• Asian-Australasian Journal of Animal Sciences
• /
• 제31권2호
• /
• pp.180-188
• /
• 2018

Objective: The aim of this study was to investigate the effect of single nucleotide polymorphisms (SNPs) of the melanogenesis associated transcription factor (MITF) and dopachrome tautomerase (DCT) genes on plumage coloration in Asian native duck breeds. MITF encodes a protein for microphthalmia-associated transcription factor, which regulates the development and function of melanocytes for pigmentation of skin, hair, and eyes. Among the tyrosinase-related family genes, DCT is a pigment cell-specific gene that plays important roles in the melanin synthesis pathway and the expression of skin, feather, and retina color. Methods: Five Asian duck varieties (black Korean native, white Korean native, commercial Peking, Nageswari, and Bangladeshi Deshi white ducks) were investigated to examine the polymorphisms associated with plumage colors. Among previously identified SNPs, three synonymous SNPs and one indel of MITF and nine SNPs in exon regions of DCT were genotyped. The allele frequencies for SNPs of the black and white plumage color populations were estimated and Fisher's exact test was conducted to assess the association between the allele frequencies of these two populations. Results: Two synonymous SNPs (c.114T>G and c.147T>C) and a 14-bp indel (GCTGCAAAC AGATG) in intron 7 of MITF were significantly associated with the black- and white-colored breeds (p<0.001). One non-synonymous SNP [c.938A>G (p.His313Arg)] in DCT, was highly significantly associated (p<0.001) and a synonymous SNP (c.753A>G) was significantly associated (p<0.05) with black and white color plumage in the studied duck populations. Conclusion: The results of this study provide a basis for further investigations of the associations between polymorphisms and plumage color phenotypes in Asian duck breeds.

• Archives of Plastic Surgery
• /
• 제33권4호
• /
• pp.495-498
• /
• 2006

Purpose: Trichoblastic fibroma originates from hair germ layer tumor which is a benign tumor mixture of epidermal and mesodermal factor. Trichoblastic fibroma was found only in adults and showed equal occurrence rate between men and women. Since it is a rare tumor, we report a case of a trichoblastic fibroma which developed on the right cheek. Methods: A 72 year-old male was treated with excisional operation 17 years ago due to a solitary tumor that developed on the same site. He returned to the hospital with an asymptomatic mass which have been increasing in size for the last 3 months. Results: In computerized tomography, a size of $2.7{\times}2.3{\times}0.8cm$ tumor was found in the subcutaneous tissue layer. Grossly, the mass was well-circumscribed, smooth-surfaced and flesh colored, and was lobulated and fragile. Pathologic observation showed diverse shaped and sized tumor cell nests and fibrocellular stroma consisting basophilic cells in dermal and subdermal layers. Immunohistopathologic staining showed positive reaction on pancytokeratin, CK-5/6, and bcl-2. Conclusion: By having no connection to the epidermis, and being positioned in the dermal and epidermal layers, typical pathologic findings make it possible to differentiate this tumor with basal cell carcinoma. This lesion is not clear whether it is a local recurrence or not, and it is necessary to observe a new recurrence in the future.

• Toxicological Research
• /
• 제20권2호
• /
• pp.143-151
• /
• 2004

This study was to investigate single and repeated-dose toxicities of CJ-11555, an anticirrhotic agent, in Sprague-Dawley (SO) rats. In single-dose oral toxicity study, the test article were administered once by gavage to males and females at dose levels of 0 and 2,000 mg/kg. No dead animals and abnormal necropsy findings were found in control and CJ-11555 treated group. Therefore, the approximate lethal dose of CJ-11555 was considered to be higher than 2,000 mg/kg in rats. In the 4-week repeated oral toxicity study, the test article was administered once daily by gavage to male and female rats at dose levels of 0, 10, 50 and 200 mg/kg/day for 4-weeks. In clinical signs, yellow-colored urine and yellow hair coat were observed in the 50 and 200 mg/kg male and female groups. In hematology, erythrocyte count and hemoglobin were significantly decreased in the 200mg/kg male and female groups. In serum biochemistry, total cholesterol was significantly increased and aspartate aminotransferase (AST) was significantly decreased in the 50 or 200 mg/kg male and female groups. In histopathological examinations, centrilobular hepatocellular hypertrophy in the liver, congestion and pigmentation in the spleen, hyaline droplets in the kidney were observed in the 50 and 200 mg/kg male and female groups. In toxicokinetic study, CJ-11555 was dose-dependent in systemic exposure and showed better absorption in female with minimum accumulation after multidosing. Based on these results, it was concluded that the 4-week repeated oral dose of CJ-11555 resulted in the suppression of AST activity and centrilobular hepatocellular hypertrophy in both sexes at a dose level of 50 or 200 mg/kg/day. The target organ was estimated to be liver, spleen and male's kidney. The no-observed-adverse-effect level (NOAEL) for CJ-11555 in rats following gavage for at least 4-week is 10 mg/kg/day.

