• Archives of Plastic Surgery
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• v.44 no.5
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• pp.361-369
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• 2017

As the popularity of fat grafting research increases, animal models are being used as the source of pre-clinical experimental information for discovery and to enhance techniques. To date, animal models used in this research have not been compared to provide a standardized model. We analyzed publications from 1968-2015 to compare published accounts of animal models in fat grafting research. Data collected included: species used, graft characteristics (donor tissue, recipient area, amount injected, injection technique), time of sacrifice and quantification methods. Mice were most commonly used (56% of studies), with the "athymic nude" strain utilized most frequently (44%). Autologous fat was the most common source of grafted tissue (52%). Subcutaneous dorsum was the most common recipient site (51%). On average, $0.80{\pm}0.60mL$ of fat was grafted. A single bolus technique was used in 57% of studies. Fat volume assessment was typically completed at the end of the study, occurring at less than 1 week to one year. Graft volume was quantified by weight (63%), usually in conjunction with another analysis. The results demonstrate the current heterogeneity of animal models in this research. We propose that the research community reach a consensus to allow better comparison of techniques and results. One example is the model used in our laboratory and others; this model is described in detail. Eventually, larger animal models may better translate to the human condition but, given increased financial costs and animal facility capability, should be explored when data obtained from small animal studies is exhausted or inconclusive.

• Journal of Ecology and Environment
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• v.38 no.2
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• pp.133-143
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• 2015

Freshwater macrophytes improve the structural heterogeneity of microhabitats in water, often providing an important habitat for zooplankton. Some studies have focused on the overall influence of macrophytes on zooplankton, but the effects of macrophyte in relation to different habitat characteristics of zooplankton (e.g., epiphytic and pelagic) have not been intensively studied. We hypothesized that different habitat structures (i.e., macrophyte habitat) would strongly affect zooplankton distribution. We investigated zooplankton density and diversity, macrophyte characteristics (dry weight and species number), and environmental parameters in 40 shallow wetlands in South Korea. Patterns in the data were analyzed using a self-organizing map (SOM), which extracts information through competitive and adaptive properties. A total of 20 variables (11 environmental parameters and 9 zooplankton groups) were patterned onto the SOM. Based on a U-matrix, 3 clusters were identified from the model. Zooplankton assemblages were positively related to macrophyte characteristics (i.e., dry weight and species number). In particular, epiphytic species (i.e., epiphytic rotifers and cladocerans) exhibited a clear relationship with macrophyte characteristics, while large biomass and greater numbers of macrophyte species supported high zooplankton assemblages. Consequently, habitat heterogeneity in the macrophyte bed was recognized as an important factor to determine zooplankton distribution, particularly in epiphytic species. The results indicate that macrophytes are critical for heterogeneity in lentic freshwater ecosystems, and the inclusion of diverse plant species in wetland construction or restoration schemes is expected to generate ecologically healthy food webs.

• Korean Institute of Interior Design Journal
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• v.19 no.3
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• pp.205-213
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• 2010

The importance of communication which is oriented to interaction, fusion and connection is more increased in the post-information society. The information environment is already realized as interface to reach immediately and freely to the databased information and knowledge. The contemporary libraries execute very important roles as an intellectual infra of modern times to deliver the great human achievement and create new culture. In the mean time, the rapid information-oriented society and the development of digital technology bring out big change in the traditional dispatch and receipt method of information. For this reason, libraries as the community space of visitors integrates physical space - electronic space and reconstructs new temporary culture and value to build the new interface that connects human to human, human to space and human to information. On the premise of these awareness, this study analysis the creative interface factor of Tama Art University New Libraries in Ito Toyo in order to research the function and the application method of modern libraries. And the results are follows. 1)We can make sure the significance of communication and the integration consciousness between digital technology and analogue sensitivity that is the characteristic of the post-information society. 2)We can classify for the creative interface factors by the character as space factor(Arcade, Gallery, Lounge, AV Booth, Cafe), facility/equipment factor(Laboratory, Media, Bar, Info Shelf, Media Seat) and furniture factor(Carrel, Desk, Mag Table, XI Shelf). 3)We can see that these interface factors change the stream of library users and that the library is constructed for library users to create and discovery something easily from books and modern technologies. And we can realize also that these factors are creative installation to lead out naturally the latent liberty sense of users.

• KIISE Transactions on Computing Practices
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• v.21 no.2
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• pp.109-114
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• 2015

This paper presents a computational model on the transfer of airborne fine particles to analyze the similarities and influences among the 25 districts in Seoul by quantifying a time series data collected from each district. The properties of each district are driven with the model of a time series of the fine particle concentrations, and the calculation of edge-based weights are carried out with the transfer entropies between all pairs of the districts. We applied a modularity-based graph clustering technique to detect the communities among the 25 districts. The result indicates the discovered clusters correspond to a high transfer-entropy group among the communities with geographical adjacency or high in-between traffic volumes. We believe that this approach can be further extended to the discovery of significant flows of other indicators causing environmental pollution.

• The Bulletin of The Korean Astronomical Society
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• v.36 no.2
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• pp.69.2-69.2
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• 2011

The discovery of dark energy from Type Ia supernovae (SN Ia) is based on the implicit assumption that the look-back time evolution of SN Ia luminosity, after light-curve corrections, would be negligible. A strong support for this assumption was the apparent insensitivity of SN Ia distances across the host galaxy morphologies. However, Hicken et al. 2009 (H09) shows a systematic difference in the Hubble residual (HR) of $0.144{\pm}0.070$ mag between the E-S0 and Scd/Sd/Irr galaxies, after light-curve corrections. If true, this indicates that the light-curve fitters used by the SN Ia community can not correct for the population age (and therefore the evolution) effect. In order to confirm this, we have combined nearby SN Ia samples and the first-year SDSS-II SN Survey. The SNANA package was used for analyzing SN Ia light-curve, both for the MLCS2k2 and SALT2 fitters. We find a systematic difference in the HR of $0.10-0.13{\pm}0.030$ mag between E-S0 and Scd/Sd/Irr galaxies, which is in agreement with the result of H09, but now at the 3-5 ${\sigma}$ level. Considering the significant difference in the mean age of stellar population between these morphological types, the difference in the HR reported here suggests that the evolution effect of SN Ia luminosity should be considered in the cosmological application of SN Ia data.

