• 혜화의학회지
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• 제12권1호
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• pp.11-26
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• 2003

Alzheimer's disease (AD) is characterized by amyloid deposition and associated loss of neunons in brain regions involved in learning and memory processes. Several causes of evidence support that the congnitive disturbance is closed associated with the deficit of cerebral acetylcholine neurotransmission, and the effect of carboxyl terminal 105 amino acid fragment (CT105) of the amyloid precursor protein (APP) on the gene expression of proinflammatory cytokines. We tested it on the scopolamine-induced amnesia model of the ICR mouse using the Morris water maze with repeated orally administration of 1st Green-Tea extract (200 mg/kg) and 2nd Green-Tea extract (200 mg/kg). The Green-Tea prevents impairment of learning and memory and neuronal loss in mouse models of cognitive disturbance and it demonstrated selectivity for inhibition of acetylcholinesterase (AChE). Furthermore, the repeated administration of Green-Tea, CT105-induced alzheimer's mouse model showed central cholinergic activity by ameliorates learning and memory impairment, and isolation of CD14 microglia showed significantly decreases intracellular release of the proinflammatory cytokines tumor necrosis factor-${\alpha}$, interleukin-$1{\beta}$ and reactive oxygen species (ROS). Because of its composite profile, oral therapeutic index and a prophylactic, Green-Tea is considered the better therapeutic candidate for the treatment of Alzheimer's disease.

• Steel and Composite Structures
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• 제22권3호
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• pp.589-611
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• 2016

The primary objectives of this research are to investigate the energy factor response of steel moment resisting frame (MRF) systems equipped with fuses subject to ground motions and to develop an energy-based evaluation approach for evaluating the damage-control behavior of the system. First, the energy factor of steel MRF systems with fuses below the resilience threshold is derived utilizing the energy balance equation considering bilinear oscillators with significant post-yielding stiffness ratio, and the effect of structural nonlinearity on the energy factor is investigated by conducting a parametric study covering a wide range of parameters. A practical transformation approach is also proposed to associate the energy factor of steel MRF systems with fuses with classic design spectra based on elasto-plastic systems. Then, the energy balance is extended to structural systems, and an energy-based procedure for damage-control evaluation is proposed and a damage-control index is also derived. The approach is then applied to two types of steel MRF systems with fuses to explore the applicability for quantifying the damage-control behavior. The rationality of the proposed approach and the accuracy for identifying the damage-control behavior are demonstrated by nonlinear static analyses and incremental dynamic analyses utilizing prototype structures.

• Steel and Composite Structures
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• 제4권6호
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• pp.419-435
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• 2004

The safety level of a structural system designed per code specifications can not be inferred directly from the reliability of members due to the load redistribution and nonlinear inelastic structural behavior. Comparison of the system and member reliability, which is scarce in the literature, is likely to indicate any possible inconsistency of design codes in providing safe and economical designs. Such a comparative study is presented in this study for moment resisting two-dimensional steel frames designed per AISC LRFD Specifications. The member reliability is evaluated using the resistance of the beam-column element and the elastic load effects that indirectly accounts for the second-order effects. The system reliability analysis is evaluated based on the collapse load factor obtained from a second-order inelastic analysis. Comparison of the system and member reliability is presented for several steel frames. Results suggest that the failure probability of the system is about one order of magnitude lower than that of the most critically loaded structural member, and that the difference between the system and member reliability depends on the structural configuration, degree of redundancy, and dead to live load ratio. Results also suggest that the system reliability is less sensitive to initial imperfections of the structure than the member reliability. Therefore, the system aspect should be incorporated in future design codes in order to achieve more reliability consistent designs.

