• Proceedings of the PSK Conference
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• 2002.10a
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• pp.194-199
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• 2002

Many oxidative metabolites of tetrahydrocannabinols (THCs), active components of marijuana, were pharmacologically active, and 11-hydroxy-THCs, 11-oxo-${\Delta}^8$-THC, 7-oxo-${\Delta}^8$-THC, 8$\beta$, 9$\beta$-epoxyhexahydrocannabinol (EHHC), 9$\alpha$, l0$\alpha$-EHHC and 3'-hydroxy-${\Delta}^9$-THC were more active than THC in pharmacological effects such as catalepsy, hypothermia and barbiturate synergism in mice. Cannabidiol (CBD), another major component, was biotransfomred to two novel metabolites, 6-hydroxymethyl-${\Delta}^9$-THC and 3-pentyl-6, 7, 7a, 8, 9, lla-hexahydro-I, 7-dihydroxy-7, 1O-dimethyldibenzo[b, d]oxepin (PHDO) through 8R, 9-epoxy-CBD and 85, 9-epoxy-CBD, respectively. Both metabolites exhibited some pharmacological effects comparable to d9 - THe. Cannabinol (CBN), the other major component, was mainly metabolized to ll-hydroxy-CBN by hepatic microsomes of animals including humans. The pharmacological effects of the metabolite were higher than those of CBN demonstrating that II-hydroxylation of CBN is metabolic activation pathway of the cannabinoid as is the case in THCs. Tolerance and reciprocal cross-tolerance developed to pharmacological effects d8 - THC and ll-hydroxy-d8-THC , and the magnitude of tolerance development produced by the metabolite was significantly higher than that by d8-THC. The results indicate that ll-hydroxy-d8-THC has an important role not only in the pharmacological effects but also its tolerance development of d8 - THe. THCs and their metabolites competed to the specific binding of CP-55, 940, an agonist of cannabinoid receptor, to synaptic membrane from bovine cerebral cortex. The Ki value of THCs and their metabolites were closely paralleled to their pharmacological effects in mice. A novel cytochrome P450 (cyp2c29) was purified and identified as a major enzyme responsible for the metabolic activation of d8-THC at the II-position in the mouse liver. cDNA of CYP2C29 was cloned from a mouse cDNA library and its sequence was determined. The oxidation mechanism of THC by cyp2c29 was proposed.

• The Korea Journal of Herbology
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• v.30 no.4
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• pp.11-20
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• 2015

Objectives : Ongyeong-tang (OGT) is a traditional herbal formula used to cure gynaecological disorders. OGT consists of 12 herbal medicines containing various bioactive components. Therefore, the development of suitable analytical method for the marker compounds is necessary for the quality control of OGT. Methods : Determination of the 18 marker compounds in OGT preparations was quantitatively performed by high-performance liquid chromatography-photodiode array detection analysis. The marker compounds were separated on a reversed-phase C ₁₈ column and the analytical method was successfully validated, which was applied to compare OGT extracts from laboratory preparation and commercial OGT granules. Results : Limit of detection and limit of quantification values were in the ranges of $0.001-0.016{\mu}g/mL$ and $0.003-0.047{\mu}g/mL$, respectively. Precision was 0.03-3.71 % within a day and 0.03-3.81 % over four consecutive days. Recovery of marker compounds ranged from 90.63-108.26 %, with relative standard deviation (RSD) values < 4.0 %. Reproducibility was < 2.5 % of the RSD value. The 18 marker compounds were stable within 16 h at $10^{\circ}C$, with the RSD value < 3.5 %. Quantitative analysis results showed that the quantities of the 18 marker compounds varied among OGT samples. Pearson coefficient evaluation and principal component analysis demonstrated that an OGT water extract produced by a laboratory method clearly differed from commercial OGT granules. Conclusions : The developed analytical method was simple, precise, and reliable. Therefore, it can be used for the quality assessment of OGT preparations.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.41 no.2
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• pp.142-149
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• 2013

The thrust vector control technique is essential for high maneuverability of unmanned aerial vehicles. In the present study, a multi-component balance was developed to quantitatively evaluate the thrust-vectoring performance of a supersonic rectangular nozzle based on the Coanda coflowing effect. Precise calibration and detailed data analysis were performed during the development. It was found that the cross-talk errors between load cells in the balance were less than 5%, and that the unwanted errors due to high-pressure supply tubes were almost negligible, which contributed to the high accuracy of the present balance design. Some preliminary test results of the thrust-vectoring performance of the present nozzle design were also obtained and analyzed.

• Journal of Navigation and Port Research
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• v.32 no.3
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• pp.207-213
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• 2008

Ship-handling simulation system has been used for maritime traffic safety assessment for harbor and fairway. There exist various environmental conditions under which ship may navigate along a fairway or in harbor. Due to the time and budget limitations, however, ship-handling simulations are usually carried out for very limited number of environmental conditions. In this paper, statistical method for effective and systematic determination of real time simulation conditions is suggested and applied to the maritime traffic safety assessment problems. In the empirical study, the principal component analysis method and the concept of empirical cumulative distribution function are suggested to estimate synthetic navigational difficulty and to select simulation conditions which would impose high difficulty on shiphandling.

