• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.73-73
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• 2002

The study of the protein complement of the genome, or proteome, represents an important new avenue for drug discovery. Proteomics research aims to quantify and characterize all of the expressed proteins in a biological system, and to determine the effect of various perturbations of the system on the expressed proteins. (omitted)

• 한국미생물·생명공학회지
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• 제18권6호
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• pp.571-577
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• 1990

경기도 광릉에서 채집한 자실체로부터 분리한 Lentinus edodes IY105균을 배양하여 얻은 균사체를 알칼리로 추출하여 얻은 물질이 면역계와 sarcoma 180이 이식된 mouse에 미치는 영향을 검토하였다. Lentinus edodes IY105 배양균사체의 알칼리 추출물은 항보체활성과 alternative complement hemolytic 활성을 가지고 있었고, carbon clearance 활성을 가지고 있었고, carbon clearance 활성을 나타내는 것으로 보아 mouse의 망내계에 존재하는 macrophage를 활성화시켜 이 물질에 대한 탐식기능을 증가시킴을 알수 있었다. 또한, 이물질은 mouse의 용혈반 형성 세포수를 증가시키는 것으로 보아 항체생산 자극효과가 있는 것으로 추측되었으며, 종양세포인 sarcoma 180이 이식된 mouse의 암을 50 정도 억제하는 효과를 나타내었다. 알칼리 추출물의 성분을 분석한 결과, 당 17, 단백질 42로 구성된 단백질다당체가 주성분으로 단백다당체는 16종의 아미노산과 52종류의 당으로 구성되어 있었다.

• 대한수의학회지
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• 제12권1호
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• pp.97-119
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• 1972

Studies on modified complement fixation (MCF) test of antiblackleg bovine serum were made and the results obtained were summarized as followings. 1. The most satisfactory antigen for the MCF test among various materials studied was found to be the vegetative cells of Cl, chauvoei grown in cooked meat medium (CMM) containing 0.5mM l-(alpha) alanine and 0.1mM manganese. The antigen was prepared by inoculating the spores of Cl. chauvoei, heated at $70^{\circ}C$. for 30 minutes, into the CMM followed by incubation at $37^{\circ}C$. for 15 hours. 2. An active component contained in the factor serum of fresh normal rabbit serum was found to be C'4 fraction. It was also shown that, furthermore, DEAE cellulose sieved C'4 fraction of the factor serum enhanced antibody titer and the highest antibody titer was resulted by the addition of 0.03 ml, of the factor serum to each tube. 3. More than four fold increases of antibody titer, in antiblbckleg bovine serum-antigen system, was made with the MCF test than that with the direct complement fixation test. 4. The MCF antibody titer of cattle vaccinated against blackleg was 128 until seven month and 64 for five months thereafter.

• Journal of Chest Surgery
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• 제19권4호
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• pp.558-562
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• 1986

The extracorporeal circulation has been much improved recently, but has yet much complex problems such as the protein denaturation and the activation of the complement system by the exposure of the blood to the foreign surface, which may result in such as the postperfusion syndrome. We studied the changes of the plasma protein fractions by the electrophoresis and the complement consumption [C3, C4] by the immunodiffusion method in the patients undergoing cardiac operation from Mar. 1, 1986 to Aug. 31, 1986. The results were summarized as follows: 1. y-globulin fraction was decreased [p<0.02 by paired t-test, N=25], but a,-globulin was increased [p<0.001 by paired t test, N=25] after operation. 2. C3,C4 were significantly reduced [p<0.001 by paired t-test, N=14] postoperatively and normalized from 24 hours after operation. 3. The consumption of C3,C4 had significant linear correlation [correlation coefficient r=0.97] and C, was more markedly reduced comparing with C3, which probably means the complement activation by classical pathway in our bubble oxygenator group.

• 대한건축학회논문집:계획계
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• 제34권11호
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• pp.67-74
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• 2018

With the rapid increase in the elderly population, numerous problems arise related to the decreased cognitive function such as the declines of reaction time and concentration which are both resulting from ageing. Recently, ICT-based smart home and other residential services are being developed as a means of complementing human cognitive functions, but the elderly, who are in most cases digital-illiterate, find it hard to utilize these tools actively and if so it usually takes longer time and endeavor for the elderly to be familiarized with ICT devices. In this context, this study suggests a configuration of the holographic system in houses that complement the cognitive function of the elderly with the consideration of the interaction with the vision which is a critical function in the cognitive process. The method of this study consists of a literature review on topics including the characteristics of the cognitive function among the elderly, holographic technology and residential services; a configuration of residential services for different space types, depending on the aspects of the cognitive function among the elderly; and finally a suggestion of a holographic system configuration and application depending on various scenarios.

