• 한국콘텐츠학회논문지
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• 제21권2호
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• pp.100-112
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• 2021

최근 빅데이터 기술시장의 성장과 함께 시각화 기술에 관한 관심은 지난 몇 년간 꾸준히 증가해왔다. 데이터 시각화는 현재 정보과학, 컴퓨터과학, 인간·컴퓨터 상호작용, 통계, 데이터마이닝, 지도학, 저널리즘 등의 광범위한 학문 분야에서 각기 조금씩 다른 의미로 사용되고 있다. 다학제적 연구가 필요한 스마트시티에서의 빅데이터 시각화는 사용자 중심의 스마트시티 서비스와 관련 정책을 전개하는데 있어 객관적이고 과학적인 접근을 가능하게 한다. 특히 공간 기반의 데이터 시각화는 도시정책 수립 과정에서 시각화 자료를 통해 다양한 이해관계자들의 효율적인 협업을 가능하게 한다. 본 논문은 선행연구를 통해 단순히 시각화 도구가 아닌 효과적인 정보전달 관점에서 공간기반의 빅데이터 시각화 표현 프로세스와 원리에 대해 고찰하였다. 데이터 시각화 모델 프로세스 및 시각화목적에 따른 시각화 표현기법, 디자인조형요소에 따른 특징과 시각화기법을 각각 도출하여 사용자 중심의 공간빅데이터 시각화 표현에 대한 방향성과 시사점을 제시하였다.

• 패션비즈니스
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• 제25권2호
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• pp.1-17
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• 2021

The development of the Internet has led to the emergence of an internet meme culture using duplication. This phenomenon has appeared in the fashion field as 'fashion memes' and its playful expression has helped it to spread. Vetements is one of the well-known brands that actively incorporates fashion memes into their fashion. The purpose of this study was to examine the playfulness of Mikhail Bakhtin's Carnival Theory and identify the playful identity, design characteristics, and implications of Vetements' fashion memes in light of Bakhtin's playfulness. The research methods were literature research and collection case analysis, and empirical content research was conducted in parallel. The scope of this study was fashion memes shown in the products from 2017 S/S to 2019 F/W. The study results showed that Bakhtin's playfulness could be divided into "playfulness in the destruction of hierarchy", "playfulness in grotesque imagery" and "playfulness in the emphasis on the lower bodily stratum". Based on these findings, the playful identity of Vetements' fashion meme images can be described as follows. First, it breaks down the existing order of fashion brands like the destruction of hierarchy in Bakhtin's theory. Second, it is grotesque; it is strange, eerie, yet ridiculous at the same time. Third, it is a playful metaphor of contamination, filth, and lower stratum. The modes of embodiment of such identity include Vetements' collaboration with famous brands, the use of cheap items, and the expression of genderless ideas.

• Molecules and Cells
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• 제39권2호
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• pp.103-110
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• 2016

As a degenerative joint disease, osteoarthritis (OA) constitutes a major cause of disability that seriously affects the quality of life of a large population of people worldwide. However, effective treatment that can successfully reverse OA progression is lacking until now. The present study aimed to determine whether two small non-coding RNAs miR-29a and miR-140, which are significantly down-regulated in OA, can be applied together as potential therapeutic targets for OA treatment. MiRNA synergy score was used to screen the miRNA pairs that potentially synergistically regulate OA. An in vitro model of OA was established by treating murine chondrocytes with IL-$1{\beta}$. Transfection of miR-29a and miR-140 via plasmids was investigated on chondrocyte proliferation and expression of nine genes such as ADAMTS4, ADAMTS5, ACAN, COL2A1, COL10A1, MMP1, MMP3, MMP13 and TIMP metallopeptidase inhibitor 1 (TIMP1). Western blotting was used to determine the protein expression level of MMP13 and TIMP1, and ELISA was used to detect the content of type II collagen. Combined use of miR-29a and miR-140 successfully reversed the destructive effect of IL-$1{\beta}$ on chondrocyte proliferation, and notably affected the MMP13 and TIMP1 gene expression that regulates extracellular matrix. Although co-transfection of miR-29a and miR-140 did not show a synergistic effect on MMP13 protein expression and type II collagen release, but both of them can significantly suppress the protein abundance of MMP13 and restore the type II collagen release in IL-$1{\beta}$ treated chondrocytes. Compared with single miRNA transfection, cotransfection of both miRNAs exceedingly abrogated the suppressed the protein production of TIMP1 caused by IL-$1{\beta}$, thereby suggesting potent synergistic action. These results provided1novel insights into the important function of miRNAs' collaboration in OA pathological development. The reduced MMP13, and enhanced TIMP1 protein production and type II collagen release also implies that miR-29a and miR-140 combination treatment may be a possible treatment for OA.

