• Journal of Korean Society for Quality Management
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• v.17 no.2
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• pp.64-69
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• 1989

This paper aims at analyzing the process capability and at determining an optimal condition by experimental designs using the 2-way classification with repitition in order to maintain lower Nacl content and to refine both of a very small quantity of fatty acid and various magnetic ions in the glycerin to use ion exchange resin treatment process. An optimal condition of each level combination in both of passing temperature of cation exchange resin($A_1$, $A_2$, $A_3$) and of anion exchange resin($B_1$, $B_2$, $B_3$) is $A_3B_3$. The process capability index is improved from 0.63 to 1.40 and is interpreted as a desirable state. This analysis of process capability by experimental designs will contribute to improving productivity and quality of products.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2003.05a
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• pp.216-220
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• 2003

Most important for meaningful forging simulation is the determination of correct process parameters. In addition a check and a compensation of the data base after the comparison between experiments and the computation of the developed process is necessary. The existence of a systematic process parameter data bank for special kinds of forming process in combination with forging specific simulation lifts the value of the products. Finite volume method is applied to simulate the hot forging process to investigate the defects for the automobile product. Three typical forging processes have been investigated; Extrusion by hydrolic press, Upsetting by crank press and Inclined upsetting by hammer press. Simulated result has compared with the experiment and provided a direction to improve the process.

• Korean Journal of Veterinary Research
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• v.50 no.4
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• pp.259-264
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• 2010

Melamine is an organic base and a trimer of cyanamide which contains 66% nitrogen by mass, but it was sometimes illegally added to food products in order to enhance the apparent protein content for the bigger profit. Many Chinese infants and pet animals fed melamine-containing formulas suffered acute kidney failure with renal crystal formation. Fish feeds were also recently found to be contaminated with melamine. This experiment has been designed to determine whether renal crystals can be experimentally induced in crucian carp (Carassius carassius) fed melamine and cyanuric acid (each at 400 mg/kg/day for 3 days) in combination, and to compare experimentally induced crystals with those from pet animals with triazine related renal failure. The results showed that all fish developed gold brown renal crystals arranged in radial spherulites in the renal tubules, similar to those detected in the pet animals.

• BMB Reports
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• v.29 no.2
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• pp.122-126
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• 1996

A series of oligonucleotides were synthesized by automatic DNA synthesizer. The purity of crude products was checked and their molecular weights determined by matrix assisted laser desorption ionization mass spectrometry (MALDI-MS) with an accuracy of better than 0.05% deviation even without using an internal standard. This mass determining technology in combination with partial digestion of oligonucleotides by 5'- and 3'-exonuclease provides a straightforward and simple method to obtain sequence information of oligonucleotides. The extension of this technology to the sequencing of modified oligonucleotides and genomic DNA and RNA might become possible.

• Journal of Microbiology and Biotechnology
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• v.20 no.4
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• pp.809-816
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• 2010

Microbial biotransformations can be used to predict mammalian drug metabolism. The present investigation deals with microbial biotransformation of valdecoxib using microbial cultures. Thirty-nine bacterial, fungal, and yeast cultures were used to elucidate the biotransformation pathway of valdecoxib. A number of microorganisms metabolized valdecoxib to various levels to yield nine metabolites, which were identified by HPLC-DAD and LC-MS-MS analyses. HPLC analysis of biotransformed products indicated that a majority of the metabolites are more polar than the substrate valdecoxib. Basing on LC-MS-MS analysis, the major metabolite was identified as a hydroxymethyl metabolite of valdecoxib, whereas the remaining metabolites were produced by carboxylation, demethylation, ring hydroxylation, N-acetylation, or a combination of these reactions. The hydroxymethyl and carboxylic acid metabolites were known to be produced in metabolism by mammals. From the results, it can be concluded that microbial cultures, particularly fungi, can be used to predict mammalian drug metabolism.

• Journal of the Korean Society for Precision Engineering
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• v.17 no.6
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• pp.143-152
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• 2000

The comer filling in shaped drawing process is an important characteristic, unlike the round drawing. It has also influence on the dimensional accuracy of the product. In this study, therefore, the shaped drawing process has been simulated by the three dimensional rigid-plastic finite element method in order to investigate the effect of process variables such as reduction in area and semi-die angle to the corner filling. The artificial neural network has also been introduced to reduce the number of simulations. To verify the results of simulations, experiments have been performed on the real industrial products. According to the results, the main process variable on the corner filling is the combination of semi-die angle in the irregular shaped drawing processes, but in the case of regular shaped drawing processes, reduction in area has great influence on the corner filling.

