• Proceedings of the KSAR Conference
• /
• 2001.10a
• /
• pp.14-17
• /
• 2001

Positional cloning (map-based cloning) of mutations or genetic variations has been served as an invaluable tool to understand in-vivo functions of genes and to identify molecular components underlying phenotypes of interest. Mice homozygous for the cerebellar deficient folia (cdf) mutation are ataxic, with cerebellar hypoplasia and abnormal lobulation of the cerebellum. In the cdf mutant cerebellum approximately 40% of Purkinje cells are ectopically located within the white matter and the inner granule cell layer (IGL). To identify the cdf gene, a high-resolution genetic map for the cdf-gene-encompassing region was constructed using 1997 F2 mice generated from C3H/HeSnJ-cdf/cdf and CAST/Ei intercross. The cdf gene showed complete linkage disequilibrium with three tightly linked markers D6Mit208, D6Mit359, and D6Mit225. A contig using YAC, BAC, and P1 clones was constructed for the cdf critical region to identify the gene. A deletion in the cdf critical region on chromosome 6 that removes approximately 150kb of DNA was identified. A gene associated with this deletion was identified using cDNA selection. cdf mutant mice with the transgenic copy of the identified gene restored the brain abnormalities of the mutant mice. The positional cloning of cdf gene provides a good example showing the identification of a gene could lead to finding a new component of important molecular pathways.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
• /
• v.25 no.3
• /
• pp.229-235
• /
• 2012

This paper dealt with the fabrication of a partial discharge (PD) analyzer for insulation diagnosis of power facilities like transformers, cables and gas-insulated switchgears. An analytic algorithm for the phase (${\phi}$), the magnitude (q), and the pulse count (n) of PD pulse was designed and a time-frequency (TF) map algorithm was applied in the system to eliminate noises by analyzing the time and the frequency component of signals. All the algorithms were operated by a LabView graphical program. The detection circuit consists of a coupling capacitor, a detection impedance, and a low noise amplifier. A plane-plane and a point-plane electrode system were fabricated to simulate different types of insulation defects. In the experiment, we could easily understand the characteristics of PD pulses using the prototype PD analyzer.

• The Journal of the Korea Contents Association
• /
• v.3 no.4
• /
• pp.23-28
• /
• 2003

This paper describes, in order to extract contour from topographic map image, an adaptive segment-length thresholding using a threshold depended on target image. First of all, after recognizing the primary symbols and detecting two edges from the projection histogram of the elevation value area, the threshold value is determined by the distance between the edges. Then, the subdivision is peformed by searching a branch point and erasing its neighboring Hack pixels. And contour components are extracted by segment-length thresholding. The experimental result shows that the final image contains non-contour component of 2.41% and contour one of 97.59%.

• The Journal of Korean Association of Computer Education
• /
• v.9 no.2
• /
• pp.101-109
• /
• 2006

We propose an adaptive digital watermarking algorithm using HVS(human visual system) and SOM(Self-Organizing Map) among neural networks. This method adjusts adaptively the strength of the watermark which is embedded in different blocks according to block classification in DCT(Discrete Cosine Transform) domain. All blocks in 3 classes out of 4 are selected to embed a watermark. Watermark sequences are embedded in 6 lowest frequency coefficients of each block except the DC component. The experimental results are excellent.

• Transactions of the Korean Society of Automotive Engineers
• /
• v.11 no.5
• /
• pp.170-175
• /
• 2003

A control algorithm is developed for highly efficient operation of auxiliary power unit (APU) that consists of a diesel engine and a directly coupled induction generator in series hybrid electric Bus (SHEB). In a series hybrid configuration the APU supplies the electric power needed for maintaining the state of charge (SOC) of the battery unit in various conditions of vehicle operation. As the rotational speed of generator does not depend on the vehicle speed, an optimized operation of engine-generator unit based on the efficiency map of each component can be achieved. The output torque of diesel engine can be controlled by the amount of fuel injection, and the power converted from mechanical to electrical energy can be adjusted by generate control unit (GCU) using the decoupling vector control of torque and flux. As for the given reference of the generating power, the multiply of speed and torque, many combinations of operating speed and torque are possible. The algorithm decides the new operating point based on the engine efficiency map and generator characteristic curve. During the transition of operating points, the speed controller saturation is avoided using variable limit and filtering of generator torque reference. A test rig and SHEB consist of a 1.5L diesel engine and a 30kw induction generator are constructed by Hyundai Motor Company.

• International Journal of Computer Science & Network Security
• /
• v.21 no.7
• /
• pp.8-16
• /
• 2021

The tourism industry is influenced by a large number of factors that affect the development scenarios of the tourism in different ways. At the same time, tourism is an important component of the national economy of any state, forms its image, investment attractiveness, is a source of income and a stimulus for business development. The aim of the article is to conduct an empirical study to identify the importance of cognitive determinants in the development of tourism. The study used general and special methods: systems analysis, synthesis, grouping, systematization, cognitive modeling, cognitive map, pulse method, predictive extrapolation. Target factors, indicators, and control factors influencing the development of tourism in Ukraine are determined and a cognitive model is built, which graphically reflects the nature of the influence of these factors. Four main scenarios of the Ukrainian tourism industry are established on the basis of creating a matrix of adjacency of an oriented graph and forecast modeling based on a scenario approach. The practical significance of the obtained results lies in the possibility of their use to forecast the prospects of tourism development in Ukraine, the definition of state policy to support the industry that will promote international and domestic tourism.

