• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.31 no.3
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• pp.79-84
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• 2003

Cold expansion of fastener holes is a mechanical process widely used in the aerospace industry. This treatment leads to an improvement of fatigue behavior due to the developed compressive residual stresses on the hole surface. Despite its importance to aerospace industries, little attention has been devoted to the accurate modeling of the process. This study is devoted to the modeling and simulation of the residual stress resulting from the cold expansion of two adjacent fastener holes. Simultaneous cold expansion of two adjacent holes lead to much higher compressive residual stress than sequential cold expansion.

• Journal of Oriental Medical Thermology
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• v.9 no.1
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• pp.8-21
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• 2011

Purpose : This study is to investigate the trends of study of cold hypersensitivity in Korean traditional medicine and to direct for future research. Methods : We searched for papers which had used cold hypersensitivity in korean journals. Results : 25 papers were found. 10 papers were associated with characteristics of cold hypersensitivity. 8 papers were associated with case study. 5 papers were associated with diagnosis. 2 papers were associated with research for treatment effect. Conclusion : Studies have been conducted on cold hypersensitivity in various fields. But evidence is not enough, so more research will be needed.

• Journal of Oriental Medical Thermology
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• v.9 no.1
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• pp.44-50
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• 2011

Purpose : The purpose of this study is to investigate effect of Hyangsayijoongtang-gamibang on Cold Hypersensitivity and accompanying perspiration. Methods : Hyangsayijoongtang-gamibang was used for a Cold Hypersensitivity patient with accompanying perspiration that was admitted to Kangnam Kyung-Hee Korean Hospital from May 2nd, 2011 to May 14th, 2011. The efficacy of the treatment was evaluated with Digital Infrared Thermal Imaging(DITI). along with objective and subjective observations. Results : After treatments of oriental medicine. the mean body temperature elevated $1.32^{\circ}C$. and the mean temperature difference between different points of the body decreased more than 50%. Subjective observation of Cold Hypersensitivity and accompanying perspiration using Visual Analog Scale(VAS) also showed improvement. Conclusion : Results suggest that Hyangsayijoongtang-gamibang is effective in treating Cold Hypersensitivity patients with accompanying perspiration.

• Journal of Haehwa Medicine
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• v.9 no.1
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• pp.399-407
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• 2000

According to the literature on the genital cold sign, results were as follows. 1. Genital cold sign is that patient feel cold the part outer reproductive system. 2. The primary cause of genital cold sign is the kidney yang vacuity, and the others are the spleen vacuity, fulling down damp-heat, vacuity consumption, frenetic movement of ministerial fire, dedilitation of kidney yin, insecurity of kidney yang, impairment spleen with vacuity consumption, 3. The primary treatment of genital cold sign is warming and recuperating kidney, and the others are enrich yin and norishing blood, supplement the vital energy and enrich blood, clearing away dampness, etc. 4. For the medical prescriptions are used PalMiHyan(八味丸), GeJiGaYongGolMoReoTang(桂枝加龍骨牡蠣湯), GoJinTang(固眞湯), GaGamNaiGoHyan(加減內固丸), SipBoHyan(十補丸), YoSuYuTang(吳茱萸湯), ChungHonTang(淸魂湯), HuiChunSan(回春散), JoYangSan(助陽散), ChungHonTang(淸魂湯), YoncDamSaGanTane(龍膽瀉肝湯), SiHo-SoengSoepTang(柴胡勝濕湯).

• The Korean Journal of Physiology and Pharmacology
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• v.25 no.5
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• pp.489-494
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• 2021

Oxaliplatin, a third-generation platinum derivative, is the mainstay of current antineoplastic medications for advanced colorectal cancer therapy. However, peripheral neuropathic complications, especially cold allodynia, undermine the life-prolonging outcome of this anti-cancer agent. Rosavin, a phenylpropanoid derived originally from Rhodiola rosea, exhibits a wide range of therapeutic properties. The present study explored whether and how rosavin alleviates oxaliplatin-induced cold hypersensitivity in mice. In the acetone drop test, cold allodynia behavior was observed from days 3 to 5 after a single injection of oxaliplatin (6 mg/kg, i.p.). Cold allodynia was significantly attenuated following rosavin treatment (10 mg/kg, i.p.). Specific endogenous 5-HT depletion by three consecutive pretreatments with parachlorophenylalanine (150 mg/kg/day, i.p.) abolished the analgesic action of rosavin; this effect was not observed following pretreatment with naloxone (opioid receptor antagonist, 10 mg/kg, i.p.). Furthermore, 5-HT_1A receptor antagonist WAY-100635 (0.16 mg/kg, i.p.), but not 5-HT₃ receptor antagonist MDL-72222 (1 mg/kg, i.p.), blocked rosavin-induced analgesia. These results suggest that rosavin may provide a novel approach to alleviate oxaliplatin-induced cold allodynia by recruiting the activity of 5-HT_1A receptors.

