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http://dx.doi.org/10.5352/JLS.2009.19.6.793

Genetic Polymorphisms of Candidate Loci and Inheritance Ppatterns of Gray Coat Color in Jeju Horses.  

Han, Sang-Hyun (Jeju-Substation, National Institute of Animal Science)
Lee, Chong-Eon (Jeju-Substation, National Institute of Animal Science)
Kim, Nam-Young (Jeju-Substation, National Institute of Animal Science)
Ko, Moon-Suck (Jeju-Substation, National Institute of Animal Science)
Jeong, Ha-Yeon (Jeju-Substation, National Institute of Animal Science)
Lee, Sung-Soo (Jeju-Substation, National Institute of Animal Science)
Publication Information
Journal of Life Science / v.19, no.6, 2009 , pp. 793-798 More about this Journal
Abstract
This study was undertaken to reveal the relationship between genetic variations and inheritance patterns and the development of a systemic white coat color frequently observed in Jeju horses. It was determined that the white coat color occurred in all basic coat colored (black, bay and chestnut) horses by combining the phenotype and MC1R genotypes. There were no polymorphisms found in Jeju horses tested for mutational loci in the KIT gene, which were previously reported as potential mutations of the congenital dominant white coat color in other horse breeds in heterogeneity. The horses that had the 4.6-kb duplication in the STX17 intron 6 specifically showed the depigmented white coat color. Based on observation and STX17 genotypes, this depigmented whitening is defined as 'Chongma' (whitening, progressive graying with age-Gray) in Jeju horses. Pedigrees showed that this is an autosomal dominant inheritance pattern distinct from the bovine albinism caused by an autosomal recessive passion eye color. Because the gray phenotype is generally not completely expressed early in Jeju horses, it often makes them indistinguishable from other horses. Further studies are recommended for classification between the gray coat color and its similar phenotypes, such as the roan with its mixed hair colors appearing since neonatal period, acquired white hairs on wounded skin by veterinary treatment, and vitiligo-like skin pigmentation. However, study results revealing the relationship between the gray phenotype and genetic background suggested that useful information may be provided in regards to molecular breeding of Jeju horses.
Keywords
Horse; MC1K KIT; STX17; gray coat color;
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1 Sambrook, J., E. F. Fritsch, and T. Manniatis. 1989. Molecular cloning: a laboratory mannual. 2nd Ed. Cold Spring Harbor Laboratory
2 Santschi E. M., A. K. Purdy, S. J. Valberg, P. D. Vrotsos, H. Kaese, and J. R. Mickelson. 1998. Endothelin receptor B polymorphism associated with lethal white foal syndrome in horses. Mamm. Genome 9, 306-309   DOI   ScienceOn
3 Schmutz, S. M., T. G. Berryere, D. C. Ciobanu, A. J. Mileham, B. H. Schmidtz, and M. Fredholm. 2004. A form of albinism in cattle is caused by a tyrosinase frameshift mutation. Mamm. Genome 15, 62-67   DOI   ScienceOn
4 Sponenberg, D. P. 2003. Equine Coat Color Genetics. Blackwell. Ames, U.S.A
5 Swinburne, J. E., A. Hopkins, and M. M. Binns. 2002. Assignment of the horse grey coat color gene to ECA25 using whole genome scanning. Anim. Genet. 33, 338-342   DOI   ScienceOn
6 Shutton, R. H. and G. T. Coleman. 1997. Melanoma and graying horse (RIRDC Research Paper Series). pp. 1-34. Barton, Australia