• 복식문화연구
• /
• 제17권4호
• /
• pp.561-574
• /
• 2009

Black has been the most important color of all since the ancient times when the recognition of black roused, as well as during most of the eras; and can especially be said as the main color which controlled the chronicles of fashion. The purpose of the study was to broaden the application of black color image make-up by inquiring into make-up design elemental characteristics of lines and textures, after classifying magazine illustrations and advertisement make-up images using black. The photos which made effective use of black among fashion illustrations, magazine advertisements after 2001 were classified in to each type, and make-up expression method and characteristics according to design element of each image type was analyzed. The conclusion of such study was the following. 'Erotic image' showed contrast effect between eye make-up and lip color by using pale tone or red color. 'Mannish image' emphasized form and texture of eyebrow by restraining the colors of eyelids with natural brown tone eye make-up; 'Modern image' expressed vague eyebrow to bring the sensation of the direction of eye shadow on eyelids and eye line as well as slant line to relief. 'Kitsch image' showed free and light imagery by creating unique hair style with various colors; expressing lips mostly with colors similar to skin tone or by restraining colors on lips. 'Decadence image' showed messy and foul sensation with unstandardized eye make-up and matt skin of shimmer, glossy and pale tone, also with black colored lips; 'Retro image' expressed reinterpretation of images from 1920${\sim}$1960 to contemporary styles.

• 복식문화연구
• /
• 제16권2호
• /
• pp.263-277
• /
• 2008

In picture bible, the picture is helpful for showing story more vividly and specifically and it is helpful for finding the meaning of bible hidden behind familiarity. It plays the role of the most powerful testimony and expression, with which human provides himself. The purpose of study was to grasp the relation among historical background of the middle age, human's characteristic and symbolic color by considering the fact that the costume expressed in Maciejowski Bible, which is a picture bible of the middle age and observing type, color and decoration of costume. Among 46 folios organizing Maciejowski Bible, 129 pictures explaining the Book of Genesis, the Book of Exodus, the Book of Leviticus, the Book of Numbers, the Book of Deuteronomy, the Book of Joshua and the Book of Judges, which belong to the former 400 years of the old Testament, were analyzed for people's costumes. The pictures shown in Maciejowski Bible portrays object, costume and behavior on the background of France of the 13th century so we can find out the precious natures of middle age's costume, weapon and armor. Especially, the portrait about finger armor of chain mail attached in hauberk becomes the outstanding evidence that can encroach the discussion over whether it was used in the end of 1300s. Regarding costumes of main characters, they wore chemise and braies as underwear, wore tunic or cotte having various lengths from the length reaching knee to the length reaching 8round as basic costume and wore mantle with different-colored lining and hose with various colors. In the war picture, we can see hauberk made with chain mail and cyclas with long slit, which was worn over hauberk, barrel helmet, norman helmet and steel school cap. Regarding cap. man usually wore coif, beret, shade-shaped cap, straw hat and woman wore the decoration using veil and hairlace and used the method to wrap whole hair with net. As the colors used in the costume of the picture bible, scarlet, blue, green and brown were usually used in order. They usually wore costumes decorated splendidly with the colors haying hish brightness and chroma.

