• 한국발생생물학회:학술대회논문집
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• 한국발생생물학회 2003년도 제3회 국제심포지움 및 학술대회
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• pp.7-8
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• 2003

Since it was first reported in 1997, somatic cell cloning has been demonstrated in several other mammalian species. On the mouse, it can be cloned from embryonic stem (ES) cells, fetus-derived cells, and adult-derived cells, both male and female. While cloning efficiencies range from 0 to 20%, rates of just 1-2% are typical (i.e. one or two live offspring per one hundred initial embryos). Recently, abnormalities in mice cloned from somatic cells have been reported, such as abnormal gene expression in embryo (Boiani et al., 2001, Bortvin et al., 2003), abnormal placenta (Wakayama and Yanagimachi 1999), obesity (Tamashiro et ai, 2000, 2002) or early death (Ogonuki et al., 2002). Such abnormalities notwithstanding, success in generating cloned offspring has opened new avenues of investigation and provides a valuable tool that basic research scientists have employed to study complex processes such as genomic reprogramming, imprinting and embryonic development. On the other hand, mouse ES cell lines can also be generated from adult somatic cells via nuclear transfer. These 'ntES cells' are capable of differentiation into an extensive variety of cell types in vitro, as well assperm and oocytes in vivo. Interestingly, the establish rate of ntES cell line from cloned blastocyst is much higher than the success rate of cloned mouse. It is also possible to make cloned mice from ntES cell nuclei as donor, but this serial nuclear transfer method could not improved the cloning efficiency. Might be ntES cell has both character between ES cell and somatic cell. A number of potential agricultural and clinical applications are also are being explored, including the reproductive cloning of farm animals and therapeutic cloning for human cell, tissue, and organ replacement. This talk seeks to describe both the relationship between nucleus donor cell type and cloning success rate, and methods for establishing ntES cell lines. (중략)

• 한국데이타베이스학회:학술대회논문집
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• 한국데이타베이스학회 1997년도 International Conference MULTIMEDIA DATABASES on INTERNET
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• pp.483-503
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• 1997

객체지향 데이터베이스 시스템에서 시간지원 데이터베이스를 다룰 때 발생하는 중요한 문제는 관계 의미에 따라 시간과 속성을 결합하는 방법에 있다. 관계형 모델처럼 속성 버전화에 대한 기존의 연구 결과는 시간지원 객체지향 모델에 적용할 수 없다. 이것은 객체지향 모델이 복합 객체를 구성하기 위해서 기존의 모델보다 더욱 강력한 구성자들을 제공하기 때문이다. 그래서 이 논문은 객체지향 데이터베이스에 시간 개념을 통합하기 위한 형식적 접근방법을 제안한다. 이 논문의 목적은 객체 사이에 관계하는 일반화, 집단화와 연관화에 따라 시간지원 객체지향 데이터베이스 표현을 연구하는 것이다. 이 논문은 시간지원 객체지향 모델에서 속성 버전화의 개념을 정의하고, 객체 사이에 존재하는 관계에 대해서 시간을 표현하는 것에 중점을 둔다. 또한 관계 의미에 대한 제약조건을 규정하고, 표현 기준에 기반하여 검토한다. 이 논문은 객체지향 데이터 모델을 형식화함으로서 대수 연산자를 설계시 강력한 연산 기능을 제공할 뿐만 아니라 모듈의 재사용성을 제공할 수 있다.

• 산업클러스터
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• 제1권1호
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• pp.1-15
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• 2007

지역혁신과 클러스터 정책은 지역정책의 새로운 아젠다로서, 최근 여러 국가와 지역에서 관심을 갖는 주제이다. 여기서 우리의 주요 관심사는 지역혁신과 클러스터 정책을 어떻게 평가할 것인가, 그리고 그 평가에 있어 어떤 모델과 방법을 사용할 것인가라는 데에 모아진다. 1990년 이후 국가 및 지방정부에서는 개선된 정책을 수립하기 위한 지식 창출의 도구로서 정책평가를 강조해 왔다. 이 논문의 목적은 지역혁신과 클러스터 정책의 평가와 관련된 주요 논의를 요약하고, 더 나은 정책평가에 기여할 수 있는 방법론을 제안하는 데에 있다. 우선 지역혁신과 클러스터 정책을 개관하고 그 정책의 주요 특성과 정책평가로 제기되는 주요 과제를 보다 상세히 분석한다. 다음으로 현재 사용되는 평가 관행을 개선시키는 데 도움이 되는 몇 가지 방법을 제안한다. 마지막으로 지역혁신과 클러스터 정책을 평가하는 데 있어 고려해야 할 몇 가지 사항을 제시한다.

