• Title/Summary/Keyword: Complete or Partial Failure

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Results in the Treatment of Nasopharyngeal Carcinoma Using Combined Radiotherapy (비인강 종양에 있어서 방사선 치료와 유도화학 요법)

  • Chung Su Mi;Yoon Sei Chul;Shinn Kyung Sub;Bahk Yong Whee;Kim Hoon Kyo;Lee Kyung Shik;Cho Seung Ho
    • Radiation Oncology Journal
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    • v.9 no.1
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    • pp.59-63
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    • 1991
  • Thirty-one patients with previously untreated and locally advanced nasopharyngeal cancer were retrospectively reviewed for comparing the effects of radical radiotherapy alone with that of combining chemotherapy and radiotherapy from 1983 to 1989 at Kangnam 51. Mavy's hospital.23/31 were evaluable for recurrence and suwival. There were 8 patients for stage III, and 15 patients for stage IV. Eleven patients were treated with radical radiation therapy done (arm I). Twelve patients were given 1~3 courses of cisplatin-5FU or cisplatin-bleomycin-vincristine prior to radiation therapy (arm II). The two arms were comparable in patient characteristics Of 11 radiotherapy Patients, complete response was 55%(6/11) and Partial response 45%(5/11). Among 12 patients after induction chemotherapy, complete response was 25%(3/12) and partial response 75%(9/12). After subsequent radiotherapy, complete response was increased to 83%(10/12) and partial response was 17%(2/12). Treatment failure was 30%(local recurrence; 3/11, and regional recurrence; 1/11) in arm 1 and 33% (local recurrence; 1/12, regional recurrence; 2/12 and distant metastasis; 1/12) in arm ll . There was no significant difference in survival between arm I and arm II (p> 0.05). The toxicities of treatment were acceptable. More controlled clinical trials must be completed before acceptance of chemotherapy as part of a standard radical treatment for locally advanced nasopharyngeal cancer.

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Combined Modality Therapy of Non-Hodgkin's Lymphoma of Waldeyer's Ring (Waldeyer's Ring 비호치킨 림프종의 병합요법)

  • Park In-Kyu;Yun Sang-Mo;Park Jun-Sik;Kim Jae-Cheol
    • Korean Journal of Head & Neck Oncology
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    • v.15 no.1
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    • pp.22-28
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    • 1999
  • Purpose: We performed this study retrospectively to evaluate local control, survival, prognostic factors, and failure patterns in patients with non-Hodgkin's lymphoma of Waldeyer's ring. Materials and Methods: From April 1984 to November 1996,41 patients with non-Hodgkin's lymphoma of Waldeyer's ring were treated with combined chemotherapy and radiation therapy. Age was ranged from 19 to 73 years old with a median age of 55 years, and there were 26 male and 15 female patients. Primary site was tonsil in 26 and base of the tongue in 7 and nasopharynx in 8, and stage distribution showed stage I in 12 and stage II in 29 patients. Pathologic classification was done according to Working Formulation. There were 1 with follicular mixed small cleaved and large cell, 8 with diffuse small cleaved cell, 7 with diffuse mixed small and large cell, and 25 cases with diffuse large cell. All patients were treated with combination of chemotherapy and radiation therapy. Chemotherapy regimen consisted of either CHOP-Bleo(cyclophosphamide, adriamycin, vincristine, prednisolone, bleomycin) or COP-BLAM III(cyclophosphamide, vincristine, prednisolone, bleomycin, adriamycin, procarbazine). Radiation dose ranged from 3600cGy to 6620cGy with a median dose of 5040cGy. Follow-up time was ranged from 15 months to 159 months(median 55 months). Results: The complete response was achieved in 98%(40/41) and partial response in 2%(1/41). The complete response rate were the followings: 66.7% for stage I and 51.7% for stage II after chemotherapy, 100% for stage I and 96.6% for stage II after overall treatment respectively. The overall survival rate and disease-tree survival rates at 5 years were 82.6% and 79.5%, respectively. Prognostic factors for overall survival were age(p=0.007), stage(p=0.03), nodal status(p=0.006) and radiation dose(p=0.003). The factors associated with disease-tree survival were stage(p=0.04), nodal status(p=0.004) and radiation dose(p=0.009). The failure patterns were analized in evaluable 35 patients with complete response. Locoregional failure was noted in 2 patients and distant metastasis in 5 patients. Conclusion: Our results suggest that combined modality therapy is the appropriate treatment for stage I-II intermediate grade non-hodgkin's lymphoma of the Waldeyer's ring. However, our material is small and the analysis is retrospective. Randomized prospective studies for combined therapy, radiation therapy alone and chemotherapy alone are needed.

