• Natural Product Sciences
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• v.27 no.4
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• pp.264-273
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• 2021

Simultaneous quantification of multiple marker compounds in herbal medicine by high performance liquid chromatography (HPLC) analysis is still a challenge due to the complexity in various parameters to be considered and co-existing multi-components. As a case study, a reliable HPLC method for simultaneous quantification of paeoniflorin from Paeoniae Radix and decursin from Angelicae Gigantis Radix in various commercial herbal medicine was developed based on analytical quality by design (AQbD) strategy. As a first step, risk assessment was performed to select the critical method parameters (CMPs) which were decided as organic mobile phase ratio and column oven temperature. In order to evaluate the effect of the CMPs on critical method attributes (CMAs) of peak resolution and tailing, central composite design (CCD) was employed. The final chromatographic conditions were optimized as follows: column- C₁₈, 4.6 × 250 mm, 5 ㎛ particle size; mobile phase- A: acetonitrile, B: 0.1% acetic acid water; detection wavelength- 235 nm for paeoniflorin, 325 nm for decursin; column oven temperature- 25℃; flow rate- 1.0 mL/min; gradient mobile phase system as Time (min) : % A, 0:14, 25:14, 30:50, 60:50, 61:100, 65:100, 66:14, 75:14. The method was successfully validated according to the International Conference on Harmonization (ICH) guidelines and piloted for ten commercial herbal medicines.

• International conference on construction engineering and project management
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• 2024.07a
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• pp.2-9
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• 2024

In Japan, when constructing frames using Precast Concrete (PCa) methods, unique building components are used. These include integrating column tops with beam ends or using cast-in-place concrete in the panel zone. Planning these components requires considering various factors such as the loading capacity of trailers, crane lifting capacity, joining methods, and equipment penetrations. Building Information Modeling (BIM) technology has become increasingly common in construction planning. However, extracting the necessary information for construction planning directly from the design BIM model is challenging. This difficulty arises because the design BIM model organizes columns and beams in different division units than those used in construction. To address this issue, our study models the concept of the "panel zone" and proposes a method for representing a PCa BIM model composed of panel zones, columns, and beams as PCa products. The study decomposes and combines columns and beams, with parametric changes applied to the panel zone range. Additionally, our study analyzes factors related to the design and planning of column and beam PCa products through interviews and questionnaire surveys conducted with general contractors. An evaluation mechanism for the proposed column and beam division was also established. Based on the findings, a BIM-based method was developed for planning the PCa construction method of the frame using a genetic algorithm. This approach provides a technological solution that supports the planning of frame division, considering the construction rationale at the early design stage.

• Journal of Korean Society of Steel Construction
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• v.27 no.1
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• pp.119-129
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• 2015

Due to reduced self weight and alleviated wind effect, the multi-column wind towers that consist of a number of circular tubes as vertical members interconnected with horizontal brace members can be a substitute for the large-scale single cylinder wind towers. It is critical to guarantee strengths of tubular joints where vertical and horizontal members are structurally connected in order to make the whole multi-column system behave as a single tower structure. In this study, strength evaluation has been conducted for T-type tubular joints that are applicable in multi-column towers. Four of available design codes, i.e., AISC, Eurocode3, ISO 19902, CIDECT have been investigated and predictor equations in the considered design codes were validated and discussed through parametric numerical study on slenderness ratios of chords and braces at joints.

• Earthquakes and Structures
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• v.7 no.6
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• pp.1001-1024
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• 2014

The size of spread footings was found to be unnecessarily large from some actual engineering practices constructed in Taiwan, due to the strict design provisions related to footing uplift. According to the earlier design code in Taiwan, the footing uplift involving separation of footing from subsoil was permitted to be only up to one-half of the foundation base area, as the applied moment reaches the value of plastic moment capacity of the column. The reason for this provision was that rocking of spread footings was not a favorable mechanism. However, recent research has indicated that rocking itself may not be detrimental to seismic performance and, in fact, may act as a form of seismic isolation mechanism. In order to clarify the effects of the relative strength between column and foundation on the rocking behavior of a column, six circular reinforced concrete (RC) columns were designed and constructed and a series of rocking experiments were performed. During the tests, columns rested on a rubber pad to allow rocking to take place. Experimental variables included the dimensions of the footings, the strength and ductility capacity of the columns and the intensity of the applied earthquake. Experimental data for the six circular RC columns subjected to quasi-static and pseudo-dynamic loading are presented. Results of each cyclic loading test are compared against the benchmark test with fixed-base conditions. By comparing the experimental responses of the specimens with different design details, a key parameter of rocking behavior related to footing size and column strength is identified. For a properly designed column with the parameter higher than 1, the beneficial effects of rocking in reducing ductility and the strength demand of columns is verified.