• 한국건축시공학회지
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• 제2권2호
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• pp.175-180
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• 2002

"Samsung Composite Shear Wall System" has its basis on "Samung Able System". "Samsung Able System" has some problems not only in the connection structure but also in waterproofing and soundproofing. We developed "Samsung Composite Shear Wall System" in order to solve these matters and expand PC system. "Samsung Composite Shear Wall System" is the compromise and complement of all the merits of full PC, half PC and in-situ concrete system.

• Journal of Veterinary Science
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• 제22권3호
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• pp.36.1-36.12
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• 2021

Background: Mouse hepatitis virus (MHV) A59 is a highly infectious pathogen and starts in the respiratory tract and progresses to systemic infection in laboratory mice. The complement system is an important part of the host immune response to viral infection. It is not clear the role of the classical complement pathway in MHV infection. Objectives: The purpose of this study was to determine the importance of the classical pathway in coronavirus pathogenesis by comparing C1qa KO mice and wild-type mice. Methods: We generated a C1qa KO mouse using CRISPR/Cas9 technology and compared the susceptibility to MHV A59 infection between C1qa KO and wild-type mice. Histopathological and immunohistochemical changes, viral loads, and chemokine expressions in both mice were measured. Results: MHV A59-infected C1qa KO mice showed severe histopathological changes, such as hepatocellular necrosis and interstitial pneumonia, compared to MHV A59-infected wild-type mice. Virus copy numbers in the olfactory bulb, liver, and lungs of C1qa KO mice were significantly higher than those of wild-type mice. The increase in viral copy numbers in C1qa KO mice was consistent with the histopathologic changes in organs. These results indicate that C1qa deficiency enhances susceptibility to MHV A59 systemic infection in mice. In addition, this enhanced susceptibility effect is associated with dramatic elevations in spleen IFN-γ, MIP-1 α, and MCP-1 in C1qa KO mice. Conclusions: These data suggest that C1qa deficiency enhances susceptibility to MHV A59 systemic infection, and activation of the classical complement pathway may be important for protecting the host against MHV A59 infection.

• Parasites, Hosts and Diseases
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• 제60권4호
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• pp.255-259
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• 2022

Heliminthic paramyosin is a multifunctional protein that not only acts as a structural protein in muscle layers but as an immune-modulatory molecule interacting with the host immune system. Previously, we found that paramyosin from Clonorchis sinensis (CsPmy) is bound to human complement C9 protein (C9). To analyze the C9 binding region on CsPmy, overlapping recombinant fragments of CsPmy were produced and their binding activity to human C9 was investigated. The fragmental expression of CsPmy and C9 binding assays revealed that the C9 binding region was located at the C-terminus of CsPmy. Further analysis of the C-terminus of CsPmy to narrow the C9 binding region on CsPmy indicated that the region flanking ⁷³¹Leu-⁷⁸⁰Leu was a potent C9 binding region. The CsPmy fragments corresponding to the region effectively inhibited human C9 polymerization. These results provide a precise molecular basis for CsPmy as a potent immunomodulator to evade host immune defenses by inhibiting complement attack.

• Korean Journal of Geomatics
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• 제3권2호
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• pp.87-91
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• 2004

Surveying and GIS have increasingly contributed to improve the quality of humane life through the development of its technology. While the surveying professions are now experiencing the crisis of identity. In this paper, we aim to study the concepts and presence of newly used terminologies, present state and future vision of surveying and GIS in Korea. To cope with various surveying consumers for expanding the market and their demands, enhancement of educational system, complement of laws legal system, construction of cooperative system in business are basically required.

• 한국실천공학교육학회논문지
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• 제1권1호
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• pp.85-90
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• 2009

본 논문에서는 평생직업능력개발을 위해서 직업능력개발 제도의 국내 외 변천사 및 동향과 한국폴리텍대학에 운영하고 있는 직업교육훈련 제도에 대해서 살펴보았다. 이를 기반으로 평생직업능력개발을 위해 한국폴리텍대학에서 자체적으로 개발하여 시행하고 있는 사례별 특성에 대해서 살펴보고 분석하였다. 이와 같은 사례들을 바탕으로 부족한 제도는 보완하고 국제적으로 선진화된 직업능력개발제도를 도입함으로써 한국에 적합한 제도로 안착하고 사회적인 변화에 부응하기 위해서는 평생직업능력개발과 관련된 다양한 방면의 검토 및 보완을 통해서 능력중심사회의 구축을 기대해 본다.