• Biomolecules & Therapeutics
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• 제26권2호
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• pp.109-114
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• 2018

Liquiritigenin (LQ) is a flavonoid that can be isolated from Glycyrrhiza radix. It is frequently used as a tranditional oriental medicine herbal treatment for swelling and injury and for detoxification. However, the effects of LQ on cognitive function have not been fully explored. In this study, we evaluated the memory-enhancing effects of LQ and the underlying mechanisms with a focus on the N-methyl-D-aspartic acid receptor (NMDAR) in mice. Learning and memory ability were evaluated with the Y-maze and passive avoidance tests following administration of LQ. In addition, the expression of NMDAR subunits 1, 2A, and 2B; postsynaptic density-95 (PSD-95); phosphorylation of $Ca^{2+}$/calmodulin-dependent protein kinase II (CaMKII); phosphorylation of extracellular signal-regulated kinase 1/2 (ERK 1/2); and phosphorylation of cAMP response element binding (CREB) proteins were examined by Western blot. In vivo, we found that treatment with LQ significantly improved memory performance in both behavioral tests. In vitro, LQ significantly increased NMDARs in the hippocampus. Furthermore, LQ significantly increased PSD-95 expression as well as CaMKII, ERK, and CREB phosphorylation in the hippocampus. Taken together, our results suggest that LQ has cognition enhancing activities and that these effects are mediated, in part, by activation of the NMDAR and CREB signaling pathways.

• 한국과학교육학회지
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• 제33권7호
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• pp.1450-1470
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• 2013

본 연구는 다수준 포함 교수법(multi-level instruction)을 적용한 초등과학 프로그램을 개발하고, 이를 적용한 수업 과정에서 나타나는 학생들 간의 언어적 상호작용을 분석한 것이다. 이러한 연구 목적을 달성하기 위하여 경기도 H시의 B초등학교 5학년 27명을 대상으로 이질적인 4명의 학생으로 소집단을 구성하였고, 매 차시마다 2개 소집단의 수업 과정을 녹화하였다. 5학년 2학기 '1. 우리의 몸' 단원을 대상으로 다수준 포함 교수법을 적용한 초등과학 프로그램을 개발하였다. 언어적 상호작용은 크게 인지적 영역과 정의적 영역 두 가지 측면으로 분석하였다. 인지적 영역은 응답, 질문, 의견제시, 의견받기로 정의적 영역은 행동참여, 분위기 조절로 세분화하여 분석하였다. 다수준 포함 교수법을 적용한 초등과학 프로그램에서 학생들의 언어적 상호작용 분석 결과는 다음과 같다. 첫째, 인지적 영역과 관련된 언어적 상호작용이 정의적 영역과 관련된 상호작용에 비해 많이 일어났다. 둘째, 인지적 영역에서는 중위수준 아동의 언어적 상호작용 빈도가 가장 높았고, 정의적 영역에서는 상위수준 아동의 빈도가 가장 높았다. 인지적, 정의적 영역에서 모두 하위수준 아동의 빈도가 가장 낮게 나타났다. 셋째, 인지적, 정의적 영역에서 상위-중위수준 아동 사이에는 언어적 상호작용의 빈도에 차이가 없었다. 그리고 상위-하위수준 아동보다 중위-하위수준 아동에게서 유의하게 차이가 있는 상호작용 유형이 더 많았다. 중위-하위수준 아동은 행동 참여를 제외한 모든 영역에서 유의한 차이가 있었다. 넷째, 시간이 지날수록 전반적으로 아동들의 언어적 상호작용의 빈도가 증가하고 있었다. 또한 성취수준에 관계없이 활발한 상호작용이 일어나고 있음을 알 수 있었다.

• 생물정신의학
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• 제3권2호
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• pp.277-287
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• 1996

본 연구는 주정중독에 동반된 우울증 환자의 치료에서 적어도 행동학적 부작용의 관점에서는 PAR이 AMI보다 우수함을 증명하였다. 이러한 PAR의 행동학적 효과의 우수성은 환자의 삶의 질을 향상시키고 결국 치료결과를 높이는데 관여하리라고 생각된다.

