• Journal of Korean Academy of Nursing
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• v.23 no.2
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• pp.157-169
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• 1993

The most effective modality for cold application and the length of the application have not been determined despite many studies about the use of cold. A quasi-experimental study was conducted to examine the most effective modality among three methods of cold application, the most effective length of time for the application and the continuing effect after each type of cold application. Thirty adult patients admitted to medical and neurosurgical unit and with high fever (above 38.2 ℃) were assigned randomly to each of three cold ap-plication methods : (a) ice bag: (b) cold compress; and (c) tepid water sponge bath. Each method was applied to the whole anterior surface except the face and neck with the patient in the supine pos-ition. Rectal temperatures and skin temperatures (mid chest, upper arm, thigh and leg) were measured be-fore each application and every 10 minutes during ,each application for a period of 60 minutes. They were also measured every 10 minutes for 30 minutes after each cold application was finished. The experiments were carried out from Dec. 22. 1992 through Feb. 26, 1993. The data were analysed using means, ANCOVA Sheffe test and Pearson's Correlation Coefficient. The results of this study are as follows : 1. There were no significant differences among the three cold application methods in the reduction of body temperature, 2. Among the ice bag, cold compress and tepid water sponge bath groups, the ice bag proved to be the most effective method for lowering skin temperature while the cold compress was least effective. 3. Both rectal and skin temperature continued to decrease during the 60 minutes of cold application, but the hunting phenomena was not observed at any of the cold application sites. 4. There were no significant correlations between mean rectal and skin temperatures. 5. Skin temperatures according to the cold application sites decreased to a range of 3.46℃ to 5.20℃ (mid chest), a range of 4.48℃ 4.96℃ (upper arm), a range of 3.86℃ to 5.05℃ (thigh), and a range of 5.42℃ -7.12℃ (leg ). 6. In continuing effect after the cold applications were finished, rectal temperatures according to ice bag, cold compress and tepid sponge bath decreased to 0.29℃, 0.23℃ and 0.09℃ respectively, while the mean skin temperatures increased to 2.39℃ , 2.04℃ and 2.22℃ respectively. In this experiment the ice bag was the most effective modality for lowering skin temperature. when-ever cold is applied for systemic effect, the continuing effect of cold should be considered. The determination of the most effective length of time for cold application needs further study.

• Nuclear Engineering and Technology
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• v.50 no.6
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• pp.989-995
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• 2018

Argonne National Laboratory of the United States and Kharkov Institute of Physics and Technology (KIPT) of Ukraine have cooperated on the development, design, and construction of a neutron source facility. The facility was constructed at Kharkov, Ukraine, and its commissioning process is underway. The facility will be used for researches, producing medical isotopes, and training young nuclear specialists. The neutron source facility is designed with a provision to include a cryogenically cooled moderator system-a cold neutron source (CNS). This CNS provides low-energy neutrons, which will be used in the scattering experiment and material structures analysis. Cold neutron guides, coated with reflective material for the low-energy neutrons, will be used to transport the cold neutrons to the experimental site. The cold neutron guides would keep the cold neutrons within certain energy and angular space concentrated inside, while most of the gamma rays and high-energy neutrons are not affected by the cold neutron guides. For the KIPT design, the cold neutron guides need to extend several meters outside the main shield of the facility, and curved guides will also be used to remove the gamma and high-energy neutron. The neutron guides should be installed inside a shield structure to ensure an acceptable biological dose in the facility hall. Heavy concrete is the selected shielding material because of its acceptable performance and cost. Shield design analysis was carried out for the CNS guide hall. MCNPX was used as the major computation tool for the design analysis, with neutron and gamma dose calculated separately. Weight windows variance reduction technique was also used in the shield design. The goal of the shield design is to keep the total radiation dose below the $5.0{\mu}Sv/hr$ guideline outside the shield boundary. After a series of iterative MCNPX calculations, the shield configuration and parameters of CNS guide hall were determined and presented in this article.

• KIEAE Journal
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• v.5 no.2
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• pp.19-26
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• 2005

Every site has a different given geometrical and climatic condition, which influenced not only the lifestyle of the humanbeings but also the regional architecture. For example, on a cold region, the reduction of the energy loss is necessary, like an igloo, which has a littlest energy loss at hemisphere. Or on a warm region, the house must be protected thermally from the overheating at the sunshining. like a huge shading. An architectural interpretation in the (extreme) moderate climate, like Korea, has always tried to satisfy the both opposite demands simultaneously. A facade, which divides out- and inside, has an ideal position to lead the regulated regional climatic conditions into the room. The Double Facade System(DFS) is well known as an innovative solution in the european countries, like Germany. It provides an reasonable alternative, which can achieve these goals at the same time. A Double Facade System provides an effective sunshade, which means a cooling energy reduction at the warm season. In addition, it enables a natural ventilation at the cold season with the preheating at the system as well as spring and autumn. An ordinary Single Facade System with a inside or outside sun blind provides a solution just for a specified season, like a summer or winter. But the Double Facade System can deal with the various climatic conditions in the moderate climate.