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A Field Survey on the Structure and Maintenance Status of Pipe Framed Greenhouses (파이프 골조 온실의 구조 및 유지관리실태 조사분석)

  • 남상운
    • Magazine of the Korean Society of Agricultural Engineers
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    • v.42 no.4
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    • pp.106-114
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    • 2000
  • An investigation was conducted to get the basic data for establishing maintenance strategy of pipe framed greenhouses. The contents of the investigation consisted of actual state of structures, maintenance status, meteorological disaster, and corrosion characteristics of pipe framework in greenhouses. the number of greenhouses investigated was 108 in total. Most multi-span greenhouses had narrower width and lower height than the standared 1-2W greenhouse, and most of single-span greenhouses were tunnel type. In multi-span greenhouses, the size and interval of frameworks such as rafter, purline, column , and cross beam were mostly suitable, but frameworks of single-span greenhouses were mostly insufficient. After about 7 years in grounds, 8 years in joints, 10 years in bending parts. and 13 years in columns. pipe surface was mostly rusted. Most weak parts in corrosion were pipes in contact with the ground, joints, roll-up shaft pipes, and pipes close to the gutter. Almost all of the greenhouse farmers didn't pay any attention to maintenance affair in a regular interval for pipe framed grenhouses. Many greenhouses have experienced the meteorologicla diaster such as uplift of foundation, partial or complete failure by the hyphoon and/or high winds.

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Standardized multi-institutional data analysis of fixed and removable prosthesis: estimation of life expectancy with regards to variable risk factors

  • Hae-In Jeon;Joon-Ho Yoon;Jeong Hoon Kim;Dong-Wook Kim;Namsik Oh;Young-Bum Park
    • The Journal of Advanced Prosthodontics
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    • v.16 no.2
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    • pp.67-76
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    • 2024
  • PURPOSE. This study aims to assess and predict lifespan of dental prostheses using newly developed Korean Association of Prosthodontics (KAP) criteria through a large-scale, multi-institutional survey. MATERIALS AND METHODS. Survey was conducted including 16 institutions. Cox proportional hazards model and principal component analysis (PCA) were used to find out relevant factors and predict life expectancy. RESULTS. 1,703 fixed and 815 removable prostheses data were collected and evaluated. Statistically significant factors in fixed prosthesis failure were plaque index and material type, with a median survival of 10 to 18 years and 14 to 20 years each. In removable prosthesis, factors were national health insurance coverage, antagonist type, and prosthesis type (complete or partial denture), with median survival of 10 to 13 years, 11 to 14 years, and 10 to 15 years each. For still-usable prostheses, PCA analysis predicted an additional 3 years in fixed and 4.8 years in removable prosthesis. CONCLUSION. Life expectancy of a prosthesis differed significantly by factors mostly controllable either by dentist or a patient. Overall life expectancy was shown to be longer than previous research.

Improving Data Availability by Data Partitioning and Partial Overlapping on Multiple Cloud Storages (다수 클라우드 스토리지로의 데이터 분할 및 부분 중복을 통한 데이터 가용성 향상)

  • Park, Jun-Cheol
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.36 no.12B
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    • pp.1498-1508
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    • 2011
  • A cloud service customer has no other way but to wait for his lost data to be recovered by the cloud service provider when the data was lost or not accessible for a while due to the provider's system failure, cracking attempt, malfunction, or outage. We consider a solution to address this problem that can be implemented in the cloud client's domain, rather than in the cloud service provider's domain. We propose a high level architecture and scheme for successfully retrieving data units even when several cloud storages are not accessible at the same time. The scheme is based on a clever way of partitioning and partial overlapping of data for being stored on multiple cloud storages. In addition to providing a high level of data availability, the scheme makes it possible to re-encrypt data units with new keys in a user transparent way, and can produce the complete log of every user's data units accessed, for assessing data disclosure, if needed.

