior of joints is obtained by model tests or numerical simulations, which leads to the low modeling efficiency of TTLSs. Therefore, this paper first utilized numerical simulation and model tests to construct a BP neural network for predicting the skeleton curve of joints, and then a numerical model for a TTLS considering the bolt slippage was established. Then, the seismic response of the TTLS under foundation displacement was studied, and the member stress changes and the failed member distribution of the tower were analyzed. The influence of foundation displacement on the seismic performance were discussed. The results showed that the trained BP neural network could accurately predict the hysteresis performance of joints. The slippage could offset part of the additional stress caused by foundation settlement and reduce the stress of some members when the TTLS with foundation settlement was under earthquakes. The failure members were mainly distributed at the diagonal members of the tower leg adjacent to the foundation settlement and that of the tower body. To accurately analyze the seismic performance of TTLSs, the influence of foundation displacement and the joint effect should be considered, and the BP neural network can be used to improve modeling efficiency.
This study develops the process and method of official administration documents which have remained ill-balanced like the official documents of the government-general of Chosun(the pro-Japanese colonial government (1910-1945)). At first, the existing Appraisal-theories are recomposed. The Appraisal-Theories of Schellenberg is focused valuation about value of records itself, but fuction-Appraisal theory is attached importance to operational activities which take the record into action. But given that the record is a re-presentation of operational activities, the both are the same on the philosophy aspect. Therefore, in the case that the process - method is properly designed, it can be possible to use a composite type between operational activities and records. Also, a method of the Curve has its strong points in the macro and balanced aspect while the Absolute has it's strength in the micro aspect, so that chances are that both alternate methodologies are applied to the study. Hereby, the existing Appraisal theories are concluded to be the mutually-complemented things that can be easily put together into various forms according to the characteristics of an object and its situation, in the terms of the specific Appraisal methodology. Especially, in the case of this article dealing with the imbalance remains official-documents, it is necessary to compromise more properly process with a indicated useful method than establishing a method and process by choosing the only one theory. In order to appraise the official-documents of the pro-Japanese colonial government (1910-1945), a macro appraisal of value has to be appraised about them by understanding a system, functions and using the historical-cultural evolution, after analysing Disposal Authority. From this, map the record so that organization function maps are constructed regarding the value rank of functions and detailed-functions. After this, establish the appraisal strategy considering the internal environment of archival agencies and based on micro appraisal to a great quantity of records remained and supplying other meaning to a small quantity of records remained for example, the oral resources production are accomplished. The study has not yet reached the following aspects ; a function analysis, historical decoding techniques, a curve valuation of the record, the official gazette of the government general of Chosun( the pro-Japanese government for 1910-1945), an analysis method of the other historical materials and it's process, presentation of appraisal output image. As the result, that's just simply a proposal and we should fill in the above-mentioned shortages of the study through development of all the up-coming studies.
