• 제목/요약/키워드: Comparative clinical study

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두통(頭痛)을 주소(主訴) 입원한 환자 25명에 관한 임상적(臨床的) 고찰(考察) (A Clinical Study of Twenty-five Patients Admitted with Headache)

  • 김지윤;홍현우;김재연;이성도;박동일;감철우
    • 대한한방내과학회지
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    • 제25권4호
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    • pp.34-44
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    • 2004
  • Objective : The purpose of this study is to investigate clinical characteristics with 25 patients who have suffered from headache and were treated. Methods : We classified 25 patients into several groups by IHS classification and evaluated the effects of oriental medical therapy on headache. Results : 1. According to the statistics, instances of migraine were more prevalent than tension headache, especially among women. 2. 28% of patient had entered for treatment within one month of onset. 3. Common associated symptoms included dizziness, nausea, dyspepsia, palpitation and insomnia. 4. In classification by the oriental medical differentiation of symptoms and signs, the rate of stagnation of the humid dam and deficiency of qi, these two types were highest. 5. 56% of patients said they were satisfied with the treatment, reporting half the frequency of headache or better from before treatment. Conclusions : The present results suggest that oriental medical therapy has effects on headache. Further clinical comparative studies on herb-medication versus acupuncture therapy for headache are urged.

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상부 소화관 질환증상에 대한 제산.소화효소제와 생약제를 함유한 복합제제 세립의 유용성 (Evaluation of Clinical Use by Comparative Efficacy and Safety Study of Fine Granvles for Upper Gastrointestinal Disorders Including Symptoms)

  • 전형식;김주현;황일순;추현광;박현철;정숙향
    • 약학회지
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    • 제37권2호
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    • pp.172-181
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    • 1993
  • The purpose of this study was to evaluate the clinical efficacy and safety of NRM which was newly developed as a combination product containing antacids, digestive enzyme and herbal drugs, and OTA powder, called OHTA'S ISAN on the morret, for the treatment of various symptoms in upper gastrointestinal diseases. 63 patients were recruited, 36 as a treated group with NRM and 27 as a controlled one with OTA. Patients were randomly allocated to receive either NRM or OTA t.i.d. for treatment of upper G-1 symptoms and undergone endoscopic, symptomatic and clinical laboratory assessments before and after 2 weeks. The results were as follows; 1. The general improvement rates of subjective symptoms in upper G-1 diseases were observed in 100%(32/32) for NRM and in 92%(23/25) for OTA. 2. The overall effective rates in terms of the symptoms and endoscopic findings were 88.9%(32/36) for NRM and 85.2%(23/27) ,or OTA respectively. 3. In NRM group, no significant side effects by NRM were observed except a mild and transient vomiting in one patient, but in OTA group treatment was discontinued due to nousea in one patient, However, there were no clinically significant changes detected in the laboratory parameters. According to the result of this trial, it is cocluded that NRM was safe and effective and (but not statistically significant) was superior to OTA in the treatment of gastrointestinal diseases caused by gastritis, gastric and duodenal ulcer, functional gastrointestinal disorder, non-ulcer dyspepsia etc.

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갱년기 여성의 안면홍조에 대한 침치료 다기관 임상시험 : 프로토콜 (The effect of acupuncture on hot flushes : A study protocol of multi-center randomized controlled clinical trial)

  • 박지은;오달석;강경원;김동일;최선미
    • Korean Journal of Acupuncture
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    • 제24권3호
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    • pp.33-45
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    • 2007
  • Background : Hot flushes are general postmenopausal symptoms which about 75% of climacteric women undergo. They affect hotness, perspirations, systemic weakness, panic disorders, insomnia. Acupuncture is effective in alleviating hot flushes in practice. Assessment effectiveness and safety of acupuncture in hot flushes would be needed through multi-center trial. Objectives : Purpose of this study is to develope the protocol of effects of acupuncture on hot flushes, a postmenopausal symptom in climacteric women. Methods & Results : It will be a multi-centered, randomized, sham controlled, comparative trial. It will be performed by Good Clinical Practice after approval of Institutional Review Board. Selection criteria will be set according those of FDA above moderate degree. There will be a notice on concomitant medication, other herbs, dietary supplements. Superficial needling on sham points will be used for control group. Treatment period will be 8 weeks with 12 weeks' follow up. Some questionnaire scale will be used as the primary and secondary outcome. Conclusions : The clinical trials based on this protocol will be performed.

