• Molecules and Cells
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• v.43 no.2
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• pp.182-187
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• 2020

When cells are stimulated by growth factors, they make a critical choice in early G₁ phase: proceed forward to S phase, remain in G₁, or revert to G₀ phase. Once the critical decision is made, cells execute a fixed program independently of extracellular signals. The specific stage at which the critical decision is made is called the restriction point or R-point. The existence of the R-point raises a major question: what is the nature of the molecular machinery that decides whether or not a cell in G₁ will continue to advance through the cell cycle or exit from the cell cycle? The R-point program is perturbed in nearly all cancer cells. Therefore, exploring the nature of the R-point decision-making machinery will provide insight into how cells consult extracellular signals and intracellular status to make an appropriate R-point decision, as well into the development of cancers. Recent studies have shown that expression of a number of immediate early genes is associated with the R-point decision, and that the decision-making program constitutes an oncogene surveillance mechanism. In this review, we briefly summarize recent findings regarding the mechanisms underlying the context-dependent R-point decision.

• The Korean Journal of Health Service Management
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• v.13 no.3
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• pp.127-136
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• 2019

Objectives: This study examined the determinants of quality of life, depending on the presence or absence of asthma in adults, based on secondary wave data. Methods: Among the 21,724 people participating in the 6th Korea National Health and Nutrition Examination Survey as it was conducted from the first to third period, 495 participants who were aged 19 or older and responded to the question of the presence or absence of asthma were included in the final analysis. Demographic characteristics were examined using the SPSS/WIN 23.0 software tool for analysis of complex sample survey data. Health-related characteristics were presented using descriptive and multivariate analysis of data. Rao_Scott ${\chi}^2$ was used for the analysis of differences in quality of life, and multiple regression analysis of complex sample survey data was used to analyze factors affecting quality of life. Results: The variable factors negatively influencing quality of life were aging, cognition of their ill health, and limited activities. Conclusions: Based on the analysis, the study suggests that practical and ongoing nursing intervention proposals to improve the quality of life of asthmatic patients should be implemented not only for physical limitations and aging but also for psychological factors that reflect subjective health statuses.

• Journal of Science and Technology Studies
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• v.13 no.1
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• pp.41-76
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• 2013

Based on an analysis of the Japanese animation director Kamiyama Kenji's Ghost in the Shell: Stand Alone Complex series, this paper discusses two important subjects in modern technoscience-cyborg and old age. In fact, age has been an important social and political category in the modern world, along with gender, race, and class. However, age has not been a significant research topic for STS scholars. Even though many of these investigators have extensively explored the complex relationship between gender and technoscience, especially after the publication of Donna Haraway's "Cyborg Manifesto" (1991), few of them have been interested in how age is reconfigured by modern science and technology. If women, as Haraway has claimed, can have a different political and cultural outlook by becoming cyborgs, then, can we expect a similar socio-cultural transformation with regard to the interaction between cyborg and old age? Do the elderly experience lesser age discrimination through the growth of biomedicine and technoscience? Indeed, it is believed that seniors are increasingly becoming cyborgs with advancing age, since their declining bodily functions are consistently replaced and assisted by various biomedical technologies. Does this enable them to overcome ageism and age discrimination as well as their alleged physiological and mental limitations? As an answer to this question, Mike Featherstone has asserted that becoming a cyborg in old age could make the wrinkled skin a mere mask and create diverse new possibilities that were hitherto unavailable to an aging person. Based on my reading of Ghost in the Shell, however, I analyze a more complex set of problems when the senile cyborg is created through the encounter between the elderly and technoscience. I argue that while the senile cyborg could challenge traditional family ideology and nationalism it would leave ageism intact and define a new individualistic life form through a body controlled within the globalized internet and capitalist economy.

