• Proceedings of the Korean Society of Postharvest Science and Technology of Agricultural Products Conference
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• 2007.11a
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• pp.27-31
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• 2007

This study relates to low and medium molecular weight isoflavone-${\beta}$-D-glucan produced by submerged liquid culture of Agaricus blazei, a method of producing the isoflavone-B-D-glucan using autolysis enzyme of Agaricus blazei mycelia, and use of the isoflavone-B-D-glucan for anti-cancer and immunoenhancing effect. In acordance with one aspect of the present study, it deals with a method of producing isoflavone-${\beta}$-D-glucan, which comprises the followings; 1) culturing and separating mushroom mycelia, 2) producing low-medium molecular weight isoflavone-${\beta}$-D-glucan from high molecular weight one. The cytotoxicity on human cnacer cell line (Caco-2, MCF-7), the expression of Cyclin D, Bcl-2, Bax protein, p21 protein, p53 protein in MCF-7 cells assessed by SDS-PAGE and immunoblotting, and other immuno related factors such as TNF-${\alpha}$ and IL-1B activities were examined. Structural identification of isoflavone-${\beta}$-D-glucan which showed cytotoxicity against cancer cell and immunoenhancing effects was carried by separation with DEAE-cellulose column chromatography, TLC, HPLC, IR, NMR. Clinical test for the cancer patients (n=119) for 6 month was carried out, and immunoenhancing factors (NK. cell number, ratio of T4/T8) were checked. We concluded the identified isoflavone-${\beta}$-D-glucan has immuno enhancing effects and could be useful for cancer chemoprevention.

• Structural Engineering and Mechanics
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• v.75 no.2
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• pp.211-227
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• 2020

The contribution of infill wall is generally not considered in the structural analysis of reinforced concrete (RC) structures due to the lack of knowledge of the complex behavior of the infilled frame of RC structures. However, one of the significant factors affecting structural behavior and earthquake performance of RC structures is the infill wall. Considering structural and architectural features of RC structures, any infill wall may have openings with different amounts and aspect ratios. In the present study, the influence of infill walls with different opening rates on the structural behaviors and earthquake performance of existing RC structures were evaluated. Therefore, the change in the opening ratio in the infill wall has been investigated for monitoring the change in structural behavior and performance of the RC structures. The earthquake performance levels of existing RC structures with different structural properties were determined by detecting the damage levels of load-carrying components. The results of the analyzes indicate that the infill wall can completely change the distribution of column and beam damage level. It was observed that the openings in the walls had serious impact on the parameters affecting the behavior and earthquake performance of the RC structures. The infill walls have a beneficial effect on the earthquake performance of RC structures, provided they are placed regularly and there are appropriate openings rate throughout the RC structures and they do not cause structural irregularities.

• Proceedings of the Korea Concrete Institute Conference
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• 2008.04a
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• pp.93-96
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• 2008

This paper deals with the shaking table test(STT), the Quasi-Static Test(QST), and the Pseudo-Dynamic Test(PDT) to evaluate the seismic performance of RC bridge piers under near fault ground motion. Five scaled specimens were constructed the weight of the superstructure was applied through the prestressing strand at the centroid of the column section during the QST and PDT. However, the STT was simulated. The lateral inertia force of the superstructure by the mass frame which was linked with the pier because of the limited payload of shaking table. Particularly for the STT, friction underneath the mass frame was minimized by special details and it was verified by a series of pre-load test. Scale factor of the RC piers was 4.25.

