• 생약학회지
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• 제51권1호
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• pp.70-77
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• 2020

Mentha arvensis is used traditional medicine to treat various disorders. In the present study, M. arvensis were extracted by the solid-phase microextraction (SPME) method and analyzed by gas chromatograph-mass spectrometry (GC-MS). We investigated the protective effects and mechanisms of a M. arvensis extract on scopolamine-induced cognitive and memory impairment. Mice were orally pretreated with a M. arvensis extract or normal saline, and then behavior tests were conducted 30 min after scopolamine injection. The antioxidant capacities were analyzed by free radical scavenging (DPPH and ABTS). Acetylcholinesterase (AChE) activity were also measured using Ellman's method ex vivo test. In behavior tests, percent of spontaneous alteration, escape latency and swimming time in target quadrant were improved by the administration of the M. arvensis extract, which suggests that the M. arvensis extract improves memory function in the scopolamine-treated mice model. In addition, M. arvensis extract showed inhibition of the free radical and AChE activity. The results of the present study suggest that the M. arvensis extract ameliorates scopolamine-induced cognitive and memory deficits through the inhibition of free radicals and AChE activity. Therefore, M. arvensis may be a promising neuroprotective agent for management of learning and memory improvements in human dementia patients.

• 대한한방내과학회지
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• 제36권4호
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• pp.507-517
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• 2015

The bark of Magnolia officinalis has been used in traditional oriental medicine to treat a variety of mental disorders including anxiety and depression. The purpose of this study was to examine the effect of M. officinalis ethanol extract on stress-induced alterations in learning and cognitive function using a passive avoidance test (PAT) and also on anxiety-related behavior using the elevated plus-maze test (EPM) in female rats . The degree of Tyrosine hydroxylase (TH) in the region of the ventral tegmental area (VTA) and the locus coeruleus (LC) was measured using an immunohistochemical method. Corticosterone concentrations in serum were also measured. The ethanol extract from Magnolia officinalis was orally administered to female rats 30 minutes before evaluating their immobilization stress and anxiety-related behavior using an elevated plus-maze test and a passive avoidance test. Time spent in the open arms of the EPM increased in the M. officinalis-treated group compared with that of the saline-treated control group. In the passive avoidance test, the memory and cognitive function improved in the M. officinalis extract-treated group. M. officinalis extracts reduced elevated corticosterone concentrations in serum. Also, stress-induced TH increases were suppressed in the M. officinalis extract-treated group in the LC and the VTA region. These results suggest that M. officinalis might prove to be an effective anxiolytic anti-stress agent.

• 지능정보연구
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• 제12권2호
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• pp.145-165
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• 2006

정보 필터링 시스템은 사용자의 요구를 충족시킬 수 있도록 설계되어 있으나 변화가 심한 사용자의 정보 요구를 충족시키기에는 정확도 저하 등의 문제점이 있다. 본 연구에서는 인간의 뇌에서의 정보처리과정을 시뮬레이션하는 인지적 브레인 매핑의 정보 필터링 시스템을 제안한다. 특정 단어나 패턴에 기초하여 필터링하는 기존의 필터링 시스템과 비교할 때 제안하는 필터링 시스템은 키워드와 키워드간의 관계를 이용하여 필터링을 하는 시스템이다. 본 연구는 키워드와 키워드간의 관계를 이용하여 정보를 기록저장하고, 저장된 정보를 지도화하여 필터링에 응용하는 것이다. 키워드를 이용한 필터링 방법과 키워드간의 관계를 이용하여 필터링하는 방법을 통합하여 필터링을 실시하고 필터링 성능에 영향을 미치는 방법을 검증하기 위해 각 방법별로 가중치를 적용하여 최적의 결합가중치를 도출해낸다.