• The Journal of Korean Physical Therapy
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• v.10 no.2
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• pp.87-95
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• 1998

The purpose of this study was to determine the effects of cold application for reducing spasticity in patients with traumatic brain min injury cerebrovascular accident who did not take neurosurgical treatment and medication except patients with spinal cord injury. The participants consisted of 24 men and 21 female were ramdomly assigned to three groups with each 15. The result were as followings after making an observation about the change of skin temperature and spasticity throughout cryotherapy which was performed with ice stick in Group I (1 min), Group II (5 min) and Group III(10 min). 1. It was found that the Group III, Croup II, Group I, in order named, had the statistically significant reduction of skin temperature, the reduction of spasticity showed statistically significance in Group III, Group II, in order named, but did not show it even though there was a little increase in Group I. 2. The reduction of skin temperature and spasticity did not continue over 24 hours at the same time every day for 5 days. 3. The longer cryotherapy was applied the mere skin temperature and spasticity reduced, the more skin temperature was reduced the more spasticity reduced.

• Journal of Microbiology and Biotechnology
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• v.10 no.6
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• pp.858-864
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• 2000

The purpose of the present study was to examine the efficacy and mechanism of the fraction IV cold ethanol fractionation and pasteurization ($60^{\circ}C$ heat treatment for 10h) steps, involved in the manufacture of albumin from human plasma, in the removal and/or inactivation of blood-born viruses. A variety of experimental model viruses for human pathogenic viruses, including the Bovine viral diarrhoea virus (BVDV), Bovine herpes virus (BHV), Murine encephalomyocarditis virus (EMCV), and Porcine parvovirus (PPV), were selected for this study. Samples from the relevant stages of the production process were spiked with the viruses, and the amount of virus in each fraction was then quantified using a 50% tissue culture infectious dose ($TCID_{50}$). The mechanism of reduction for the enveloped viruses (BHV and BVDV) during fraction IV fractionation was inactivation rather than partitioning, however, it was partitioning in the case of the non-enveloped viruses (EMCV and PPV). The log reduction factors achieved during fraction IV fractionation were ${\geq}6.9$ BHV, $\geq5.2$ for BBDV, 4.9 for EMC, and 4.0 for PPV. Pasteurization was found to be a robust and effective step in inactivating the enveloped viruses as well as EMCV. The log reduction factors achieved during pasteurization were $\geq7.0$ for BHV, $\geq6.1$ for BVDV, $\geq6.3$ for EMCV, and 1.7 for PPV. These results indicate that the production process for albumin has sufficient virus-reducing capacity to achieve a high margin for virus safety.

• Biotechnology and Bioprocess Engineering:BBE
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• v.6 no.1
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• pp.25-30
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• 2001

Viral safety is a prerequisite for manufacturing clinical albumin and immunoglobulins from human plasma pools. This study was designed to evaluate the efficacy of cold ethanol fractionation and pasteurization (60$\^{C}$ heat treatment for 10h) for the removal/inactivation of human immunodeficiency virus type 1 (HIV-1) during the manufacturing of albumin and immunoglobulins. Samples from the relevant stages of the production process were spiked with HIV-1, and the amount of virus in each fraction was quantified by the 50% tissue culture infectious dose(TCID(sub)50). Both fraction IV fractionation and pasteurization steps during albumin processing were robust and effective in inactivating HIV-1, titers of which were reduced from an initial 8.5 log(sub)10 TCID(sub)50 to undetectable levels. The log reduction factors achieved were $\geq$ 4.5 and $\geq$ 6.5, respectively. In addition, fraction III fractionation and pasteurization during immunoglobulins processing were robust and effective in eliminating HIV-1. HIV-1 titers were reduced from an initial 7.3 log(sub)10 TCID(sub)50 to undetectable levels. The log reduction factors achieved in this case were $\geq$ 4.9 and $\geq$ 5.3, respectively. These results indicate that the process investigated for the production of albumin and immunoglobulins have sufficient HIV-1 reducing capacity to achieve a high margin of safety.