• 패션비즈니스
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• 제16권5호
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• pp.146-163
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• 2012

This thesis aims to present how to make secure the identity of the brand with enhancing the esthetic expression of the brand and making the ways of emotional communication in variety, through investigating closely the case of Prada representative of the typical brands that have established the unique identity by cooperating the fashion with culture and art through their ingenious and consistent efforts. In the conclusion, the culture and art was found to be applied in two fields i.e. one of design and the other of marketing. In terms of the design, the method of inserting the image into the surface of the clothing and accessories was used. In the context, the illustration techniques, photographic patterns and applying the image of the art piece could be summarized to be used. In terms of marketing, the sponsorship of the art and exhibitions, look books, animations and fashion films, epicenter, the collaboration with the other kinds of enterprise, could be regarded as four ways of the approaches. The innovation and creativity, futuristic hybrid, nonprofit support of the art, the integration and consistency of the image of the arts could be concluded to be four major points defining the characteristics of the Prada renowned for the use of the culture and arts to its property.

• 복식
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• 제63권7호
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• pp.134-147
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• 2013

Today, the convergence of fashion design and digital technology has become a popular method and accordingly been tried variously in the fashion area. This study aimed to analyze the character of the collaboration with fashion and technology, and the meaning of technology as emotional expression methods. Selected designer's collections, literature and other related studies were reviewed in order to analyze the generative structure of the meaning and the binary-opposition in the convergence of body, fashion design and technology. Literatures and selected designer's collections were reviewed and quantitatively studies were performed to classify the convergence of human bodies, fashion design and technology through Greimas Semiotics rectangle based on binary-opposition of meaning and isotophy analysis. The research presents three types of fashion technology methods: mechanical movement, light/digital media, and virtual image. The convergence of fashion and technology was classified as the direct convergence and the indirect convergence. The direct convergence was characterized by variability and has automatic, independent movement, but the indirect convergence was shown closed and to have contradistinctive images.

• 한국의류산업학회지
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• 제16권5호
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• pp.689-697
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• 2014

This study aims to analyze the representation forms of bloggers' personal style on the fashion blogs and enlighten their values which can be actively applied to design and marketing in fashion industry. Image representation of fashion bloggers is reflected by the characteristics in the digital environment, which are the creative manipulation of expression and the production of virtual and fantastic images by taking advantage of the composite medium such as images, music, videos, articles, etc. Also real time updates in blog indicate the latest trends in terms of the representation of image as the actual currency. The study conducted case studies of 5 women's personal fashion blogs through the verification of a variety of global fashion media and blog ranking sites: Style Bubble, Style Rookie, The Cherry Blossom Girl, The Blond Salad, and Fashion Toast. Research findings are as follows. First, the application of creative design elements is indicated as symbolic items, self-made designs, DIY, and various mix and match emphasizing design elements such as color, patterns, proportion, etc. Second, the virtual representation is very highlighted on the story telling applied by film like production or digital effect. Third, the commercial application with mainly sponsored wardrobe and designer collaboration indicates promoting a updated trend as well as a specific brand or designer to make their business profits.

• BMB Reports
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• 제41권9호
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• pp.626-634
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• 2008

Novel cancer biomarkers are required to achieve early diagnosis and optimized therapy for individual patients. Cancer is a disease of the genome, and tumor tissues are a rich source of cancer biomarkers as they contain the functional translation of the genome, namely the proteome. Investigation of the tumor tissue proteome allows the identification of proteomic signatures corresponding to clinico-pathological parameters, and individual proteins in such signatures will be good biomarker candidates. Tumor tissues are also a rich source for plasma biomarkers, because proteins released from tumor tissues may be more cancer specific than those from non-tumor cells. Two-dimensional difference gel electrophoresis (2D-DIGE) with novel ultra high sensitive fluorescent dyes (CyDye DIGE Fluor satulation dye) enables the efficient protein expression profiling of laser-microdissected tissue samples. The combined use of laser microdissection allows accurate proteomic profiling of specific cells in tumor tissues. To develop clinical applications using the identified biomarkers, collaboration between research scientists, clinicians and diagnostic companies is essential, particularly in the early phases of the biomarker development projects. The proteomics modalities currently available have the potential to lead to the development of clinical applications, and channeling the wealth of produced information towards concrete and specific clinical purposes is urgent.