• Magazine of the Korea Concrete Institute
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• v.9 no.2
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• pp.167-177
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• 1997

In thtx design of ductile moment -1csist1ng frnmcls (DMRFs) f'ollow~ng the. stlong columnweakbeam design philosophy, it is desirable that the joint and column remain essentiallyelastic in order to insure proper energy dissipation and lateral stability of the structure.Thv joint has been identifid as the "weak link: in DMRFs because any stiffness orstrength deterioration in this region can lead to substantial drifts and the possibility ofcollapse due to t'-delta effects. h3oreove1.. the tngintw is faced with the difficult task ofdetailing an element whose size is determined by theframing members, but \vhich mustresist a set of loads very different from those used in the design of the beams and columns.Four 3 -scale beam-column-slab joint assemblies were designed according to existing cod\ulcornerrequirements of' ACI 318-89. representing perimeter joints of DMRFs with reinforced highstrength concrete. The influence on aseismic behavior of beam-column joints due tomonolithic slab, has been investigated.lab, has been investigated.

• Steel and Composite Structures
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• v.27 no.6
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• pp.727-745
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• 2018

The design criteria and the corresponding performance levels characterize the response of extended stiffened end-plate beam-to-column joints. In order to guarantee a ductile behavior, hierarchy criteria should be adopted to enforce the plastic deformations in the ductile components of the joint. However, the effectiveness of thesecriteria can be impaired if the actual resistance of the end-plate material largely differs from the design value due to the potential activation of brittle failure modes of the bolt rows (e.g., occurrence of failure mode 3 in the place of mode 1 per bolt row). Also the number and the position of bolt rows directly affect the joint response. The presence of a bolt row in the center of the connection does not improve the strength of the joint under both gravity, wind and seismic loading, but it can modify the damage pattern of ductile connections, reducing the gap opening between the end-plate and the column face. On the other hand, the presence of a central bolt row can influence the capacity of the joint to resist the catenary actions developing under a column loss scenario, thus improving the joint robustness. Aiming at investigating the influence of these features on both the cyclic behavior and the response under column loss, a wide range of finite element analyses (FEAs) were performed and the main results are described and discussed in this paper.

• Steel and Composite Structures
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• v.17 no.1
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• pp.83-103
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• 2014

The objective of this research is to study the ultimate moment capacity of the connections between steel I-beams and concrete-filled steel tube columns using different stiffener configurations. The main parameters considered are column cross section shape, square or circular, and filling the column with concrete. This analytical study includes finite element models using ANSYS program taking geometric and material nonlinearities into consideration. These models are verified against the experimental results obtained from previous researches and current design guides. The results show that using proper stiffener configuration affects the stress distribution through the connection and increases the ultimate moment capacity of the connections. Also, circular column is advantageous than the square column for all stiffener configurations and dimensions.

• Journal of the Korean Society of Safety
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• v.20 no.2 s.70
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• pp.79-83
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• 2005

Recently, column-supported wall structural system is frequently adopted in mixed-use high-rise buildings. Due to the sudden change of stiffness at the transfer floor proper load transfer and avoiding stress concentration are very important in column-supported wall structural system. It is revealed by many investigators that 2-dimensional analysis is not reliable and inappropriate selection of element for modeling may lead to erroneous result for gravitational loading. In this study, structural behavior of column-supported wall structure at transfer floor subject to lateral loading is compared by changing modeling methods.

• Journal of Environmental Science International
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• v.7 no.6
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• pp.773-782
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• 1998

The adsorption experiment of phenol(Ph) from aqueous solution on granular activated carbon was studied in order to design the fixed-bed adsorption column. The experimental data were analyzed by unsteady-state, one-dimensional heterogeneous model. Finite element method(FEM) was applied to analyze the sensitivity of parameter and to predict the fixed-bed adsorption column performance on operation variable changes. The prediction model showed similar effect to mass transfer and intraparticle diffusion coefficient changes suggesting that both parameter present mass transfer rate limits for GAC-phenol system. The Freundlich constants had a greater effect than kinetic parameters for the performance of fixed-bed adsorption column. FEM solution facilitated prediction of concentration history in solution and within adsorbent particle.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.11 no.4
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• pp.431-439
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• 1999

A generator-GAX combined rectification system of an ammonia absorption heat pump was investigated to get the optimum design values. The mass and heat transfer phenomena of the rectification system were analysed. The number of column plates, equilibrium temperature of solution on each plate and flow rates of solution and vapor generated were predicted. The characteristics of mass and heat transfer of the generator-GAX combined rectification system, i.e. concentration difference of leaving solution and vapor on each column plate, were found to be mainly governed by the pressure of generator, reflex ratio and temperature difference of analyser coolant. The number of rectification column plates for each different pressure in generator was obtained. The optimum locations for installing the feeder from solution-cooled absorber and GAX desorber in generator were predicted. The improvement of COP was followed by the increase of the rectifier efficiency and the number of column plate, and the decrease of reflex ratio.