Surgical Treatment of Primary Tumors and Cysts of the Mediastinum (원발성 종격동 종양에 대한 외과적 치료)

  • 오태윤
    • Journal of Chest Surgery
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    • v.23 no.2
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    • pp.299-308
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    • 1990
  • A review of 50 patients with primary mediastinal tumors or cysts has been done to evaluate clinical and pathological behavior of this heterogeneous group of tumors proved by either excision or biopsy from January 1980 to August 1989 at the cardiovascular department of surgery in Kyungpook National University Hospital. There were 30 males and 20 females in this series. The ages of patients ranged from 4 months to 64 years. The mean age of subjects was 30.4 years. Neurogenic tumors [14 cases, 28%] and teratoma [14 cases, 28%] were most frequently encountered and followed by thymoma [10 cases, 20%] and benign cysts [4 cases, 8%]. The anatomic location of the primary mediastinal tumors or cysts was classified as anterior mediastinum and middle or visceral mediastinum and paravertebral or costovertebral mediastinum on the basis of the Shields’ proposition. In 32 patients[64%], the tumors or cysts were located in anterior mediastinum and in 13 patients[26%], the tumors or cysts were located in paravertebral or costovertebral mediastinum. And the rest 5 patients[10%] had middle or visceral mediastinal tumors or cysts. One of the characteristic features of primary mediastinal tumors or cysts is that some mediastinal tumors or cysts have their own preferred location in the mediastinum. In our series, all of the 14 patients with teratoma and 10 patients with thymoma had the anterior mediastinal location, while 13 of the 14 patients with neurogenic tumors had the paravertebral mediastinal location. 14 patients[28%] were asymptomatic and they all were discovered via so-called “Routine” chest x-ray examination. 39 of 50 patients[78%] were benign. 11 patients[22%] were malignant and they were all symptomatic. 40 patients[80%] were treated with complete resection. 5 patients[10%] were treated with partial resection : 2 of malignant thymoma, 3 of lipoma, neuroblastoma, primary squamous cell carcinoma. The rest 5 patients[10%] were only biopsied: 2 of undetermined malignancy and 3 of hemangioma, lymphoma, primary squamous cell carcinoma. 4 of the 10 patients were treated with combination of irradiation and chemotherapy. Postoperative complications were as followings: Horner’s syndrome [4cases, ado], respiratory failure [3 cases, 6%], pleural effusion[3 cases, 6%], Wound infection[2 cases, 4%] and bleeding, pneumothorax, empyema. There were 5 postoperative deaths [10%]. One patient with neuroblastoma died from intraoperative massive bleeding, 3 patients died early postoperatively from respiratory failure with undetermined malignancy died late postoperatively from congestive heart failure due to direct invasion of the tumor to the heart.

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Treatment of Unresectale Non-Small-Cell Lung Cancer with Curative Radiotherapy (비소세포성폐암의 방사선치료 성적)

  • Kim Il Han;Ha Sung Whan;Park Charn Il;Shim Young Soo;Kim Noe Kyeong;Kim Keun Youl;Han Yong Chol
    • Radiation Oncology Journal
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    • v.2 no.2
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    • pp.203-211
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    • 1984
  • From 1979 to 1982, 80 patients with unresectable non-small-cell lung cancer without metastasis were treated with high-dose radiotherapy to the primary and to regional lymph nodes with or without supraclavicular lymphatics in the Department of Therapeutic Radiology, Seoul National University Hospital. Of these, 56 patients$(70\%)$ were completely evaluable, and 59 patients$(74\%)$ had squamous cell carcinoma, 13a large cell undifferentiated carcinoma and 831 adenocarcinoma. 21 patients$(26\%)$ had Stage II and 59 patients$(74\%)$ had Stage III. The complete and partial response rate in the high-dose$(\approx\;6,000\;rad)$ radiotherapy was $70\%\;with\;19\%$ complete response. 69 patients$(86\%)$ failed in the treatment, by the failure pattern, $64\%$ had local failure alone, $35\%$ had local failure and distant metastasis and $1\%$ had distant metastasis alone. The failure rate in the thorax were $76\%$ in squamous cell carcinoma, $40\%$in adenocarcinoma and $20\%$ in large cell undifferentiated carcinoma Preliminary result shows that actuarial survival at 1, 2 and 3 years were $56\%,\;26\%\;and\;20\%$ in overall patients and $64\%,\;37\%\;and\;21\%\;in\;Stage\;II\;and\;54\%1,\;21\%\;and\;18\%$ in Stage III, respectively. Overall median survival was 14 months; 17 months in Stage II and 13 months in Stage m. 8 patients$(10\%)$ have lived a minimum of 2 years with no evidence of disease. There was no fatal complication confirmed to be induced by radiotherapy, so definitive high-dose radiotherapy was tolerated well without major problems and resulted in good local control and survival.

