• Korean Journal of Radiology
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• 제23권9호
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• pp.921-930
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• 2022

Objective: To identify epidermal growth factor receptor (EGFR) mutations in lung adenocarcinoma based on ¹⁸F-fluorodeoxyglucose (FDG) PET/CT radiomics and clinical features and to distinguish EGFR exon 19 deletion (19 del) and exon 21 L858R missense (21 L858R) mutations using FDG PET/CT radiomics. Materials and Methods: We retrospectively analyzed 179 patients with lung adenocarcinoma. They were randomly assigned to training (n = 125) and testing (n = 54) cohorts in a 7:3 ratio. A total of 2632 radiomics features were extracted from the tumor region of interest from the PET (1316) and CT (1316) images. Six PET/CT radiomics features that remained after the feature selection step were used to calculate the radiomics model score (rad-score). Subsequently, a combined clinical and radiomics model was constructed based on sex, smoking history, tumor diameter, and rad-score. The performance of the combined model in identifying EGFR mutations was assessed using a receiver operating characteristic (ROC) curve. Furthermore, in a subsample of 99 patients, a PET/CT radiomics model for distinguishing 19 del and 21 L858R EGFR mutational subtypes was established, and its performance was evaluated. Results: The area under the ROC curve (AUROC) and accuracy of the combined clinical and PET/CT radiomics models were 0.882 and 81.6%, respectively, in the training cohort and 0.837 and 74.1%, respectively, in the testing cohort. The AUROC and accuracy of the radiomics model for distinguishing between 19 del and 21 L858R EGFR mutational subtypes were 0.708 and 66.7%, respectively, in the training cohort and 0.652 and 56.7%, respectively, in the testing cohort. Conclusion: The combined clinical and PET/CT radiomics model could identify the EGFR mutational status in lung adenocarcinoma with moderate accuracy. However, distinguishing between EGFR 19 del and 21 L858R mutational subtypes was more challenging using PET/CT radiomics.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2003년도 The 8th Asian Symposium on Precision Forging ASPF
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• pp.158-161
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• 2003

Extrusion of forward-gear and backward-rod by combined extrusion with controlling the extrusion velocity using a counter tool is studied. In the combined forward-backward extrusion with controlling extrusion velocity, only parts with short gear can be formed. To obtain longer gear parts, extrusion with reverse ram motion is carried out after the combined forward-backward extrusion process. In this method, combined forward-backward extrusion is carried out until excessive extrusion length is attained and then, the motion of the punch is stopped and the counter tool is moved in the inverse direction and returned to the position for obtaining the desired extrusion length. The experiment is carried out by using lead for billets as a model material. With reverse ram motion, longer gear teeth without under-filling defect can be formed than that by only combined extrusion with controlling extrusion velocity.

• Structural Engineering and Mechanics
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• 제72권4호
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• pp.443-454
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• 2019

In order to reduce the residual drift of a structure in structural engineering field, a combined structural system (dual) consisting of steel buckling-restrained braced frame (BRBF) along with shear wall is proposed. In this paper, BRBFs are used with special reinforced concrete shear walls as combined systems. Some prototype models of the proposed combined systems as well as steel BRBF-only systems (without walls) are designed according to the code recommendations. Then, the nonlinear model of the systems is prepared using fiber elements for the reinforced concrete wall and appropriate elements for the BRBs. Seismic responses of the combined systems subjected to ground motions at maximum considered earthquake level are investigated and compared to those obtained from BRBFs. Results showed that the maximum residual inter-story drift from the combined systems is, on average, less than half of the corresponding value of the BRBFs. In this research, mean of absolute values of the maximum inter-story drift ratio demand obtained from combined systems is less than the 3% limitation, while this criterion has not been fulfilled by BRBF systems.

• Structural Engineering and Mechanics
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• 제17권2호
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• pp.187-201
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• 2004

A shaking table test on a three-story one-bay steel frame model with metallic yield dampers and their parallel connection with oil dampers is carried out to study the dynamic characteristics and seismic performance of the energy dissipation system. It is found from the test that the combined energy dissipation system has favorable reducing vibration effects on structural displacement, and the structural peak acceleration can not evidently be reduced under small intensity seismic excitations, but in most cases the vibration reduction effect is very good under large intensity seismic excitations. Test results also show that stiffness of the energy dissipation devices should match their damping. Dynamic analysis method and mechanics models of these two dampers are proposed. In the analysis method, the force-displacement relationship of the metallic yield damper is represented by an elastic perfectly plastic model, and the behavior of the oil damper is simulated by a velocity and displacement relative model in which the contributions of the oil damper to the damping force and stiffness of the system are considered. Validity of the analytical model and the method is verified through comparison between the results of the shaking table test and numerical analysis.

