• Food Science and Biotechnology
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• v.17 no.2
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• pp.384-388
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• 2008

Alzheimer's disease (AD) is the most common neurodegenerative disorder and is responsible for more than 50% of all dementia cases. There is significant interest in finding new sources of compounds that inhibit acetylcholinesterase (AChE) to be used in the treatment of AD, since only a few AChE inhibitors, such as galanthamine, physostigmine, and tacrine, are available for clinical use. In the present study, ICR mice were treated with a 1 mg/kg scopolamine, which caused impaired cognitive ability. The steady consumption of a water extract of Chrysanthemum indicum Linne flowers for 3 months significantly prevented the scopolamine induced deficit of the spatial cognitive capability of mice. It also improved long-term memory in mice with amnesia induced by scopolamine, as assessed by the Morris water maze and passive avoidance tests. In addition, water extract consumption significantly decreased AChE activity in mouse brain, leading to inhibition of acetylcholine hydrolysis.

• Journal of Korean Elementary Science Education
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• v.26 no.1
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• pp.49-62
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• 2007

The higher cognitive functions of the human brain including teaming are hypothesized to be selectively distributed across large-scale neural networks interconnected to the cortical and subcortical areas. Recently, advances in functional imaging have made it possible to visualize the brain areas activated by certain cognitive activities in vivo. Neural substrates for teaming and motivation have also begun to be revealed. Functional magnetic resonance imaging (fMRI) provides a non-invasive indirect mapping of cerebral activity, based on the blood- oxygen level dependent (BOLD) contrast which is based on the localized hemodynamic changes following neural activities in certain areas of the brain. The fMRI method is now becoming an essential tool used to define the neuro-functional mechanisms of higher brain functions such as memory, language, attention, learning, plasticity and emotion. Further research in the field of education will accelerate the verification of the effects on loaming or help in the selection of model teaching strategies. Thus, the purpose of this study was to review brain study methods using fMRI in science education. In conclusion, a number of possible strategies using fMRI for the study of elementary science education were suggested.

• Women's Health Nursing
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• v.14 no.2
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• pp.83-92
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• 2008

Purpose: This study aimed to analyze the trends in nursing research on sexuality in Korea and to provide guidance to the future research in sexual health. Method: Total 163 published articles in Korea from 2000 to 2007 year were reviewed using a structured analysis form which consists of the domains of nursing journal, research designs, research purpose, research subjects, and the key words. Result: Of those articles, 25.8% was published in J. of Korean Academy of Women Health Nursing and 13.5% in J. of Korean Academy of Community Health Nursing. In terms of the research design, quantitative research methods were commonly used in 88.4% of them which only 6.1% used qualitative methods. The nursing process on purpose were classified assessment(86.3%), nursing intervention(11.3%), and nursing evaluation(2.5%); Most of subjects were early adults(35.3%), adolescents(27.9%), and adults(25.6%); The most frequently reported key words were classified into socio-psychological domain(33.5%), cognitive domain(25.6%), clinical domain(12.6%). Conclusion: Research on sexuality in nursing have been continued. The major key words were founded in socio-psychological and cognitive domains. It is recommended that more various subjects, research methodology, and various key words be investigated.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.30 no.4
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• pp.104-130
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• 2017

Objectives : This study was designed to signpost the study of brain, intelligence and memory, while interpreting the concept of 'Chongmyeong(聰明)' neotrically and linking it to the clinic of Korean medicine. Methods : In this paper, the meaning of the word 'Chongmyeong(聰明)' is divided into two parts, intelligence and memory. We also explored the relationship between brain science and 'Chongmyeong(聰明)' based on complex system theory, cognitive science and embodied cognition. Results : Through the process of refining the concept of 'Chongmyeong(聰明)' neoterically, we proposed the new method to understand the concept of 'Chongmyeong(聰明)'. Conclusions : The concept of 'Chongmyeong(聰明)' should be interpreted not as a reductionistic viewpoint of brain science but as a viewpoint of brain science based on visual and auditory system and complex system. Human cognition is physically embodied in the environment, from the viewpoint of embodied cognition that it is constituted and formed in an interactive context with society and culture connected with the environment.