• Journal of the Institute of Electronics and Information Engineers
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• v.51 no.7
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• pp.149-154
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• 2014

Modern data computing developments have led to big improvements in graphic capabilities and there are many new possibilities for data displays. The visualization has proven effective for not only presenting essential information in vast amounts of data but also driving complex analyses. Big-data analytics and discovery present new research opportunities to the computer graphics and visualization community. In this paper, we discuss the patent analysis of big data visualization technology development in major countries. Especially, we analyzed 160 patent applications and registered patents in four countries on November 2012. According to the result of analysis provided by this paper, the text clustering analysis and 2D visualization are important and urgent development is needed to be oriented. In particular, due to the increase of use of smart devices and social networks in domestic, the development of three-dimensional visualization for Big Data can be seen very urgent.

• Journal of Preventive Medicine and Public Health
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• v.55 no.5
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• pp.415-423
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• 2022

Economic evaluations in the healthcare are used to assess economic efficiency of pharmaceuticals and medical interventions such as diagnoses and medical procedures. This study introduces the main concepts of economic evaluation across its key steps: planning, outcome and cost calculation, modeling, cost-effectiveness results, uncertainty analysis, and decision-making. When planning an economic evaluation, we determine the study population, intervention, comparators, perspectives, time horizon, discount rates, and type of economic evaluation. In healthcare economic evaluations, outcomes include changes in mortality, the survival rate, life years, and quality-adjusted life years, while costs include medical, non-medical, and productivity costs. Model-based economic evaluations, including decision tree and Markov models, are mainly used to calculate the total costs and total effects. In cost-effectiveness or costutility analyses, cost-effectiveness is evaluated using the incremental cost-effectiveness ratio, which is the additional cost per one additional unit of effectiveness gained by an intervention compared with a comparator. All outcomes have uncertainties owing to limited evidence, diverse methodologies, and unexplained variation. Thus, researchers should review these uncertainties and confirm their robustness. We hope to contribute to the establishment and dissemination of economic evaluation methodologies that reflect Korean clinical and research environment and ultimately improve the rationality of healthcare policies.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.26 no.8
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• pp.1148-1157
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• 2022

In 2019, COVID-19 changed many people's lives. Among them, metaverse supports non-face-to-face services through various methods, replacing daily tasks. This phenomenon was created and formed like a culture due to the prolonged COVID-19. In this paper, the fun elements used in the existing game were organized to find out the fun factors of the metaverse, and the items and contents were reclassified according to the metaverse with five experts. Classification was classified using reproducibility, sensory fun [graphic, auditory, text, manipulation, empathy, play, perspective], challenging fun [absorbedness, challenging, discovery, thrill, reward, problem-solving], imaginative fun [new story, love, freedom, agency, expectation, change], social fun[rules, competition, social behavior, status, cooperation, participation, exchange, belonging, currency transaction], interactive fun[decision making, communication sharing, hardware, empathy, nurturing, autonomy], realistic fun[sense of unity in reality, easy of learning, adaptation, intellectual problems solving, pattern recognition, sense of reality, community], and creative fun[application, creation, customizing, virtual world].

• Journal of the Korea Convergence Society
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• v.13 no.5
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• pp.517-522
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• 2022

Mid-life is a period of transition and crisis in human development. A multidimensional approach is needed to understand the meaning of the mid-life crisis. In order to understand the crisis of middle age, it is required to understand the psychological aspects of individuals, behavioral and social aspects. Jung referred to the middle age as the period of individuation. In other words, it is a process of stabilizing and integrating several individuals with fragmented personalities. The discovery of the meaning in life in middle age relates to the meaning of existence and to become a true community member through understanding of others and oneself. The sense of crisis in middle age has a deep correlation with the meaning in life, and the sense of crisis in middle age can be lowered through the meaning of life. However, in the process of discovering the meaning in life, adaptation to family and social crises and coping with stress will be important factors.

• BMB Reports
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• v.55 no.11
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• pp.547-552
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• 2022

Sorafenib, originally identified as an inhibitor of multiple oncogenic kinases, induces ferroptosis in hepatocellular carcinoma (HCC) cells. Several pathways that mitigate sorafenib-induced ferroptosis confer drug resistance; thus strategies that enhance ferroptosis increase sorafenib efficacy. Orphan nuclear receptor estrogen-related receptor γ (ERRγ) is upregulated in human HCC tissues and plays a role in cancer cell proliferation. The aim of this study was to determine whether inhibition of ERRγ with DN200434, an orally available inverse agonist, can overcome resistance to sorafenib through induction of ferroptosis. Sorafenib-resistant HCC cells were less sensitive to sorafenibinduced ferroptosis and showed significantly higher ERRγ levels than sorafenib-sensitive HCC cells. DN200434 induced lipid peroxidation and ferroptosis in sorafenib-resistant HCC cells. Mechanistically, DN200434 increased mitochondrial ROS generation by reducing glutathione/glutathione disulfide levels, which subsequently reduced mTOR activity and GPX4 levels. DN200434 induced amplification of the antitumor effects of sorafenib was confirmed in a tumor xenograft model. The present results indicate that DN200434 may be a novel therapeutic strategy to re-sensitize HCC cells to sorafenib.