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아킬레스건 파열의 수술적 치료 비교: 최소 절개 봉합술과 관혈적 봉합술 (A Comparative Study of Surgical Treatment in the Ruptured Achilles Tendon: Minimal incision and Open repair)

  • 공규민;곽희철;김전교
    • 대한족부족관절학회지
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    • 제16권3호
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    • pp.181-189
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    • 2012
  • Purpose: The purpose of this study was to compare and analyse the clinical outcomes of minimal incision repair and open repair in ruptured Achilles tendon. Materials and Methods: We retrospectively analyzed the outcomes of 10 patients with minimal incision repair (group 1) and 19 patients with open repair (group 2) from February 2007 to June 2011. The postoperative clinical evaluations were done by Arner-Lindholm scale, AOFAS score, overall patient's satisfaction and cosmetic satisfaction of scar. Results: There was no statistical difference between two groups in Arner-Lindholm scale, AOFAS score, overall patient's satisfaction (p=1.21, 0.87, 1.07). There was statistically high rate of cosmetic satisfaction in group 1(p<0.001). There were no complications in group 1. Complications occurred in three patients (deep infection, rerupture, deep vein thrombosis) of group 2. Conclusion: Treatment of minimal incision repair in Achilles's tendon ruptures showed high rate of cosmetic satisfaction and low rate of complication's, but there were no significant differences with open repair in other clinical outcomes. The minimal incision repair could be recommended as one of the effective treatment for the Achilles's tendon ruptures.

여드름 흉터의 한의학 치료에 대한 국내 임상 연구 동향 (Review of Clinical Studies on Korean Medicine for Acne Scar)

  • 제하경;황미리;안재현;정현아
    • 한방안이비인후피부과학회지
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    • 제31권2호
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    • pp.86-103
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    • 2018
  • Objectives : The purpose of this study is to analyze various Korean medical treatments on acne scar and to propose better methods on clinical studies and effective treatments. Methods : Key word 'Acne Scar', published year '2010-2018' were searched on three domestic database systems (RISS, KISS, NDSL). Results : Among 9 studies, 8 studies were case reports and 1 study was comparative study. The treatment used in 9 studies were acupuncture(Subcision, Microneedle Therapy System, laser), pharmacopuncture, external application, dermabrasion, high frequency therapy. 7 out of 9 studies used more than 2 different treatments. The most popular treatment method was 'subcision', followed by 'MTS'. The most popular methods of assessment was QGASC. All studies using assessment methods measuring the severity of acne scar reported improvement, though only 1 study was proved to be statistically different. 1 study reported the side effect, and other 4 studies reported flushing, itching, pain. Conclusions : This study shows the effectiveness of Korean medical treatment on acne scar. It will be expected to use this various treatments and study methods for treating acne scar with Korean medicine, and conducting further clinical studies with higher credibility and reproducibility.

