• 인터넷정보학회논문지
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• 제13권4호
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• pp.45-52
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• 2012

감염된 미생물에서 유래한 단백질 펩타이드가 HLA에 결합하여 숙주의 세포표면에 제시되면, T 세포가 이를 인식하여 면역반응을 유발함으로써 감염원을 제거하게 된다. HLA와 펩타이드간의 결합이 안정적일수록 T 세포반응이 강하게 일어나 효율적으로 감염원을 제거할 수 있다고 알려져 있다. 따라서 특정 HLA에 안정적으로 결합할 수 있는 펩타이드(HLA binder)를 찾아낼 수 있다면 감염질환이나 암의 예방을 위한 펩타이드 백신의 개발에 활용될 수 있다. 그런데 HLA는 매우 다형하기 때문에 하나의 집단 내에서도 어느 정도의 빈도를 가지는 대립유전자의 수가 매우 많다. 따라서 이들 모든 대립유전자들에 대해 가능한 펩타이드조합을 제작한 후 직접 실험을 통해 안정적으로 결합하는 펩타이드를 찾아내는 것은 매우 비효율적이다. 이를 극복하기 위하여 특정 HLA에 안정적으로 결합하는 펩타이드를 예측하는 정보전산적인 방법이 최근 개발되어 왔다. 이들 방법을 통해 제시된 펩타이드에 대해서만 직접 생물학적 실험을 시행함으로써 연구자는 검증해야 할 후보 펩타이드의 수를 현격히 감소시킬 수 있게 된다. 본 논문에서는 HLA 결합 펩타이드 예측을 위해 기계학습을 이용한 방법을 소개할 뿐만 아니라, 지금까지 HLA 결합 펩타이드 예측에 시도된 적이 없는 '지식기반 유전자 알고리즘(knowledge-based genetic algorithm)'이라는 새로운 모델을 제시하고자 한다. 이것은 유전자알고리즘(GA)에 기반한 것이었지만 전문가 지식을 접목함으로써 GA보다 더 향상된 성능으로 한국인에 흔한 HLA에 결합하는 펩타이드를 예측하였다. 뿐만 아니라 이것은 결합하는 펩타이드의 규칙을 한국인에 흔한 HLA 대립유전자에 대하여 추출해 줄 수 있는 새로운 방법이었다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제2권6호
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• pp.312-332
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• 2008

Password-based authentication key exchange (PAKE) protocols in the literature typically assume a password that is shared between a client and a server. PAKE has been applied in various environments, especially in the “client-server” applications of remotely accessed systems, such as e-banking. With the rapid developments in modern communication environments, such as ad-hoc networks and ubiquitous computing, it is customary to construct a secure peer-to-peer channel, which is quite a different paradigm from existing paradigms. In such a peer-to-peer channel, it would be much more common for users to not share a password with others. In this paper, we consider password-based authentication key exchange in the three-party setting, where two users do not share a password between themselves but only with one server. The users make a session-key by using their different passwords with the help of the server. We propose an efficient password-based authentication key exchange protocol with different passwords that achieves forward secrecy in the standard model. The protocol requires parties to only memorize human-memorable passwords; all other information that is necessary to run the protocol is made public. The protocol is also light-weighted, i.e., it requires only three rounds and four modular exponentiations per user. In fact, this amount of computation and the number of rounds are comparable to the most efficient password-based authentication key exchange protocol in the random-oracle model. The dispensation of random oracles in the protocol does not require the security of any expensive signature schemes or zero-knowlegde proofs.

