• International Journal of Vascular Biomedical Engineering
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• v.1 no.1
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• pp.41-47
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• 2003

The patency rates of small diameter vascular grafts are disappointing because of the formation of thrombus and intimal hyperplasia. Among the various factors influencing the success of graft surgery, the compliance and the size of a graft are believed to be the most important physical properties of a vascular graft. Mismatch of compliance and size between an artery and a graft alters anastomotic flow characteristics, which may affect the formation of intimal hyperplasia. Among the hemodynamic factors influencing the development of intimal hyperplasia, the wall shear stress is suspected as the most important one. The wall shear stress distributions are experimentally measured near the end-to-end anastomosis models in order to clarify the effects of compliance and diameter mismatch on the hemodynamics near the anastomosis. The effects of radial wall motion, diameter mismatch and impedance phase angle on the wall shear rate distributions near the anastomosis are considered. Compliance mismatch generates both different radial wall motion and instantaneous diameter mismatch between the arterial portion and the graft portion during a flow cycle. Mismatch in diameter seems to be affecting the wall shear rate distribution more significantly compared to radial wall motion. The impedance phase angle also affects the wall shear rate distribution.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2003.06a
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• pp.1302-1305
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• 2003

In this paper we analyzed the effect of compliance mismatch with respect to the thickness variation of elastic foundation(fatty tissue) in end-to-end anastomosis. This study considered the preliminary deformed shape induced by suturing in the anastomosis of coronary artery and PTFE with different diameters using simplified suturing model and the fatty tissue surrounding heart and coronary artery for more accurate result using finite element method. Area compliance(C$\sub$A/) was used to analyze the final deformed shape of the anastomotic part with respect to the thickness variation of fatty tissue under mean blood pressure, 100 mmHg(13.3kPa). The results obtained were as follows : 1. When the elastic foundation, assumed to be incompressive material, surrounded the grafts in anastomosis, the compliance mismatch of artery and PTFE was improved by 47∼72%. 2. As the initial diameter ratio(R$\sub$I/) became larger, the higher difference of compliance was induced in spite of elastic foundation surrounding grafts.

• Journal of Biomedical Engineering Research
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• v.13 no.2
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• pp.165-174
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• 1992

Compliance mismatch across an end-to-end anastomosis was measured In the In vitro experimental setup. A 35mm camera was used and Image process was done in Gould/ DeAnza Image processor. The results showed that compliances of Penrose tubing and synthetic PTFE grafts were In good agreement with the previously reported In vivo data. PTFE grafts exhibited a nonlinear behavior with compliance decreasing with Increasing transmural pressure, whereas the compliance of the Penrose tubing remained relatively constant within the range of the pressures in which data were obtained. The lumen cross sections at the anastomosis were affected by the suture and the mismatch In compliance between the Penrose tubing and vascular grafts. The varla~lons In the lumen dtameter at the anastomosis was more pronounced with increasing transmural pressures. From the present study, it was clearly demonstrated that the compliance of prosthetic grafts Is much lower than that of the arteries. In addition to the hemodynamlc consequences, compliance mismatch across the anastomosis has been known to lead to Increased anastomotlc and suture stresses with resultant suture line dehlscence and false aneurysm formation. Thus, there are good hemodynamic reasons to suppose that Introduction of a less compliant arterial graft Into the arterial circulation wlll be damaging and that grafts should be made to match the elastic behavior of their host arteries as closely possible.

• Journal of Biomedical Engineering Research
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• v.15 no.2
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• pp.143-150
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• 1994

Wall shear rate or stress is believed to be a major hemodynamic variable influencing atherosclerosis and artery-graft anastomic intimal hyperplasia. The purpose of this study is to verify the effects of radial wall motion, artery-graft compliance and diameter mismatch, and impedance phase angle on the wall shear rate distribution near an end-to-end artery-graft anastomosis model. The results show that radial wall motion of the elastic artery model lowers the mean wall shear rates under pulsatile flow condition by 15 to 20 % comparing to those under steady flow condition at the same mean flow rate. Impedance phase angle seems to have small effects on the mean and amplitude of the wall shear rate distribution. In order to study the effects of compliance and diameter mismatch on the wall shear rates, two models are studied-Model I has 6% and Model I has 6% and Model II has 11% smaller graft diameter. Divergent geometry caused by diameter mismatch near the distal sites reduces the mean wall shear rates significantly, and this low shear region is believed to be prone to intimal hyperplasia.

• Proceedings of the KSME Conference
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• 2001.11a
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• pp.442-447
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• 2001

A finite element analysis of end-to-end artery/PTFE anastomosis has been presented in this study to evaluate the distribution of compliance in the vicinity of the anastomosis due to any mismatch in compliance characteristics. But, In these studies it was assumed that the artery and PTFE have the simple cylindrical shape representing the fatty tissue surrounding the coronary artery. And the fatty tissue was considered as the elastic surrounding materials in the finite element analysis. The simulation results were obtained as follows : 1. A fatty tissue was effect to reduce the compliance mismatch in the vicinity of a artery/PTFE anastomosis of different material because a hypercompliant zone become narrorw and a compliance discrepancy decrease between the artery and the PTFE about 70%. And radial direction displacement distribution with respect to distance in the vicinity of a artery/PTFE anastomosis was similiar. 2. The variation of PTFE thckness reduce the compliance mismatch in the vicinity of a artery/PTFE anastomosis about 25%.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.27 no.1
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• pp.34-41
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• 2003