하악 2급 이개부 병변 치료시 비흡수성 차폐막과 혈소판 농축 혈장의 임상적 효과에 대한 비교 연구 (A comparative study of the clinical effects of PRP and non-absorbable membrane in the treatment of mandibular class II furcations)

  • 김창호;임성빈;정진형;홍기석
    • Journal of Periodontal and Implant Science
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    • 제34권3호
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    • pp.509-522
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    • 2004
  • This study was performed to compare the clinical effectiveness of two regenerative techniques for class II furcation involvements in human: a combination of bone grafts with PRP vs. GTR with bone grafts. The e-PTFE group was treated with non-absorbable membrane and bone grafts, the PRP group was treated with PRP and bone grafts Pocket depth, clinical attachment level, and gingival recession were measured at baseline and postoperative 6 months. Vertical and horizontal furcation depth were measured by re-entry surgeries at 6 months post-treatment Both groups were statistically analyzed by Wilcoxon signed Ranks Test & Mann-whitney Test using SPSS program (5% significance level). The results were as follows: 1. The change of pocket depth, clinical attachment level, vertical furcation depth and horizontal furcation depth in both groups was decreased significantly at 6 months than at baseline. (p<0.05) 2. The change of gingival recession in both groups was increased significantly at 6 months than at baseline. (p<0.05) 3. The change of alveolar crest absorption in both groups was increased at 6 months than at baseline but there were no statistically significant differences. 4. The change of pocket depth, clinical attachment level, vertical furcation depth and horizontal furcation depth in both groups was increased significantly at 6 months, but there were no statistically or clinically significant differences with both groups. 5. The change of gingival recession and alveolar crest absorption in both groups was increased at 6 months, but there were no statistically or clinically significant differences with both groups. In conclusion, the use of bone graft with PRP or GTR technique improved clinical index of the soft and hard tissue in mandibular class II furcation involvement but there were no statistically or clinically significant differences between bone graft with PRP and GTR technique.

2급 이개부 병변을 동종골과 혈소판 농축 혈장으로 치료시 차폐막 사용에 따른 임상적 효과의 비교 연구 (A comparative study of clinical effects following treatment of class II furcations using allograft and PR with and without bioabsorbable membrane)

  • 박순재;임성빈;정진형
    • Journal of Periodontal and Implant Science
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    • 제32권3호
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    • pp.631-642
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    • 2002
  • The present study evaluated of regeneration effect of platelet rich plasma on the treatment of classII furcation involvement, with allograft in humans. The control was treated without bioabsorbable membrane, and the test was treated with bioabsorbable membrane. Pocket depth, clinical attachment level, and gingival recession were measured at baseline, postoperative 3, 6months. Both groups were statistically analyzed by Wilcoxon signed Ranks Test & Mann-whitney Test using SPSS program (5% significance level). The results were as follows: 1. The change of pocket depth and clinical attachment level in both groups was decreased significantly at 3, 6months.(p<0.05) 2. The change of gingival recession in both groups was increased significantly at 3, 6months than at baseline.(p (0.05) 3. The change of pocket depth and clinical attachment level in both groups was increased significantly at 3, 6months, but there were no statistically or clinically significant differences with both groups. 4. The change of gingival recession in both groups was increased significantly at 3, 6months, but there were no statistically or clinically significant differences with both groups. 5. The significant reduction of the pocket depth and clinical attachment level exhibited marked changes at 3 months in both groups. In conclusion, the results of this study suggest that there are no statistically or clinically significant differences between with and without bioabsorbable membrane on treatment of classII furcations using allograft and PRP

치근 피개 술식시 치근에 도포된 테트라사이클린의 효과에 관한 임상적 연구 (Clinical Study of Tetracycline HCl Conditioning in the Treatment of Gingival Recession. A Comparative Study)

