• BMB Reports
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• 제51권1호
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• pp.14-20
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• 2018

Biomedical research involving nanoparticles has produced useful products with medical applications. However, the potential toxicity of nanoparticles in biofluids, cells, tissues, and organisms is a major challenge. The '-omics' analyses provide molecular profiles of multifactorial biological systems instead of focusing on a single molecule. The 'omics' approaches are necessary to evaluate nanotoxicity because classical methods for the detection of nanotoxicity have limited ability in detecting miniscule variations within a cell and do not accurately reflect the actual levels of nanotoxicity. In addition, the 'omics' approaches allow analyses of in-depth changes and compensate for the differences associated with high-throughput technologies between actual nanotoxicity and results from traditional cytotoxic evaluations. However, compared with a single omics approach, integrated omics provides precise and sensitive information by integrating complex biological conditions. Thus, these technologies contribute to extended safety evaluations of nanotoxicity and allow the accurate diagnoses of diseases far earlier than was once possible in the nanotechnology era. Here, we review a novel approach for evaluating nanotoxicity by integrating metabolomics with metabolomic profiling and transcriptomics, which is termed "metabotranscriptomics."

• Journal of the Ergonomics Society of Korea
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• 제31권5호
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• pp.629-636
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• 2012

Objective: The purpose of this study is to compare the characteristics of single and double finger gestures related on the web browser and to extract the appropriate finger gestures. Background: As electronic equipment emphasizes miniaturization for improving portability various interfaces are being developed as input devices. Electronic devices are made smaller, the gesture recognition technology using the touch-based interface is favored for easy editing. In addition, user focus primarily on the simplicity of intuitive interfaces which propels further research of gesture based interfaces. In particular, the fingers in these intuitive interfaces are simple and fast which are users friendly. Recently, the single and double finger gestures are becoming more popular so more applications for these gestures are being developed. However, systems and software that employ such finger gesture lack consistency in addition to having unclear standard and guideline development. Method: In order to learn the application of these gestures, we performed the sketch map method which happens to be a method for memory elicitation. In addition, we used the MIMA(Meaning in Mediated Action) method to evaluate gesture interface. Results: This study created appropriate gestures for intuitive judgment. We conducted a usability test which consisted of single and double finger gestures. The results showed that double finger gestures had less performance time faster than single finger gestures. Single finger gestures are a wide satisfaction difference between similar type and difference type. That is, single finger gestures can judge intuitively in a similar type but it is difficult to associate functions in difference type. Conclusion: This study was found that double finger gesture was effective to associate functions for web navigations. Especially, this double finger gesture could be effective on associating complex forms such as curve shaped gestures. Application: This study aimed to facilitate the design products which utilized finger and hand gestures.

• Journal of the Korean Society of Tobacco Science
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• 제13권1호
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• pp.19-26
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• 1991

Ames test using special strains which are histidine requiring mutant of Salmonella typhimufium , is widely utilized as short-term bioassay to evaluate the genotoxicity of chemicals. This method requires the liver microsome(5-9 fraction) to provide mammalian metabolism of the compounds, Therefore, the mutagenic potency of the chemicals is affected by not only the intrinsic properties of them but also the efficiency of the in vitro microsomal activation system. For this reason, the complex mixtures such as environmental pollutants from occupational sources, natural products or cigarette smoke condensates(CSC) , might be often appeared the false results. Induction of sister chromatid exchange(SCE) in cultured cells is known as another sensitive and powerful tool for the measurement of genotoxicity and the method has also an advantage which is able to apply to the in vitro and in vivo systems. In the present study, the inducibilities of revertant colonies in tester strain TA98 and SCE in human Iymphocytes by positive controls and total particulated materials(TPM) obtained from various brand(domastic and imported) cigarettes were compared in order to investigate whether the results in Ames test are in agreement with those in SCE analysis. The mutagenic activities of well known mutagens such as B(a)P showed excellent dose-response in the both methods although the induction mechanism was different each other, but cyclophosphamide resulted such effect only in SCE analysis. Most TPM tested showed a similar pattern in the mutagenic activities in those methods. However, only two(one imported brand and one domestic sample cigarettes) among the TMP obtained from various cigarettes appeared the higher induction in SCE than Ames test.