• Steel and Composite Structures
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• v.4 no.6
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• pp.419-435
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• 2004

The safety level of a structural system designed per code specifications can not be inferred directly from the reliability of members due to the load redistribution and nonlinear inelastic structural behavior. Comparison of the system and member reliability, which is scarce in the literature, is likely to indicate any possible inconsistency of design codes in providing safe and economical designs. Such a comparative study is presented in this study for moment resisting two-dimensional steel frames designed per AISC LRFD Specifications. The member reliability is evaluated using the resistance of the beam-column element and the elastic load effects that indirectly accounts for the second-order effects. The system reliability analysis is evaluated based on the collapse load factor obtained from a second-order inelastic analysis. Comparison of the system and member reliability is presented for several steel frames. Results suggest that the failure probability of the system is about one order of magnitude lower than that of the most critically loaded structural member, and that the difference between the system and member reliability depends on the structural configuration, degree of redundancy, and dead to live load ratio. Results also suggest that the system reliability is less sensitive to initial imperfections of the structure than the member reliability. Therefore, the system aspect should be incorporated in future design codes in order to achieve more reliability consistent designs.

• Food preservation and processing industry
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• v.6 no.2
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• pp.11-13
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• 2007

This study relates to low and medium molecular weight isoflavone-${\beta}$-D-glucan produced by submerged liquid culture of Agaricus blazei, a method of producing the isoflavone-B-D-glucan using autolysis enzyme of Agaricus blazei mycelia, and use of the isoflavone-B-D-glucan for anti-cancer and immunoenhancing effect. In acordance with one aspect of the present study, it deals with a method of producing isoflavone-${\beta}$-D-glucan, which comprises the followings; 1) culturing and separating mushroom mycelia, 2) producing low-medium molecular weight isoflavone-${\beta}$-D-glucan from high molecular weight one. The cytotoxicity on human cnacer cell line (Caco-2, MCF-7), the expression of Cyclin D, Bcl-2, Bax protein, p21 protein, p53 protein in MCF-7 cells assessed by SDS-PAGE and immunoblotting, and other immuno related factor such as TNF-a and IL-1B activities were examined. Structural identification of isoflavone-${\beta}$-D-glucan which shoed cytotoxicity against cancer cell and immunoenhancing effects was carried by separation with DEAE-cellulose column chromatography, TLC, HPLC, IR, NMR, Clinical test for the cancer patients (n=119) for 6 month was carried out, and immunoenhancing factors(NK cell number, ratio of T4/T8) were checked. We concluded the identified isoflavone-${\beta}$-D-glucan has immuno enhancing effects and could be useful for cancer chemoprevention.

• Journal of the Earthquake Engineering Society of Korea
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• v.10 no.1 s.47
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• pp.41-49
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• 2006

Through the 1982 Urahawa-ohi and the 1995 Kobe earthquakes, a number of bridge columns were observed to develop a flexural-shear failure due to the bond slip as a consequence of premature termination of the column longitudinal reinforcement. Because the seismic behavior of RC bridge piers is largely dependent on the performance of the plastic hinge legion of RC bridge piers, it is desirable that the seismic capacity of RC bridge pier is to evaluate as a curvature ductility. The provision for the lap splice of longitudinal steel was not specified in KHBDS(Korea Highway Bridge Design Specification) before the implementation of 1992 seismic design code, but the lap splice of not more than 50%, longitudinal reinforcement was newly allowed in the 2005 version of the KHBDS. The objective of this research is to investigate the distribution and ductility of the curvature of RC bridge column with the lap splice of longitudinal reinforcement in the plastic hinge legion. Six (6) specimens were made in 600 mm diameter with an aspect ratio of 2.5 or 3.5. These piers were cyclically subjected to the quasi-static loads with the uniform axial load of $P=0.1f_{ck}A_g$. According to the slip failure of longitudinal steels of the lap spliced specimen by cyclic loads, the curvatures of the lower and upper parts of the lap spliced region were bigger and smaller than the corresponding paris of the specimen without a lap splice, respectively. Therefore, the damage of the lap spliced test column was concentrated almost on the lower part of the lap spliced region, that appeared io be failed in flexure.

