• Title/Summary/Keyword: Cold Plasma

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Stimulation of the Immune Response by Herbal Formulas for Wind-Cold and Heat Pain Symptom (대표적인 풍한열(風寒熱)에 의한 통증 치료 처방의 면역 활성화 비교 연구)

  • Jung, Da-Young;Ha, Hye-Kyung;Lee, Ho-Young;Lee, Jin-Ah;Lee, Jun-Kyoung;Huang, Dae-Sun;Shin, Hyeun-Kyoo
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.24 no.4
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    • pp.616-623
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    • 2010
  • Three herbal formulas (Bangpungtongsung-san, Ohyaksungi-san, and Ojeok-san) for wind-cold and heat pain symptom were applied to investigate the immunological activities on antigen (Ag)-specific or Ag-non-specific immune responses in murine macrophage cell line (RAW 264.7) and ovalbumin (OVA)-immunized mice. This study was carried out in nitric oxide (NO) synthesis in RAW 264.7 cells and cellular proliferation in mouse splenocytes according to three herbal formulas. C57BL/6 mice were immunized intraperitonially with OVA/aluminium ($100\;{\mu}g/200\;{\mu}g$/mouse) on day 1, 8, and 15. Three herbal formulas were administrated to mice orally for 3 weeks from day 1. On day 22, OVA-, lipopolysaccharide (LPS)-, and concanavalin A (Con A)-stimulated splenocyte proliferation and antibodies (OVA-specific antibodies of the IgG, lgG1, and total IgM classes) in plasma were measured. Ohyaksungi-san increased NO synthesis in RAW 264.7 cells. Ojeok-san and Ohyaksungi-san significantly enhanced cellular proliferation by LPS and Con A in splenocytes from OVA-immunized mice (p<0.001). Three herbal formulas for wind-cold and heat pain symptom also significantly enhanced plasma OVA-specific IgG, IgG1, and total IgM levels compared with the OVA/Alum group. These results suggested that three herbal formulas for wind-cold and heat pain symptom could be used as stimulator of immune response.

The Characteristics of Coal Gasification using Microwave Plasma (마이크로웨이브 플라즈마를 이용한 석탄가스화 특성 연구)

  • Kim, Doo-Il;Lee, Jae-Goo;Kim, Yong-Ku;Yoon, Sang-Jun
    • Transactions of the Korean hydrogen and new energy society
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    • v.23 no.1
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    • pp.93-99
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    • 2012
  • The investigation of clean and environment-friendly coal utilization technology is actively progressed due to high oil price and serious climate change caused by greenhouse gas emissions. In this study, the plasma gasification was performed using a 6kW microwave plasma unit under various reaction conditions: the particle sizes of coal ($45{\mu}m-150{\mu}m$), $O_2$/fuel ratio (0 - 1.3), and steam/fuel ratio (0 - 1.5). The $H_2$ composition decreases with decreasing coal particle size. With increasing $O_2$/fuel ratio, the $H_2$ composition in the syngas decreased while the $CO_2$ composition increased. As the steam/fuel ratio increased from 0 to 1.5, the $H_2$ composition in the syngas increased while the $CO_2$ composition decreased. From the results, it was proven that the variation of syngas composition greatly affected by $O_2$/fuel ratio than steam/fuel ratio. The $H_2$ composition in the syngas, carbon conversion, and cold gas efficiency increased with increasing plasma power.

Immobilization and Grafting of Acrylic Acid on Polyethylene Surface by Ar-plasma Treatment (알곤 플라즈마처리에 의한 폴리에틸랜 표면상의 아크릴산 고정화와 그라프팅)

  • 김민정;서은덕
    • Polymer(Korea)
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    • v.26 no.2
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    • pp.279-286
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    • 2002
  • For surface modification of polymers with hydrophilic functional groups, acrylic acid was grafted and immobilized on the surface of polyethylene(PE) by cold-plasma treatment using Ar gas. The modifications were identified by analysis of ATR-IR spectrum and by the measurement of contact angles. Compared to virgin PE significant decreases in contact angle were observed for both the grafted PE and the immobilized PE. The decreases of contact angle were in the range of 47~$53^{\circ}$ for grafted PE and 23~$26^{\circ}$ for immobilized PE. The degree of hydrophilicity depended strongly on the plasma-treating time and discharge power. For the case of grafting it has show that the longer plasma-treating time, the higher hydrophilic character. For the case of immobilization, whereas, higher discharge power and longer exposure to plasma have shown the detrimental effect for the preparation of hydrophilic PE surface due to the decrease of carboxyl group by ablation effect. The decrease in adhesion strength of immobilized PE. compared to grafted PE, was also attributed to the ablation of carboxyl group.