• The Journal of Pediatrics of Korean Medicine
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• v.13 no.2
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• pp.1-39
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• 1999

A infancy is the period in that growth and development of man are the most fast and neutrial requirement is the most big on his life. The insufficient neutrition of this period can have bad effect uppon man's whole life health not only physically but also pscychogenically and emotionally. Therefore a proper feeding at a proper time is very important to form the good food behavior and emotional development. The rate of using the commercial weaning food in Korea has gradually increased since 1970 and expected to be more increasing in future. In this paper, I investigate the general weaning status, stneutrial component and material content of infant weaning foods marketing in Korea at present. The material for this study have been collected in the exposition of products and data from manufacturing companies and etc. The conclusion is following. 1. The proper weaning period is from $4{\sim}6$ momth to 12 momth, but recently it is inclined to prolong. 2. In weaning methods, using a spoon is superior to using a bottle in food behavior and neutrial status. 3. The commercial weaning foods have two type, the powder type and formula type, but except gober's, all products marketing in Korea are the powder type and a sort of product is very simple. Therefore it is necessary to develp the more various kind of weaning foods, especially the formula type. 4. In the neutrial component, Son-Sik (flour of grain) cannot be up to international standards and the greater parts of weaning foods have too much suger over the standards.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.32 no.7
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• pp.105-116
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• 2004

The design of pico-/nano-satellites is particularly challenging due to constraints in mass, volume, power, and surface area. An efficient low-cost picosatellite HAUSAT-1 Electrical Power Subsystem (EPS) is developed to supply the power for various loads during the full mission life. This paper addresses design and analysis results of solar arrays, batteries, power conditioning and distribution units. The component selection, manufacturing and test results are presented by considering appropriate development cost and performance. The simulation results of power system are also illustrated, according to operational modes, through energy balance analysis. Finally, the EFS design feasibility is verified by comparing analysis results with functional and environmental test results at the system and component levels, respectively.

• Elastomers and Composites
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• v.47 no.3
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• pp.188-193
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• 2012

The fatigue analysis and lifetime evaluation are very important in design procedure to assure the safety and reliability of the rubber components. Recently, the design, analysis and evaluation technology was required to achieve the high quality, fidelity, reliability of rubber products. However, rubber manufacturing companies of our country have uesd the method of trial and error and experience in the process of a compound mixing, manufacturing and improvement of rubber properties. The objectives of this study are to establish the test methods of rubber material and to make the database of rubber material properties and to evaluate the performance of rubber components and to construct the prediction system of fatigue life. Fatigue lifetime prediction methodology of the rubber component was proposed by incorporating the finite element analysis and fatigue damage parameter from fatigue test.

• Journal of Korea Water Resources Association
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• v.38 no.10 s.159
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• pp.895-906
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• 2005

The diversity of observed hydrologic data and the development of geographic information system leads significant progress for developing distributed runoff models in the world. One of the typical examples is TOPMODEL, but the spatial coverage of its application Is limited on small headwater basins. The purpose of this study attempts to overcome its limitation and consequently develops a semi-distributed TOPMODEL. The developed model is composed of two components: a watershed runoff component for a lumped representation of hydrologic runoff process on the catchment scale and a kinematic wave type hydraulic channel routing component lot routing the catchment outflows. The application basin is the $2,703km^2$ upper Soyang dam site and several daily and hourly events are selected for model calibrations and verifications. The model parameters are estimated on 1990 daily event. The model performance on correlation coefficient between observed and computed flows are above 0.90 for the verification events. It is concluded that the developed model in this study can be used for flood analysis in large drainage basins.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.31 no.6A
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• pp.399-408
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• 2011

Development of smart sensors for structural health monitoring and damage detection has been advanced remarkably in recent years. Nowadays fiber optic sensors, especially fiber Bragg grating (FBG) sensors, have attracted many researchers' interests for their attractive features, such as multiplexing capability, durability, lightweight, electromagnetic interference immunity. In this paper, a damage detection approach of jacket-type offshore structures by principal component analysis (PCA) technique using FBG sensors are presented. An experimental study for a tidal current power plant structure as one of the jacket-type offshore structures was conducted to investigate the feasibility of the proposed method for damage monitoring. It has been found that the PCA technique can efficiently eliminate environmental effects from measured data by FBG sensors, resulting more damage-sensitive features under various environmental variations.

• Cross-Cultural Studies
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• v.35
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• pp.237-268
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• 2014

Examining swear words found in Korean and English, we aim to answer the following two questions: (i) 'What words develop into swear words?' and (ii) 'Why they do?' The utility of a swear word is frequently recognized as intimidation directed towards an opponent, emotional catharsis, and solidarity building among in-group members (Jay 1992, 2000, Kim 1997). We seek to go beyond this simple enumeration of possible functions of swearing and suggest an underlying mechanism at work to explain how these functions are achieved and why only certain types of words are employed in this pursuit. A close examination reveals that a swear word must contain either taboo or sadism as an essential component. Sexual pleasure adds another dimension to the basic components. Thus, if an expression contains a subset of the component set {taboo, sadism, sex} in its semantics, it becomes available for swearing (one of the underlined components must be included in the set). For example, many religiously sacred expressions and words for excretion are common swear words as they violate social and religious taboo. On the other hand, words referring to social minorities are a convenient target for sadism. Furthermore, words describing sexual activity contain all three components, violating social taboo, evoking sadism, and giving the initiator guilty sexual pleasure. A combination of the components can produce an emotional effect called catharsis for the initiator. When directed towards others, these components, especially taboo and sadism, can be exploited as a verbal attack, an intimidation, preceding or replacing a physical attack. However, solidarity building is analyzed as a secondary function of swearing, achieved by sharing a sense of accomplice when in-group members behave badly together, such as violating social taboo and committing sadism.