• Journal of Life Science
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• v.29 no.6
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• pp.747-753
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• 2019

Cognitive decline is characterized by reduced long-/short-term memory and attention span, and increased depression and anxiety. Such decline is associated with various degenerative brain disorders, especially Alzheimer's disease (AD) and Parkinson's disease (PD). The increases in elderly populations suffering from cognitive decline create social problems and impose economic burdens, and also pose safety threats; all of these problems have been extensively researched over the past several decades. Possible causes of cognitive decline include metabolic and hormone imbalance, infection, medication abuse, and neuronal changes associated with aging. However, no treatment for cognitive decline is available. In neurodegenerative diseases, changes in the gut microbiota and gut metabolites can alter molecular expression and neurobehavioral symptoms. Changes in the gut microbiota affect memory loss in AD via the downregulation of NMDA receptor expression and increased glutamate levels. Furthermore, the use of probiotics resulted in neurological improvement in an AD model. PD and gut microbiota dysbiosis are linked directly. This interrelationship affected the development of constipation, a secondary symptom in PD. In a PD model, the administration of probiotics prevented neuron death by increasing butyrate levels. Dysfunction of the blood-brain barrier (BBB) has been identified in AD and PD. Increased BBB permeability is also associated with gut microbiota dysbiosis, which led to the destruction of microtubules via systemic inflammation. Notably, metabolites of the gut microbiota may trigger either the development or attenuation of neurodegenerative disease. Here, we discuss the correlation between cognitive decline and the gut microbiota.

• Korean Journal of Cognitive Science
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• v.17 no.2
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• pp.139-150
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• 2006

Speech recognition errors cause fatal results in a spoken dialogue system. When a system can not determine the speech-act of u utterance due to speech recognition errors, a dialogue system has a difficulty in continuing conversation. In this paper, we propose strategies for sub-dialogue generation by inferring the speech-act of an utterance with patterns of recognition errors on the field of form-filling dialogue. We used the proposed method on a plan-based dialogue model, corrected 27% of incomplete tasks, and acquired overall 89% of task completion rate.

• Korean Journal of Cognitive Science
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• v.3 no.2
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• pp.291-309
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• 1992

The computer manipulation by means of natural language prcessing will be not only helpful to use the computer with more simple and more comfortable but also flexiable to communicate between human and computers.In this paper the natural language interfaces will be applied to an intelligent geography tutoring systems(IGTS),and we will inspect the something to consider in the case of its implementation.Each module of IGTS is connected to the interface module and correspondence with each other for the sake of natural conversation between system and learner.

• Korean Journal of Cognitive Science
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• v.3 no.2
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• pp.249-270
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• 1992

The purpose of this paper is to classify the types of input characters,printed Hangul characters,using Maximum Run Length Projection(MRLP)that is used to extract features of input character.Because the number of Hangul characters is large and its structure is complex,there exists close similarities among characters.This paper,therefore,tried to increment the type classification rate using fuzzy resoning.The Maximum Run Length Projection is very immune to noise,and also useful to extracting the demanding information efficiently.In a test case with the most frequently use 917 printed Hangul characters,it achieved 98.58%correct classification rate.

• Korean Journal of Cognitive Science
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• v.3 no.2
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• pp.271-289
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• 1992

In this paper,a cursive on-line Hangul recognition system which permits cursive writing between graphemes is presented.In general,the recognition of cursive Hangul writing has a difficulty of graheme segmentation and a complexity in matching procedure due to the increasing number of character candidates.To manage efficiently these problems,we propose a double segmentation method.Based on this segmentation,a recognition algorithm based on the line segment matching is proposed.Through the experimental result,it is show that the proposed recognition method is suitable for the cursive Hangul writings.

• Korean Journal of Cognitive Science
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• v.3 no.2
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• pp.311-328
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• 1992

The level and accuracy of English sentence that is generated by a man or machine translator are determined by the content of the verb dictionary and effective generation algorithm.The conventional English critiques is not adequate for foreigners because they do not have the verb dictionary including verb pattern or the important grammatical constraints. In this paper,Ipropose a structure of verb dictionary and an English sentence critique based on extended verb pattern that is useful to check and correct mistakes of English sentences generated by machine translator.