• 한국조경학회지
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• 제19권3호
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• pp.1-15
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• 1991

The current status of evergreen ground-cover plants as of in the winter months in 50 places selected at random in Seoul was assessed to see how they are at the present, and the following matters of evergreen ground-cover plants were observed to be common aspect of them today during the year of 1989 and 1990 and in winter of Seoul. 1. Ground-cover area in 50 different places of Seoul was 36% of the green area, and the evergreen ground-cover area was 3% of total ground-cover area. As the result, most of ground cover plants founded to be zoysia grasses. 2. Total number of evergreen ground-cover plants species was 24, and the species most frequently found were Juniperus chinensis and horizontalis, Buxus koreana, Liriope platyphylla var. nana. Taxus cuspidats, Rhododendron lateritium, Pleioblastus pygmaea, Poa pratensis in that order of the number of plasces assessed, and sere Poa pratensis, Agrostis tennuis, Liriope platyphylla, Buxus koreana, Juniperus chinensis and horizontalis, Taxus cuspidata. var. nana, Rhododendron lateritium in the order of area planted. 3. Woody plants included 9 species and occupied 16% in the area, also introduced plants included 14 species and occupied 79% in the area. As introduced evergreen grasses occupied, almost of evergreen ground-cover herbs, planting of evergreen ground-cover herbs and native plants are thought to be desirable. 4. Flowering plants of 16 species were found to be 16% of the total evergreen ground-cover area. 5. The ratio of topographical difference, such as plain versus slope for planting site, was 82 and 18% respectively, and sunny versus shady and intermediate places were 72, 15 and 13% respectively. 6. Although appearance of plants was generally fair, poor and drying plants were assessed 33% for the number of places planted, and 11% for the area. It seems to be necessary to manage those plants to their growth characteristics, and desiable to introduce various plant species adaptable to the winter climate of Seoul and grow for the winter landscaping purpose. 7. The poor use and lack of evergreen ground-cover plants are regarded to be deficient in the valus and reconization of them, particularly in the landscaping works. It is therefore considered important to bring out pertinent measures against these inadequate situations.

• 보건행정학회지
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• 제3권1호
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• pp.124-145
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• 1993

General practitioners, internists, pediatricians, and family physicians are classified as so-called primary care physicians in the United States. We carried out this study for the purpose of answering the following question; "Who are the primary care physicians in Korea\ulcorner" We analyzed the 663, 154 claims which were drawn from the health insurance processing file made during the period of one month, April 1992 on the basis of systemic random sampling technique. The 663, 154 cases were matched with the doctor's file registered at the National Federation Medical Insurance by using the indivisual physician code number and analyzed according to the kind of specialty. If we follow the Geyman's definition of primary care physician in the United States, this study shows that they can take care of 43.2% of the total private clinic's claims in Korea. Provided that general practitioners and family physicians are considered the same way as in the United Kingdom, they could with only 8.3% of the total claims in Korea. The most frequent diseases are those which rank first to 46th in the total private clinic's claims. The proportion of the most frequent diseases was highest for pediatricians(90.4%) and followed by internists(81.4%), otolaryngologists(78.7%) and family physicians(76.5%). The proportion of the most frequent diseases in the most common 46 diseases was highest for radiologists(80.4%) and the next was as follows : general practitioners(78.3%), family physicians(67.4%), and internists(67.4%). We classified the most common 20 diseases of each specialty into 17 categories of ICD-9 and compared it with those of general practitioners. The specialists who had managed a similar disease pattern to those of general practitioners were identified as anesthesiologists, family physicians, general surgeons, and internists. Some specialists practicing at private clinics managed the diseases which were not quite appropriate for their specialties. After we evaluated each specialty by the most common diseases, the most frequent diseases, and the most frequent 20 diseases of each specialty in terms of the 17 categories of ICD-9, a tentative assumption is made that the primary physicians in the Republic of Korea are general practitioners, anesthesiologists, family physicians, internists, and general surgeons. This study has concluded that the categories of the primary care physicians are so diverse that their roles and distributions are distorted accordingly. Vigorous health policy efforts in correcting the malcomposition need to be made for the better provision of primary health care in Korea. in Korea.

