• Childhood Kidney Diseases
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• v.23 no.1
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• pp.43-47
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• 2019

Atypical hemolytic uremic syndrome (aHUS), a rare form of thrombotic microangiopathy, is distinguished from the typical form by the absence of a preceding verotoxin-producing Escherichia coli infection. Notably, aHUS occurs in association with genetic or acquired disorders causing dysregulation of the alternative complement pathway. Patients with aHUS may show the presence of anti-complement factor H (CFH) autoantibodies. This acquired form of aHUS (antiCFH-aHUS) primarily affects children aged 9-13 years. We report a case of a 13-year-old Lao girl with clinical features of aHUS (most likely anti-CFH-aHUS). The initial presentation of the patient met the classical clinical triad of thrombotic microangiopathy (microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury) without preceding diarrheal illness. Low serum levels of complement 3 and normal levels of complement 4 indicated abnormal activation of the alternative complement pathway. Plasma infusion and high-dose corticosteroid therapy resulted in improvement of the renal function and hematological profile, although the patient subsequently died of infectious complications. This is the first case report that describes aHUS (possibly anti-CFH-aHUS) in Laos.

• Journal of Physiology & Pathology in Korean Medicine
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• v.26 no.2
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• pp.212-220
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• 2012

In this study, we tried a study on a direction of the field of oriental medicine on accepting complementary alternative medicine by analyzing the related thesis, journals and papers on the complementary alternative medicine published in the field of oriental medicine. As the result of analyzing the present study of the field of oriental medicine on the complementary alternative medicine, there have been 22 studies on the complementary alternative medicine. Thesis, papers were mainly experimental papers about the bee venom therapy, energy therapy, fasting therapy, and colon therapy, and the journals were actively studied in order of clinical paper, experimental paper, and reference paper about the bee venom therapy, energy therapy, and reflexolgy. The acceptance of complementary alternative medicine by the field of oriental medicine through a scientific relation should be conducted more systemically by setting the main academy taking charge of the study on common characteristics of the complementary alternative medicines on the classification of NCCAM as well as the related academies taking charge of the study on the unique characteristic of each complementary alternative medicine. First, additional studies are needed to make the most of characteristics of each complementary alternative medicine through the main academy and the related academies, and for the next, additional studies are necessary to complement the research trend on each complementary alternative medicine through the main academy and related academies.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.8 no.3
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• pp.314-323
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• 2001

Purpose : Complementary and alternative therapies(CAT) are defined as those treatments and healthcare practices not taught widely in medical schools, not generally used in hospitals, and not usually reimbursed by health care insurance. Recently, CAT have become increasingly popular with health care consumers and health care professionals. This study investigated nurses' perceptions and experiences with CAT. Method: 124 nurses who were working in university hospitals in Seoul and Inchon were randomly selected as participants for this study. They answered open and closed questionnaires on their Perceptions and experiences with CAT. Results: Most of the subjects recognized the existence of CAT (86.3%), and expected a treatment effect from CAT when it is combined with conventional therapy (84.7%). Nurses accepted CAT positively as complement for conventional therapy and useful modalities of psychological support when its effects have been proven scientifically. Forty nurses (32.3%) had learned CAT including soojichim, aroma therapy, relaxation, meditation, music therapy, massage, and acupressure. Eight nurses (6.5%) used CAT with patients including soojichim, hand massage, relaxation, and music therapy. Conclusion: In spite of the nurses' positive perceptions of CAT, the nurses' professional experiences were quite limited. Nurses need authorized training programs and continuing education opportunities in CAT. This would increase their ability to use CAT. But to improve scientific knowledge more evidence based research is.