• 가정과삶의질연구
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• 제26권4호
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• pp.55-71
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• 2008

Many studies on the relationships between mothers-in-law and daughters-in-law tended to regard the relationship as a conflicting one. This study, unlike the previous ones, aimed to explore the relationship as it is and to describe the experience of the real relationship. Another aim of this study, on the basis of the results, was to provide the basic data for social services to develop and maintain the positive relationships between mothers and daughters-in-law. To achieve these aims, the central question of the study was, "What are the daughters-in-law's experiences with their mothers-in-law like?" The participants for the study consisted of 12 daughters-in-law who volunteered to be interviewed. Data were collected through in-depth interviews and analyzed according to the grounded theory presented by Strauss and Corbin. As a result, 154 concepts and 42 sub-categories were induced, and finally 18 categories were induced in the course of classifying and integrating these sub-categories. This study discovered that the relationship might be both positive and negative, and that it might even be possible to change from one to the other. The results of the study showed that many factors influenced the quality of the relationship, and that the husband's role was one of the most important factors. Using this study's results as guidance, general programs designed to cultivate more positive relationships between mothers and daughters-in-law can be created and implemented; additionally programs that help the husbands understand the complex relationship and roles can be devised.

• 한국축산시설환경학회지
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• 제11권2호
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• pp.97-102
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• 2005

Anaerobic decomposition is one of the most common processes in nature and has been extensively used in waste and wastewater treatment for several centuries. New applications and system modifications continue to be adapted making the process either more effective, less expensive, or suited to the particular waste in question and the operation to which it is to be applied. Animal manure is a highly biodegradable organic material and will naturally undergo anaerobic fermentation, resulting in release of noxious odors, such as in manure storage pits. Depending on the presence or absence of oxygen in the manure, biological treatment process may be either aerobic or anaerobic. Under anaerobic conditions, bacteria carry on fermentative metabolisms to break down the complex organic substances into simpler organic acids and then convert them to ultimately formed methane and carbon dioxide. Anaerobic biological systems for animal manure treatment include anaerobic lagoons and anaerobic digesters. Methane and carbon dioxide are the principal end products of controlled anaerobic digestion. These two gases are collectively called biogas. The biogas contains $60\~70\%$ methane and can be used directly as a fuel for heating or electrical power generation. Trace amounts of ammonia and hydrogen sulfide ($100\~300\;ppm$) are always present in the biogas stream. Anaerobic lagoons have found widespread application in the treatment of animal manure because of their low initial costs, ease of operation and convenience of loading by gravity flow from the animal buildings. The main disadvantage is the release of odors from the open surfaces of the lagoons, especially during the spring warm-up or if the lagoons are overloaded. However, if the lagoons are covered and gases are collected, the odor problems can be solved and the methane collected can be used as a fuel. Anaerobic digesters are air-tight, enclosed vessels and are used to digest manure in a well-controlled environment, thus resulting in higher digestion rates and smaller space requirements than anaerobic lagoons. Anaerobic digesters are usually heated and mixed to maximize treatment efficiency and biogas production. The objective of this work was to review a current anaerobic biological treatment of animal manure for effective new technologies in the future.

• 한국조경학회지
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• 제33권5호통권112호
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• pp.15-30
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• 2005

A deserted town once vibrant with active commercial activities around a railroad station now tries to find a way to escape from depression and revive its life with a renewed civic pride. An open space adjacent to the Main Street, the commercial district of Buzzards Bay, Massachusetts, is waiting to be transformed and reconfigured to be a new ecological park to boost the economy of the community. Bridge Park is 26-acre land abutting the Cape Cod Canal with a railroad bridge as a backdrop. The existing condition of the site with a small salt marsh, woodland, lawn, and the vestige of old railroad easement along with the proximity to the commercial district poses an interesting question of how to make a medium scaled ecological park within an urban context. This paper examines the winning design proposals for the Bridge Park submitted to the International Design Competition held in April, 2005. Six winning proposals were introduced and discussed in terms of categories related to the trend of contemporary landscape design such as; 1) ecological ordinariness and geometric figures, 2) topography and spatial imagination, 3) minimal programs and open put 4) time and process oriented design, 5) park and economic effects and 6) diagrammatic plan and photo montage. Bridge Park Design Competition confirms the complex characteristics representing the contemporary landscape design overcoming the dichotomy between nature and culture and the 'pastoral ecological design' and 'landscape as an art'. The Park becomes the activating agent for the community rejecting the conventional and passive role as a romantic picturesque landscape. Bridge Park International Design Competition is a meaningful event to test the idea of new ecological urban park, and to fine-tune the trend of the contemporary urban park design.

• 한국언론정보학보
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• 제70권
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• pp.66-94
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• 2015

포스트식민주의는 근자의 글로벌 사회 문화 현상을 설명하고 이해하는 데 중요한 이론적 자원으로 자리잡아 왔다. 문화가 갖는 보편성이나 초월적 진정성을 부정하는 포스트식민주의 이론은 근본주의적 가정을 벗어나 주체와 정체성이 재개념화되는 길을 열어 주며, 지리적 경계를 가로질러 부유하는 디아스포라의 혼종적 문화 경험을 통해 기존의 지배적인 문화적 상상과 사회관계에 대한 담론 질서를 전복시킬 수 있는 가능성을 그려 내기도 한다. 그러나 전 세계 문화의 차이와 다양성을 강조하는 포스트식민주의 서사는 변화와 재조정 과정에 있으나 여전히 강고하게 자리 잡고 있는 중심부와 주변부 국가들 간 불평등한 권력 관계 속에서 특정한 지역민들과 이주민들이 새로운 형태의 피착취 집단으로 구성되고 있는 현실을 제대로 조명하지 못하는 경향이 있다. 이 글의 목적은 포스트식민주의 이론이 전개되고 전유되어 온 과정에 대한 비판적 리뷰를 통해 지금 시기 글로벌 수준에서 발생하고 있는 부정의의 문제들을 보다 비판적으로 성찰할 수 있는 방안을 모색하는 것이다.