• Industrial Engineering and Management Systems
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• 제15권2호
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• pp.156-172
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• 2016

Complex and uncertain issues in supply chain result in integrated decision making processes in supply chains. So decentralized (distributed) decision making (DDM) approach is considered as a crucial stage in supply chain planning. In this paper, an uncertain DDM through coordination mechanism is addressed for a multi-product supply chain planning problem. The main concern of this study is comparison of DDM approach with centralized decision making (CDM) approach while some parameters of decision making are assumed to be uncertain. The uncertain DDM problem is modeled through fuzzy mathematical programming in which products' demands are assumed to be uncertain and modeled using fuzzy sets. Moreover, a CDM approach is customized and developed in presence of fuzzy parameters. Both approaches are solved using three fuzzy mathematical optimization methods. Hence, the contribution of this paper can be summarized as follows: 1) proposing a DDM approach for a multi-product supply chain planning problem; 2) Introducing a coordination mechanism in the proposed DDM approach in order to utilize the benefits of a CDM approach while using DDM approach; 3) Modeling the aforementioned problem through fuzzy mathematical programming; 4) Comparing the performance of proposed DDM and a customized uncertain CDM approach on multi-product supply chain planning; 5) Applying three fuzzy mathematical optimization methods in order to address and compare the performance of both DDM and CDM approaches. The results of these fuzzy optimization methods are compared. Computational results illustrate that the proposed DDM approach closely approximates the optimal solutions generated by the CDM approach while the manufacturer's and retailers' decisions are optimized through a coordination mechanism making lasting relationship.

• Journal of the Korea Academia-Industrial cooperation Society
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• 제22권1호
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• pp.786-791
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• 2021

In this paper, in order to minimize limitations such as signal interference and positioning errors in existing indoor positioning systems, a smart LED-based positioning system for excellent line-of-sight radio environments and precise location tracking is proposed to improve accuracy. An IEEE 802.4 Zigbee module is mounted on the SMPS board of a smart LED; RSSI and LQI signals are received from a moving tag, and the system is configured to transmit the measured data to the positioning server through a gateway. For the experiment, the necessary hardware, such as the gateway and the smart LED module, were separately designed, and the experiment was conducted after configuring the system in an external field office. The positioning error was within 70cm as a result of performing complex calculations in the positioning server after transmitting a vector value of the moving object obtained from the direction sensor, together with a signal from the moving object received by the smart LED. The result is a significantly improved positioning error, compared to an existing short-range wireless communications-based system, and shows the level at which commercial products can be implemented.

• Journal of the Korean Society of Manufacturing Process Engineers
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• 제16권2호
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• pp.28-33
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• 2017

Recently, the operation of precision pocket machining has been studied for the high speed and accuracy in industry to increase production and quality. Moreover, the demand for products with complex 3D free-curved surface shapes has increasing rapidly in the development of computer systems, CNC machining, and CAM software in various manufacturing fields, especially in automotive engineering. The type of aluminum (Al6061) that is widely used in aerospace fields was used in this study, and end-mill down cutting was conducted in fillet cutting at a corner with end-mill tools for various process conditions. The experimental results may demonstrate that the end mill cutter with four blades is more advantageous than that of the two blades on shape forming in the same condition precise machining conditions. It was also found that cutting forces and tool deformation increased as the cutting speed increased. When the tool was located at $45^{\circ}$ (four locations), the corner was found to conduct the maximum cutting force rather than the start point of the workpiece. The experimental research is expected to increase efficiency when the economical precision machining methods are required for various cutting conditions in industry.

• Journal of the Society of Naval Architects of Korea
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• 제45권2호
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• pp.192-201
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• 2008

The design process becomes more difficult due to the increasing complexity of products. Thus, without any proper design experience, designer cannot handle his design problems systematically. Besides, the conventional optimal design method cannot be used effectively at the early design stage, since most design problems must be formulated in terms of objective and constraint functions based on the mathematical concepts of Operation Research. Thus, in this paper, new design concept based on FBS (Function-Behavior-Structure) design model is introduced to help the novice designer formulate the complex design problems systematically into a mathematical form. In this FBS model, function means the designer's new intents designer wants to create for, structure stand for a final product configuration and behaviour is a product's performance. FBS design model is thus rather totally different concept used for formulating design problem, compared with conventional optimal design method. To validate this new FBS model, 330K VLCC design case is performed, and we found, though it is one design example case, that this new design concept could be effectively used for future ship design problems since, during the formulating design problem, the only engineering terminology such as function, structure, and behaviour of design product is used based on the engineering concepts, instead of mathematical terminology such as objective and constraints.