Journal of Dental Rehabilitation and Applied Science
/
v.18
no.3
/
pp.145-155
/
2002
The results of the present feasibility study are summarized as follows, 1. The three unit bridge of knitted material and UD fibre reinforcement has both the rigidity and the strength against a vertical occlusal load of 75N. 2. Stress concentration at the junctional area between the bridge and the abutments, i.e. between the pontic and the knitted caps was observed. In the case of the bridge with reinforcement straps, it was partly shown that the concentration problem could be improved by simply increasing the fillet size at the area. Further refining in the surface of the junctional area will be needed to ensure a further improvement in the stress distribution. This will require some trade off in the level of the stress and the available space. A parametric study will help to decide the appropriate size of the fillet. 3. Design refinement is a must to improve the stress distribution and realize the most favourable shape in terms of fabrication. The current straight bar with a constant cross section area can be redesigned to a tapered shape. The curve from the dental arch should also be placed on the pontic design. In accordance with design refinement, the resistance of the bridge frame to other load cases should be evaluated. 4. Although not included in the present feasibility study, it is estimated that bridges of the anterior teeth can be made strong enough with the knitted material without further reinforcement using unidirectional materials. In this regard, a feasibility study on design concepts and stress analysis for 3, 4, 5 unit bridge is suggested. 5. Two types of bridge were analysed in terms of fatigue. The safe life design concept, i.e. fatigue design concept, looks reasonable for the bridge where if cracks should form and propagate there is virtually nothing a dentist to do. The bridge must be designed so that no crack will be initiated during the life span. In the case of crowns, however, if constructed with composite resin with knitted materials, it might be possible to repair them, which in general is impossible for crowns of PFM or of metal. Therefore for composite resin crowns, a damage tolerance design concept can be applied and reasonably higher operational stresses can be allowed. In this case, of course, a periodic inspection program should be established in parallel. 6. Parts of future works in terms of structural viewpoint which need to be addressed are summarized as the following: 1) To develop processing technology to accommodate design concepts; 2) More realistic modelling of the bridge and analysis-geometry and loading condition. Thickness variation in the knitted material, taper in the pontic, design for anterior tooth bridge, the effect of combined loads, etc, will need to be included; 3) To develop appropriate design concepts and design goals for the fibre composite FPD aiming at taking the best advantage of knitted materials, including the damage tolerance design concept; 4) To develop testing method and perform test such as static ultimate load test, fatigue test, repair test, etc, as necessary.
Transition metal oxide, which undergoes a conversion reaction in the negative electrode material for a lithium-ion batteries, has a high specific capacity, but still has several critical problems. In this study, manganese pyrophosphate (Mn2P2O7), nickel pyrophosphate (Ni2P2O7), and carbon composite materials with pyrophosphates as novel negative electrode materials instead of transition metal oxide, are synthesized through simple solid-state reaction. The initial reversible capacity of Mn2P2O7 and Ni2P2O7 are 333 and 340 mAh g-1, and when the composite materials are composed with carbon, the reversible capacity increases to 433 and 387 mAh g-1, respectively. The initial Coulombic efficiency is also improved by about 10%. The Mn2P2O7 and carbon composite material has the highest initial capacity and efficiency, and has the best cycle performance. Mn2P2O7 containing polyanion, has a lower specific capacity due to the large mass of polyanion compared to MnO (manganese oxide). However, since Mn2P2O7 shows a voltage curve with a slope, the charging (lithiation) voltage increases from 0.51 to 0.57 V (vs. Li/Li+), and the discharge (delithiation) voltage decreases from 1.15 to 1.01 V (vs. Li/Li+). Therefore, the voltage efficiency of the cell is improved because the voltage difference between charging and discharging is greatly reduced from 0.64 to 0.44 V, and the operating voltage of the full cell increases because the negative electrode potential is lowered during the discharging process.
The objectives of this study were to evaluate a protease suitable for the enzymatic hydrolysis of a snow crab processing by-product (SPB) and to optimize the hydrolysis conditions using response surface methodology (RSM). The SPB was hydrolyzed at $50^{\circ}C$ and pH 7.0-7.2 to obtain various degree of hydrolysis (DH) using Flavourzyme at an enzyme/substrate (E/S) ratio of 3.0%. The reaction progress curve exhibited an initial fast reaction rate followed by a slowing of the rate. The DH was increased to 30% at 90 min with a final DH 32 to 36%. A central composite experimental design having three independent variables (reaction temperature, reaction time, and E/S ratio) with five levels was used to optimize the enzymatic hydrolysis conditions. Based on the DH data, the optimum reaction conditions for the enzymatic hydrolysis of the SPB were a temperature of $51.8^{\circ}C$, reaction time of 4 hr 45 min, and an E/S ratio of 3.8%. It was demonstrated that the enzymatic hydrolysate of SPB could be used as a flavoring agent or a source of precursors for the production of reaction flavors.
