• 대한조현병학회지
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• 제20권1호
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• pp.15-22
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• 2017

Objectives : It has been shown that early intervention is crucial for favorable outcome in patients with schizophrenia. However, development of biomarkers for predicting prognosis of psychotic disorder still requires more research. In this study, we aimed to investigate whether baseline mismatch negativity (MMN) predict prognosis in patients with first episode psychosis (FEP). Methods : Twenty-four patients with FEP and matched healthy controls (HCs) were examined with MMN at baseline, and their clinical status were re-assessed after 1 year. Repeated-measures analysis of variance was performed to compare baseline MMN between the two groups. Multiple regression analysis was used to identify factors predicting prognosis in FEP patients during the follow-up period. Results : MMN amplitudes at baseline were significantly reduced in patients with FEP compared to healthy controls. In the multiple regression analysis, baseline MMN amplitude significantly predicted later improvement of performances on digit span and delayed recall of California Verbal Learning Test. However, baseline MMN did not predicted improvement of clinical symptoms. Conclusion : These results indicate that MMN may be a possible predictor of improvement in cognitive functioning in patients with FEP. Future study with larger sample and longer follow-up period would be needed to confirm the findings of the current study.

• 대한치매학회지
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• 제23권1호
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• pp.1-10
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• 2024

Background and Purpose: Voice, reflecting cerebral functions, holds potential for analyzing and understanding brain function, especially in the context of cognitive impairment (CI) and Alzheimer's disease (AD). This study used voice data to distinguish between normal cognition and CI or Alzheimer's disease dementia (ADD). Methods: This study enrolled 3 groups of subjects: 1) 52 subjects with subjective cognitive decline; 2) 110 subjects with mild CI; and 3) 59 subjects with ADD. Voice features were extracted using Mel-frequency cepstral coefficients and Chroma. Results: A deep neural network (DNN) model showed promising performance, with an accuracy of roughly 81% in 10 trials in predicting ADD, which increased to an average value of about 82.0%±1.6% when evaluated against unseen test dataset. Conclusions: Although results did not demonstrate the level of accuracy necessary for a definitive clinical tool, they provided a compelling proof-of-concept for the potential use of voice data in cognitive status assessment. DNN algorithms using voice offer a promising approach to early detection of AD. They could improve the accuracy and accessibility of diagnosis, ultimately leading to better outcomes for patients.

• 보건교육건강증진학회지
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• 제12권2호
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• pp.109-119
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• 1995

As the population of elderly in Korea is increasing rapidly since the 1990's and will more rapidly in the 21st Century, the demand of their health care would be a great burden to health care expenditure. Then it would be necessary to contemplate the functional status and life satisfaction for elderly to make them live more independently. The objectives of this study were find out the functional status in life and life satisfaction for the elderly aged 65 or over who had resided in urban area of two Gus in Pusan and rural area of two Myuns in Haman Gun in Kyeognam Province, and to provide basic data for planning systematic health care programme. The study period was two weeks from February 6 to February 18, 1995 and the subjects were 274 elderly of which 143 were urban residents, 131 were rural residents, and the study method was by structured questionnaire. The data were analyzed with SAS/PC/sup +/ programme using Chi-square test, t-test, ANOVA, Pearson's correlation coefficients, and multiple regression analysis. The results were as follows; 1. To see the pattern of living together, those living with partners were the most common, 39.1% ; 37.8% of urban elderly lived with married sons, 32.2% of them lived with partners, but 46.6% of rural elderly lived with partners, 16.8% of them lived with married sons, which showed difference between residence(p<0.005). 2. Elderly who had jobs were 64.1% in rural residents, and 7.7% in urban residents, which showed significant difference(p<0.05). 3. The score of cognitive function of total subjects was 24.7, that of urban elderly was 23.8, and that of rural elderly was 25.7, then it was higher in rural ones and low for old-elders and those who had no jobs. 4. The score of PADL was 26.8 for urban elderly, 30.1 for rural elderly, and that of IADL was 22.2 for urban elderly, 25.6 for rural elderly, which showed higher activities of daily living for rural elderly than urban elderly(p<0.001). 5. The score of domestic performance was 21.9 for urban elderly, and 30.5 for rural elderly, which showed higher score for rural elderly(p<0.001). 6. The score of life satisfaction was 20.7 for urban elderly, 29.8 for rural elderly, then it was higher for rural elderly(p<0.01). 7. As a result of ANOVA for functional status in living by general characteristics; the score of cognitive function differed by age, job; that of PADL differed by age, job, education, and the pattern of living together, that of IADL differed by age, job, and the pattern of living together. The score of domestic role performance differed by age, job, marital status, and the pattern of living together. 8. ANOVA for life satisfaction showed that the score of life satisfaction differed by job(p<0.001) and the pattern of living together(p<0.01). 9. The correlations between functional status in living and life satisfaction showed that the higher the score of cognitive function was(r=0.39), the higher the score of activities of daily living was(r=0.50), and the higher the score of domestic role performance was(r=0.41), the higher the score of life satisfaction. 10. Stepwise multiple regression analysis for life satisfaction pointed out that residence was responsible for 39.9% of the variance. cognitive function was for 5.3%, and domestic role performance was for 1.2%.