• KIEAE Journal
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• v.13 no.6
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• pp.23-28
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• 2013

Green Standard for Energy and Environmental Design(G-SEED) has been used for environmental friendly building certification since 2002. The certification criteria initialed with multi-residential building and now it expands to 10 criteria for new and existing building types. The purpose of this study is to understand current recognition of G-SEED from the survey of multi-complex residences in newtown. From the general question, 75.2% of responders answered the period of living term between 1~3 years, 58.6% lived in $102.48{\sim}132.23m^2$ residential area and 65.2% owned their residences. The 43.2% of respondents recognized that their residences gained G-SEED certification by G-SEED emblem(31.6%). This is the significant meaning to understand public recognition of G-SEED and how to approach the strategy for raising the G-SEED recognition. The responders expected positive influence for economical value from G-SEED and also 75.3% of responders agreed with that G-SEED would be a decision make to buy and rent their residences. Second, residents responded that the consideration issue for green building is energy & prevention of environmental pollution(27.7%) which carries equal concern in G-SEED criteria category. The result of this survey verifies that the current level recognition of G-SEED of the responder's perspectives still is not well-known but it confirmed they have a positive expectation. Therefore, from this result, G-SEED needs to draw road map with detail plans for developing G-SEED with public participation.

• International Neurourology Journal
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• v.22 no.4
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• pp.260-267
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• 2018

Purpose: A major question remaining in approaches to tissue engineering and organ replacement is the role of native mobilized native cells in the regeneration process of damaged tissues and organs. The goal of this study was to compare the cell mobilizing effects of the chemokine CXCL12 and cell therapy on the urinary sphincter of nonhuman primates (NHP) with chronic intrinsic urinary sphincter dysfunction. Methods: Either autologous lenti-M-cherry labeled skeletal muscle precursor cells (skMPCs) or CXCL12 were injected directly into the sphincter complex of female NHPs with or without surgery-induced chronic urinary sphincter dysfunction (n=4/treatment condition). All monkeys had partial bone marrow transplantation with autologous lenti-green fluorescent protein (GFP) bone marrow cells prior to treatment. Labeled cells were identified, characterized and quantified using computer-assisted immunohistochemistry 6 months posttreatment. Results: GFP-labeled bone marrow cells (BMCs) were identified in the bone marrow and both BMCs and skMPCs were found in the urinary sphincter at 6-month postinjection. BMCs and skMPCs were present in the striated muscle, smooth muscle, and lamina propria/urothelium of the sphincter tissue. Sphincter injury increased the sphincter content of BMCs when analyzed 6-month postinjection. CXCL12 treatment, but not skMPCs, increased the number of BMCs in all layers of the sphincter complex (P<0.05). CXCL12 only modestly (P=0.15) increased the number of skMPCs in the sphincter complex. Conclusions: This dual labeling methodology now provides us with the tools to measure the relative number of locally injected cells versus bone marrow transplanted cells. The results of this study suggest that CXCL12 promotes mobilization of cells to the sphincter, which may contribute more to sphincter regeneration than injected cells.

• International Journal of Computer Science & Network Security
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• v.21 no.7
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• pp.63-69
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• 2021

Flipped learning is necessary for modern education but quite difficult to implement. In pedagogical science, the question remains to what extent the practical work of the teacher in combination with the technologies of flipped learning will improve the quality of higher education. The aim of this article is to study the effectiveness and feasibility of using flipped learning technologies, assessing their perception by students (advantages and problems), identified an algorithm for introducing flipped learning technology in higher education institutions. Research methods. The main method is an experiment. An evaluation of the effectiveness of the study was conducted using a questionnaire and observation method. Statistical methods were used to evaluate the results of the experiment. The research hypothesis is that flipped learning allows the teacher to spend more time on an individual approach, to understand the real needs of students, and provide effective feedback, thereby improving the quality of learning and motivation of students, especially while studying complex material. The results of the study are to prove the effectiveness of the technology of flipped education in the study of complex disciplines, courses, topics. The use of flipped learning strategies improves the self-regulation of the educational process, group work skills, improves students' ability to learn, overcome difficulties. The technology of flipped learning in the presence of modern technical means and constant work on improving the level of digital literacy is an effective means for students to master complex topics and problematic issues that require additional consideration and discussion. The perspective of further research is the consideration of integrated approaches to the application of flipped learning technologies to the principles of STEAM-education, multilingual and multicultural programs, etc. It is also worth continuing to develop a set of methods aimed at enhancing the student's learning activities, the formation of group work skills, direct participation in creating the foundations of higher education.