• 인지과학
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• 제27권3호
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• pp.469-499
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• 2016

본 논문에서는 한국어의 통사적 부정문(예를 들면, 침대는/시계는 가구에 속한다/속하지 않는다)과 어휘적 부정문(예를 들면, 호랑이는/나비는 꼬리가 있다/없다)을 이용하여 부정어 처리의 인지신경기제를 확인하고 부정문 처리의 언어 보편적/특수적 기제를 밝히기 위한 진리치 판단과제 및 ERP(Event-related potentials) 실험연구를 진행하였다. 총 23명의 피험자가 전체 실험에 참여하였고 이들 중 15명의 뇌파 반응 데이터를 ERP 분석을 위하여 사용하였다. 실험 결과, 진리치 판단과제에 있어서는 영어를 이용한 선행연구들과 동일하게 긍정-참 >긍정-거짓>부정-거짓>부정-참의 순서를 확인할 수 있었다(높은 정확도, 짧은 반응 시간 순서). 그러나 ERP 결과에서는 선행 연구와는 다른 몇 가지 점을 발견하였다. 우선 어휘적 부정문의 경우 이른 시간 구간(250-350ms)에서의 N400효과를 확인할 수 있었지만 긍정문과 부정문을 아우르는 진리치 요인의 주 효과는 나타나지 않았다. 그러나 통사적 부정문의 경우 부정-참에 비하여 부정 거짓문장에서 P600 효과를 발견하였다. 이러한 결과는 표층적으로 나타나는 부정의 형태 및 위치와 같은 언어 특수적 요인에 대한 처리 전략은 각 언어별, 부정 종류별로 달라질 수 있지만 부정 처리의 결과로 얻어지는 문장의 최종 표상 및 이에 대한 진리치 판단의 기제는 언어 및 부정어 종류의 영향을 받지 않는 보편적인 특성을 지닌다는 것을 보여준다.

• 한국학교보건학회지
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• 제28권2호
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• pp.56-66
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• 2015

The purpose of this study was to investigate factors associated with coping responses in Korean public high school students. Methods: This study employed a descriptive survey research design. The sample included 263 high school students who responded to a self-report questionnaire. Variables included socio-demographic characteristics, health-related characteristics, academic stress, somatization symptoms, social support, and coping responses. Data were analyzed using descriptive statistics, t-tests, ANOVA, Pearson's correlations, and multiple regressions. Results: Participants, regarding their school life, reported moderate levels of academic stress ($M{\pm}SD=2.3{\pm}0.52$) and somatization symptoms ($M{\pm}SD=2.3{\pm}0.71$), and a relatively high level of social support ($M{\pm}SD=4.2{\pm}0.67$). All the variables were associated with the use of multiple coping responses. Active-cognitive coping ($M{\pm}SD=2.9{\pm}0.68$) was most frequently used, followed by active-behavioral coping ($M{\pm}SD=2.5{\pm}0.56$). and avoidant coping ($M{\pm}SD=2.3{\pm}0.75$). Significant relationships were found among the measured variables: positive relation between academic stress and somatization symptoms, but, negative between academic stress and both somatization symptoms and social support. Students who had higher stress and more somatization symptoms were more likely to use avoidant coping than the others. In multiple regression analysis, while factors associated with each coping response differed, gender appeared to be a significant factor in all methods. Variables included in the final model explained 27% of the variance in avoidant coping (F=11.40, p<.001). Conclusion: Based on the study results, schools should provide tailored educational programs to help high school students reduce multisource stress and somatization symptoms at school and cope with them in more active and effective ways.

• 한국콘텐츠학회논문지
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• 제15권10호
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• pp.495-503
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• 2015

