• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.13
• /
• pp.5417-5421
• /
• 2014

Objectives: The identification of cutaneous T cell lymphoma (CTCL) biomarkers may serve as a predictor of disease progression and treatment response. The aim of this study was to map potential biomarkers in CTCL plasma. Design and Methods: Plasma metabolic perturbations between CTCL cases and healthy individuals were investigated using metabolomics and ultrahigh performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-QTOF/MS). Results: Principal component analysis (PCA) of the spectra showed clear metabolic changes between the two groups. Thirty six potential biomarkers associated with CTCL were found. Conclusions: Based on PCA, several biomarkers were determined and further identified by LC/MS/MS analysis. All of these could be potential early markers of CTCL. In addition, we established that heparin as a nticoagulant has better pre-treatment results than EDTA with the UHPLC-QTOF/MS appraoch.

• The KSFM Journal of Fluid Machinery
• /
• v.13 no.5
• /
• pp.35-42
• /
• 2010

This paper deals with the development of analytical model of a turbocharger and its detail rotordynamic analysis. Two analytical models, which are verified by experimental modal testing, are proposed and the analytical model including rotor shaft extended to compressor and turbine wheel end side is chosen. A rotordynamic analysis includes the critical map, Campbell diagram, stability, and unbalance response, especially nonlinear transient response considering nonlinear fluid film force at bearings. Although the linearized analysis accurately predicts the critical speeds, stability limit, and stability threshold speed, the predicted vibration results are not valid for speeds above the stability threshold speed since the rotor vibrates with a subsynchronous component much larger than the one synchronous with rotor speed. Hence, for operating speed above the stability threshold, a nonlinear transient analysis considering nonlinear fluid film force must be performed in order to accurately predict vibration responses of rotor and guarantee results of analysis.

• Korean Journal of Remote Sensing
• /
• v.27 no.3
• /
• pp.359-367
• /
• 2011

A suitable pan-sharpening method has to be chosen with respect to the used spectral characteristic of the multispectral bands and the intended application. The research on pan-sharpening algorithm in improving the accuracy of image classification has been reported. For a classification, preserving the spectral information is important. Other applications such as road detection depend on a sharp and detailed display of the scene. Various criteria applied to scenes with different characteristics should be used to compare the pan-sharpening methods. The pan-sharpening methods in our research comprise rather common techniques like Brovey, IHS(Intensity Hue Saturation) transform, and PCA(Principal Component Analysis), and more complex approaches, including wavelet transformation. The extraction of matching pairs was performed through SIFT descriptor and Canny edge detector. The experiments showed that pan-sharpening techniques for spatial enhancement were effective for extracting point and linear features. As a result of the validation it clearly emphasized that a suitable pan-sharpening method has to be chosen with respect to the used spectral characteristic of the multispectral bands and the intended application. In future it is necessary to design hybrid pan-sharpening for the updating of features and land-use class of a map.

• Proceedings of the KSEEG Conference
• /
• 1999.04a
• /
• pp.90-93
• /
• 1999

We present a high frequency electromagnetic (EM) inversion scheme for detecting and characterizing a fracture using single-hole data. At high frequencies, say above tens of mega-hertz, since displacement currents cannot be ignored, electrical permittivity as well as electrical conductivity is to be considered together for analyzing the EM scattering data. In this paper, we have developed a three-step inversion scheme to map the fracture and to evaluate its electrical conductivity and permittivity. We performed EM profiling along the z-axis using three-component receivers for each source. The model was excited by a vertical magnetic dipole and the resistant magnetic fields were inverted using the non-linear least-squares method. Background resistivity and permittivity were easily obtained using vertical magnetic fields below 1 MHz and above 10 MHz, respectively. Both the vertical and dipping sheets were successfully mapped using the phase difference between 40 and 41 MHz. The electrical property of the sheet was well resolved using the information obtained in the previous two steps and secondary magnetic fields. Our study shows the potential of imaging the fracture in single-hole survey environment using the high frequency EM method.

• Magazine of the Korean Society of Agricultural Engineers
• /
• v.37 no.3_4
• /
• pp.23-33
• /
• 1995

Geographic data which are difficult to handle by the characteristics of spatial variation and variety turned into a possibility to analyze with tlie computer-aided digital map and the use of Geographic Information System(GIS). The purpose of this study is to develop and apply a GIS application model (GISCELWAB) for the spatial simulation of surface runoff from a small watershed. This paper discribes the modeling procedure and the applicability of the cell water balance model (CELWAB) which calculates the water balance of a cell and simulates surface runoff of watershed simultaneously by the interaction of cells. The cell water balance model was developed to simulate the temporal and spatial storage depth and surface runoff of a watershed. The CELWAB model was constituted by Inflow-Outflow Calculator (JOC) which was developed to connect cell-to-cell transport mechanism automatically in this study. The CELWAB model requests detail data for each component of a cell hydrologic process. In this study, therefore, BANWOL watershed which have available field data was selected, and sensitivity for several model parameters was analyzed. The simulated results of surface runoff agreed well with the observed data for the rising phase of hydrograph except the recession phase. Each mean of relative errors for peak discharge and peak time was 0.21% and2.1 1% respectively. In sensitivity analysis of CELWAB , antecedent soil moisture condition(AMC) affected most largely the model.