• Steel and Composite Structures
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• 제18권3호
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• pp.623-639
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• 2015

Self-compacting Concrete (SCC) Filled Square steel Tubes (SCFST) was used to strengthen square RC columns. To establish the efficiency of this strengthening method, 17 columns were tested under axial compression loading including 3 RC columns without any strengthening (WRC), 1 RC column strengthened with concrete jacket (CRC), 13 RC columns strengthened with self-compacting concrete filled square steel tubes (SRC). The experimental results showed that the use of SCFST is interesting since the ductility and the bearing capacity of the RC columns are greatly improved. The improvement ratio is significantly affected by the nominal wall thickness of steel tubes (t), the strength grade of strengthening concrete (C), and the length-to-width ratio (L / B) of the specimens. In order to quantitatively analyze the effect of these test parameters on axial loading behavior of the SRC columns, three performance indices, enhancement ratio (ER), ductility index (DI), and confinement ratio (CR), were used. The strength of the SRC columns obtained from the experiments was then employed to verify the proposed mode referring to the relevant codes. It was found that codes DBJ13-51 could relatively predict the strength of the SRC columns accurately, and codes AIJ and BS5400 were relatively conservative.

• Steel and Composite Structures
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• 제22권6호
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• pp.1239-1259
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• 2016

The modified couple stress-based third-order shear deformation theory is presented for sigmoid functionally graded materials (S-FGM) plates. The advantage of the modified couple stress theory is the involvement of only one material length scale parameter which causes to create symmetric couple stress tensor and to use it more easily. Analytical solution for dynamic instability analysis of S-FGM plates on elastic medium is investigated. The present models contain two-constituent material variation through the plate thickness. The equations of motion are derived from Hamilton's energy principle. The governing equations are then written in the form of Mathieu-Hill equations and then Bolotin's method is employed to determine the instability regions. The boundaries of the instability regions are represented in the dynamic load and excitation frequency plane. It is assumed that the elastic medium is modeled as Pasternak elastic medium. The effects of static and dynamic load, power law index, material length scale parameter, side-to-thickness ratio, and elastic medium parameter have been discussed. The width of the instability region for an S-FGM plate decreases with the decrease of material length scale parameter. The study is relevant to the dynamic simulation of micro structures embedded in elastic medium subjected to intense compression and tension.

• Restorative Dentistry and Endodontics
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• 제6권1호
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• pp.123-132
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• 1980

The author conducted a dental survey of a college girl students and compared with that of E college students 10 years ago which based on the same criteria. The items of this survey included the prevalence of dental caries, DMFT and the kinds of restored material. All college students 1,414 were examined in May 1978, with the recommended criteria and method of W.H.O.. Among them, the data of 1,393 were analyzed for this study. The following results were obtained: 1. The average number of present teeth were 28.97${\pm}$1.64. 2. The prevalence of dental caries was 84.92% and D.M.F. index was 15.51. Average D.M.F. teeth were 4.49${\pm}$3.69. 3. The average number of decayed (D) teeth were 2.09${\pm}$2.16. 4.30% of the present decayed teeth was secondary decay, and 2.44% of the decayed teeth was indicated for extraction. 4. The average number of missing(M) teeth were 0.32${\pm}$0.79. It included 8.56% of root fragements. 5. Average number of filled(F) teeth were 2.09${\pm}$3.17. F-ratio of this group was 46.45%. The analysis revealed 50.88% of amalgam alloy, 31.41% of gold inlays, and 1.20%, the least among the filling materials, silicate cement or composite resin. 6. While the prosthodontic treatment, such as crown and bridge has reduced than that of 10 years ago, the fillings and inlays as the conservative means has increased.