• 한국지능시스템학회:학술대회논문집
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• 한국퍼지및지능시스템학회 2007년도 춘계학술대회 학술발표 논문집 제17권 제1호
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• pp.473-476
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• 2007

본 논문에서는 LBT(Listen Before Talk) 방식을 사용하는 ZigBee와 FH(Frequency Hopping) 방식을 사용하는 DCP, RFID, Bluetooth 등의 소출력 무선기기가 공유주파수대역에 공존할 경우 요구되는 적정 채널수를 산출하고 전체 공유주파수대역폭 산출법을 제시하였다. 한정된 주파수 대역에서 LBT 및 FH 방식을 사용하는 총 User 수가 포용되는 공유주파수대역폭 산출은 중요한 작업이다. 소출력 무선기기 시스템의 간섭 회피 기술로 사용되는 FH 방식과 LBT 방식에 대기행렬이론(Queueing Theory)을 적용하였으며, 주위의 전파환경을 감지하여 유휴 주파수대역을 찾아 데이터전송을 시도하는 LBT 방식은 random하게 주파수채널을 이동하며 통신을 시도하는 FH 방식과는 구별된다. 채널수 별 User의 통신시도 시간간격을 통계적으로 처리하여 Throughput을 분석한 결과, Throughput 70% 조건에서 FH 방식과 LBT 방식을 사용하는 250mW 소출력 무선기기들이 공존하는 공유주파수대역의 적정 채널수는 30개를 가지며, 전체 공유주파수대역폭은 채널수에 채널당 대역폭의 곱으로 산출이 가능하다.

• Fisheries and Aquatic Sciences
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• 제17권4호
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• pp.461-469
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• 2014

Polychlorinated biphenyls (PCBs) are persistent pollutants in aquatic environments, often causing the decline or disappearance of wild populations. In this study, we used a random amplified polymorphic DNA (RAPD) assay to evaluate the effects on the genomic DNA of olive flounder embryo and larval stages of exposure to Aroclor 1254 at concentrations of 1, 5, 10, 20, and $40{\mu}g/L$. We compared RAPD fingerprints of exposed and non-exposed samples. Polymorphisms were revealed as the presence and/or absence of DNA fragments between the two samples. A dose-dependent increase in the number of polymorphic bands was observed with Aroclor 1254 treatment. Also, RAPD profiles of animals exposed to Aroclor 1254 exhibited an increase in the frequency values (FV) compared to the control. A phenogram constructed using neighbor-joining method indicated that genomic template stability in developing embryo and larval stages was significantly affected at ${\geq}5{\mu}g/L$. This study suggested that DNA polymorphisms detected by RAPD analysis could be used as an investigative tool for environmental toxicology and as a useful biomarker in early life stages for the detection of potential genotoxicants.

• Industrial Engineering and Management Systems
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• 제1권1호
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• pp.87-92
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• 2002

A stochastic process {$A_n$, n = 1, 2, ...} is an arithmetic process (AP) if there exists some real number, d, so that {$A_n$ + (n-1)d, n =1, 2, ...} is a renewal process (RP). AP is a stochastically monotonic process and can be used for modeling a point process, i.e. point events occurring in a haphazard way in time (or space), especially with a trend. For example, the vents may be failures arising from a deteriorating machine; and such a series of failures id distributed haphazardly along a time continuum. In this paper, we discuss estimation procedures for an AP, similar to those for a geometric process (GP) proposed by Lam (1992). Two statistics are suggested for testing whether a given process is an AP. If this is so, we can estimate the parameters d, ${\mu}_{A1}$ and ${\sigma}^{2}_{A1}$ of the AP based on the techniques of simple linear regression, where ${\mu}_{A1}$ and ${\sigma}^2_{A1}$ are the mean and variance of the first random variable $A_1$ respectively. In this paper, the procedures are, for the most part, discussed in reliability terminology. Of course, the methods are valid in any area of application, in which case they should be interpreted accordingly.