• 헤리티지:역사와 과학
• /
• 제56권3호
• /
• pp.76-98
• /
• 2023

국립중앙박물관 소장 《회혼례도첩》(덕수6375)에 묘사된 남녀 등장인물의 복식을 분석하고 《회혼례도첩》의 제작 시기를 추정한 결과는 다음과 같다. 첫째, 주인공 노신랑은 <전안례도>와 <교배례도>에서는 평소 관원으로 착용하던 흑단령을 착용하였다. 그 외 <헌수례도>와 <접빈도>, <중뢰연도>에서는 패영 없는 자립에 옥색 포, 홍색 세조대를 둘렀다. 기럭아범은 자립에 귀 옆에 묶은 패영을 달고 흉배를 부착한 무문 흑단령을 착용하였다. 성인 남자 자손과 하객들은 도포 등 당시의 대표적인 포 종류를 착용하였는데 특히 무관으로 추정되는 인물들은 철릭, 직령을 착용하고 붉은 색 띠와 청색 계통의 띠를 신분에 맞추어 착용하였다. 징씨(徵氏) 등 안내자는 중치막과 홍단령을 착용하였으며 어린 동자들과 시동(侍童)은 중치막을 착용하였다. 술을 따르고 음식을 나르는 총각들은 땋은 머리에 소창의(小氅衣)를 입고 성인들은 전립(氈笠)에 소창의를 착용하였다. 군영 소속의 세악수들은 소색 소창의에 흑색 전복, 그리고 허리에 남색 포대 등 군복을 착용하였다. 둘째, 노신부는 <교배례도>에서는 거두미와 초록원삼 차림을 하였고 <헌수연도>에서는 남치마·옥색저고리 차림이 확인되었다. 여자 자손들은 어여머리에 비녀와 반자, 진주댕기 등의 칠보장식을 하였고 다양한 색상의 저고리에 남색과 홍색, 옥색 등의 치마를 입었다. 남치마에 초록 장옷을 입은 부인도 확인되었다. 홍치마에 초록색 회장저고리를 입은 <교배례도>의 동녀(童女) 4명은 낭자머리에 비녀 꽂고 도다익 댕기를 길게 드리웠으며 칠보족두리를 썼다. 비자(婢子)들은 어여머리에 가리마를 썼으며 양반 부인들과 유사한 치마·저고리를 착용하였으나 색상이 연했고 치마의 길이가 짧았으며 치마의 부풀림 정도가 약하였다. 기녀는 양반 부인과 비슷한 모습이었으나 색상이 덜 화려하였으며 어여머리에는 칠보장식이 없었다. 셋째, 주인공의 자립 착용, 철릭과 직령을 입은 하객들, 군영 소속 세악수 참여 등에 근거하여 회혼례의 주인공이 병조나 군영과 관련된 인물이었을 가능성을 제시하였으며 군영 악대의 전복의 소매 길이와 잠화 사용, 어여머리의 형태와 댕기, 저고리의 길이와 치마의 부풀린 형태 등에 근거하여 《회혼례도첩》의 제작 시기를 1760년대~1780년대로 추정하였다.

• Archives of Plastic Surgery
• /
• 제34권5호
• /
• pp.659-662
• /
• 2007

Purpose: Multiple skin leiomyoma and uterine myoma bearing autosomal dominant traits are benign smooth muscle tumors which originate in skin or female uterus. Skin leiomyoma occurs after gene mutation originating from arrector pili muscle of hair follicle where its clinical manifestations vary significantly from person to person. Our department hereby reports the histological findings and genetic evaluations of this very rare disease. Methods: A 57-year-old woman presented in our institute with multiple tumors in the left and central parts of her back that started to appear since 19 years ago. The patient was diagnosed as having uterine myoma 15 years ago and underwent hysterectomy. Biopsy has been done on the specimen, and genomic DNA was separated from Fumarate hydratase gene for it to go through PCR amplification. The results of PCR amplification were aligned by sequencer. Results: According to the results of biopsy, tumor cells were spindle-shaped and were aligned in a bundle where there was no dysplasia or mitosis. Moreover, these cells had abundant eosinophilic cytoplasm with elongated nucleus, and benign leiomyoma that showed positive reactions to SMA stain were found. In genetic examination, mutations such as heterozygous single nucleotide substitutions were found in alignments of amplified DNA. Conclusion: Multiple skin leiomyoma and uterine myoma are relatively uncommon diseases that are transmitted through autosomally dominant traits from genetic mutations. When a patient's chief complaint lies upon skin-colored or brown masses that occur in multiples appearing in the trunk or extremities with characteristic clinical symptoms and histological findings, and when the patient's family history is acknowledged such as skin or uterine leiomyoma or renal tumor, necessary genetic examination on multiple skin leiomyoma and uterine myoma could be done, and thereby precise diagnosis could also be made.