Fatigue cracks of rib-to-deck (RD) joints have been frequently observed in the orthotropic steel decks (OSD) using conventional U-ribs (CU). Thickened edge U-rib (TEU) is proposed to enhance the fatigue strength of RD joints, and its effectiveness has been proved through fatigue tests. In-depth full-scale tests are further carried out to investigate both the fatigue strength and fractography of RD joints. Based on the test result, the mean fatigue strength of TEU specimens is 21% and 17% higher than that of CU specimens in terms of nominal and hot spot stress, respectively. Meanwhile, the development of fatigue cracks has been measured using the strain gauges installed along the welded joint. It is found that such the crack remains almost in semi-elliptical shape during the initiation and propagation. For the further application of TEUs, the design curve under the specific survival rate is required for the RD joints using TEUs. Since the fatigue strength of welded joints is highly scattered, the design curves derived by using the limited test data only are not reliable enough to be used as the reference. On this ground, an experiment-numerical hybrid approach is employed. Basing on the fatigue test, a probabilistic assessment model has been established to predict the fatigue strength of RD joints. In the model, the randomness in material properties, initial flaws and local geometries has been taken into consideration. The multiple-site initiation and coalescence of fatigue cracks are also considered to improve the accuracy. Validation of the model has been rigorously conducted using the test data. By extending the validated model, large-scale databases of fatigue life could be generated in a short period. Through the regression analysis on the generated database, design curves of the RD joint have been derived under the 95% survival rate. As the result, FAT 85 and FAT 110 curves with the power index m of 2.89 are recommended in the fatigue evaluation on the RD joint using TEUs in terms of nominal stress and hot spot stress respectively. Meanwhile, FAT 70 and FAT 90 curves with m of 2.92 are suggested in the evaluation on the RD joint using CUs in terms of nominal stress and hot spot stress, respectively.
Genomics is providing targets faster than we can validate them and combinatorial chemistry is providing new chemical entities faster than we can screen them. Historically, the drug discovery cascade has been established as a sequential process initiated with a potency screening against a selected biological target. In this sequential process, pharmacokinetics was often regarded as a low-throughput activity. Typically, limited pharmacokinetics studies would be conducted prior to acceptance of a compound for safety evaluation and, as a result, compounds often failed to reach a clinical testing due to unfavorable pharmacokinetic characteristics. A new paradigm in drug discovery has emerged in which the entire sample collection is rapidly screened using robotized high-throughput assays at the outset of the program. Higher-throughput pharmacokinetics (HTPK) is being achieved through introduction of new techniques, including automation for sample preparation and new experimental approaches. A number of in vitro and in vivo methods are being developed for the HTPK. In vitro studies, in which many cell lines are used to screen absorption and metabolism, are generally faster than in vivo screening, and, in this sense, in vitro screening is often considered as a real HTPK. Despite the elegance of the in vitro models, however, in vivo screenings are always essential for the final confirmation. Among these in vivo methods, cassette dosing technique, is believed the methods that is applicable in the screening of pharmacokinetics of many compounds at a time. The widespread use of liquid chromatography (LC) interfaced to mass spectrometry (MS) or tandem mass spectrometry (MS/MS) allowed the feasibility of the cassette dosing technique. Another approach to increase the throughput of in vivo screening of pharmacokinetics is to reduce the number of sample analysis. Two common approaches are used for this purpose. First, samples from identical study designs but that contain different drug candidate can be pooled to produce single set of samples, thus, reducing sample to be analyzed. Second, for a single test compound, serial plasma samples can be pooled to produce a single composite sample for analysis. In this review, we validated the issue whether the second method can be applied to practical screening of in vivo pharmacokinetics using data from seven of our previous bioequivalence studies. For a given drug, equally spaced serial plasma samples were pooled to achieve a 'Pooled Concentration' for the drug. An area under the plasma drug concentration-time curve (AUC) was then calculated theoretically using the pooled concentration and the predicted AUC value was statistically compared with the traditionally calculated AUC value. The comparison revealed that the sample pooling method generated reasonably accurate AUC values when compared with those obtained by the traditional approach. It is especially noteworthy that the accuracy was obtained by the analysis of only one sample instead of analyses of a number of samples that necessitates a significant man-power and time. Thus, we propose the sample pooling method as an alternative to in vivo pharmacokinetic approach in the selection potential lead(s) from combinatorial libraries.