• 영재교육연구
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• 제23권4호
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• pp.523-535
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• 2013

본 연구의 목적은 과학영재의 학업성취도와 인지적 특성, 성격적 특성과의 상관관계를 살펴보고 학업성취도 수준에 따라 학업성취에 영향을 미치는 인지적 성격적 변인에 어떠한 차이가 있는지 살펴보고자 한다. 이를 위해, 과학영재학생 125명의 학업성적, 학습능력검사(인지능력 변인)와 성격검사(NEO 성격변인)결과를 수집하여 분석하였다. 학업성취도와 인지 및 성격요인들간의 상관분석을 실시한 결과, 학업성취도는 집중력, 실행력, 학습동기와 상관관계가 높은 것으로 나타났다. 학업성취도 수준에 따라서는 성취도가 '상'인 그룹의 영재들은 성실성(r=.439, p<.01)이 높을수록, 학업성취도가 '중'인 그룹의 영재들은 실행력(r=.380, p<.01)과 학습동기(r=.376, p<.01)가 높을수록, 그리고 외향성(r=-.248, p<.01)이 낮을수록 학업성취가 높았다. 그리고 학업성취도가 '하'인 그룹에서는 집중력(r=.367, p<.01)이 낮을수록 학업성취도가 낮은 것으로 나타났다. 과학영재들의 학업성취도에 영향을 주는 변인으로는 인지능력의 실행력과 성격요인의 외향성이 유의한 변인으로 나타났다. 학업성취도 수준에 따라서는 학업성취도가 '상'인 그룹의 경우 성실성, '중'인 그룹은 실행력과 학습동기, 그리고 '하'인 그룹은 집중력이 학업성취도를 예측하는 유의한 변인으로 나타났다.

• 대한물리의학회지
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• 제9권1호
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• pp.83-91
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• 2014

PURPOSE: The purpose of this study was to investigate the effects of task oriented circuit exercise(TOCE) on the balance and cognition in mild dementia patients. METHODS: The subjects of the study were 30 patients with mild dementia and assigned to the TOCE(task oriented circuit exercise) group(n=15) and aerobic exercise(AE) group(n=15). TOCE group performed six task three times weekly for 12 weeks. AE group underwent the cycle ergometer and treadmill exercise three times a week during the experimental period respectively. Timed up and go test(TUG), Berg balance scale(BBS) and AP1153 Biorescue were used to assess the parameters for the balance. Korean-mini mental state examination and Global deterioration scale(GDS) were used to assess the parameters for the cognition. For the statistical analysis, paired t-test and independent t-test were used to compare the differences among two groups. RESULTS: Each group showed improvement in balance and possibility for improving cognitive function. TOCE group especially, there were significant improvements in limit of stability. CONCLUSION: The results of the study suggest that TOCE is a more diverse exercise programs introduced in the study. Furthermore, TOCE can be a helpful to improve the balance and cognition in mild dementia patients.