본 연구는 소비자가 실제 제품이나 브랜드 사용 이외에 광고나 판매촉진 등 기업의 마케팅활동에 의해서도 브랜드를 경험할 수 있고 이러한 경험을 통하여 자아인식과 소비자-브랜드관계가 향상될 수 있음을 밝히고자 하였다. 총 248명을 대상으로 갤럭시S 스마트폰 브랜드에 대한 조작물로 브랜드를 경험하게 한 결과 브랜드경험 이후 긍정적 감정과 자아인식이 향상되었고, 긍정적 감정 또한 자아인식을 향상시킬 수 있는 것으로 나타났다. 이는 실제 브랜드를 이용하여 브랜드경험이 자아인식에 미치는 효과를 검증하였다는 점에서 중요하다. 또한 브랜드경험과 이를 통한 자아인식의 향상은 소비자-브랜드관계에 유의한 영향을 미치게 되며 궁극적으로 만족도, 추천의도 및 재구매 의도 등을 포함하는 브랜드 애호도까지 영향을 미치게 된다. 따라서 강력하고 매력적인 브랜드를 경험하는 것은 소비자에게 긍정적 감정의 형성이라는 혜택을 줄 수 있으며, 기업차원에는 소비자-브랜드관계를 통하여 구매의도 및 추가지불의도에까지 영향을 미칠 수 있는 관계를 밝혀낸 점이 주목할 만하다.

• Journal of Neurogastroenterology and Motility
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• 제24권4호
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• pp.512-527
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• 2018

This review provides a comprehensive overview of brain imaging studies of the brain-gut interaction in functional gastrointestinal disorders (FGIDs). Functional neuroimaging studies during gut stimulation have shown enhanced brain responses in regions related to sensory processing of the homeostatic condition of the gut (homeostatic afferent) and responses to salience stimuli (salience network), as well as increased and decreased brain activity in the emotional response areas and reduced activation in areas associated with the top-down modulation of visceral afferent signals. Altered central regulation of the endocrine and autonomic nervous responses, the key mediators of the brain-gut axis, has been demonstrated. Studies using resting-state functional magnetic resonance imaging reported abnormal local and global connectivity in the areas related to pain processing and the default mode network (a physiological baseline of brain activity at rest associated with self-awareness and memory) in FGIDs. Structural imaging with brain morphometry and diffusion imaging demonstrated altered gray- and white-matter structures in areas that also showed changes in functional imaging studies, although this requires replication. Molecular imaging by magnetic resonance spectroscopy and positron emission tomography in FGIDs remains relatively sparse. Progress using analytical methods such as machine learning algorithms may shift neuroimaging studies from brain mapping to predicting clinical outcomes. Because several factors contribute to the pathophysiology of FGIDs and because its population is quite heterogeneous, a new model is needed in future studies to assess the importance of the factors and brain functions that are responsible for an optimal homeostatic state.

• Clinical Psychopharmacology and Neuroscience
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• 제16권4호
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• pp.422-433
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• 2018

Objective: Neuropsychiatric manifestations like depression and cognitive dysfunction commonly occur in inflammatory bowel disease (IBD). In the context of the brain-gut axis model, colitis can lead to alteration of brain function in a bottom-up manner. Here, the changes in the response of the hypothalamic-pituitary-adrenal axis and inflammation-related markers in the brain in colitis were studied. Methods: Dextran sodium sulfate (DSS) was used to generate a mouse model of colitis. Mice were treated with DSS for 3 or 7 days and sacrificed. We analyzed the gene expression of brain-derived neurotrophic factor (BDNF), cyclooxygenase 2 (COX-2), and glial fibrillary acidic protein (GFAP), and the expression of GFAP, in the hippocampus, hypothalamus, and amygdala. Additionally, the levels of C-reactive protein (CRP) and serum cortisol/corticosterone were measured. Results: Alteration of inflammatory-related markers varied depending on the brain region and exposure time. In the hippocampus, COX-2 mRNA, GFAP mRNA, and GFAP expression were upregulated during exposure to DSS. However, in the hypothalamus, COX-2 mRNA was upregulated only 3 days after treatment. In the amygdala, BDNF and COX-2 mRNAs were downregulated. CRP and corticosterone expression increased with DSS treatment at day 7. Conclusion: IBD could lead to neuroinflammation in a bottom-up manner, and this effect varied according to brain region. Stress-related hormones and serum inflammatory markers, such as CRP, were upregulated from the third day of DSS treatment. Therefore, early and active intervention is required to prevent psychological and behavioral changes caused by IBD, and region-specific studies can help understand the precise mechanisms by which IBD affects the brain.