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A Case of Duodenal Web Associated with Intestinal Malrotation (장이상회전이 동반된 십이지장 막양구조(Web) 1례)

  • Kim, Jin-Suk;Lee, Jhoo-Taek;Park, Jae-Ock;Shin, Sang-Mann
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.2 no.1
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    • pp.99-103
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    • 1999
  • Duodenal web is an uncommon lesion that infrequently cause partial or complete intestinal obstruction. If the duonenal web is incomplete and only partially obstructs the duodenal lumen, the onset of symptoms may be delayed for years, and obstructive symptoms will be only minimal and intermittent. Congenital duodenal obstruction is occasionally associated with intestinal malrotation. We experienced a case of duodenal web associated with intestinal malrotation in a 9-year-old girl who had been suffered from intermittent projectile vomiting since birth without failure to thrive. The diagnosis was made by UGI series & abdominal CT. Patient remained asymptomatic after operation.

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Crash analysis of military aircraft on nuclear containment

  • Sadique, M.R.;Iqbal, M.A.;Bhargava, P.
    • Structural Engineering and Mechanics
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    • v.53 no.1
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    • pp.73-87
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    • 2015
  • In case of aircraft impact on nuclear containment structures, the initial kinetic energy of the aircraft is transferred and absorbed by the outer containment, may causing either complete or partial failure of containment structure. In the present study safety analysis of BWR Mark III type containment has been performed. The total height of containment is 67 m. It has a circular wall with monolithic dome of 21m diameter. Crash analysis has been performed for fighter jet Phantom F4. A normal hit at the crown of containment dome has been considered. Numerical simulations have been carried out using finite element code ABAQUS/Explicit. Concrete Damage Plasticity model have been incorporated to simulate the behaviour of concrete at high strain rate, while Johnson-Cook elasto-visco model of ductile metals have been used for steel reinforcement. Maximum deformation in the containment building has reported as 33.35 mm against crash of Phantom F4. Deformations in concrete and reinforcements have been localised to the impact region. Moreover, no significant global damage has been observed in structure. It may be concluded from the present study that at higher velocity of aircraft perforation of the structure may happen.

Radiotherapy Results of Midline Malignant Reticulosis (MMR) (중심선 악성 세망증의 방사선 치료 결과)

  • Yun, Sang-Mo;Kim, Jae-Cheol
    • Radiation Oncology Journal
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    • v.14 no.4
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    • pp.291-297
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    • 1996
  • Purpose : This study was performed to evaluate survival, failure patterns, and prognostic factors of MMR patients after radiation therapy. We also discussed the need for chemotherapy. Materials and Methods : A retrospective analysis was done for 23 patients with MMR who were treated with radiation therapy from June 1985 to November 1992. There were 19 male and 4 female patients, The patients' age ranged from 17 to 71 years (median 39 years). Systemic symptoms including fever, weight loss, or malaise were found in $30\%$ of the patients. The nasal cavity was most frequently involved No patients had nodal involvement at diagnosis. There were 2 patients with distant metastasis at presentation. Radiation therapy was delivered five times a week, 1.8 Gy daily, total $45\~54$ Gy (median 50.4 Gy) using 6 MV X-ray No patients received chemotherapy as initial treatment. Results : Overall 5-year and 10-year survival rates were $52.4\%$ and $44.1\%$, respectively. Seventy Percent(12/17) of the patients achieved complete response to radiotherapy, and $29.4\%$ (5/17) achieved partial response. The Patients with complete response showed a better 5-year survival rate than those with partial response ($66.9\%$ vs. $20\%$. p=0.004). Symptom duration before diagnosis, the presence of systemic symptom, and the number of primary sites had no influence on survival. The patterns of failure were as follows: local failure(1), failure in adjacent site(1), local and distant failure(1) distant metastasis(2). and conversion to malignant lymphoma(1). We could not find factors associated with the patterns of failure. Conclusion : The most important facto associated with survival was the response to radiotherapy. Seventeen percent of the patients had distant metastasis, and the salvage after distant metastasis was not successful. However. about $50\%$ of the patients could achieve long-term survival with local radiation therapy alone. Therefore, chemotherapy of MMR should be done after a prospective randomized study for the factors associated with distant metastasis.

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