• 대한한의학방제학회지
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• 제24권3호
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• pp.225-231
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• 2016

Objectives : Liver cancer usually appears in the setting of underlying liver disease. Liver transplantation has potentials to improve survival for patients with liver cancer. This case report was designed to assess the clinical effect of Korean medicine on liver transplant patient's cerebral infarction.Methods : We provided Chiganpung Granule(Chodeungsan) to a patient who was 58 year old man complained of cognitive impairment and dysarthria. We checked the change of symptoms(K-MMSE, Aphasia Rapid Test) and liver function test and kidney function test.Results : We observed that Chiganpung Granule(Chodeungsan) decreased cognitive impairment and dysarthria. Liver function test and Kidney function test was improved.Conclusions : From the above results, it is considered that Korean medicine treatments is effective on liver transplant patient's cerebral infarction.

• 대한인간공학회지
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• 제28권3호
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• pp.115-123
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• 2009

The purpose of this research is to develop a protocol which can quantitatively evaluate cognitive ability that is needed when elderly people use mobile phone. Since previous methods for measuring the cognitive ability of elderly people was mainly for clinical evaluation, they would not be adequate to measure cognitive ability for mobile phone development. Therefore, this study suggests cognitive areas which are necessary to use the mobile phone based on the existing evaluation tools. The cognitive areas consist of language, visuospatial ability, memory, executive function and perception. New questionnaire was developed to evaluate the individual cognitive ability for the elderly. They include 9 questions for button comprehension test, 8 for icon button comprehension test, 10 for vocabulary comprehension test, 8 for menu comprehension test, 3 for icon size test, and 2 for font size test. The protocol can be used in the field although further modification may be necessary for betterment.

• 한국식생활문화학회지
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• 제7권2호
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• pp.149-155
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• 1992

This study was carried out to find out the effect of dietary intake on cognitive function retardation in old age using dietary survey and cognitive function test. The subjects were 332 men of 50-94 years old and their activities of daily living were very similar. The cognitive function was tested by Mini Mental State Examination (MMSE)-K which was translated from MMSE, and the 24-hour recall method was used for dietary survey. Scoring of MMSE-K was a little different from MMSE, that is, in case of no education, one to four points were added to exclude the effect of education which has been considered as a confounder by many researchers. The number of subjects belonging to below 23 of MMSE-K score was increased by increasing age. Even though points were added in case of no education, the ratio of below 23 MMSE-K score group was diminished by increasing education. Therefore, education seems not to be a confounder but a independent variable on cognitive function. Income, past occupation, family type, self-evaluated health status did not play any effect on cognitive function significantly. On the other hand, the correlation between each nutrients and the score of cognitive function test showed that the more consumption of vitamin A and protein, the higher cognitive function score was obtained. In case of iron and Ca, even though it was not statistically significant, there was a tendency of increasing cognitive function score by increasing the intake of those nutrients. This study suggests that micronutrient intakes might be more related to cognitive function than macronutrients.

• 대한통합의학회지
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• 제4권3호
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• pp.49-59
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• 2016

Purpose : The study was aimed to evaluate the improvement of cognitive and hand functions after the application of a complex rehabilitation intervention program on patients with mild cognitive impairment (MCI) and dementia who were living a regional community from. Methods : Subjects who were living in a regional sanatorium or who were outpatients of a community health center were enrolled from 2012. 2 to 2013.2 All subjects were enforced 8 cycles of a complex rehabilitation intervention program including RON dance, physical activity using therabands, reality awareness training, space retrieval training and handicraft activities. Results : There were significant improvement in LOTCA-G cognitive function and JTHFT hand function test after the application of a complex rehabilitation intervention program. Conclusion : The result shows a significant improvement in cognitive and hand functions after the application of a complex rehabilitation intervention program in patients with MCI and dementia. Therefore the authors suggest the vast studies of the cognitive function program development and hand function vitalization by the application of a complex rehabilitation intervention program.

