• IMMUNE NETWORK
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• v.22 no.1
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• pp.5.1-5.22
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• 2022

The approval of immunotherapies such as checkpoint inhibitors (CPIs), adoptive cell therapies and cancer vaccines has revolutionized the way cancer treatment is approached. While immunotherapies have improved clinical outcome in a variety of tumor types, some cancers have proven harder to combat using single agents, underscoring the need for multi-targeted immunotherapy approaches. Efficacy of CPIs and cancer vaccines requires patients to have a competent immune system with adequate cell numbers while the efficacy of adoptive cellular therapy is limited by the expansion and persistence of cells after infusion. A promising strategy to overcome these challenges is combination treatment with common gamma-chain cytokines. Gamma-chain cytokines play a critical role in the survival, proliferation, differentiation and function of multiple immune cell types, including CD8 T-cells and NK cells, which are at the center of the anti-tumor response. While the short halflife of recombinant cytokines initially limited their application in the clinic, advancements in protein engineering have led to the development of several next-generation drug candidates with dramatically increased half-life and bioactivity. When combining these cytokines with other immunotherapies, strong evidence of synergy has been observed in preclinical and clinical cancer settings. This promising data has led to the initiation of 70 ongoing clinical trials including IL-2, IL-7, IL-15 and IL-21. This review summarizes the recent advancements of common gamma-chain cytokines and their potential as a cancer immunotherapy.

• KIISE Transactions on Computing Practices
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• v.21 no.12
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• pp.745-750
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• 2015

LiDAR(Light Detection and Ranging) technology provides realistic 3-dimension image information, and it has been widely utilized in various fields. However, the utilization of this technology in the military domain requires prompt responses to dynamically changing tactical environment and is therefore limited since LiDAR technology requires complex processing in order for extensive amounts of LiDAR data to be utilized. In this paper, we introduce an Unmanned Aircraft Platform Based Real-time LiDAR Data Processing Architecture that can provide real-time detection information by parallel processing and off-loading between the UAV processing and high-performance data processing areas. We also conducted experiments to verify the feasibility of our proposed architecture. Processing with ARM cluster similar to the UAV platform processing area results in similar or better performance when compared to the current method. We determined that our proposed architecture can be utilized in the military domain for tactical and combat purposes such as unmanned monitoring system.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.8
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• pp.468-474
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• 2020

Metal ducts for transporting air conditioning and heating inside ships have recently been replaced by cloth ducts that have the advantage of delivering air evenly to the compartments, with excellent noise reduction in major compartments, such as combat command rooms, steering rooms, and sound detector cabins. Since the performance requirements of fabric ducts for vessels are strict, and the entire length of the ducts was imported from Korea, the government wants to create economic effects through localization of fabric ducts. Air permeability and fire prevention performance tests verified the applicability to naval vessels of fabric ducts developed by Hyundai Heavy Industries and HiDact, and performance requirements presented in the POS were verified. As a result of the tests, the fabric ducts met the requirements for air permeability and fireproof performance.

• Journal of the Korea Society for Simulation
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• v.21 no.4
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• pp.65-73
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• 2012

Due to the development of technology related to a weapon system and the info-communication, the battle system of a warship has to manage many kinds of human intervention tactics according to the complicated battlefield environment. Therefore, many kinds of studies about M&S(Modeling & Simulation) have been carried out recently. The previous M&S system based on an agent, however, has simply used non-flexible(or fixed) tactics. In this paper, we propose an agent modeling methodology which has reinforcement learning function for spontaneous(active) reaction and generation evolution learning Function using Genetic Algorithm for more proper reaction for warship battle. We experiment with virtual 1:1 warship combat simulation on the west sea so as to test validity of our proposed methodology. We consequently show the possibility of both reinforcement and evolution learning in a warship battle.

• Journal of the Korea Society for Simulation
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• v.21 no.4
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• pp.81-90
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• 2012

Presented in this paper is a study for construction of a simulation system for the engagement of ground weapon systems. This paper proposes architecture for the simulation system based on agent simulation design methodology. Every entity of the proposed architecture is developed by assembling modularized agent components, and it enhances the reusability and composability of the entity. Consequently, time, costs, and efforts that are required to develop a new simulation system is able to be reduced by the enhancement. In the case of ground engagement simulation, it is very important to reflect environmental effects. Synthetic battlefield of the proposed architecture has environmental data of the battlefield and interacts with entities in the simulation system. The proposed architecture based simulation system can build swiftly various simulation models by the objectives and derive reasonable results from behaviors of entities that include environmental effects. This paper contains the construction of an example system based on the proposed architecture to verify the advantages of the architecture.