• Clinical and Experimental Pediatrics
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• v.50 no.10
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• pp.931-937
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• 2007

The hemolytic uremic syndrome (HUS) is a rare disease of microangiopathic hemolytic anemia, low platelet count and renal impairment. HUS usually occurs in young children after hemorrhagic colitis by shigatoxin-producing enterohemorrhagic E. coli (D+HUS). HUS is the most common cause of acute renal failure in infants and young children, and is a substantial cause of acute mortality and morbidity; however, renal function recovers in most of them. About 10% of children with HUS do not reveal preceding diarrheal illness, and is referred to as D- HUS or atypical HUS. Atypical HUS comprises a heterogeneous group of thrombomicroangiopathy (TMA) triggered by non-enteric infection, virus, drug, malignancies, transplantation, and other underlying medical condition. Emerging data indicate dysregulation of alternative complement pathway in atypical HUS, and genetic analyses have identified mutations of several regulatory genes; i.e. the fluid phase complement regulator Factor H (CFH), the integral membrane regulator membrane cofactor protein (MCP; CD46) and the serine protease Factor I (IF). The uncontrolled activation of the complement alternative pathway results in the excessive consumption of C3. Plasma exchange or plasma infusion is recommended for treatment of, and has dropped the mortality rate. However, overall prognosis is poor, and many patients succumb to end-stage renal disease. Clinical presentations, response to plasma therapy, and outcome after renal transplantation are influenced by the genotype of the complement regulators. Thrombotic thrombocytopenic purpura (TTP), another type of TMA, occurs mainly in adults as an acquired disease accompanied by fever, neurologic deficits and renal abnormalities. However, less frequent cases of congenital or hereditary TTP associated with ADAMTS-13 (a disintegrin and metalloprotease, with thrombospondin 1-like domains 13) gene mutations have been reported, also. Recent advances in molecular genetics better allow various HUS to be distinguished on the basis of their pathogenesis. The genetic analysis of HUS is important in defining the underlying etiology, predicting the genotype-related outcome and optimizing the management of the patients.

• Korean Journal of Adult Nursing
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• v.14 no.1
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• pp.62-72
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• 2002

Purpose: This study was performed to develop a scale for evaluation of attitudes toward complementary and alternative therapies (CAT) and to investigate nurses' attitudes toward CAT. Method: The subjects were 263 nurses working at a university hospital in Seoul and Inchon. The personally designed questionnaire was tested for its reliability and validity. Nurses' attitudes to CAT were evaluated using the questionnaire. Results: Cronbach's $\alpha$ coefficient was 0.7405. 23 items were selected by item analysis and 4 factors including application, therapeutic effect, social interest and communication about CAT were classified by factor analysis. The mean score of attitudes and its subcategories were high, especially that of communication was very high. Nurses had a positive response to CAT in several items; acceptance as nursing intervention, its therapeutic value, complement for conventional medicine, and open communication about CAT. Attitudes were different significantly according to education and number of working years. There were high relationships between attitudes and its subcategories except communication. Conclusion: The Scale of attitudes toward CAT was proven to be reliable and valid. Positive nurses' attitudes toward CAT will help the patients be provided with a proper and safe way to take CAT.

• Journal of the Korea Safety Management & Science
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• v.17 no.2
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• pp.107-115
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• 2015

The study targeted Japanese employees who have visited hospital for spinal disorder. The study analyzed work environment and pain relief methods of work-related back pain patients, and the relationship between back pain and other body parts. The purpose of this study was to provide draw up measures for patients with back pain and to provide basic data for the sustainable prevention program. The study result of back pain, in other words, employees suffering from lumbago, had disparity between occupations; the highest number of patients were made up of 16-years or above long-serving employees, and below 5-years of short-serving employees. There were more patients complaining of chronic lumbago than acute lumbago, and patients recognized poor posture as the primary cause of lumbago. Furthermore, 99.5% of spinal disorder patients complain back pain, 23.2% use only alternative therapy, and 15.2% visit clinic and hospital with alternative therapy. Patients showed pain reduction and high satisfaction after using alternative therapy. The study targeted Japanese employees where complement therapy is more generalized than that of Korea, and thus there should be multilateral management programs provided in Korea as well.