  • 김종애;정진형;임성빈
    • Journal of Periodontal and Implant Science
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    • 제30권1호
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    • pp.133-146
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    • 2000
  • Histological studies indicate a tetracycline HCl similar to citric acid to induce connetive tissue repair in animals. When tetracycline HCl was used as a root conditioning agent in humans, there was a trend toward more connective tissue attachment than in root planing alone. The purpose of this study was to evaluate clinical effect of tetracycline HCl in the treatment of gingival recession. 44 teeth in 12 patients with bilaterally gingival recession & Miller classification I, II gingival recession were selected and 22 teeth were treated with 125mg/ml tetracycline HCl , the others was not treated with tetracycline HCl. Gingival recession, pocket depth, clinical attachment level, width of keratinized gingiva were observed at baseline, postoperative 4, 12, 20weeks. Both groups were statistically analyzed by Wilcoxon signed Ranks Test & Wilcoxon's rank sum test(Mann-whitney test) using SPSS program.(5% significance level) The results were as follows: 1........The change of gingival recession, clinical attachment level, keratinized gingiva in both groups were increased significantly at 4, 12, 20 weeks. 2.......The pocket depth exhibited no marked changes throughout the entire investigation in both groups. 3........The change of gingival recession in tetracycline group was increased significantly than control group at 4, 12, 20 weeks and the percentage of root coverage was 93% in tetracycline group and 83% in control group. 4........The change of clinical attachment level, pocket depth, keratinized tissue from baseline to 4, 12, 20 weeks was not differ significanltly in both group.

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편측성 하악과두증식증에서 수술방법에 의한 술후 골격구조의 대칭성에 관한 비교연구 (COMPARATIVE STUDY OF POSTOPERATIVE SKELETAL SYMMETRY RELATED TO SURGICAL METHODS IN UNILATERAL CONDYLAR HYPERPLASIA (CONDYLECTOMY VS RAMUS SURGERY))

  • 이정구;홍광진;민병진;이원학;조윤주
    • Maxillofacial Plastic and Reconstructive Surgery
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    • 제18권2호
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    • pp.200-207
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    • 1996
  • In patients with unilateral condylar hyperplasia, increased length of the condylar neck causes deviation of the mandible to the opposite site, resulting in facial asymmetry, but the arch form and general contour of the displaced mandible is approximately symmetric. So, the unilateral condylectomy have been prefered surgical method among the surgeons. The purpose of this study is to analyze the postoperative results comparatively following two different surgical methods, condylectomy and ramus surgery, in unilateral condylar hyperplasia. Case of 6 patients with the unilateral condylar hyerplasia were analyzed in this study, 3 case of the condylectomy only, 3 cases of the ramus surgery, Clinical and radiographic evaluations were tried for comparison. In conclusion, comparative results between two groups did not show any significant difference, but we confirmed that unilateral condylectomy could be a excellent surgical methods in unilateral condylar hyperplasia thinking over the unique morphological characteristics of it.

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가미생화탕(加味生化湯) 가(加) 녹용(鹿茸) 처방(處方)으로 산모(産母)의 빈혈(貧血)이 개선(改善)된 치험 3례 (A Clinical Study on Three Cases of Anemia in Postpartum Women Treated by Gamisaengwha-tang with Deer Antler)

  • 박선민;유동열
    • 대한한방부인과학회지
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    • 제24권3호
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    • pp.212-221
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    • 2011
  • Objectives: The purpose of this study is to report the effect of Gamsaengwha -tang with Deer antler on three postpartum women with anemia. Methods: The three postpartum women with severe anemia among postpartum women who admitted our hospital were treated by oriental treatments such as herbal medicine(Gamisaengwha-tang with Deer antler). Results: After treatment, the measurements of hemoglobin was increased and Anemia was improved. Conclusion: After delivery, many postpartum women have tendency to become anemic. Saengwha-tang and Deer antler became known to be good for anemia in oriental medicine. So the three postpartum women with severe anemia among postpartum women who admitted our hospital were treated by Gamisaengwha-tang with Deer antler. After treatment, the measurements of hemoglobin were increased comparative quickly, and anemia was improved. This case report shows that the Gamisaengwha-tang with Deer antler is effect for treatng anemia. Anemia will improve not only treating by Saengwha-tang except Deer antler but also treating by iron supplement, so we need more comparative study and observation and need more practical use of herbal medicine with Deer antler for anemia and disease of postpartum women.