• Korean Journal of Acupuncture
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• v.21 no.4
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• pp.101-115
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• 2004

Objective : The present studies investigated the effects of 120 Hz high frequency electroacupuncture (EA) on the stress-induced stomach dysfunction in relation to its effect on the level of stress hormones and gastric mucosal damages. The gastric mucosal injury was induced by cold-restraint stress and two acupoints corresponding to Zusanli and Sanyinjiao in man were used. Methods : Cold-restraint stress produced typical gastric lesions in all rats of the stressed groups, but the number of ulcers as well as the mean ulcer diameter were reduced by 120 Hz EA pre-treatment. Results : The degranulation value of gastric mast cell was significantly higher in cold-restrained rats than in control ones. However, with the significant reduction of degranulation values of gastric mast cells in EA pre-treated rats compared with cold-restrained rats. Cold-restarint stress induced an elevated mRNA expression of pro-inflammatory gene such as cyclooxygenases-2 and tumor necrosis factor $(TNF)-{\alpha}$, but these expression were down-regulated in EA pre-treated rats. Immunohistochemical analysis showed that while the $inhibitory-{\kappa}B{\alpha}$ and $TNF-{\alpha}$ immunorection in the surface epithelium of the stomach tended to increase, both reactions in the EA pre-treated rats showed similar pattern as observed in controls. Conclusion : These results suggest that 120 Hz EA may act as a therapeutical means for gastric mucosal damages through an activation of pituitary adrenal system. It could be concluded that 120 Hz high frequency electroaucupuncture affords a good protective potential against stress-induced gastrointestinal dysfunction.

• Journal of the Korean Academy of Clinical Electrophysiology
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• v.5 no.2
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• pp.85-93
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• 2007

Summary of background data: It is researched until now and the researches against the effect of position cold treatment the effect which pain threshold, change of skin temperature, researches the effective stiffness, the coldness in the patient it applied and relax an inflammation do the researches against were insufficient. Purpose: This project was to see how much it gives effect by using the cold air therapy an inflammation relief of rheumatoid arthritis patient. Methods: The medical subjects were 10 people from standard to diagnosis category of American College of Rheumatology(ACR) who had rheumatoid arthritis and to inspect informations about inflammation relief, have inspected ESR(erythrocyte sedimentation rate) and WBC(white blood cells). The experiment method was to let the patient bend the joint and lay down flat and treat with cold air from 10 cm away from joint line repeating 5 minutes treatment 1 minute rest and 3 minutes treatment. ESR and WBC cold air therapy reported with 5 days gap and each patient has been applied for 3 times. Result: The 5th day and 10th days ESR and WBC value shows when using cold air therapy, there was a reduction on rejected group but didn't last long, but 15th day it showed only on WBC it had its attention. Conclusions: So the cold air therapy shows it has positive effects on inflammation relief of rheumatoid arthritis patient.

• Transactions of the Korean Society of Automotive Engineers
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• v.16 no.3
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• pp.94-101
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• 2008

Since regulations of exhaust emissions are continuously reinforced, studies to reduce harmful emissions during the cold start period of SI engines have been carried out very extensively worldwide. During the cold start period, raising the temperature of cold exhaust gas is a key strategy to minimize the light-off time of three way catalysts. In this study, a synthetic gas containing a large amount of hydrogen was injected into the exhaust manifold to raise the exhaust gas temperature and to reduce harmful emissions. The authors tried to evaluate changes in exhaust gas temperature and harmful emissions through controlling the engine operating parameters such as ignition timings and lambda values. Also the authors investigated both combustion stability and reduction of harmful emissions. Experimental results showed that combustion of the synthetic gas in the exhaust manifold is a very effective way for solving the problems of harmful emissions and light-off time. The results also showed that the strategy of retarded ignition timings and increased air/fuel ratios with ESGI is effective in raising exhaust gas temperature and reducing harmful emissions. Futhermore, the results showed that engine operating parameters ought to be controlled to lambda = 1.2 and ignition timing = $0{\sim}3^{\circ}$ conditions to reduce harmful emissions effectively under stable combustion conditions.

• Journal of Photoscience
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• v.12 no.1
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• pp.33-39
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• 2005

Plants possess the ability to dissipate the excitation energy for the protection of photosynthetic apparatus from absorbed excess light. Heat dissipation is regulated by xanthophyll cycle in thylakoid membranes of chloroplasts. We investigated the mechanistic aspects of xanthophyll cycle-dependent photoprotection against low-temperature photoinhibition in plants. Using barley and rice as chilling-resistant species and sensitive ones, respectively, chilling-induced chlorophyll fluorescence quenching, composition of xanthophyll cycle pigments and mRNA expression of the zeaxanthin epoxidase were examined. Chilled barley plants exhibited little changes in chlorophyll fluorescence quenching either of photochemical or non-photochemical nature and in the photosynthetic electron transport, indicating low reduction state of PS II primary electron acceptor. In contrast to the barley, chilled rice showed a marked decline in those parameters mentioned above, indicating the increased reduction state of PS II primary electron acceptor. In addition, barley plants were shown to have a higher capacity to elevate the pool size of xanthophyll cycle pigments in response to cold stress compared to rice plants. Such species-dependent regulation of xanthophyll cycle activity was correlated with the gene expression level of cold-induced zeaxanthin epoxidase. Chilled rice plants depressed the gene expression of zeaxanthin epoxidase, whereas barley increased its expression in response to cold stress. We suggest that chilling-induced alterations in the pool size of xanthophyll cycle pigments related to its capacity would play an important role in regulating plant's sensitivity to chilling stress.