• 생물정신의학
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• 제12권2호
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• pp.173-180
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• 2005

Purpose:We investigated the effect of menopausal duration on cognitive function using adjunctive hormone replacement therapy(HRT) in postmenopausal women with depression. Method:Twelve postmenopausal women with depressive disorder were enrolled. Six patients having menopausal duration of less than 3 years was assigned to the short duration group and six patients of more than 3 years to the long duration group. Each patient was treated with conjugated equine estrogen(1.25mg) plus medroxyprogesterone(5mg) for 8 weeks. Cognitive performance was measured by the Verbal Memory Test, Visual Memory Test, Trail Making Test, Digit Symbol Test, and Attention Shift Test. The Beck Depression Inventory was used for evaluation of depressed mood. The reproductive hormone levels were also measured. Results:The long duration group showed the lower performance only in Trail Making Test B compared with the short duration group at baseline. After 8 weeks, the long duration group performed significantly better in the Trail Making Test B compared with the short duration group. The differences in change of depressive mood and gonadal hormone level between two groups were not significant. Conclusion:Menopausal duration before HRT may influence the effect of estrogen on cognition in some cognitive domains. This might be related with estrogen receptor hypersensitivity which induced by the longer estrogen deficiency.

• 한국산학기술학회논문지
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• 제18권8호
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• pp.294-303
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• 2017

고령인구가 증가하면서 각종 노인성 만성질환 및 치매질환의 유병률 또한 빠르게 증가하고 있으며, 치매는 우리사회의 큰 관심 질환으로 대두되고 있다. 본 연구에서는 노인복지시설에서 거주하고 있는 인지장애 노인을 대상으로 비타민 보충제의 영양 강화요법이 경도인지기능 노인에게 미치는 효과를 보고자 하였다. 자료는 K지역에 위치한 노인복지시설 2개의 다른 건물에 입소한 노인 48명을 대상으로 각각 다른 건물에서 하나의 건물에서는 실험군 집단을 하나의 건물에서는 대조군 집단을 선정하였으며, 4,8,12주에 걸쳐 비타민 보충제를 복용한 후 호모시스테인 혈중농도와 인지기능을 평가하였다. 표집방법은 자료수집의 용이함을 고려하여 임의 표집방법을 이용분석을 위해 Chi-Square test, Fisher's Exact test와 independent t-test, Repeated Measure ANOVA, Contrast test, Repeated Measure ANCOVA, Wilks' lambda test를 실시하였으며, 인지기능 향상 효과에 대한 Contrast test를 실시한 결과, 12주차(p<.001) 에서 유의한 효과가 있는 것으로 나타났다. 경구 비타민제를 복용한 실험군의 인지기능 12주에서 대조군보다 각 시기별 차이를 분석한 결과 12주차(p<.05)에 실험군의 인지기능이 대조군보다 높게 나타났고, 호모시스테인 효과에 대한 12주(p<.01)에서 비타민제 복용이 효과가 유의하게 발생하여 대조군보다 호모시스테인이 감소한 것으로 나타났다. 결과적으로 경구비타민을 복용한 노인에게서 인지기능이 증가하였고, 호모시스테인 혈중농도가 주별 지속적으로 감소하였다. 이러한 결과는 치매로 갈 수 있는 경도인지장애 대상자들에게 비타민 보충제 복용은 상대적으로 비용이 저렴하고, 복용이 간편하여 추후 인지기능 저하 및 치매발생을 예방할 것으로 기대된다.

• 한국전문물리치료학회지
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• 제5권3호
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• pp.21-33
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• 1998

