• Journal of Veterinary Science
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• v.23 no.1
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• pp.16.1-16.13
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• 2022

Background: Xylazole (Xyl) is a veterinary anesthetic that is structurally and functionally similar to xylazine. However, the effects of Xyl in vitro remain unknown. Objectives: This study aimed to investigate the anesthetic mechanism of Xyl using fetal rat nerve cells treated with Xyl. Methods: Fetal rat nerve cells cultured for seven days were treated with 10, 20, 30, and 40 ㎍/ mL Xyl for 0, 5, 10, 15, 20, 25, 30, 45, 60, 90, and 120 min. Variations of amino acid neurotransmitters (AANTs), Nitric oxide-Cyclic GMP (NO-cGMP) signaling pathway, and ATPase were evaluated. Results: Xyl decreased the levels of cGMP and NO in nerve cells. Furthermore, Xyl affected the AANT content and Na⁺-K⁺-ATPase and Ca²⁺-Mg²⁺-ATPase activity in nerve cells. These findings suggested that Xyl inhibited the NO-cGMP signaling pathway in nerve cells in vitro. Conclusions: This study provided new evidence that the anesthetic and analgesic effects of Xyl are related to the inhibition of the NO-cGMP signaling pathway.

• Journal of Korean Medical classics
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• v.19 no.3
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• pp.165-183
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• 2006

A study of scientific methods in a study of comparative on the oriental medicine and the western medicine evidence to find on the cause-effect relationship. The rationality in a study of process and the confidence in a study of result were improved by a study of methods on the cause-effect relationship. Also a comparative study on the Jeong(精) of the oriental medicine and the cell of the western medicine, after established a model of the cause-effect relationship secured a suitability of a comparative subject and operationalization of a comparative variable to the rationality in a study of process. The Jeong(精) and the cell are the character of a unit and the character of a matter on the human body. The Jeong(精) and the cell are a point of similarity in the function. The Jeong(精) and the cell are a relation in the mechanism. Our paper reviewed a study of comparative methods on the oriental medicine and the western medicine, and suggest an identic interpretation on the human body.

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2002.11a
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• pp.122-130
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• 2002

• Genomics & Informatics
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• v.2 no.3
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• pp.113-120
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• 2004

• Clinical and Experimental Reproductive Medicine
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• v.49 no.1
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• pp.16-25
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• 2022

In mammalian species, females are born with a number of oocytes exceeding what they release via ovulation. In humans, an average girl is born with over a thousand times more oocytes than she will ovulate in her lifetime. The reason for having such an excessive number of oocytes in a neonatal female ovary is currently unknown. However, it is well established that the oocyte number decreases throughout the entire lifetime until the ovary loses them all. In this review, data published in the past 80 years were used to assess the current knowledge regarding the changing number of oocytes in humans and mice, as well as the reported factors that contribute to the decline of oocyte numbers. Briefly, a collective estimation indicates that an average girl is born with approximately 600,000 oocytes, which is 2,000 times more than the number of oocytes that she will ovulate in her lifetime. The oocyte number begins to decrease immediately after birth and is reduced to half of the initial number by puberty and almost zero by age 50 years. Multiple factors that are either intrinsic or extrinsic to the ovary contribute to the decline of the oocyte number. The inflammation caused by the ovulatory luteinizing hormone surge is discussed as a potential contributing factor to the decline of the oocyte pool during the reproductive lifespan.

• Journal of Veterinary Science
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• v.23 no.1
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• pp.13.1-13.12
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• 2022

Background: Toxoplasma gondii can infect humans and most animals and has a very high infection rate worldwide, including in China. The number of people infected with T. gondii in China increases with the number of cats. Objectives: We investigated the seropositive rate of T. gondii in cats over the last five years and analyzed the risk factors via meta-analysis. Methods: We retrieved 20 studies, with a total of 5,158 cats, published between 2016 and 2020, used the DerSimonian-Laird model and calculated seroprevalence estimates with the variance stabilizing double arcsine transformation. Results: The overall seroprevalence rate after sinusoidal conversion was 19.9% (95% confidence interval [CI], 15.9-23.9; 966/5,158), lower than the domestic report from 1995 to 2015 (24.5%, 95% CI, 20.1-29.0). There was substantial heterogeneity among studies (χ² = 262.32; p < 0.001; I² = 64.6%). Regression analysis of possible heterogeneous causes and subgroup analysis showed that age and whether cats were stray or not have a significant effect on the seropositive rate. Conclusions: Articles published in recent five years suggest that the seroprevalence estimates of Toxoplasma gondii in cats has decreased. Cats, as the final host of T. gondii, are an important cause of the spread of the parasite, and this is an important concern for public health.