Preparation of Composite Membranes for Recovery of Unreacted Olefin Monomers (미반응 올레핀계 모노머 회수를 위한 복합막의 제조)

  • Kim, Hyun-Gi;Kim, Sang-Yong;Kim, Sung-Soo
    • Membrane Journal
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    • v.20 no.4
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    • pp.297-303
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    • 2010
  • Composite membranes were prepared for membrane/cold condensation process for recovery of unreacted olefin monomer from the polyolefin polymerization process by solution coating and plasma polymerization processes. Poly(dimethylsiloxane) (PDMS) solution was coated on polysulfone (PSF) support and increase of prepolymer content in solution made more dense membrane structure to result in the increase of separation factor while absolute flux decreased. Permeation of organic materials through the composite membranes follows the sorption and diffusion mechanism, which brought about the results that separation factor increased with critical temperature of the organic materials, and that flux increased with the increase of the molar volume. Crosslinking period affected the permeation characteristics. Other types of composite membranes were fabricated by plasma polymerization of siloxane materials on polypropylene (PP) and PSF supports. PP was tested as a support for composite membranes, which had not been used so far in solution coating process, and plasma polymerization made the composite membranes equivalent performances to those of membranes prepared by solution coating process.

Changes in microbial and chemical properties of rough rice treated with cold plasma by storage temperatures and periods (저온 플라즈마 처리한 벼의 저장온도 및 기간에 따른 미생물학적 및 이화학적 특성 변화)

  • Woo, Koan Sik;Yong, Hae In;Jo, Cheorun;Lee, Seuk Ki;Lee, Byong Won;Lee, Byoungkyu;Lee, Yu-Young;Oh, Sea-Kwan;Kim, Hyun-Joo
    • Food Science and Preservation
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    • v.24 no.7
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    • pp.908-914
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    • 2017
  • Cold plasma (CP) was applied to examine microbial safety and physicochemical properties of rough rice. CP was generated in a square-shaped plastic container (250 W, 15 kHz, ambient air) and dielectric barrier discharge plasma treatment was applied for periods of 0, 10, and 20 min during 2 weeks at 4 and $25^{\circ}C$. As a result of observing changes in growth of microorganisms, 3.46-3.86 log CFU/g of total aerobic bacteria and 2.27-2.86 log CFU/g of mold were detected in the early stage of storage. The growth of total aerobic bacteria and mold was increased depending on the storage temperature and period, but there was no big difference between cultivars. Microbial analysis after storage showed that microorganisms of plasma-treated group were less grown approximately 1.50 log CFU/g. Moisture content of rough rice was decreased by storage temperature and periods. As for the amylose content, changes in the content by plasma were not observed in Samkwang, Cheongpum and Misomi, whereas Palbangmi showed a tendency to increase. The results of this study indicated that CP treatment improved the microbial quality of rough rice, but further studies should be conducted to reduce the deterioration of sensory quality induced by CP.

Variation of Floating Potential in the Topside Ionosphere Observed by STSAT-1

  • Lee, Junhyun;Lee, Ensang;Lee, Jaejin;Kim, Khan-Hyuk;Seon, Jongho;Lee, Dong-Hun;Jin, Ho;Kim, Eung-Hyun;Jeon, Hyun-Jin;Lim, Seong-Bin;Kim, Taeyoun;Jang, Jaewoong;Jang, Kyung-Duk;Ryu, Kwangsun
    • Journal of Astronomy and Space Sciences
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    • v.31 no.4
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    • pp.311-315
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    • 2014
  • In this study, we investigated the effect of space plasmas on the floating potential variation of a low-altitude, polar-orbiting satellite using the Langmuir Probe (LP) measurement onboard the STSAT-1 spacecraft. We focused on small potential drops, for which the estimation of plasma density and temperature from LP is available. The floating potential varied according to the variations of plasma density and temperature, similar to the previously reported observations. Most of the potential drops occurred around the nightside auroral region. However, unlike the previous studies where large potential drops were observed with the precipitation of auroral electrons, the potential drops occurred before or after the precipitation of auroral electrons. Statistical analysis shows that the potential drops have good correlation with the temperature increase of cold electrons, which suggests the small potential drops be mainly controlled by the cold ionospheric plasmas.