• Smart Structures and Systems
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• v.30 no.3
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• pp.333-338
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• 2022

Planning activity is complex process assuming the term "complexity" as a group of elements interconnected each other. The common knowledge about city planning underlines its main aim as: figuring the present, imaging the future, governing every day the territory and the way people use and live it at different scales. When considering the strength of technological opportunities and the spreading of ICT and IoT devices within everyday life, that mean within the life of cities, the complex nature of the urban system increases with the intensification of information and their connections. Recent orientations about urban and regional planning try to carry the discipline to a more flexible approach in respect to the hyperdeterminant role of direct technical applications. This passage is a fundamental aspect considering the faster and faster modifications of social and economic assets at the global and local scale. At the same time, the "environment question" became more and more relevant at the worldwide scale within the 2015 UN 2030 Agenda for Sustainable Development. Another relevant aspect about the recent urban planning orientations regards the role of the different subjects that are part of the planning process. Approaching the government of smart cities means to define how every subject, with different roles (public or private), could enrich the knowledge of the functioning of the "urban machine" and the awareness of participation of people and city users in the quality of urban life. In the paper author starts defining recent approaches in urban planning, then the nature of the city as a complex system is analyzed from the point of view of planners and of the different subjects that act in the city. Then the smart city is introduced as a further level of complexity and finally author propose the basic element of a Planning Support System.

• The Bulletin of The Korean Astronomical Society
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• v.46 no.2
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• pp.37.3-38
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• 2021

One of the key questions on star formation is how the organic molecules are synthesized and delivered to the planets and comets since they are the building blocks of prebiotic molecules such as amino acid, which is thought to contribute to bringing life on Earth. Recent astrochemical models and experiments have explained that complex organic molecules (COMs; molecules composed of six or more atoms) are produced on the dust grain mantles in cold and dense gas in prestellar cores. However, the chemical networks and the roles of physical conditions on chemistry are not still understood well. To address this question, hot (> 100 K) cores in high mass young stellar objects (M > 8 Msun) are great laboratories due to their strong emissions and larger samples than those of low-mass counterparts. In addition, CH₃OH masers, which have been mostly found in high mass star forming regions, can provide constraints due to their very unique emerging mechanisms. We investigate twelve high mass star forming regions in ALMA band 6 observation. They are associated with 44/95 GHz Class I and 6.7 GHz Class II CH3OH masers, implying that the active accretion processes are ongoing. For these previously unresolved regions, 66 continuum peaks are detected. Among them, we found 28 cores emitting COMs and specified 10 cores associated with 6.7 GHz Class II CH3OH masers. The chemical diversity of COMs is found in cores in terms of richness and complexity; we identified up to 19 COMs including oxygen- and nitrogen-bearing molecules and their isotopologues in a core. Oxygen-bearing molecules appear to be abundant and more complex than nitrogen-bearing species. On the other hand, the COMs detection rate steeply grows with the gas column density, which can be attributed to the effective COMs formation in dense cores.

• Journal of Agricultural Extension & Community Development
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• v.10 no.1
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• pp.77-85
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• 2003

Globalization and the WTO agenda have aggravated socioeconomic problem in rural Koreas. People think that agriculture is out-of-data industry and rural areas lose their vitality. The main question is: What will be the future of the rural areas? Rural tourism is perhaps one of the solution that help improve the situation in rural areas. Rural tourism is however a complex notion and difficult to implement. This paper is an exploratory study of rural tourism and its application. The objective of this study is 1) to explore the idea of rural tourism, 2) to analyze the planning process, and 3) to examine the application of rural tourism in Mundangri, as a study case.

• Journal of Contemporary Eastern Asia
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• v.12 no.2
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• pp.19-34
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• 2013

Previous research assessed media reporting on nuclear accidents and risks, whilst studies about the Fukushima accident focused on the impact of the Internet on coverage of the incident. However, little research has addressed news framing or comparisons of the perceptions of journalists in relation to reporting nuclear accidents. The aim of this study is to apply framing analysis to news content in The New York Times, the Los Angeles Times, and USA Today about the Fukushima accident. It explores the question of how journalists view reporting on complex events. Content analysis of these three newspapers shows that conflict, responsibility, and economic consequences were the most frequently used frames. According to the journalists interviewed, the biggest problem was the inability to assess information due to contrary positions held by experts. It is argued that the Fukushima accident was framed as a conflict of experts and officials' opinions, utility and government officials' responsibility, and economic consequences for the United States. Adherence to professional norms of objectivity and impartiality was signified as the best approaches to risk reporting.