• The Journal of the Korea Contents Association
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• v.9 no.1
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• pp.285-292
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• 2009

The purpose of this study was to demonstrate immune-activities by heat therapy. To exam, furthermore, the immune effect is investigated from the healthy volunteer(male:15, female:15) by monitoring changes of immune substances such as complements(C1q, C3, and C4), a comparative study with warm water immersion($40.8{\pm}0.3^{\circ}C$) and infrared(250W) was carried out. The plasma analysis showed that the percentage of C1q, C3, and C4 was decreased in warm water immersion-stimulated group, but not in infrared-applied group, compared with control group from healthy volunteer. Therefore, these results suggest that the thermo-stimulation improved immune activity and inhibited complement-related inflammation through the warm water immersion-dependent classical pathway.

• Journal of Korean Academy of Nursing
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• v.43 no.5
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• pp.669-680
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• 2013

Purpose: This study was done to explore the process of accepting CATs among nurses who experienced CATs in Korea. Methods: Grounded theory methodology was utilized. Data were collected from 10 nurses during individual in-depth interviews. Theoretical sampling was used until the data reached saturation. Data were analyzed using the constant comparative analysis method. Results: The core category emerged as "resolving the doubt and integrating" explaining the process of accepting CATs. The nurses engaged in three stages: need awareness, look for solution and integration. Causal conditions were interest as a nursing intervention and orthodox medical limitations. Context was lack of basis for application and increase in social interest. Strategies were new knowledge acquisition, having a strong will, combined with existing knowledge, and individualized intervention. Intervening conditions were others' eye, exhaustion for nurses and physical environment. Consequences were expanding of the nursing role and improved nurse satisfaction. Conclusion: The results of the study should facilitate application of CATs in nursing practice. To help nurses who are interested in CATs, there is a need for education programs, and further research on CATs.

• Physical Therapy Korea
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• v.19 no.4
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• pp.46-54
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• 2012

Ely's test is commonly used to assess rectus femoris muscle flexibility. however, a reliability limit of this test was demonstrated by a previous study. In this study, we present an alternative method using an application for a digital horizontal level in a smartphone (DHLS) to complement the reliability limit of Ely's test. The aim of this study was to examine the reliability of Ely's test using DHLS on the pelvis, compared to using visual observation (VO) of pelvic and hip motions. Nineteen patients with lumbar extension-rotation syndrome were recruited for this study. An examiner examined the rectus femoris flexibility (both pass/fail and goniometer scoring) through Ely's test using both DHLS and VO. A retest session was completed two hours later for within-day reliability and seven days later for between-day intra-rater test-retest reliability. Results showed higher Kappa values for pass/fail scoring and higher intraclass correlation coefficient values for goniometer scoring in Ely's test using DHLS, compared to using VO. Measurement error and Bland and Altman plots further demonstrated the degree of intra-rater variance during Ely's test using DHLS in a clinical setting, compared to using VO. These results demonstrated that Ely's test using DHLS showed acceptable reliability compared to using VO. Ely's test using DHLS could be widely used for measuring the rectus femoris muscle flexibility in patients with lumbar extension-rotation syndrome, although the inter-rater reliability needs to be established first.

• Journal of the Korea Convergence Society
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• v.10 no.4
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• pp.257-264
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• 2019

The purpose of this study was to investigate the main results of the nursing intervention program for reducing depression in menopausal women in Korea and to investigate the effects of systematic review of literature. Research methods were searched for RISS, KMbase, KoreaMed and KISS as domestic databases and limited to domestic papers published in last 10 years from 2006 to 2015. The analysis of 14 articles showed that exercised therapy among the various nursing intervention programs provided significant effects on reducing depression. The intervention methods provided oral education, demonstration training, and practical training, 6 sessions, 60 sessions per session, 5~10 weeks for intervention, and 6~12 weeks for intervention. Depression in menopausal women is not a temporary or short-term emotional state. So it is necessary to provide appropriate exercises that can be applied for their own, regardless of daily life.