Finite element analysis of end-to-end artery/PTFE anastomosis recently have been researched. But, these studies were carried out without the compensation for the error of finite element analysis and assumed the artery and PTFE as the simple cylindrical shape in spite of being the fatty tissue which covers the heart. Therefore, we performed the convergency study with respect to increasing the element numbers and considered the fatty tissue as the elastic foundation in the finite element analysis. The results are as fallow ： 1. An anastomosis with the thinner thickness and larger diameter PTFE than artery could reduce the compliance disagreement. 2. A fatty tissue was affected to reduce the compliance mismatch in the vicinity of anastomosis of different material. Therefore a hypercompliant zone become narrorw and a compliance discrepancy decrease between the artery and the PTFE about 70%. And radial displacement with respect to longitudinal direction of an artery and the PTFE anastomosis was similar to a sectional compliance.

• Journal of the Korean Society for Precision Engineering
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• v.21 no.8
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• pp.188-195
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• 2004

In this paper we analyzed the mechanical behavior with respect to the thickness variation of elastic foundation(fatty tissue) in end-to-end anastomosis. This study considered the preliminary deformed shape induced by suturing in the anastomosis of coronary artery and PTFE with different diameters using simplified suturing model and the fatty tissue surrounding heart and coronary artery for more accurate result using finite element method. Area compliance(CA) was used to analyze the final deformed shape of the anastomotic part with respect to the thickness variation of fatty tissue under mean blood pressure, 100mmHg(13.3㎪). And Equivalent and circumferential stresses in the anastomosis were also analyzed with respect to the change of initial diameter ratio( $R_1$) and fatty tissue thickness( $T_{F}$). The results obtained were as follows : 1 When the elastic foundation, assumed to be incompressive material, surrounded the grafts in anastomosis, the compliance mismatch of artery and PTFE was reduced by 47 -72%. 2. As the initial diameter ratio( $R_1$) became larger, the higher difference of compliance was induced in spite of elastic foundation surrounding grafts. 3. The maximum nondimensional circumferential stress is twice or three times as high as the maximum nondimensional equivalent stress in the anastomotic part.t.

• Journal of Biomedical Engineering Research
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• v.20 no.5
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• pp.593-599
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• 1999

수축절정기에 0.2mm, 0.4mm 두께의 소구경 인조혈관의 내경3.2mm의 동맥에 문합한 단단문합 주위의 유동과 구조해석을 동시에 수행하였다. 유동해석 결과 속도분포 및 벽단전률은 타 연구결과와 매우 유사하며 이론해와 매우 유사함을 보였다. 유동에 의해서 문합부 주위에 작용하는 응력은 문합부에 집중되며 이는 수십만 pa에 달했다. 또한 인조혈관과 동맥에 작용하는 원주방향의 응력을 이론해와 비교한 결과 서로 유사함을 보였으며 두께가 얇은 인조혈관을 사용하는 경우 문합부의 compliance mismatch 는 개선되나 반대로 응력은 더 많이 받음을 알 수 있었다. 본 연구를 통해서 유체에 의하여 혈관이 영향을 받는 심혈관계 현상을 연구하는데 있어서 이와 같은 유체-구조 상호작용을 고려하여 동시에 해결 하는 방법은 매우 유용할 것으로 생각된다.

• Journal of the Korean Society for Precision Engineering
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• v.20 no.2
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• pp.192-198
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• 2003

A finite element analysis of end-to-end artery/PTFE anastomosis has been presented in this study to evaluate the distribution of compliance and stresses in the vicinity of the anastomosis due to any mismatch in compliance characteristics. The artery wall was assumed to be made of linear isotropic material in this simplified model and a nonlinear analysis and convergency study with respect to increasing meshed element numbers were performed with a mean artery pressure loading of the artery-PTFE model. Also, sub-modeling method was Introduced to progress the accuracy of the finite element analysis. The results are as follow : 1. A hypercompliant zone on the artery side was observed around 4.Omm from the anastomosis and a high hoop stresses in the wall of artery and PTFE was dominant. 2. An artery displays large deformation so that nonlinear analysis and sub-modeling method was used. 3. An anastomosis with the thinner thickness and larger diameter PTFE (B type) could reduce the compliance disagreement.

• Proceedings of the KSME Conference
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• 2001.06a
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• pp.877-882
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• 2001

A finite element analysis of end-to-end artery/PTFE anastomosis has been presented in this study to evaluate the distribution of compliance and stresses in the vicinity of the anastomosis due to any mismatch in compliance characteristics. The artery wall was assumed to be made of linear isotropic material in this simplified model and a nonlinear analysis and convergency study with respect to increasing meshed element numbers were performed with a mean artery pressure loading of the artery-PTFE model. Also, sub-modeling method was introduced to progress the accuracy of the finite element analysis. The results are as follow : 1. A hypercompliant zone on the artery side was observed around 4.0mm from the anastomosis and a high hoop stresses in the wall of artery and PTFE was dominent. 2. An artery displays large deformation so that nonlinear analysis and sub-modeling method was used. 3. An anastomosis with the thinner thickness and larger diameter PTFE (C type) could reduce the compliance disagreement.