The purposes of this study were to ascertain differences of the sensory system, central processing system, effector system, and balance ability according to general characteristics (sex, fall experience, and age), and to identify the contributions of the sensory, central processing, and effector system to balance ability in 83 healthy elderly subjects. The subjects were elderly (over 60 years) who live in Wonju City. All subjects participated in six tests (position sense test, visual acuity, vestibular stepping test, Mini-Mental Status Exam-Korea, strength of dorsiflexors, and Berg Balance Test). Collected data were analyzed by the independent t-test, one-way ANOVA, and stepwise multiple regression. The results were as follows: 1. The results of the six tests according to sex showed that vestibular function was significantly better in women than in men. But visual acuity, cognitive function, strength of dorsiflexors, and balance ability were significantly better in men than in women (p<0.05). 2. There were no significant differences in position sense, visual acuity, vestibular function, cognitive function, strength of dorsiflexors, and balance ability between fallers and non-fallers (p>0.05). 3. However, the results of the six tests according to age (group A: 60-69 years, group B: 70-79 years, group C: 80-89 years) showed significant differences in five tests. In the Scheff$\acute{e}$ test, position sense, visual acuity, and cognitive function showed significantly different results between in group A and group C: the strength of the dorsiflexors was significantly different between in group A and group B, and balance ability was significantly different between in group A and group C, and between in group B and group C (p<0.05). 4. Cognitive function and position sense were positively associated with balance ability. Their power of explanation regarding balance ability was 38% (p<0.05). These results suggest that cognitive function and position sense play an important role in balance ability. This would seem to suggest that programs for evaluation or improvement of elderly's balance ability in the elderly should consider cognitive function and position sense.

• 생물정신의학
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• 제14권3호
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• pp.184-193
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• 2007

목 적: 소뇌가 운동조절 뿐아니라 인지기능과 정신과적 증상에도 중요한 역할을 하고있다는 증거들은 많다. 정신분열병에서 소뇌기능은 많은 연구들에서 대뇌고위기능의 조정곤란(Cognitive dysmetria)이라는 개념을 통해 주목 받아왔다. 다시말하면, 전전두엽-소뇌-시상핵-전전두엽 회로의 이상은 정신분열병에서 인지기능의 손상과 임상증상으로 나타날 수 있는 것이다. 본 연구의 주 목적은 남자 정신분열병 환자에서 소뇌기능이상을 ICARS를 통해 반정량적으로 평가하고, 이것이 임상 및 인지기능과 어떤 연관성이 있는지 알아보는 것이다. 방 법: 저자들은 DSM-IV-TR 진단기준에 따라 정신분열병으로 진단된 47명의 남자 정신분열병 환자와 이와 성별과 나이를 맞춘 건강한 대조군 30명을 소뇌의 신경학적 징후를 ICARS로 점수화하여 비교하였다. 반정량적으로 100점의 총점을 가진 ICARS는 자세와 보행, 사지운동기능, 언어장애, 안구운동장애의 4개의 구획으로 나뉜 19개 항목으로 구성되어 있다. 모든 실험군은 한국형 간이정신상태검사(K-Mini Mental status examination, MMSE), 언어유창성 검사(Verbal fluency test), 시계그림검사(Clock drawing test)를 통해 인지기능검사를 받았다. 환자군에서 임상증상의 심각도는 한국형 양성 및 음성 증상 척도Positive and Negative Symptom Scale(PANSS)로 평가하였다. 환자군에서 ICARS의 높은 점수가 추체외로증상이나 지발성운동장애와 같이 약물사용으로 인한 부작용과 관련이 있는지 여부를 확인하기위하여 Abnormal Involuntary Movement Scale(AIMS)를 시행하였다. 실험군과 변수들에서 통계적 유의성을 보기위해 독립표본 t 검증과 편상관분석을 사용하였다. 결 과: 정신분열병 환자들은 대조군에 비해 ICARS-자세와 보행장애, 운동기능, 안구운동장애-에서 유의하게 높은 점수를 보였다. 환자들은 인지기능검사에서도 보다 심각한 손상을 보였다. ICARS 점수와 PANSS로 평가한 환자들의 음성증상 총점과는 유의한 상관관계가 있었으며, 인지기능검사에서는 시계그림검사, 언어유창성 검사가 음성증상과 유의하게 연관이 있었다. 또, 시계그림검사는 ICARS 점수와 연관이 있었다. 정신분열병 환자에서 발병연령, 유병기간 및 AIMS 점수가 줄수있는 혼란변수는 회귀분석을 사용하여 평가하였으며, AIMS 점수는 ICARS의 점수와 연관성을 보이지 않았다. 결 론: 정신분열병은 발달학적 혹은 신경발달학적 질환으로 개념 내려지고 있다. 대부분의 연구자들은 정신분열병을 가진 환자들이 대뇌고위기능의 조정곤란(Cognitive dysmetria)이라고 불리는 전전두엽-시상핵-소뇌회로의 이상으로 인해 고통받고 있다고 하였다. 본 연구에서 저자들은 정신분열병 환자들이 인지기능과 소뇌기능에서 심각한 손상을 가지고 있고, 특히 이것은 환자들의 음성증상의 정도와 상관관계가 있다는 것을 확인하였다. 이 결과는 정신분열병에서 소뇌의 역할에 대해 지지하고 있다. 또, 정신분열병 환자들의 연성신경학적 징후를 평가하는데 있어 ICARS라는, 구조화되어 다른 검사자들에게도 통용될 수 있는 도구를 사용했다는 것에서 의미가 있다고 볼 수 있겠다. 향후 유사한 연구에서는 질병의 경과에 따라 신경학적 징후의 변화에 대해 설명할 수 있기를 기대한다.