• Biomolecules & Therapeutics
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• 제27권2호
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• pp.160-167
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• 2019

Depression is a major mood disorder. Abnormal expression of glial glutamate transporter-1 (GLT-1) is associated with depression. Schisantherin B (STB) is one bioactive of lignans isolated from Schisandra chinensis (Turcz.) Baill which has been commonly used as a traditional herbal medicine for thousands of years. This paper was designed to investigate the effects of STB on depressive mice induced by forced swimming test (FST). Additionally, we also assessed the impairment of FST on cognitive function in mice with different ages. FST and open field test (OFT) were used for assessing depressive symptoms, and Y-maze was used for evaluating cognition processes. Our study showed that STB acting as an antidepressant, which increased GLT-1 levels by promoting PI3K/AKT/mTOR pathway. Although the damage is reversible, short-term learning and memory impairment caused by FST test is more serious in the aged mice, and STB also exerts cognition improvement ability in the meanwhile. Our findings suggested that STB might be a promising therapeutic agent of depression by regulating the GLT-1 restoration as well as activating PI3K/AKT/mTOR pathway.

• Advances in Traditional Medicine
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• 제7권2호
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• pp.182-190
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• 2007

Alzheimer's disease is a neurodegenerative disorder associated with a decline in cognitive abilities. Dementia is one of the aged related mental problems and a characteristic symptom of Alzheimer's disease. Nootropic agents like piracetam and cholinesterase inhibitors like $Donepezil^{\circledR}$ are used in situations where there is organic disorder in learning abilities, but the resulting side-effects associated with these agents have limited their utility. Foeniculum (F.) vulgare Linn. is widely used in Indian traditional systems of medicines and also as a house remedy for nervous debility. The present work was undertaken to assess the potential of F. vulgare as a nootropic and anti-cholinesterase agent in mice. Exteroceptive behavioral models such as Elevated plus maze and Passive avoidance paradigm were employed to assess short term and long term memory in mice. To delineate the possible mechanism through which F. vulgare elicits the anti-amnesic effects, its influence on central cholinergic activity was studied by estimating the whole brain acetylcholinesterase activity. Pretreatment of methanolic extract of fruits of F. vulgare Linn. for 8 successive days, ameliorated the amnesic effect of scopolamine (0.4 mg/kg) and aging induced memory deficits in mice. F. vulgare extract significantly decreased transfer latencies of young mice and aged mice, increased step down latency and exhibited significant anti-acetyl cholinesterase effects, when compared to piracetam, scopolamine and control groups of mice. F. vulgare might prove to be a useful memory restorative agent in the treatment of dementia seen in the elderly.

• Environmental Analysis Health and Toxicology
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• 제27권
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• pp.7.1-7.7
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• 2012

Objectives: Modafinil is a waking drug prescribed to narcolepsy patients, but its usage among healthy individuals is increasing to enhance their alertness or to mitigate fatigue. This study was conducted to investigate practical use and toxic effects on neuro-immune interaction of modafinil. Methods: This study reviewed the significance of psychoactive drugs, and discussed the benefits and risks of the application of modafinil, which seems to be ideal as an anti-psychotic or anti-fatigue agent. Results: Modafinil is known to have less or no adverse effects than those found in traditional psychostimulants such as amphetamine, methylphenidate or cocaine. It can be applied as an anti-psychotic or anti-fatigue agent. However, the waking mechanism of modafinil is yet to be fully revealed. Recent studies reported that modafinil may be subject to abuse and addiction. In addition prolonged sleeplessness induces stress responses and impairs immune function. Conclusions: Modafinil can be used by anyone, who wishes to work late, stay awake, enhance their cognitive reactions, or brighten their moods. Users may already be under a great level of stress, i.e. cancer patients or soldiers in a battle field. A psychoneuroimmunological approach is thus needed to investigate the multi-functional effects of modafinil.

• 인터넷정보학회논문지
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• 제10권6호
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• pp.123-143
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• 2009

본 연구는 실험처치방법을 사용해 프레젠스의 요인들을 측정하기 위한 연구이다. 본 연구의 디자인은 새로운 기술 기반의 콘텐츠를 사용하는 온라인 강의 플랫폼을 위한 에이전트의 차원들(자막, 음성, 2D, 3D, 실사, 캐릭터 성별)을 통해 제시되는 프레젠스 분석에 있다. 이를 위해 232명에게 실험을 실시하였고, 에이전트 차원과 이용자 유형에 의한 프레젠스 인지적 의식을 측정하였다. 연구 결과, 이용자 유형과 프레젠스의 상관관계는 유의미한 것으로 나타났지만, 차원에 대해서는 통계적으로 유의미한 결과가 나타나지 않았다. 그러나 응답자의 성별에 따라 캐릭터의 성별, 음성 여부, 자막 여부, 캐릭터의 차원에서 어느 정도 유의미한 차이가 나타났다.