• Proceedings of the Safety Management and Science Conference
• /
• 2007.04a
• /
• pp.113-123
• /
• 2007

Through so that accident of semiconductor industry deduces unsafe factor of the person center on unsafe behaviour that incident history and questionnaire and I made starting point that extract very important factor. It served as a momentum that make up base that analyzes factors that happen based on factor that extract factor cause classification for the first factor, the second factor and the third factor and presents model of human error. Factor for whole defines factor component for human factor and to cause analysis 1 stage in human factor and step that wish to do access of problem and it do analysis cause of data of 1 step. Also, see significant difference that analyzes interrelation between leading persons about human mistake in semiconductor industry and connect interrelation of mistake by this. Continuously, dictionary road map to human error theoretical background to basis traditional accidental cause model and modern accident cause model and leading persons. I wish to present model and new model in semiconductor industry by backbone that leading persons of existing scholars who present model of existent human error deduce relation. Finally, I wish to deduce backbone of model of pre-suppression about accident leading person of the person center.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
• /
• v.18 no.4
• /
• pp.335-342
• /
• 2000

This study is to integrate and to analyzegraphic and attribute data in features which should be preceding for the ITS construction. A 1:5000 scale map as a national basemap was used and was checked for feasibility. For the convenience of position confirmation, the analysis component was developed and was linked to addresses. Also, the attribute information was considered on the shortest route, and optimal route was selected by investigating traffic volumes on main crossroads depending on the time zone. The optimal route could be selected by analyzing user's demands, position and statistical data, and the position information could be provided efficiently by combining the graphic information with the land register information.

• Journal of Information Processing Systems
• /
• v.14 no.3
• /
• pp.666-679
• /
• 2018

The discrete wavelet transform (DWT) has good multi-resolution decomposition characteristic and its low frequency component contains the basic information of an image. Based on this, a fragile watermarking using the local binary pattern (LBP) and DWT is proposed for image authentication. In this method, the LBP pattern of low frequency wavelet coefficients is adopted as a feature watermark, and it is inserted into the least significant bit (LSB) of the maximum pixel value in each block of host image. To guarantee the safety of the proposed algorithm, the logistic map is applied to encrypt the watermark. In addition, the locations of the maximum pixel values are stored in advance, which will be used to extract watermark on the receiving side. Due to the use of DWT, the watermarked image generated by the proposed scheme has high visual quality. Compared with other state-of-the-art watermarking methods, experimental results manifest that the proposed algorithm not only has lower watermark payloads, but also achieves good performance in tamper identification and localization for various attacks.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.19 no.2
• /
• pp.501-507
• /
• 2005

Shikonin is a chemically characterized component of traditional herbal medicine, the root of Lithospermum erythrorhizon and has been shown to possess antitumor activities. Here we investigated anticancer potential of shikonin and its possible mechanism of action in LLC cells. Shikonin inhibited the proliferation of LLC cells in a concentration-dependent manner. It was also demonstrated that shikonin induced apoptosis in LLC cells by Annexin V staining and TUNEL staining analysis. Shikonin treatment was caused that decrease of Bcl-2, activation of caspases and cleavage of PARP. And shikonin also induced that the activation of mitogen-activated protein kinases (MAPKs), such as extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and p38. Interestingly, the cell proliferation inhibition induced by shikonin was recovered by specific inhibitors of JNK and p38 but the inhibitor of MEK, the upstream kinase of ERK, did not recover. Additionally, shikonin administration at doses of 5 mg/kg in C57BL/6 mice strongly inhibited the primary tumor growth of LLC. Taken together, these results suggest that shikonin may suppress LLC cell proliferation by inducing an apoptotic process via activation of caspases and MAPKs

• Journal of Korea Multimedia Society
• /
• v.19 no.8
• /
• pp.1310-1319
• /
• 2016

Face detection is the first step in a wide range of face applications. However, detecting faces in the wild is still a challenging task due to the wide range of variations in pose, scale, and occlusions. Recently, many deep learning methods have been proposed for face detection. However, further improvements are required in the wild. Another important issue to be considered in the face detection is the computational complexity. Current state-of-the-art deep learning methods require a large number of patches to deal with varying scales and the arbitrary image sizes, which result in an increased computational complexity. To reduce the complexity while achieving better detection accuracy, we propose a fully convolutional network-based face detection that can take arbitrarily-sized input and produce feature maps (heat maps) corresponding to the input image size. To deal with the various face scales, a multi-scale network architecture that utilizes the facial components when learning the feature maps is proposed. On top of it, we design multi-task learning technique to improve detection performance. Extensive experiments have been conducted on the FDDB dataset. The experimental results show that the proposed method outperforms state-of-the-art methods with the accuracy of 82.33% at 517 false alarms, while improving computational efficiency significantly.