• Journal of Internet Computing and Services
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• v.21 no.1
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• pp.211-219
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• 2020

One of the major advancements of the Fourth Industrial Revolution is the use of Internet of Drones (IoD), which combines the Internet of Things (IoT) and drone technology. IoD technology is especially important for efficiently and economically operating C4ISR operations in actual battlefields supporting various combat situations. The purpose of this study is to solve the problems of limited battery capacity of drones and lack of budgeting criteria for military drone transcription, introduction, and operation. If the mission area is defined and corresponding multi-drone hovering check points and mission completion time limits are set, then an energy and time co-optimized scheduling and operation control scheme is needed. Because such a scheme does not exist, in this paper, a Drone Force Deployment Optimization (DFDO) scheme is proposed to help schedule multi-drone operation scheduling and networked based remote multi-drone control.

• Journal of Internet Computing and Services
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• v.21 no.2
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• pp.73-80
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• 2020

Due to the expansion of cyber space, war patterns are also changing from traditional warfare to cyber warfare. Cyber warfare is the use of computer technology to disrupt the activities of nations and organizations, especially in the defense sector. However, the defense against effective cyber threat environment is inadequate. To complement this, a new cyber warfare operation concept is needed. In this paper, we study the concepts of cyber intelligence surveillance reconnaissance, active defense and response, combat damage assessment, and command control in order to carry out cyber operations effectively. In addition, this paper proposes the concept of cyber warfare operation that can achieve a continuous strategic advantage in cyber battlefield.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.3
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• pp.453-459
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• 2020

It is important to increase the probability that all developed weapon systems can be operated in a steady state at any time. In the case of Integrated Logistics Support, this probability is referred to as operational availability, and the numerical value is quantified during the development process. There are several ways to improve operational availability for successful development of weapon systems. One of the methods is to reduce total corrective maintenance time through Automatic Test Equipment(ATE). Recently, customers in the defense market have become aware of this and demand ways to improve operational availability of weapon systems. Therefore, this paper proposes ways to improve operational availability of weapon systems by changing the method of operating the ATE. The detailed method is to allow field maintenance personnel to carry out field maintenance support onsite. This is an effective way to reduce the total corrective maintenance time of weapon systems by reducing the travel time of field maintenance personnel. The proposed ATE is proved to be able to achieve superior maintenance and operational availability.

• Strategy21
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• s.44
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• pp.28-53
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• 2018

The U.S. has recently developed Free and Open Indo-Pacific strategy and Distributed Lethality strategy based on a common perception that they are responding to China's threats. In the future, it is anticipated the following. Strengthen cooperation of the U.S.-India-Vietnam navy, Maximizing the combined combat power between the U.S. and regional navies, Improving its ability to restore damage control, Economic cooperation between the Pacific and Indian countries. The meanings given to the Korean navy are as follows. First, South Korea should pursue cooperation with the Indian Navy, which will grow into a regional balance on China's growth. The growth of the Indian navy is expected to increase cooperation with other Pacific countries. The government should seek ways to promote cooperation with india navy in various fields. Secondly, it is a joint drill between the U.S. Navy and the Korean Navy. Recently, the Korea-U.S. joint drill has not been conducted and many changes are expected to be made regarding the implementation of the joint drill in the future. Therefore, it is necessary to respond to possible changes in the naval relationship between Korea navy and the U.S. navy Also, due to distributed lethality strategy, preparations for operations and training with U.S.navy will be necessary. Lastly, it should contribute to cooperation among regional countries in preparation for maritime territorial disputes. The growth of the Chinese navy and the territorial disputes in the East and South China sea has raised the possibility of accidental military clashes at sea. Therefore, the government should make efforts to create multilateral security cooperation systems that can continue to promote the prevention of armed conflict.

• International Journal of Computer Science & Network Security
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• v.21 no.3
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• pp.134-140
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• 2021

The development of technology speeds up the process of obtaining information and its analysis to track the level of corruption in different countries and develop countermeasures. This study examines the role of information and analytical support of anti-corruption policy as a tool for government accountability and analysis, evaluation, combating corruption in Eastern Europe. The purpose of the article is to identify the components of the information-analytical system that help reduce the level of corruption. The research methodology is based on a qualitative content analysis of the functioning of information and analytical systems of Ukraine used by anti-corruption bodies. A quantitative analysis of the CPI score was conducted, according to Transparency International, to identify the effectiveness of anti-corruption policies in developing countries. The results show similar trends in countries developing on the effect of the use of information and analytical systems in the implementation of anti-corruption policies, strategies and measures. The strategy to combat corruption mainly involves increasing the independence and powers of anti-corruption bodies. Therefore, the development of information and analytical support is aimed at automating the processes of pre-trial investigations and criminal proceedings, information protection. As a tool for accountability, information and analytical systems may be ineffective due to the abuse of power by higher anti-corruption bodies due to political pressure from elite structures. Restrictions on political will are a major problem for the effectiveness of anti-corruption policies.