• Journal of the Korea Concrete Institute
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• v.20 no.2
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• pp.193-202
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• 2008

Seismic design for bridge columns of the current Korea Highway Bridge Design Specifications which adopt full ductility design concept results in reinforcement congestion problems in construction site. It is due to large amount of confining steel is required even for small ductility demand which is a normal case in low and moderate seismicity regions like Korean peninsular. Therefore a new seismic design method based on limited ductility concept was proposed, which is called ductility demand based design method. It uses the new confining steel design equation considering ductility demand and aspect ratio of the column as well as material strength. The purpose of this study is to verify safety of the ductility demand based design method by the confining steel design equation. Eighty nine circular column test results are selected and investigated in terms of ductility factor and its safety. The safety factor for the circular column test results ranges between 1.11 and 3.98, and the average is 1.90. In this paper, the basic concept and detailed design procedure of the ductility demand based design method are also introduced as well as the investigation of the safety with respect to the major variables in confining steel design.

• Journal of the Korea Concrete Institute
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• v.21 no.2
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• pp.169-178
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• 2009

An equation for calculating confining reinforcement amount of RC bridge columns, specified in the current bridge design codes, has been made to provide additional load-carrying strength for concentrically loaded columns. The additional load-carrying strength will be equal to or slightly greater than the resistant strength of a column against axial load, which is lost because the cover concrete spalls off. The equation considers concrete compressive strength, yield strength of transverse reinforcement, and the section area ratio as major variables. Among those variables, the section area ratio between the gross section and the core section, varying by cover thickness, is a variable which considers the strength in the compression-controlled region. Therefore, the cross section ratio does not have a large effect in the aspect of ductile behavior of the tension-controlled region, which is governed by bending moment rather than axial force. However, the equation of the design codes for calculating confining reinforcement amount does not directly consider ductile behavior, which is an important factor for the seismic behavior of bridge columns. Consequently, if the size of section is relatively small or if the section area ratio becomes excessively large due to the cover thickness increased for durability, too large an amount of confining reinforcement will be required possibly deteriorating the constructability and economy. Against this backdrop, in this study, comparison and analysis were performed to understand how the cover thickness influences the equation for calculating the amount of confining reinforcement. An equation for calculating the amount of confining reinforcement was also modified for reasonable seismic design and the safety. In addition, appropriateness of the modified equation was examined based on the results of various test results performed at home and abroad.

• Journal of the Korea Concrete Institute
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• v.18 no.2 s.92
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• pp.161-168
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• 2006

An experimental investigation was conducted to examine the hysteretic behaviors of ultra-high strength concrete tied columns. The purpose of this study is to investigate the safety of ultra-high strength concrete columns with 100 MPa compressive strength for the requirement of ACI provisions. Eight 1/3 scaled columns were fabricated to simulate an 1/2 story of actual structural members with the cross section $300{\times}300mm$ and the aspect ratio 4. The main variables are axial load ratio, configurations and volumetric ratios of transverse reinforcement. The results show that the deformability of columns are affected by the configurations and volumetric ratios of transverse reinforcement. Especially, it has been found that the behavior of columns are affected by axial load ratio rather than the amounts and the configurations of transverse reinforcement. Consequently, to secure the ductile behavior of 100 MPa ultra-high strength concrete columns, ACI provisions for the requirement of transverse steel may considered axial load level and the details of transverse reinforcement.

• Journal of Korean Society of Steel Construction
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• v.18 no.4
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• pp.457-468
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• 2006

An experimental study was performed to investigate the maximum energy dissipation and the ductility capacity of shear-dominated steel plate walls with thin web plates. Three specimens of three-story plate walls with thin web plates were tested. The parameters for the test specimens were the aspect ratio of the web plate and the shear strength of the column. A concentrically braced frame and a moment-resisting frme were a also tested for comparison. The steel plate walls exhibited much better ductility and energy dissipation capacity than the concentrically braced frame and the moment-resisting frame. The results showed that unlike other structural systems, the sh as well as strength, and can therefore be used as an effective earthquake-resisting system. A method of predicting the energy dissipation capacity of a steel plate wall was proposed.