Combustion Characteristics Study using Hyper-mixer in Low-enthalpy Supersonic Flow (하이퍼 혼합기를 사용한 저엔탈피 초음속 유동장 내연소 특성 연구)

  • Kim, Chae-Hyoung;Jeung, In-Seuck
    • Journal of the Korean Society of Propulsion Engineers
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    • v.17 no.6
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    • pp.75-80
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    • 2013
  • In this study, a forced ignition method with a plasma jet torch is studied in Mach 2 laboratory scaled wind-tunnel. The hyper-mixer is used as a mixer. For two normal injection cases, the one is collided against a wedge plate of the hyper-mixer and the other is directly injected into the cold main flow. For the first case, the hyper-mixer disperses the injected fuel, leading to the mixing enhancement. Furthermore, the fuel-air mixture is provided into the plasma hot gas, which enhances the combustion performance. However, the direct injection into the main flow method spends amount of fuel without ignition in the cold supersonic flow. In the end, for the forced combustion, it is important to supply the fuel-air mixture into the heat source.

Operational Properties and Microbial Inactivation Performance of Dielectric Barrier Discharge Plasma Treatment System (유전체장벽방전 플라즈마 장치의 조작특성과 살균력)

  • Mok, Chulkyoon;Lee, Taehoon
    • Food Engineering Progress
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    • v.15 no.4
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    • pp.398-403
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    • 2011
  • A dielectric barrier discharge plasma (DBDP) treatment system was fabricated and the optimum operating conditions for the plasma generation were determined in order to explore the potential of cold plasma as a non-thermal proessing technology. The microbial inactivation performance of the system was also evaluated against Staphyloocus aureus. The system consisted of power supply, transformer, electrode assembly and sample treatment plate. The input power was 220 V single phase AC and amplified to 10.0-50.0 kV on a transformer. A pulsed sine wave of frequency 10.0-50.0 kHz was introduced to the electrode embedded in ceramic as a dielectric barrier material in order to generate plasma at atmospheric pressure. Higher currents and consequently greater power were required for the plasma generation as the frequencies increased. A homogeneous and stable plasma was generated at currents of 1.0-2.0, and frequencies of 32.0-35.3 kHz. The optimum electrode-gaps for the plasma generation were 1.85 mm without loaded samples. More power was consumed as the electrode-gaps increased. The practically optimum electrode- gap was, however, 2.65 mm when samples were treated on slide-glasses for microbial inactivation. The maximum temperature increase after 10 min treatment was less than 20$^{\circ}C$, indicating no microbial inactivation effect by heat and thereby insuring a non-thermal method. The DBDP inactivation effect against Staphyloocus aureus increased linearly with treatment time up to 5 min, but plateaued afterward. More than 5 log reduction was achieved by 10 min treatment at 1.25 A.

Pharmacokinetic Analysis of Montelukast in Healthy Korean Volunteers by High Performance Liquid Chromatography-Tandem Mass Spectrometry

  • Jo, Min-Ho;Park, Mi-Sun;Seo, Ji-Hyung;Shim, Wang-Seob;Yim, Sung-Vin;Lee, Kyung-Tae
    • Journal of Pharmaceutical Investigation
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    • v.41 no.5
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    • pp.289-294
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    • 2011
  • A rapid and specific high performance liquid chromatography-tandem mass (LC/MS/MS) method for the analysis of montelukast in human plasma has been developed and validated. After cold acetonitrile-induced precipitation of the plasma samples, montelukast and glipizide (internal standard, IS) were eluted on a reverse-phase $C_{18}$ column by isocratic mobile phase consisted of 10 mM ammonium formate buffer (adjusted to pH 3.5 with formic acid) and acetonitrile (3:97, v/v). Acquisition was performed with multiple reaction monitoring (MRM) mode by monitoring the transitions: m/z 587.2${\rightarrow}$ 423.2 for montelukast and m/z 446.0${\rightarrow}$321.2 for IS. Ranges of concentration for calibration curves (10-1000 ng/mL) showed correlation coefficients ($r^2$) were better than 0.9948. Precision of intra- and inter-day ranged from 3.70 to 11.68% and from 3.04 to 12.95%, accuracy of intra-day and inter-day ranged from 93.34 to 102.75% and from 100.79 to 107.63%, respectively. The described method provides a fast and sensitive analytical tool for determining montelukast levels in plasma, and was successfully applied to a pharmacokinetic study in 16 healthy human subjects after oral administration of 10mg tablet formulation of montelukast sodium under fasting conditions.