• Steel and Composite Structures
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• 제33권2호
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• pp.307-318
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• 2019

This is the first attempt to consider the nonlinear bending analysis of porous functionally graded (FG) thick annular and circular nanoplates resting on Kerr foundation. The size effects are captured based on modified couple stress theory (MCST). The material properties of the porous FG nanostructure are assumed to vary smoothly through the thickness according to a power law distribution of the volume fraction of the constituent materials. The elastic medium is modeled by Kerr elastic foundation which consists of two spring layers and one shear layer. The governing equations are extracted based on Hamilton's principle and two variables refined plate theory. Utilizing generalized differential quadrature method (GDQM), the nonlinear static behavior of the nanostructure is obtained under different boundary conditions. The effects of various parameters such as material length scale parameter, boundary conditions, and geometrical parameters of the nanoplate, elastic medium constants, porosity and FG index are shown on the nonlinear deflection of the annular and circular nanoplates. The results indicate that with increasing the material length scale parameter, the nonlinear deflection is decreased. In addition, the dimensionless nonlinear deflection of the porous annular nanoplate is diminished with the increase of porosity parameter. It is hoped that the present work may provide a benchmark in the study of nonlinear static behavior of porous nanoplates.

• Journal of the Optical Society of Korea
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• 제7권1호
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• pp.20-27
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• 2003

A theoretical presentation of evanescent coupling is offered with respect to the refractive indexes between a side-polished optical fiber and an infinitely planar waveguide with a conductor cladding (PWGCC). The PWG is suspended at a constant distance from an unclad fiber core and attached with the perfect conductor (PEC) on one side. The behavior of the distributed couple. is examined using a coupled mode model, which takes account of the two dimensions of the waveguide configuration. The coupling and propagation of light were found to depend on both the relationship between the refractive index values of each structure and the configuration of the side-polished fiber used in the PWGCC. The spreading of light in the unconfined direction of the PWGCC is described in terms of a simple geometrical interpretation of the synchronization condition that is in agreement with a previous investigation of the problem based on the coupled-mode theory (CMT). The power of the light propagation in the fiber decreased exponentially along the fiber axis as it was transferred to the PWGCC, where it was carried away.

• Journal of Korea Trade
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• 제24권5호
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• pp.35-54
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• 2020

Purpose - It seems common sense that corporate social responsibility (CSR) is a key driver of business sustainability. Nevertheless, there has been little research on the performance of socially responsible activities, including economic and environmentally responsibility activities, in internationally diversified firms. Design/methodology - The purpose of this study was to evaluate the effects of CSR activities on management performance. For this evaluation, an empirical analysis was conducted with total of 2,520 cases, selected from companies listed on the Korea Composite Stock Price Index market for six years from 2013 to 2018. As proxies for management performance, financial data such as a total asset net profit ratio and a total asset operating ratio were used. A multivariate regression analysis was conducted to test hypotheses. Findings - The results of this analysis indicated that firms in the CSR outstanding group were ranked significantly higher than other groups in management performance. In addition, CSR activities of internationally diversified firms positively influenced the total asset net profit ratio and total asset operating ratio. Originality/value - The results suggest that the CSR activities of these firms can play a significant role in enhancing management performance in the economic status of Korea, where the degree of export dependency is high.

• Steel and Composite Structures
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• 제30권6호
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• pp.603-615
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• 2019

In the present work, free vibration of beams made of imperfect functionally graded materials (FGMs) including porosities is investigated. Because of faults during process of manufacture, micro voids or porosities may arise in the FGMs, and this situation causes imperfection in the structure. Therefore, material properties of the beams are assumed to vary continuously through the thickness direction according to the volume fraction of constituents described with the modified rule of mixture including porosity volume fraction which covers two types of porosity distribution over the cross section, i.e., even and uneven distributions. The governing equations of power law FGM (P-FGM) and sigmoid law FGM (S-FGM) beams are derived within the frame works of classical beam theory (CBT) and first order shear deformation beam theory (FSDBT). The resulting equations are solved using separation of variables technique and assuming FG beams are simply supported at both ends. To validate the results numerous comparisons are carried out with available results of open literature. The effects of types of volume fraction function, beam theory and porosity volume fraction, as well as the variations of volume fraction index, span to depth ratio and porosity volume fraction, on the first three non-dimensional frequencies are examined in detail.