• 한국임상약학회지
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• 제26권3호
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• pp.254-263
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• 2016

Objective: Written information could be helpful for senior population to adhere to complex medication therapies, but must be well prepared and empirically assessed to achieve such end. We purposed to develop a drug information leaflet for senior citizens by applying 'performance-based user-testing.' Methods: We employed a user-testing, a mixed method to figure difficulties out with patients' leaflets from the user perspective. The cycle made of test and revision can be repeated as necessary. We recruited senior citizens with age of 65 or above who were taking antihypertensive medications at the point of participating and excluded the elderly who suffered illiteracy. We firstly rectified a drug information leaflet of antihypertensive medications for the general public distributed by the Korean authority based on focus group interviews (9 participants). The revised leaflets were tested four times with 8~12 participants in each round (40 seniors in total). We targeted to develop a leaflet which more than 80% of participants understood 10 key information. Main outcomes measures were to be able to find information and be able to understand information. This study was approved by the Yeungnam University Research Ethics Committee. Results: Focus group interviews identified difficulties with small font of words, professional language, long information, and a poor structure. The leaflet was revised and in the first round questionnaire found problems with 4/10 information points; interviews disclosed all but one (normal blood pressure range) were ill-understood. The second round questionnaire and interview found fewer problems but the comprehensiveness of participants was still poor in several points. For the third and fourth rounds we revised the leaflets in the individual-targeted manner. Finally, the fourth round showed all key information found and understood by at least 80% of participants except one question about drug name. Conclusion: The drug leaflets need to be developed in a personalized mode for the seniors. There was a limit for Korean seniors to understand nonproprietary name of their drugs because they used to producers' trade names which the Korean health system predominantly works with.

• Investigative Magnetic Resonance Imaging
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• 제20권3호
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• pp.152-157
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• 2016

Purpose: Operating room management is the serious and complex task for hospital managers and the common approach is to develop relevant standard operational procedures. From patient and staff safety perspective, operating room management should be well-studied and hospital should identify and address any potential risks. Simultaneous usage of different imaging and less-invasive treatment technologies demands strong management control. Materials and Methods: We have formed the multidisciplinary expert panel (surgeons, anesthesiologists, radiologists, healthcare managers etc.) for hybrid theater management standard operational procedure development. On the first stage the general concept of hybrid room design and patient routing was developed. The second stage included the technical details discussion. For patient safety improvement we modified the Surgical Safety Check-list in accordance with potential MRI-related safety challenges and concerns. Results: WHO Surgical Safety Checklist is a simple and easy-to use tool which includes three blocks of question (grouped by the surgery process). We have developed two additional blocks of questions for the intraoperative magnetic resonance investigation. It is very important to have a special detailed routing with a strong control of ferromagnetic devices and anesthesiology care. Conclusion: High-energy MRI (1.5-3.0T) is characterized by potential influence on patient and staff safety in case of hybrid surgery. It is obvious to have a strong managerial control of ferromagnetic devices and anesthesiology care. Surgical Safety Checklist is the validated tool for improving patient safety. Modification and customization of this check-list potentially provides the opportunity for surgery processes improving.

• World Technopolis Review
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• 제7권1호
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• pp.2-14
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• 2018

Nowadays, we are standing in front of the $4^{th}$ Industrial Revolution that is featured by a great range of new and advanced technologies that influences all the domains of economies and industries. The great question that this revolution raises is how it can lead to a future that reflects the peoples' common objectives and values on how these advanced technologies can affect the life and transform the economic, social, cultural, and human environment. It is commonly agreed that to be adapted to these changes and needs and shape a society with competitive economies with highly-skilled individuals, we need to encourage innovation, entrepreneurship, new knowledge generation and exchange and true and effective collaboration and communication. In this complex scene, education seems to have a central and critical role on finding new ways of developing expertise and innovation within the existing knowledge procedures, with more and better cooperation between the key players. This paper argues the concepts, opportunities and challenges that are related to the learning ecosystem towards the needs raised by the $4^{th}$ Industrial Revolution. The education is discussed as catalyst but also as carrier of innovation and innovation practices and the basis of a relevant framework is presented that takes into account all the aspects, domains and key players of educational world and interacting domains. Having introduced the ideas of innovation, collaboration and technology advancement in this environment, this paper also presents a real case of practice, focusing on how more than 5.000 schools around Europe succeeded the last four (4) years to implement innovation activities in a collaborative way and under a unique but also flexible pedagogical innovation framework.