• 복식
• /
• 제22권
• /
• pp.159-176
• /
• 1994

This study's purpose is to find the ancient costume of the folk song's words on Dunhuang manuscripts in the background wass-carvings sculptures and several art works. Dunhuang had played the part of major route between ancient China and Europe. It is located on kam-suksong the west of China. 1. In the aspect of costume arrangement hair Styling is represented by Naegagyo, Wangyesa, Kyongburak, Bonkwyun, Pogurak, Chonsonja, Namgaja, Tongson-ga, Ojesa, Chanboja in Dunhuang manuscripts. tugue is sim-ilar to Sabyokkwanja in Naegagyo as of that time these kinds of Kwan-ja was very popular. It was told that emperor's wife concubine and maid of honor would wear kwnaja favorably. And the kinds of Tugeu is PuyongKwyunkye, Aangunkye, Chunkye from Kyuwanjon except Sangunkye, Ounkye in Dunhuangsa. 2. Jangdaegy is guoted from Kyuw-anjon -A series of the chinese history book-tells us about women's make-up . The narmes of make-up are Hongjang Unjan--g, Yiljang chwejang, Tam-ajang Murgjang, Sanagjang, Light-make up are referred in Naegagyo is included as packjang Besides we can find other make-up skills Huphwaro and Rujang from the Kaewonch onbon-wisa which was Yangkwibi's episodes. We can find the a corpus of song's words about cosmetic custom in Kor-ea. Which is 'Haecho' folk song in the souther-en costal regions 'Jinggum' folk song in Kim-hae regions and so on.... It's words is similar to Dunhuangsa in China. 3. Bichun inherited to China with India Bud-dism art in the middle of Dunhuang wall-pain-tings is one of the important Buddist saint. Sometimes it is painted with Giakchun Its arms of fly-dnacing in heaven with colored belt on body has almost the form of play on the musical instrument, We can see seasily the form in the painting of Buddist ser-mon. It was progressed and changed with the background of chinese traditional culture. When Dang's period came the color was chan-ged lighting dark blue has rhythmical and viv-id power of life. 4. Among the corpus of song's words which express the singers' system and rites of their tradition or habits. Dunhuang manuscripts des-cribes on behalf of the folk song's words in tra-ditional costume. This is following: (1) Naegagyo o sabyokwanja o Chyrasam o Rashang (2) Wangyesa o Sokryugun o Costume for fisher man (3) Bungajang of the chanboja o Ajang (4) Pongkwyun o Chongui (5) Tongsongs o Junofore (6) Namgaja o thin-Rasam (7) Yuchungnang o Hongsam o Sokryugun : The color of red costume (8) Kyongburak o Hongrasam o Sokryugun : Costume for charming woman Therefore traditional costume could be extracted according to the Dunhuang folk song's words out of culture such as learning rit-es three-obedience four-virtues and in-struction. As the same time it reflects ancient China's characteristics directly. I would endeavor to development for the history of the costume furher creative design and participat-ed in research activity with concerns forward continuously.

• 생명과학회지
• /
• 제19권6호
• /
• pp.793-798
• /
• 2009

본 연구는 제주마에서 빈번하게 관찰되는 전신성 백모색 발생의 유전 양상과 유전적 변이와의 상관을 구명하기 위해 수행하였다. 백모색은 표현형과 MC1R 유전자형 분석 자료의 조합을 근거로 결정한 가라, 유마, 적다 등 모든 기본 모색에서 관찰되었다. 제주마에서는 타 품종들에서 KIT 유전자의 이형 접합성에 의해 발생하는 선천성 백색에 대한 잠재적 돌연변이 들은 발견되지 않았다. STX17 유전자의 intron 6 에서 4.6-kb 중복을 보유한 개체들에서 특이적으로 탈색된 백모색이 관찰되었다. 관찰기록과 STX17 유전자형에 따라 제주마에서 관찰되는 탈색된 백화현상은 총마(점진적 백화증, Gray) 로 확인되었다. 가계도 분석에서 총마 형질은 상동염색체성 우성유전형 질로 나타났으며 상동염색체성 열성형질인 albinism과도 구분되었다. 제주마에서 총마 모색이 자마 시기에는 명확하게 발현되는 않으며, 종종 다른 표현형들과 혼동을 일으키기도 하기 때문에, 총마와 이와 유사한 표현형으로 출생 시부터 혼합 모색을 나타내는 조모색, 상처 치료 후 백화, 백반 유사피부 백색증 등에 대한 추가 연구가 요구된다고 하겠다. 그럼에도 불구하고 총마와 유전적 배경의 관계를 구명한 본 연구결과는 제주마에서 분자육종을 위한 유용한 정보를 제공할 것으로 사료된다.

• 한국임상수의학회지
• /
• 제19권4호
• /
• pp.401-404
• /
• 2002

6개월령 수컷 아메리칸 코커스파니엘이 심한 소양감, 탈모 그리고 머리를 심하게 흔드는 증상으로 내원하였다 신체검사에서 전신적으로 가피. 비듬, 구진. 발적의 병변이 관찰되었다. 전반적인 피부검사결과 개선충, 귀진드기, 구균과 Malasseria의 혼합 감염으로 진단하였다. Selamectin 6mg/kg을 주 2회로 총 4회 경부 피부에 적용하였다 마지막 적용 후 14일에 피부를 재검사 하였을 때 개선충과 귀진드기는 관찰되지 않았으며 소양증과 비듬의 증상이 현저하게 개선되었다. 개선충과 귀진드기에 대한 치료가 끝난 후 구균과 Malassezia 치료를 위해 clavamox 와 ketoconazole을 3주간 투여 하였으며 동시에 sebolytic 샴푸와 chlorohexidine 샴푸를 3주동안 주 2회 실시하였다. 2개월 후 피부 증상은 현저히 감소하였고 피부 병변은 회복되었다. 이 치료법에 따른 selamectin 적용은 고가이지만 개선충과 귀진드기가 감염된 개에서 매우 효과적이며 임상적으로 scabies 감염증의 치료적 진단법으로 유용한 제제로 판단된다