• Environmental Mutagens and Carcinogens
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• v.10 no.2
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• pp.93-106
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• 1990

The Drosophila temperature-sensitive mutant shibire (shi) is paralyzed at restrictive temperature by a reversible block in synaptic transmission. To explore the functional relationship among shi gene products, viability and temperature-sensitive paralytic behavior were quantitaively analyzed for four shi alleles, shi$^{ts1}$, shi$^{ts2}$, shi$^{ts4}$, and shi$^{ST139}$, and their heteroallelic combinations. The hemizygous combination of shi alleles over deficiency was not completely lethal. shi$^{ts2}$ exhibited distinctively higher viability than other alleles. A novel behavior, bang sensitivity, was also found in shi/Df(1). This bang-sensitive paralytic behavior was compared with that of the typical bang-sensitive mutant flies. Heterozygotes, shi/+, are more severe in temperature sensitivity than deficiency hemizygotes, Df(1)/+. Heteroallelic combinations of shi were less sensitive to high temperature than homozygotes. Among all allelic combinations, shi$^{ts2}$/shi$^{ts4}$ showed an unexpected extreme reduction in temperature sensitivity. The results of allelic interactions among 4 shi alleles suggest that the shi mutations examined behave as antimorphic alleles and that the gene product of shi are likely to function in multimeric forms.

• Journal of Korean Institute of Industrial Engineers
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• v.23 no.3
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• pp.501-514
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• 1997

Manufacturing is fast entering a new age of industrial excellence that is being called "Agile Manufacturing." The goal of Agile Manufacturing is to link customers, suppliers, and the manufacturing system into a super-efficient confederation to produce a variety of products quickly and at a low cost. In order to improve the quality of the study of production input control(PIC) in a job shop manufacturing system by reducing the significant gap between research models and models of actual manufacturing systems, the previous line of research on PICs in a job shop manufacturing system is extended by integrating customers and suppliers with the manufacturing system. Then, a set of measures is developed to evaluate PICs, measures that reflect concerns of customers and suppliers as well as concerns of the manufacturer. Also, a weighted overall measure (with various cases to represent different possible weights of manufacturer's emphasis on the performance measures) is used to synthesize all the performance measures. Then, for each case, various existing PICs are evaluated in combination with various priority dispatching rules(PDRs).

• Korean Management Science Review
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• v.20 no.1
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• pp.77-88
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• 2003

Supply-Chain Management (SCM) was the integration of the activities that procure materials, transform them into intermediate goods and final products, and deliver them to customers. These activities include the traditional purchasing function, plus other activities that were important to the relationship with suppliers and distributors. P company was the first vendor in motor industry of Korea and had a flexible relationship with motor industry through SCM. However, p company had independent information with motor Industry and it caused many troubles In the operation of the P company. Considering these facts, authors had developed the inventory control system which was the part of order-fulfillment process and could make a progress in the operation of the inventory. The core factor of the developed inventory control system was the combination of the theoretical factors and the empirical factors. That is, the factors which were excluded in existing inventory theory revealed to be important.

• Journal of Sericultural and Entomological Science
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• v.39 no.1
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• pp.30-35
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• 1997

A rapid and sensitive detection of BmNPV contamination in silkworm rearing room was carried by Plymerase chain reaction(PCR). Silkworm nuclear polyhedra were dissolved for the extraction of viral DNA within 30 minutes followed by the treatment of alkaline solution. The combination of primers of NP3 and NP2 was superior in PCR to the other 7 primers applied. Each primer was designed with 20 base in size and Newly designed NP3 of sense and the already reported NP2 for antisense were better in reaction than other primers. PCR products appeared 500bp in size. And annealing was confirmed proper at 55$^{\circ}C$ condition. Amplifiable template DNA amount was confirmed at least 100 ng to 0.1 ng and regarded as applicative for the assay of silkworm rearing environmental condition of sericultural farm. In case of the detection of BmNPV from the dust, sensitivity by PCR was as high as 1,000,000 times than that of microscopic observation.