• 재활치료과학
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• 제9권4호
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• pp.69-81
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• 2020

목적 : 본 연구의 목적은 인지기능저하 노인을 선별할 수 있는 이중과제를 활용한 노인인지기능 선별검사를 개발하는 것이다. 연구방법 : 2019년 5월부터 8월까지 경기도 및 충청도에 있는 지역사회 기관에서 60세 이상 노인 229명을 대상으로 개발된 Y-DuCog(Yonsei Dual Task Cognitive Screening Test)의 신뢰도 및 타당도 검증과 인지기능저하 노인의 분류 기준점을 확인하였다. 결과 : MMSE-K, MoCA-K와 Y-DuCog와의 상관분석을 실시한 결과 Y-DuCog의 이중과제 효과와 이중과제 초당 정답 수에서 상관관계를 보였다. 내적 일치도 분석 결과 이중과제 효과와 이중과제 초당 정답 수의 Cronbach's-α 값은 각각 .848(p<.01), .916(p<.01)의 신뢰도를 보였고, 검사-재검사 신뢰도는 ICCs가 .969~.996으로 높게 나타났다. 선별기준점은 총 수행시간 DTE에서 31.76초를 기준으로 88.7%의 민감도와 83.5%의 특이도를, 총 이중과제 CRR에서 0.38개를 기준으로 84.5%의 민감도와 76.6%의 특이도를 보였다. 결론 : 본 연구를 통해 Y-DuCog의 신뢰도 및 타당도가 검증되었다. Y-DuCog는 기존 지필 평가의 제한점인 교육수준과 문자에 영향을 받지 않으며 간편하고 빠르게 검사를 시행할 수 있어 노인의 인지기능 평가 및 중재 방법에 대한 효과성 검증 시 사용될 수 있을 것으로 기대한다.

• 한국임상보건과학회지
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• 제8권2호
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• pp.1426-1435
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• 2020

Objective: This study aims to develop CFT, a screening test for dementia that can be conducted on patients with mild cognitive impairment or early dementia. Methods: This study was conducted on therapists working at occupational therapy hospital in Gyeongsangnam-do. The data collection period is two months from July to September 2020, and the research participants were briefed on the purpose, significance, and anonymity of the research in consideration of ethical issues. A total of 33 copies of the data were finally analyzed, excluding those containing insufficient answers and errors, by distributing 40 copies of the data. SPSS Data Access pack 8.0 was used for data analysis, Cronbach's α value was evaluated for internal consistency reliability of each item, and Pearson Correlation coeffient between the lower scales of the assessment tool was measured. Results: The Cronbach's α value of the CFT was shown as .892 and the reliability of the assessment paper was shown to be quite high. The Cronbach's α value for each item in the cognitive assessment tool was the highest at .899 in the subtraction item, with exercise control (mook Chi Pa) at 888, visual memory, plus .887. The correlation of each item of cognitive assessment tools was found to be most correlated with the number of sustained concentrates and word2 to .934; in the stop word-numeric item and visual memory to be .85; and in the addition to the auditory memory item .739. Conclusion: Therefore, this study developed cognitive evaluation tools that can distinguish the diversity and cognitive level of screening tests and clarify standards, which are different from the existing dementia screening tools in Korea. Furthermore, the cognitive assessment tools of this study can be verified by applying them to patients with mild cognitive impairment and early dementia, and the criteria for generalization can be established.