• 한국의상디자인학회지
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• 제23권2호
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• pp.115-132
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• 2021

The purpose of this study was to suggest multiple directions of fashion design by producing differentiated athleisure fashion designs with functional materials based on existing sportswear. A design utilizing handcraft skill was developed by applying the design characteristics of Laszlo Moholy-Nagy's paintings. With respect to the study methods, the background of Laszlo Moholy-Nagy's paintings were analyzed and their historical background was investigated by employing previous studies and literature review. The design characteristics were classified by issue and time-period. The results are as follows; First, the feasibility of creative artwork expression was found by pursuing collaboration with artwork and fashion by applying the motives of the fashion with the characteristics by the times, lines, forms, colors, and overlapping in Moholy-Nagy's paintings. Second, athleisure fashion, which can mix-match with casual wear, was found to enhance not only creativity but also add value by applying design, which added multiple handcraft elements, as well as characteristics of functionality, aesthetics, practicality, appealability, ostentation, activity, and dynamism. Third, potential harmony was found with achromatic and chromatic colors that can express more dynamic and active images. Based on the study results, further studies are anticipated using multiple paintings.

• Childhood Kidney Diseases
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• 제25권2호
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• pp.92-111
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• 2021

Purpose: Nephrotic syndrome (NS) is the most common form of glomerulopathy in children. Most pediatric patients respond to glucocorticosteroid treatment (steroid-sensitive NS, SSNS), while approximately 10-15% will remain unresponsive or later become steroid-resistant. There has been a long-standing effort to find biomarkers that may predict steroid responsiveness. Methods: We systematically reviewed current studies which investigated clinically relevant biomarkers for predicting steroid responsiveness in pediatric NS. We performed a PubMed and EMBASE search to identify eligible articles. We collected data on urinary markers, blood/serum markers (including cellular phenotypes and mRNA expression), genotypes and HLA allele frequency. Results: A total of 659 articles were identified following electronic and manual searches. After reviewing the titles, abstracts, and full texts, 72 eligible articles were finally included. Vitamin D-binding protein (VDBP) seemed to be significantly elevated in SRNS than in SSNS, in both serum and urine specimen, although further validation is required. Conclusions: The present paper narratively illustrates current understandings of potential biomarkers that may help predict steroid responsiveness. Further investigation and collaboration involving a larger number of patients are necessary.

• 한국콘텐츠학회논문지
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• 제12권8호
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• pp.429-437
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• 2012

본 연구는 신체표현을 활용한 색깔과 화음, 다이내믹을 연결하여 일어나는 변화에 목적을 두고 있다. 본 연구를 통하여 영상미디어 음악치료 프로그램 모형개발을 위한 기초 자료 수집을 위해 심리적으로 화음과 다이내믹이 색깔에 변화를 준다는 것을 탐색하였다. 영상매체에서 음악은 비언어적 의사소통으로 많은 분야에서 사용된다. 특히 음과 색깔 관계의 심리적 변화를 통하여 가상과 현실의 갭을 줄이는 데에 가장 효과적인 도구이며 사용자는 메시지와 의미에 대해 우리의 감성을 유도한다. GIM (Method of Guided Imagery and Music)은 인간의 내면세계를 탐색하고 음악에 유도된 다양한 심상 경험을 통해 상징적 의미와 통찰로 자신을 이해하고 문제를 해결해가도록 하는 음악치료방법으로 인간의 내적세계를 광범위하게 다룬다. 본 연구를 통하여 영상미디어라는 도구를 기존의 음악치료에서 사용되어져 왔던 수동적이고 소극적인 음악 감상 활용방법에서 탈피하고 직접 몸으로 체험하는 능동적이고 적극적인 음악치료 프로그램 모형을 적용시켜 나아가 오늘날 급격히 변화하는 청소년기의 사회적응문제에서 긍정적 효과를 줄 수 있는 음악치료 프로그램개발 모형을 위한 기초 자료로 삼고자 한다.