• 지역사회간호학회지
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• 제24권3호
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• pp.323-331
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• 2013

Purpose: The study attempted to examine whether the group art therapy using a collage medium and reminiscence therapy prevented or reversed dementia, prevented depression, and improved the quality of life of elderly women at high risk for dementia in community public health centers. Methods: As a quasi-experimental study with a non-equivalent control group, this study used a pre-post design. The subjects consisted of a random sample of women over 65 years of age who had been registered as being at high-risk for dementia at the Public Health Center of the G City, and the Dementia Support Center. Of these elders, 30 were assigned to the experimental group and 33 to the control group. The intervention was conducted twice a week for 5 weeks. $x^2$-test, t-test, Wilcoxon test were used to analyze the data. Results: After the program, cognitive function, depression, and quality of life were significantly better in the experimental group than in the control group. Conclusion: The group art therapy can be utilized in community-based nursing practices by identifying and registering those who are at high risk for dementia. The results should prove useful when designing future intervention strategies targeting elderly individuals residing in communities.

• 정신신체의학
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• 제25권1호
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• pp.63-72
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• 2017

연구목적 본 연구는 주의력결핍 과잉행동장애(attention-deficit/hyperactivity disorder, ADHD) 환자들을 대상으로 다양한 실행기능과 정량화 뇌파간의 상관성을 알아보고자 하였다. 방법 31명의 소아청소년 ADHD 환자를 대상으로 정량화 뇌파를 측정하였다. 종합주의력검사(Comprehensive Attention Test, CAT), 스트룹 색-단어 추론 검사(Color-Word Inference Test, CWIT), 선추적 검사(Trail Making Test, TMT), 카드분류검사(Card Sorting Test, CST)가 시행되었고 한국어판 주의력결핍 과잉행동장애 평정척도(Korean version of the ADHD Rating Scale, K-ARS)가 측정되었다. 결과 CAT 검사 점수와 알파, 베타 파워가 양적 상관이 있는 반면, 델타 파워와는 부적 상관이 있었다. CWIT 검사에서는 감소된 델타 파워와 증가된 베타 파워가 높은 수행수준과 관련 있었다. 높은 TMT 검사 점수는 증가된 알파 대역 파워와 관련이 있었으며, CST 검사에서 델타 파워는 높은 수행수준과 부적 상관이 있는 반면 알파, 하이 감마파의 파워와는 양적 상관을 보였다. K-ARS 점수는 알파 파워와 부적 상관을 보였다. 결론 정량화 뇌파는 ADHD 환자들의 실행기능과 상관성을 보이며 신경생리학적 지표로서의 유용성이 시사된다.

• 인지과학
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• 제6권1호
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• pp.47-71
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• 1995

글자의 이중상으로 인한 심리적 혼란감을 '글자멀미'라 정의하였고,눈운동 및 글자 인식 과정이 교란될 때 글자 멀미가 발생한다는 가설을 검증하기 위하여 자극의 노출시간과 글자의 친숙도가 글자 멀미에 미치는 효과를 측정하였다.글자 멀미는 자극 노출 시간이 50ms,100ms,3000ms로 길어짐에 따라,덜 친숙한 외국 문자보다는 친숙한 한글에서 유의미한 단어보다는 무의미한 단어에서 큰것으로 나타났다.이러한 실험발견은 이중상을 제거하려는 눈 운동이 실효를 거두지 못함에 따라 글자 멀미가 발생한다는 것,친숙한 글자일수록 글자 인식 과정의 개입을 더 강화하며 그결과 이중상에 의한 교란 효과가 증폭된다는것,글자 형태는 친숙하지만 의미추출이 어렵게 되면 이중상의 교란효과가 가중된다는 것을 암시한다.의미를 처리하는 경향이 클수록 이중상에 의한 글자 멀미가 심해진다는 가설을 좀 더 분명히 검증하기 위하여 여섯 개의 점으로 구성된 점자를 시각적으로 인식하도록 피험자들을 학습시킨 결과,학습율이 증가함에 따라 글자 멀미가 증가하는 것으로 나타나, 하나의 자극을 의미있는 상징으로 취급하여 해석하려 할때 글자멀미가 증가한다는 결론을 얻었다.