• 한국멀티미디어학회논문지
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• 제25권8호
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• pp.1156-1166
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• 2022

In this study, we examined voice shopping interaction in which consumers can be involved in the decision-making process. Sixteen kinds of voice shopping interaction were designed with differences in the existence of screen/product involvement/conversation style. Their effects on trust, cognitive load, satisfaction, and continuous intention to use were evaluated through a survey experiment. The main effect of conversation style was significant, and it was found that the more deeply involved users have higher trust. The interaction effect between conversation style and product involvement was also significant. Low involvement product buyers had the most positive user experience from the conversation style that included 'Ask for preference,' while high involvement product buyers had the most positive user experience from the conversation style that included both 'Ask for preference' and 'Question and Answer.' The main effect and interaction effect of the existence of screen was not significant. The results indicate that a positive user experience can be obtained when users are deeply involved in consumer decision-making, especially in purchasing high-involvement products.

• 한국산학기술학회논문지
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• 제10권9호
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• pp.2492-2500
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• 2009

본 연구에서는 베트남전 참전 군인 중 고엽제 후유(의)증 환자와 한국전쟁 참전 상이군인을 대상으로 전반적인 심리적 특성을 파악하기 위해 로샤 검사를 실시하고 반응결과를 한국전 참전 재향 군인 집단과 비교분석하였다. 이를 위해 베트남 참전 군인 중 고엽제 후유의증 환자 20명과 한국전쟁 참전 재향군인 21명을 대상으로 개별적으로 로샤 검사를 실시했다. 각각의 변인들을 Exner 종합체계(2006)의 구조적 요약의 대표적 군집들을 중심으로 비교분석하였다. 즉 핵심영역, 반응결정인, 결정적 특수지표에서의 차이를 비교분석하였다. 그 결과 베트남 참전 집단은 6.25 참전집단에 비해 (1)인지적 경직성 (2) 문제해결에 있어서의 비효율성, (3)정서억압 (4)과잉경계 (5)불안 (6)우울 등의 가능성이 더 높은 것으로 나타내었다. 이러한 결과들은 베트남전쟁 참전 재향군인에서 과거 전쟁 경험에서의 정신적 외상과 관련된 후유증이 지속되고 있을 가능성을 보여주는 것이다. 마지막으로 본 연구의 제한점과 시사점에 대해 논의하였다.

• 한국항해항만학회지
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• 제44권6호
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• pp.469-476
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• 2020

해상교통 분야와 같이 선박, 항해사, 관제센터, 해운선사, 기상시스템, 지리정보시스템 등의 복잡하고 넓은 범위의 요구사항을 갖는 시스템의 모델링 및 시뮬레이션(Modeling and Simulation, M&S)을 위해서는 인간을 포함한 체계가 필요하다. 해상교통을 모의하기 위해서는 주요 요소인 항해사의 인적요인에 대한 모델링이 필요하다. 즉, 현실감 있는 해상교통 상황의 재현 및 예측을 위해 항해사의 행동양식, 항해전문성, 항해오류 등을 모델링하여 반영하는 것이 필요하다. 본 논문에서는 에이전트 기반의 해상교통 시뮬레이션을 위해서 항해사의 충돌회피를 위한 행동 분석을 수행하였으며, 기초 데이터의 확보를 위해 설문조사를 실시하였다. 설문조사를 통해 분석된 정보를 이용하여 선박 충돌상황에서 항해사의 행동과 유사한 에이전트 기반의 항해행동 모델을 개발하였으며, 해상교통분석 시뮬레이션 플랫폼의 개발을 위해 활용될 것이다.