• 대한한의학방제학회지
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• 제27권2호
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• pp.121-136
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• 2019

Objective : To investigate the effect of sihogayonggolmoryeotang (SY) on Single Prolonged Stress(SPS)-induced Post Traumatic Stress Disorder(PTSD). Method : To confirm the effects of SY on SPS-induced PTSD, Changes in body weight, sucrose intake open field test(OFT) and forced swimming test(FST)were observed. After behavioral tests, the plasma corticosterone(CORT) from the abdominal aorta, serotonin(5-HT) from prefrontal cortex, hippocampus, amygdala and striatum, norepinephrine(NE) and dopamine(DA) from hippocampus was measured by ELISA. mRNA expression of brain-derived neurotrophic factor(BDNF) and cAMP response element-binding protein(CREB) in hippocampus was measured by RT-PCR. Result : Weight change and sucrose intakes of rats in 14th day after the administration of SY were significantly increased in the SPS + SY450 group compared to the SPS group (p<0.05). Numbers of crossing in the central zone in the OFT were significantly increased in the SPS + SY450 group (p<0.05) compared with the SPS group. The immobility time of FST was significantly decreased in SPS + SY450 group compared with SPS group (p<0.05). The change of plasma CORT concentration was significantly decreased in SPS + SY450 group compared with that in SPS group (p<0.05). The change of 5-HT concentration was significantly increased in the SPS + SY450 group at hippocampus and amygdala compared with the SPS group (p<0.05). The concentration of DA was significantly increased in the SPS + SY450 group compared with the SPS group (p<0.05). The expression of BDNF and CREB were significantly increased in SPS + SY450 group compared with the SPS group (p<0.05). Conclusion : SY administration lowered the increase of CORT caused by PTSD and increases the 5-HT concentration and reversed the decreased expression of NE and DA and BDNF and CREB by PTSD. It is postulated that SY is effective in treating PTSD by restoring cognitive function, memory impairment, unstable emotional disturbances.

• 대한간호학회지
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• 제28권2호
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• pp.403-413
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• 1998

The Resilience is described as the personal capacity which brings psychosocial comeback. The role of nursing is to do its best to rehabilitate patients and to explore the individual in order to promote patients psychosocial change. However, as the current nursing is heavily physical nursing oriented, the identity of the nursing would be lost. Therefore this researcher reviewed if the concept of resilience can be applied to the nursing after examing the concept of resilience by Documents and Fieldwork. The methodology of this research is Hybrid Model developed by Schwartz-Barcott and Kim for the concept development and analysis. The process and procedure consist of The Theoretical Phase, The Fieldwork Phase and The Final Analytical Phase in accodance with the Hybrid Model. The followings the summary of the Research. 1. The Concept of Resilience Finally Analyzed by Documents and Fieldwork (1) The Redefinition of Resilience The resilience is the latent psychosocial capacity which minimize the negative emotion and promote the adaptation under adversity. Resilience appears as cognitive, emotional and behavioral response in the course of changing from negative response to positive response through the interaction of the individual and the enviroments in a given time. Resilience changes and decreases according to time and situation and it can be nurtured. Resilience is the higher concept including hardiness, sense of coherence and self-strength which maintain the health under stress. (2) The Attribute of Resilience The attribute of resilience was devided into psychological and social dimension. In psychological attributes, there are admittion of reality of situation, denial of negative emotion, desire to live, responsibility, confidence, courage, hope, pursuit of positive meaning, identification and pursuit of goal, self-esteem, reception, spontaneity, planning, positiveness, will power, flexibility and creativity. In social attributes, there are a sense of belonging, perception of social support and active social relations. (3) The Process of Resilience There are 4 resilience phases which were the process minimizing the possibility of the negative chain reactions under adversity, the process minimizing the negative emotion under adversity, the process gaining the desire to live and the process exposing the active social relations. 2. The Application Possibility of Resilience Concept to Nursing The resilience concept is the psychosocial capacity with which an individual manages adversity. As many nursing scientists have developed nursing theory based on this capacity and the identification of nursing has been established in this field, resilience is not the new conception in nursing. However, since resilience appears in the attributes related with the resilience process concretely, it would help a lot when nurses execute psychosocial nursing.