• The Journal of the Korea institute of electronic communication sciences
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• 제8권7호
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• pp.1033-1038
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• 2013

Petrochemical complex has been a lot of research for the development of a more mature product and analysis for mid-process and finished products is essential in these process. But these analyzes are still by hand work samples being manufactured in many parts. Moreover they are exposed to hazardous chemical and such as the analysis is being made in a very poor working conditions. In this paper, in order to solve such problems the multi control system has been developed for the automated analysis. In addition, the organic behavior of these systems and the development of a program for the automated applied, and throughout the experiment to verify the reliability of this device for the accuracy of the dosing pumps for the standard solution prepared with a range of error of ${\pm}0.01m{\ell}$ was able to get a very good experimental results.

• Genomics & Informatics
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• 제7권2호
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• pp.122-130
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• 2009

A systems biology approach for the identification of perturbed molecular functions is required to understand the complex progressive disease such as breast cancer. In this study, we analyze the microarray data with Gene Ontology terms of molecular functions to select perturbed molecular functional modules in breast cancer tissues based on the definition of Gene ontology Functional Code. The Gene Ontology is three structured vocabularies describing genes and its products in terms of their associated biological processes, cellular components and molecular functions. The Gene Ontology is hierarchically classified as a directed acyclic graph. However, it is difficult to visualize Gene Ontology as a directed tree since a Gene Ontology term may have more than one parent by providing multiple paths from the root. Therefore, we applied the definition of Gene Ontology codes by defining one or more GO code(s) to each GO term to visualize the hierarchical classification of GO terms as a network. The selected molecular functions could be considered as perturbed molecular functional modules that putatively contributes to the progression of disease. We evaluated the method by analyzing microarray dataset of breast cancer tissues; i.e., normal and invasive breast cancer tissues. Based on the integration approach, we selected several interesting perturbed molecular functions that are implicated in the progression of breast cancers. Moreover, these selected molecular functions include several known breast cancer-related genes. It is concluded from this study that the present strategy is capable of selecting perturbed molecular functions that putatively play roles in the progression of diseases and provides an improved interpretability of GO terms based on the definition of Gene Ontology codes.

• Proceedings of the Korean Society of Grassland Science Conference
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• 한국초지조사료학회 2002년도 창립 30주년 International Symposium
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• pp.131-156
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• 2002

Although economically viable, the livestock industry is currently facing a number of challenging environmental problems and highly complex social issues, many of which are related to its size and geographically concentrated nature. Increased emphasis on environmental quality has also placed new demands on livestock producers to ensure that their production practices are in harmony with natural environment. In terms of sustainable agricultural systems, ruminants have served and will continue to serve a valuable role. They are particularly useful in converting vast renewable resources from rangeland, pasture, and crop residues or other by-product into food edible for human. With ruminants, land that is too poor or too erodable to cultivate becomes productive. Also, nutrients in by-products are utilized and do not become a waste-disposal problem. In Korea, however, native and dairy cattle production is not consistent with the advantageous roles of ruminant livestock in sustainable agricultural system because imported feed grains become the main basis for cattle raising. At present the ruminant livestock producers are heavily concentrated in and around the urban areas. About 75% of all the nation's cattle herds are kept on the outskirts of urban areas. As a result, the amount of pasture and forage land available per head of cattle is generally small. Furthermore, animals are raised in a cattle shed with high density. This situation is rather unfavorable for the national economic and environmental points of view As nation income increased, the demand for livestock products grew at an unforeseeable pace. But the pasture area involving in current utilization is tended to decrease during recent years. Based on the above figures more than 250,000 ha of pasture ought to be available for the present herd of cattle. It is obvious that these needs can scarcely be met with arable lands. Lands area for the establishment of new grassland have to be found in the hills and mountains which have not yet been used for crop framing or livestock. The development of extensive grasslands in the hill and woodland areas is now a declared aim. The starting point of the present work is the lack of knowledge of forage production and utilization in hill pasture and woodland in spite of indispensable necessity for livestock production in Korea. The importance of pastoral system in hill region and woodland is particularly emphasized in a standpoint of sustainable livestock production. Main chapter comprises the principle and techniques applicable for improving the utilization of hill pasture and woodland. We finally discussed the problems to solve and future works for a successful livestock production in hill and mountainous area in Korea.