• Journal of Korean Medicine Rehabilitation
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• v.26 no.1
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• pp.1-11
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• 2016

Objectives The purpose of this study was to investigate the effect of Hyulboochucke-tang on the collagenase induced intracerebral hemorrhage in white rats. Methods To identify the effect of the Hyulboochucke-tang on intracerebral hemorrhage, intracerebral hemorrhage was induced in the right caudate nuclei of white rats. For normal group (n=12) and comparative group (n=12), saline was dosed, and vaccum evaporated Hyulboochucke-tang extract was dosed to treatment group (n=12), 3 and 10 days after the collagenase injection, the body weight, the brain weight, the size of hematoma, the size of the area of malacia, the number of apoptotic cell and the change in pathological histology were observed. Results 3 days after the injection, the brain weight(g) was considerably decreased in treatment group (n=12) compared to comparative group (n=12). The brain weight after 10 days of the injection was also considerably decreased in treatment group (n=6) against comparative group (n=6). The cross section(mm) of cerebral malacia after 10 days of the injection was considerably decreased in treatment group (n=6) compared to comparative group (n=6). The number of apoptotic cell in normal intracerebral around the area of malacia did not show considerable change between treatment group and comparative group. 12 days after the injection, the multiplication of gitter cells, astrocyte and newly formed capillaries around the area of malacia was distinct. Conclusions On the basis of these results, We sugggest that Hyulboochucke-tang controls swelling caused by hemorrhage and contributes to absorption of hematoma by multiplication of newly formed capillaries and recovery of damaged cerebral tissue by multiplication of gitter cells and astrocyte.

• Korean Journal of Oriental Medicine
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• v.1 no.1
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• pp.29-46
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• 1995

In the literature study by the comparative method was carried out on the book of an Introduction to oriental medicine, which was published in China, recently. The results were as follows: The contents of the book was divided by Introduction, Um-Yang-O-Hang(陰陽五行), Qi-Hyul-Chinec(氣血津液), Jang-Bu(臟腑學說), Meridian(經絡), Etiology, Diagnosis, and treatment. This study did not treat the Ancient Chineses character hard to understnad, methodlolgy of traditional literature, and comparison to the western medicine.

• Korean Journal of Oriental Medicine
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• v.18 no.3
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• pp.63-74
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• 2012

Objectives : This study aims to find out comparative results from Sasang Constitutional Medicine, Eight Constitution and Five Elements Constitution. Methods : Searching the records, papers, documents and analyzing. Results and Conclusions : Sasang Constitutional Medicine Theory is organized with Taeyang, Taeum, Soyang, Soum. Eight Constitution is classified mokyang, Mokum, Toyang, Toum, Keumyang, Keumum, Suyang, Suum. and Five Elements Constitution is explained to Yin Yang and Five Elements.

• The Journal of Korean Medical History
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• v.27 no.2
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• pp.1-9
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• 2014

Objectives : Most academic societies have their own journals. Those journals represent the trends of academic societies' studies. Therefore, it is important to review articles in journals. Korean Society of Medical History (KSMH) has Journal of Korean Society of Medical History (J. of KSMH). We analyze articles in J. of KSMH and try to recognize the trends. Methods : From Vol. 12 No. 2 in 1999 to Vol. 27 No. 1 in 2014 of the J. of KSMH, we retrieved article's headings and analyzed those subjects. Results : We got 342 research articles about ; book 97, person 44, theory 65 (medical theory 48, thought 8, origin of word and story 9), clinical research 42 (disease 19, method 16, treatment 7), system of medicine and medical treatment 22 (system of medicine 10, system of medical treatment 12), mutual and comparative study in medicine 18 (mutual study 14, comparative study 4), etc. 56 (materia medica and prescription 23, trends study and essay 18, traditional medicine informatics 10, community medicine 5). Conclusions : J. of KSMH contained several subjects based on medical history ; book, person, theory, thought, origin of word and story, clinical research, mutual and comparative study in medicine, etc. However, the subjects were biased to books and persons.