• 제목/요약/키워드: College of pharmacy

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A New Stilbene Glucoside from the Roots of Polygonum multiflorum Thunb.

  • Xu, Ming-Lu;Zheng, Ming Shan;Lee, Yeon-Kyong;Moon, Dong-Cheol;Lee, Chong-Soon;Woo, Mi-Hee;Jeong, Byeong-Seon;Lee, Eung-Seok;Jahng, Yurng-Dong;Chang, Hyeun-Wook;Lee, Seung-Ho;Son, Jong-Keun
    • Archives of Pharmacal Research
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    • 제29권11호
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    • pp.946-951
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    • 2006

  • One new stilbene glucoside (6), along with five known compounds (1-5), were isolated from the roots of Polygonum multiflorum Thumb., and their chemical structures established based on physicochemical and spectroscopic data. Of the compounds, compound 3 showed DNA topoisomerase I and II inhibitory activities.

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Sesquiterpenes and Sterols from Aster glehni

  • Min, Yong-Deuk;Kwon, Hak-Cheol;Choi, Sang-Zin;Lee, Sung-Ok;Kim, Soo-Hak;Lee, Won-Bin;Yang, Min-Cheol;Chung, Ae-Kyung;Lee, Kyu-Ha;Nam, Kyu-Ha;Lee, Kang-Ro
    • 대한약학회:학술대회논문집
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    • 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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    • pp.200.2-200.2
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    • 2002

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Acanthoic acid blocks production of pro-inflammatory mediators by inhibiting the ERK activation in trypsin-stimulated human leukemic mast cells

  • Kang, Ok-Hwa;Tae, Jin;Choi, Yeon-A;Kwon, Dong-Yeul;Kim, Yun-Kyung;Cai, Xing-Fu;Kim, Young-Ho;Bae, Ki-Hwan;Lee, Young-Mi
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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    • pp.88.3-89
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    • 2003

  • Acanthoic acid (AA) is a pimaradiene diterpene isolated from the Korean medicinal plant, Acanthopanax koreanum (Araliaceae), which has been traditionally used as a tonic and sedative as well as in the treatment of rheumatism and diabetes in korea. Proteinase-activated receptor-2 (PAR-2) agonist trypsin plays a role in inflammation, and human leukemic mast cells (HMC-l) express PAR-2. In the present study, the effect of acanthoic acid on production of tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) and tryptase in trypsin-stimulated HMC-1 was examined. (omitted)

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