7 Yang, G. C., D. Croaker, A. L. Zhang, P. Manglick, T. Cartmill, and D. Cass. 1998. A dinucleotide mutation in the endothelin-B receptor gene is associated with lethal white foal syndrome (LWFS); a horse variant of Hirschsprung disease (HSCR). Hum. Mol. Genet. 7, 1047-1052   DOI   ScienceOn
8 Zhao, Z. Z., D. L. Duffy, S. A. Thomas, N. G. Martin, N. K. Hayward, and G. W. Montgomery. 2009. Polymorphisms in the syntaxin 17 gene are not associated with human cutaneous malignant melanoma. Melanoma Res. [Epub ahead of print]
9 Marklund, L., M. J. Moller, K. Sandberg, and L. Andersson. 1996. A missense mutation in the gene for melanocyte-stimulating hormone receptor (MC1R) is associated with the chestnut coat color in horses. Mamm. Genome 7, 895-899   DOI   ScienceOn
10 Marklund, S., M. J. Moller, K. Sandberg, and L. Andersson. 1999. Close association between sequence polymorphism in the KIT gene and the roan coat color in horses. Mamm. Genome 10, 283-288   DOI   ScienceOn
11 Metallinos, D. L., A. T. Bowling, and J. Rine. 1998. A missense mutation in the endothelin-B receptor gene is associated with Lethal White Foal Syndrome: an equine version of Hirschsprung Disease. Mamm. Genome 9, 426-431   DOI   ScienceOn
12 Pielberg, R. G., A. Golovko, E. Sundstrom, I. Curik, J. Lennartsson, M. H. Seltenhammer, T. Druml, M. Binns, C. Fitzsimmons, G. Lindgren, K. Sandberg, R. Baumung, M. Vetterlein, S. Stromberg, M. Grabherr, C. Wade, K. Lindblad-Toh, F. Ponten, C. H. Heldin, J. Solkner, and L. Andersson. 2008. A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse. Nat. Genet. 40, 1004-1009   DOI   ScienceOn
13 Pielberg, G., S. Mikko, K. Sandberg, and L. Andersson. 2005. Comparative linkage mapping of the grey coat colour gene in horses. Anim. Genet. 36, 390-395   DOI   ScienceOn
14 Polus, W. L. and F. B. Hutt. 1969. Lethal dominant white in horses. J. Hered. 60, 59-63
15 Oetting, W. S. and R. A. King. 1999. Molecular basis of albinism: mutations and polymorphisms of pigmentation genes associated with albinism. Hum. Mutat. 13, 99-115   DOI   ScienceOn
16 Rieder, S., S. Taourit, D. Mariat, B. Langlois, and G. Guerin. 2001. Mutations in the agouti (ASIP), the extension (MC1R), and the brown (TYRP1) loci and their association to coat color phenotypes in horses (Equus caballus). Mamm. Genome 12, 450-455   DOI   ScienceOn
17 Gronskov, K., J. Ek, and K. Brondum-Nielsen. 2007. Oculocutaneous albinism. Orphanet. J. Rare Dis. 2, 43   DOI   ScienceOn
18 Blaszczyk, W. M., L. Arning, K. P. Hoffmann, and J. T. Epplen. 2005. A Tyrosinase missense mutation causes albinism in the Wistar rat. Pigment Cell Res. 18, 144-145   DOI   ScienceOn
19 Blaszczyk, W. M., C. Distler, G. Dekomien, L. Arning, K. P. Hoffmann, and J. T. Epplen. 2007. Identification of a tyrosinase (TYR) exon 4 deletion in albino ferrets (Mustela putorius furo). Anim. Genet. 38, 421-423   DOI   ScienceOn
20 Giebel, L. B., M. A. Musarella, and R. A. Spritz. 1991. A nonsense mutation in the tyrosinase gene of Afghan patients with tyrosinase negative (type IA) oculocutaneous albinism. J. Med. Genet. 28, 464-467   DOI
21 Haase, B., S. A. Brooks, A., Schlumbaum, P. J. Azor, E. Bailey, F. Alaeddine, M. Mevissen, D. Burger, P. A. Poncet, S. Rieder, and T. Leeb. 2007. Allelic heterogeneity at the equine KIT locus in dominant white (W) horses. PLoS Genet. 3, e195   DOI   ScienceOn
22 Imes, D. L., L. A. Geary, R. A. Grahn, and L. A. Lyons. 2006. Albinism in the domestic cat (Felis catus) is associated with a tyrosinase (TYR) mutation. Anim. Genet. 37, 175-178   DOI   ScienceOn