• Journal of the Korea Convergence Society
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• v.13 no.4
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• pp.71-78
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• 2022

Parkinson's disease (PD) is clinically characterized by a variety of motor and non-motor symptoms, including cognitive and neuropsychiatric symptoms. Integrating a large variety of symptoms into a small number of clinical subtypes could be valuable for appropriate and early therapeutic intervention. As a first step toward this aim, this study attempted to identify correlation patterns among motor, cognitive and neuropsychiatric symptoms in PD without dementia. One hundred four non-demented patients with PD underwent a comprehensive motor, neuropsychological, and neuropsychiatric assessments. Factor analysis was performed to identify correlation patterns among demographic, motor, cognitive and neuropsychiatric variables. The eight factors were extracted: 1 motor-related, 3 cognitive-related and 4 neuropsychiatric factors. We indentified that characteristics of correlation can have associated symptom pattern in the disease process of Parkinson's disease. The current results suggest that a broad range of motor and non-motor symptoms in PD may be reducible to a small number of clinical parameters, which may be useful for identifying clinical subtypes of PD for individual patients.

• Korean Journal of Psychosomatic Medicine
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• v.17 no.1
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• pp.30-36
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• 2009

Objectives : Thyroid function is associated with psychiatric disturbance such as mood symptoms, cognitive functions, anxiety and sleep problem. We evaluate the effects of thyroid dysfunction on negative symptoms of schizophrenia, mood symptoms and somatic symptoms in patients with schizophrenia. Methods : Sixty five patients with schizophrenia were recruited. The patients were classified into two groups; the patients with the history of abnormal thyroid indices level(group of abnormal thyroid function) and the patients without the history of normal thyroid indices level(group of normal thyroid function). At baseline and 8 weeks later, psychiatric symptoms were assessed with the Scale for the Assessment of Negative Symptoms (SANS), the Scale for the Assessment of Positive Symptoms(SAPS), and Beck Depression Inventory(BDI), Somatosensory Amplication Scale(SSAS). Results : During 8 weeks, there were significant differences in the changes of SANS, BDI, SSAS between group of abnormal thyroid function and group of normal thyroid function. Compared to group of normal thyroid function, group of abnormal thyroid function showed greater reduction of the scores of SANS(23.3%), BDI (19.6%), and SSAS(16.2%), respectively. However, there was no significant correlation between the scores of SANS, BDI, and SSAS. Conclusion : Our study suggested that abnormal thyroid indices would predict the prognosis of negative symptoms, mood symptoms, and somatic symtpoms in patients with schizophrenia.