• 한국축산식품학회지
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• 제40권2호
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• pp.183-196
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• 2020

The protective effect of pig skin gelatin water extracts (PSW) and the low molecular weight hydrolysates of PSW generated via enzymatic hydrolysis with Flavourzyme® 1000L (LPSW) against scopolamine-induced impairment of cognitive function in mice was determined. Seventy male ICR mice weighing 20-25 g were randomly assigned to seven groups: Control (CON); scopolamine (SCO, 1 mg/kg B.W., intraperitoneally (i.p.); tetrahydroaminoacridine 10 [THA 10, tacrine; 10 mg/kg B.W. per oral (p.o.) with SCO (i.p.)]; PSW 10 (10 mg/kg B.W. (p.o.) with SCO (i.p.); PSW 40 (40 mg/kg B.W. (p.o.) with SCO (i.p.); LPSW 100 (100 mg/kg B.W. (p.o.) with SCO (i.p.); LPSW 400 (400 mg/kg B.W. (p.o.) with SCO (i.p.). All treatment groups, except CON, received scopolamine on the day of the experiment. The oxygen radical absorbance capacity of LPSW 400 at 1 mg/mL was 154.14 μM Trolox equivalent. Administration of PSW and LPSW for 15 weeks did not significantly affect on physical performance of mice. LPSW 400 significantly increased spontaneous alternation, reaching the level observed for THA and CON. The latency time of animals receiving LPSW 400 was higher than that of mice treated with SCO alone in the passive avoidance test, whereas it was shorter in the water maze test. LPSW 400 increased acetylcholine (ACh) content and decreased ACh esterase activity (p<0.05). LPSW 100 and LPSW 400 reduced monoamine oxidase-B activity. These results indicated that LPSW at 400 mg/kg B.W. is a potentially strong antioxidant and contains novel components for the functional food industry.

• 생물정신의학
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• 제9권2호
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• pp.103-111
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• 2002

Neurocognitive research focusing on cognitive deficits in Depression has resulted in several important but yet potentially contradictory findings. Much literature documents the presence of significant neurocognitive impairments in depressive patients. Studies have shown that dysthymic disorder patients demonstrate a diffuse pattern of cognitive impairment which is frequently indistinguishable from that of focal braindamaged patients. Some reports have suggested that there is a focal pattern of deficit, such as anterior cingulate dysfunction, frontal lobe impairment, or dysfunction of the temporal-limbic cortex. The aim of this study is to evaluate the neurocognitive functions in dysthymic disorder patients, and to compare the functions with those of major depressive disorder patients. The subjects are 17 dysthymic disorder patients. And their neurocognitive functions are compared with those of 23 major depressive episode patients. Patients with a history of neurologic disease, alcohol dependence, substance abuse and mental retardation are excluded. They are assessed with a part of Vienna Test System which is computerized neurocognitive function tests and can evaluate attention, eductive ability, reproductive ability, visuoperceptual analysis, vigilance, visual immediate memory, the speed of information-processing, judgement, and fine motor coordinations. There are no other specific difference between two groups, except the result of cognitrone test. This study provides information about the neurocognitive functions and some difference between major depressive disorder patients and carefully diagnosed dysthymic disorder patients.