Huang, Yonghui;Liu, Airong;Pi, Yong-Lin;Bradford, Mark A.;Fu, Jiyang
Steel and Composite Structures
/
v.34
no.1
/
pp.1-15
/
2020
This paper presents experimental and numerical studies on effects of local damages on the in-plane elastic-plastic buckling and strength of a fixed parabolic steel tubular arch under a vertical load distributed uniformly over its span, which have not been reported in the literature hitherto. The in-plane structural behaviour and strength of ten specimens with different local damages are investigated experimentally. A finite element (FE) model for damaged steel tubular arches is established and is validated by the test results. The FE model is then used to conduct parametric studies on effects of the damage location, depth and length on the strength of steel arches. The experimental results and FE parametric studies show that effects of damages at the arch end on the strength of the arch are more significant than those of damages at other locations of the arch, and that effects of the damage depth on the strength of arches are most significant among those of the damage length. It is also found that the failure modes of a damaged steel tubular arch are much related to its initial geometric imperfections. The experimental results and extensive FE results show that when the effective cross-section considering local damages is used in calculating the modified slenderness of arches, the column bucking curve b in GB50017 or Eurocode3 can be used for assessing the remaining in-plane strength of locally damaged parabolic steel tubular arches under uniform compression. Furthermore, a useful interaction equation for assessing the remaining in-plane strength of damaged steel tubular arches that are subjected to the combined bending and axial compression is also proposed based on the validated FE models. It is shown that the proposed interaction equation can provide lower bound assessments for the remaining strength of damaged arches under in-plane general loading.
In this work, Ag3PO4/In2S3 nanocomposites with low loading of In2S3 (5-15 wt %) are fabricated by two step chemical precipitation approach. The microstructure, composition and improved photoelectrochemical properties of the as-prepared composites are studied by X-ray diffraction pattern (XRD), field emission scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), photocurrent density, EIS and amperometric i-t curve analysis. It is found that most of In2S3 nanoparticles are deposited on the surfaces of Ag3PO4. The as-prepared Ag3PO4/In2S3 composite (10 wt%) is selected and investigated by SEM and TEM, which exhibits special morphology consisting of lager size substrate (Ag3PO4), particles and some nanosheets (In2S3). The introduction of In2S3 is effective at improving the charge separation and transfer efficiency of Ag3PO4/In2S3, resulting in an enhancement of photoelectric behavior. The origin of the enhanced photoelectrochemical activity of the In2S3-modified Ag3PO4 may be due to the improved charge separation, photocurrent stability and oriented electrons transport pathways in environment and energy applications.
Kim Moo-Han;Kim Jae-Hwan;Kim Yong-Ro;Kim Young-Duck
Journal of the Korea Concrete Institute
/
v.17
no.2
s.86
/
pp.263-271
/
2005
HPFRCC(High Performance Fiber Reinforced Cementitious Composite) is a class of FRCCs(Fiber Reinforced Cementitious Composites) that exhibit multiple cracking. Multiple cracking leads to improvement in properties such as ductility, toughness, fracture energy, strain hardening, strain capacity, and deformation capacity under tension, compression, and bending. These improved properties of HPFRCCs have triggered unique and versatile structural applications, including damage reduction, damage tolerance, energy absorption, crack distribution, deformation compatibility, and delamination resistance. These mechanical properties of HPFRCCs become different from the kinds and shapes of used fiber, and it is known that the effective size of fiber in macro crack is different from that in micro crack. This paper reports an experimental findings on the mechanical properties of HPFRCCs reinforced with the micro fiber(PP50, PVA100 and PVA200) and macro fiber(PVA660, SF500). Uniaxial compressive tests and three point bending tests are carried out in order to compare with the mechanical properties of HPFRCCs reinforced with micro fibers or hybrid fibers such as compressive strength, ultimate bending stress, toughness, deformation capacity and crack pattern under bending, etc.,
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