• Asian Journal of Business Environment
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• 제12권1호
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• pp.17-24
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• 2022

Purpose: This study aims to determine the effect of economic agents, such as the amount of government expenditure on the environment, households, manufacturing industry, and shipping activities; on environmental degradation in Indonesia. Research design, data, and methodology: This study is conducted with 264 observations from panel data of 33 provinces during 2010-2017. Environmental degradation is measured by using the environmental quality index collected from Indonesian Ministry of Forestry and Indonesian Central Bureau of Statistics. Three testing models are used to test the panel data, namely Common Effect Model (CEM), Fixed Effect Model (FEM), and Random Effect Model (REM). Results: The research findings show that the amount of government expenditure on the environment, households, and shipping activities have a negative and significant effects on environmental degradation, while the number of manufacturing industry has positive and significant effect on environmental degradation. Unlike the previous studies, the result also shows that government expenditure on environmental has a positive and significant effect on environmental quality index. Conclusion: It can be concluded that even though Indonesian government spent a low budget on environment, their environmental regulation has succeeded both in reducing environmental degradation and increasing the environmental quality as indicated by Indonesian environmental quality index.

• Journal of Ecology and Environment
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• 제47권3호
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• pp.75-84
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• 2023

Background: Knowledge of the spatial trends of plant invasions in different habitats is essential for a better understanding of the process of these invasions. We examined the variation in invasive alien plant species (IAS) richness and composition at two spatial scales defined by elevation and habitat types (roadside, forest, and cultivated lands) in the Makawanpur district of Nepal. Following an elevation gradient ranging from 500 to 2,400 m asl along a mountain road, plant species cover was recorded within sample plots of size 10 m × 5 m. Systematic random sampling was adopted in every 100 m elevation intervals on three habitat types. Results: Altogether 18 invasive alien plants belonging to eight families were recorded within 60 plots, of which 14 species (representing 80%) were from tropical North and South America. The most common plants by their frequency were Ageratina adenophora, Chromolaena odorata, Bidens pilosa, Lantana camara, and Parthenium hysterophorus. We found a significant relationship between species composition and elevation in the study area. Low-elevation regions had a higher number of alien species as compared to high-elevation regions within different habitat types. Conclusions: The species richness and density of IAS were higher in the road site followed by the cultivated land and forest sites. This pattern occurred throughout the elevation range and habitats. IAS were found mostly in the open land with high sunlight availability. Information from such scientific assessment of invasive alien plants will assist in developing appropriate management plans in the Makawanpur district.

• 한국도로학회논문집
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• 제18권6호
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• pp.115-122
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• 2016

OBJECTIVES : This study develops an evaluation method, which is useful to inspect pavement condition of specific boroughs. This is because pavement condition is broadly divided into five grades via visual inspection, which does not consider the types of deteriorations, and is decided by an investigator having a subjective viewpoint. This visual inspection method is not a satisfactory method for accurate maintenance when various deteriorations occur. METHODS : The performance model considers several factors such as crack, rutting, and IRI. This method is also modified from borough SPI based on SPI (Seoul Pavement Index). Considering limited budget of borough, PI (prediction index) is suggested, which is related to the grade of pavement condition evaluation and type of materials. Practical correlation review is also conducted with statistical verification by using the Monte Carlo simulation. RESULTS : The results of the study show that modified criteria are reasonable. First, the comparison between the visual inspection result and the SPI result indicates that the R-square value is sufficiently high. Second, through the common section, each evaluation method could be compared, and the result shows considerable similarity, which increases when the range is modified. Finally, PI for predicting remaining life and the random number SPI have common parts, which means that each indicator would be adequate to be used as an evaluation method. CONCLUSIONS : Comparison and analysis results show that the developed evaluation method is reasonable for specific boroughs where financial support is inadequate for the evaluation process by using the newer equipment. Moreover, for more accurate evaluation method, previous visual inspection data should be utilized, and the database of inspection equipment have to be collected.