• Journal of Physiology & Pathology in Korean Medicine
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• v.36 no.5
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• pp.147-154
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• 2022

In order to secure practising rapid pattern(證, zheng) differentiation against acute infectious diseases like corona virus disease-19(COVID-19) showing rapid variation and contagion, a simplified classification of stages centering on the exterior-interior pattern identification with 2 step-subdivision by cold, heat, deficiency, excess pattern and pathogens is proposed. Pattern differentiation by compound patterns of 8 principles is made for the non-severe stage of general cold and the early mild stage of epidemic disease. Compound pattern's names of 8 principles about external infectious diseases are composed of three stages, that is disease site-characters-etiology. Based on early stage symptoms of fever or chilling etc., exterior, interior and half exterior and half interior patterns are determined first, and then cold, heat, deficiency, excess patterns of exterior and interior pattern respectively are determined, and then more concrete differentiation on pathogens of wind, dryness, dampness and dearth of qi, blood, yin, yang accompanied with constitutional and personal illness factors. Summarizing above descriptions, 4 patterns of exterior cold, exterior heat, exterior deficiency, exterior excess and their secondary compound patterns of exterior cold deficiency and exterior cold excess and so on are classified together with treatment method and available decoction for a standard measure of eight principle pattern differentiation.

• The Journal of Korean Obstetrics and Gynecology
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• v.22 no.2
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• pp.222-230
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• 2009

Purpose: This study intends to report the effects of Koong Gui Tang on Cold Hypersensitivity caused by acute and chronic Blood Deficiency. Methods: The patients having Cold Hypersensitivity were treated with oriental medicine including herbal medication therapy. Thereafter their health status was analyzed with their own empirical assessments and VAS. Results: After the series of medical treatment, Cold Hypersensitivity caused by acute and chronic Blood Deficiency has shown considerable improvement. Conclusion: This case study shows that Koong Gui Tang therapies are medically effective on Cold Hypersensitivity caused by acute and chronic Blood Deficiency.

• Korean Journal of Veterinary Research
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• v.64 no.1
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• pp.2.1-2.8
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• 2024

This study was performed to assess the antiapoptotic effect of canine platelet-rich plasma (PRP) treated on the canine adipose-derived mesenchymal stem cells (cMSCs) under cold ischemic conditions. The effect of preventing apoptosis of cMSCs was evaluated in the apoptotic condition induced by cold ischemic injury in vitro. To determine the progression of apoptosis, the changes in cell nucleus were observed using 4',6-diamidino-2-phenylindole (DAPI) fluorescence staining. In addition, we examined the mitochondrial membrane potential (MMP) and caspase-3 activity. When the cold hypoxic injury was applied to cMSCs, the apoptotic change was observed by DAPI staining, mitochondrial staining for MMP, and caspase-3 assay. PRP significantly decreased the number of apoptotic cells. Nuclear shrinkage and fragmentation of apoptotic cells in control groups were observed by DAPI staining. The MMP was recovered by the treatment of PRP. In addition, when the luminescence intensity was measured for caspase-3 activity, the value was significantly higher in the PRP treated groups than the control groups. The results of this study showed that the PRP may have a beneficial effect on apoptosis induced by cold ischemic injury.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2008.10a
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• pp.203-206
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• 2008

Transformation of austenite to martensite during cold rolling has been widely used to strengthen metastable austenitic stainless steel grades. Aging treatment of cold worked metastable austenitic stainless steels, including ${\alpha}'$-martensite phase, results in the further increase of strength, when aging is performed in $200^{\circ}C$ to $450^{\circ}C$ temperature range. The purpose of the present study was to evaluate the effect of time and temperature on the stress-strain behavior of cold worked austenitic stainless steels. The amount of ${\alpha}'$-martensite during cold working and aging was examined by ferrite scope and X-ray diffraction (XRD). During aging at $450^{\circ}C$ for 1hr, tensile strength dramatically increased by 150MPa. Deformed metastable austenitic steels containing the "body-centered" ${\alpha}'$-martensite are strengthened by the diffusion of interstitial solute atoms during aging at low temperature.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2004.05a
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• pp.400-403
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• 2004

A non-heat기leafed steel does not need quenching and tempering processes that are called a heat treatment differently from conventional steel. Since the tensile strength of this steel is higher than 900MPa, a conventional forming process should be changed to incremental forming process such as a cross wedge rolling that requires lower load capacity than conventional ones. In this paper, the cold cross wedge rolling (CWR) die has been designed using CAD/CAE In order to produce near-net-shaped component of ball stud of non-heat-treated cold steel. Finite element analyses were applied in order to investigate process parameters of CWR. Results provide that the stretching angle and the forming angie at knifing zone in CWR process is important parameter to be the stable process under the low friction coefficient condition.