• 한국해안해양공학회지
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• 제13권2호
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• pp.177-188
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• 2001

전난류에서 파와 해류가 합성하였을 때 발생하는 해저면 마찰력을 계산하는 방법을 고찰하였다. 전난류에서 일방향 흐름에 의한 마찰력의 산정방법으로 절점조정법을 제시하였으며, Bijker의 관측자료와 비교하여 절점조정치를 산정하였다. 파와 해류의 합성류에 의한 마찰력 계산방법으로 수정된 Bkjker 모형(BYO Model)과 수정된 Fredsoe 모형(FY Model)을 Bijker의 관측자료에 적용하였으며, BYO 모형에서 최대마찰력을 산정하는데 있어 새로운 개선책을 제시하였다.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2006년도 춘계학술대회
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• pp.425-428
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• 2006

Natural gas hydrate has been a major problem for its plugging nature in the pipeline. With the demand of deep-water production, the importance of flow assurance technology, preventing hydrate, asphaltene and wax in the pipeline becomes bigger Kinetic models combined with the flow simulator are being developed to explain the nature of hydrate plug formation in the pipeline. To simulate the hydrate plug formation, each stage including the nucleation, growth and agglomeration should be considered. The hydrate nucleation is known to be stochastic and is believed hard to be predicted. Recent publications showed hydrate growth and agglomeration can be observed rigorously using a particle size analyzer. However properties of the hydrate should be investigated to model the growth and agglomeration. The attractive force between hydrate particles, supposed to be the capillary force, was revealed to be stochastic. Alternative way to model the hydrate agglomeration is to simulate by the discrete element method. Those parameters, particle size distribution, attractive force, and growth rate are embedded into the kinetic model which is combined Into the flow simulator. When compared with the flowloop experimental data, hydrate kinetic model combined into a flow simulator showed good results. With the early results, the hydrate kinetic model is promising but needs more efforts to improve it.

• 응용통계연구
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• 제37권3호
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• pp.297-309
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• 2024

본 논문에서는 자기회귀 신경망 모형과 지수평활법을 결합(NNARX+ETS 모형)하고 그 성능을 평가한다. 제안된 결합 모형은 시계열 자료를 예측하기 위하여 NNARX 모형의 외생변수로서 ETS 모형의 구성 성분을 활용한다. 이 모형의 주요 아이디어는, 신경망 모형이 원시계열 자료의 과거 시차만을 고려하는 것을 한계를 넘어서서 전통적 시계열 예측 방법인 지수평활법에 의해서 추출된 정제된 시계열 구성 성분까지도 추가로 신경망 모형의 입력값으로 사용하는 것이다. 예측 성능 평가는 2가지 실제 시계열 자료를 사용하였으며 제안된 모형을 NNAR 모형 및 전통적 시계열 분석 방법인 ETS와 ARIMA 모형과 비교하였다.

• Advances in Computational Design
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• 제2권2호
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• pp.169-183
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• 2017

This paper shows optimal dimensioning for the corner combined footings to obtain the most economical contact surface on the soil (optimal area), due to an axial load, moment around of the axis "X" and moment around of the axis "Y" applied to each column. The proposed model considers soil real pressure, i.e., the pressure varies linearly. The classical model is developed by trial and error, i.e., a dimension is proposed, and after, using the equation of the biaxial bending is obtained the stress acting on each vertex of the corner combined footing, which must meet the conditions following: 1) Minimum stress should be equal or greater than zero, because the soil is not withstand tensile. 2) Maximum stress must be equal or less than the allowable capacity that can be capable of withstand the soil. Numerical examples are presented to illustrate the validity of the optimization techniques to obtain the minimum area of corner combined footings under an axial load and moments in two directions applied to each column.

• 한국소음진동공학회논문집
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• 제12권2호
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• pp.141-149
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• 2002

Although the finite element method has become an indispensible tool for the dynamic analysis of structures, difficulty remains to quantify the errors associated with discretization. To improve the modeling accuracy, this paper proposes a method to make a combined use of finite elements and exact dynamic elements. Exact interpolation functions for the Timoshenko beam element are derived using the exact dynamic element modeling (EDEM) and compared with interpolation functions of the finite element method (FEM). The exact interpolation functions are tested with the Laplace variable varied. A combined use of finite element method and exact interpolation functions is presented to gain more accurate mode shape functions. This paper also presents a combined use of finite elements and exact dynamic elements in design/reanalysis problems. Timoshenko flames with tapered sections are tested to demonstrate the design procedure with the proposed method. The numerical study shows that the combined use of finite element model and exact dynamic element model is very useful.

• 한국농공학회지
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• 제34권E호
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• pp.12-19
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• 1992

The effects of drainage system on evapotranspiration and drainage flows are studied. Data from drainage field experiment at Castalia in North Central Branch, Ohio Agricultural Research and Development Center were used in this study. A water table management model, ADATP (Agricultural Drainage and Pesticide Transport), which was developed by combining the GLEAMS and the subsurface drainage part of the DRAINMOD model with several modifications, was evaluated and used to predict hydrologic components. The ET is very much affected by the presence of tile drainage system but not significantly affected by the surface drainage system. The combined surface and subsurface drainage system gives the largest total outflow values while the surface drainage only system gives the smallest. Comparisons of model predicted and measured values of surface runoff only, subsurface drainage only, and combined surface runoff and subsurface drainage system are in satisfactory agreement. The model predicted values are within the range of the variations of the observed replications in general. Based on the results of the model evaluation study, it is concluded that ADAPT model can be used to design water table management systems.