• New & Renewable Energy
• /
• v.16 no.4
• /
• pp.33-40
• /
• 2020

The research topics of more than 1,900 wind energy papers registered in the Korean Journal Citation Index (KCI) were modeled into 25 topics using latent directory allocation (LDA), and their consistency was cross-validated through principal component analysis (PCA) of the document word matrix. Key research topics in the wind energy field were identified as "offshore, wind farm," "blade, design," "generator, voltage, control," 'dynamic, load, noise," and "performance test." As a new method to determine the similarity between research topics in journals, a systematic evaluation method was proposed to analyze the correlation between topics by constructing a journal-topic matrix (JTM) and clustering them based on topic similarity between journals. By evaluating 24 journals that published more than 20 wind energy papers, it was confirmed that they were classified into meaningful clusters of mechanical engineering, electrical engineering, marine engineering, and renewable energy. It is expected that the proposed systematic method can be applied to the evaluation of the specificity of subsequent journals.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• v.17 no.1
• /
• pp.165-184
• /
• 2023

The ARX-based lightweight block cipher is widely used in resource-constrained IoT devices due to fast and simple operation of software and hardware platforms. However, there are three weaknesses to ARX-based lightweight block ciphers. Firstly, only half of the data can be changed in one round. Secondly, traditional ARX-based lightweight block ciphers are static structures, which provide limited security. Thirdly, it has poor diffusion when the initial plaintext and key are all 0 or all 1. This paper proposes a new dynamic ARX-based lightweight block cipher to overcome these weaknesses, called DABC. DABC can change all data in one round, which overcomes the first weakness. This paper combines the key and the generalized two-dimensional cat map to construct a dynamic permutation layer P1, which improves the uncertainty between different rounds of DABC. The non-linear component of the round function alternately uses NAND gate and AND gate to increase the complexity of the attack, which overcomes the third weakness. Meanwhile, this paper proposes the round-based architecture of DABC and conducted ASIC and FPGA implementation. The hardware results show that DABC has less hardware resource and high throughput. Finally, the safety evaluation results show that DABC has a good avalanche effect and security.

• Journal of the Korean Association of Geographic Information Studies
• /
• v.4 no.3
• /
• pp.41-50
• /
• 2001

Recently our nature of environment has destroyed by a large scaled forest fire. In order to manage these forest fires, forecasting of it is considered as the most important thing. In this paper the database related to forest fire was first built and the efficient forest fire information management system was implemented by using GIS. The main goal of this system is that forest fire managers have GUI(graphic user interface) to analyze data of forest fire effectively and update and retrieve information in database. For the efficient GUI, this system is built in Visual Basic 6.0 and Map Object 2.0. Map Object 2.0 is combined to have various and powerful functionality of GIS analysis as component ware. The Oracle 8.0 is used as DBMS in this study to manage all the spatial and attributed information in database effectively. In the future, this system will play a critical role as making a decision supporting system for scientific forest fire protection and help real time forest fire hazard information offers service for public welfare administration business management.

• Journal of Acupuncture Research
• /
• v.18 no.4
• /
• pp.101-115
• /
• 2001

Objective : To characterize the antitumorigenic potential of Apamin, one of the major components of bee venom, its effects on cell proliferation and the mitogen-activated protein kinase (MAPK) signal transduction pathway were characterized using the human melanoma cell line SK-MEL-2. Methods & Results : Cell counting analysis for cell death demonstrated that consistent with a previous results, SK-MEL-2 cells treated with $0.5-2.0{\mu}g/ml$ of Apamin showed no recognizable cytotoxic effect whereas detectable induction of cell death was identified at concentrations over $5.0{\mu}g/ml$. [3H]thymidine incorporation assay for cell proliferation demonstrated that DNA replication of SK-MEL-2 cells is inhibited by Apamin in a dose- and time-dependent manner. To explore whether Apamin-induced growth suppression is associated with the MAPK signaling pathway, phosphorylation of Erk, a function mediator of MAPK growth-stimulating signal, was examined Western blot assay using a phospho-specific Erkl/2 antibody. A significant increase of Erkl/2 phosphorylation level was observed in Apamin-treated cells compared with untreated control cells. Qantitative RT-PCR analysis revealed that Apamin inhibit expression of MAPK downstream genes such as c-Jun, c-Fos, and cyclin D1 but not expression of MAPK pathway component genes including Ha-Ras, c-Raf-1, MEK1, and Erk. Conclusion : It is strongly suggested that the antitumorigenic activity of Apamin might result in part from its inhibitory effect on the MAPK signaling pathway in human melanoma cells SK-MEL-2.