• 한국임상약학회지
• /
• 제34권2호
• /
• pp.118-125
• /
• 2024

Background: Numerous studies have consistently demonstrated that depression can be associated with cognitive function decline, primarily focusing on older adults due to the neurodegenerative characteristics of dementia. With persistent depression frequently reported in patients with early-onset or young-onset dementia, this study aimed to assess the impact of depression, specifically the changes in depressive symptoms over time, on the risk of cognitive function decline in middle-aged adults in Korea. Methods: This retrospective study utilized data from the first four waves (2006-2012) of the Korean Longitudinal Study of Aging (KLoSA), focusing on middle-aged adults with normal cognitive function at baseline. Changes in depressive symptoms were categorized into four groups based on the CES-D score, and their association with cognitive function decline was evaluated using a multivariate logistic regression model. Results: Of the initial 10,254 participants, 3,400 were included in the analysis. Depressive status, particularly newly onset (adjusted odds ratio [aOR] 1.96; 95% confidence interval [CI] 1.32-2.93) and persistent depression groups (aOR 5.59; 95% CI 2.90-10.78), were significantly associated with cognitive function decline. In contrast, recovery from depressive symptoms was not significantly associated with cognitive function decline (p=0.809). Conclusions: Our study showed a significant association between changes in depressive symptoms and cognitive function decline in middle-aged Korean adults. This suggests that management of depressive symptoms could be crucial for the prevention of cognitive function decline in this population.

• 보건의료산업학회지
• /
• 제10권3호
• /
• pp.147-158
• /
• 2016

Objectives : The aim of this study was to investigate predictors of cognitive function decline among community dwelling elderly. Methods : Data were analyzed from the Survey of Living Condition of Elderly panel study. Cognitive function was measured with the MMSE-KC at baseline and year 3. The study subjects were 5,464 community dwelling people aged 65 years or older who had no disability at baseline. Logistic regression analysis was used to predict cognitive function decline. Results : From 2008-2011, 4,417(80.8%) elderly people had no cognitive decline, and 1,074(19.2%) showed cognitive function decline measured by the MMSE-KC. After adjusting for demographics and baseline MMSE-KC score, the best predictors for cognitive function decline at 36 months were diabetes mellitus, smoking, low intensity physical activity, relationship with relatives and friends. Conclusions : Health promotion programs that are focused on the elderly are essential in preventing cognitive function decline. Promoting regular physical activity, and social relationships should be included in health promotion for elderly. When treating patients with diabetes, preventing cognitive impairment should be considered through education and counseling.

• 성인간호학회지
• /
• 제29권2호
• /
• pp.200-210
• /
• 2017

Purpose: The purpose of this study was to assess the relationship between menopausal symptoms and decline in cognitive functioning of menopausal women with mediating effects of health promoting behavior. Methods: Using a convenience sampling, 140 menopausal women were recruited for the cross-sectional survey. Data were collected by using the Menopause Rating Scale, Health Promoting Lifestyle Profile, Everyday Cognition, and Korean Mini-Mental State Examination. Results: The mean scores for menopausal symptoms, health promotion behavior, and subjective cognitive decline were 14.40, 153.79, and 67.40 respectively. Health promotion behavior was directly affected by menopausal symptom ($R^2=8%$). Cognitive decline was directly affected by menopausal symptom ($R^2=11%$). Menopausal symptom (${\beta}=.33$, p<.001) and health promotion behavior (${\beta}=.21$, p=.014) were found to be predictive factors in subjective cognitive decline and explained 14%. Health promotion behavior had a partial mediating effect in the relationship between menopausal symptom and perceived cognitive decline (Sobel test: Z=2.05, p=.040). Conclusion: Based on the findings of this study, developing nursing intervention programs focusing on decreasing menopausal symptoms and encouraging health promotion behavior are recommended to improve cognitive decline in menopausal women.

• 대한물리의학회지
• /
• 제15권4호
• /
• pp.67-74
• /
• 2020

PURPOSE: The progression of the center of pressure (COP) velocity of the stance phase may have important roles for predicting gait speed in older adults with cognitive decline. This study was conducted to identify the correlation between gait speed and the velocity of COP progression during the stance phase in older adults with cognitive decline. METHODS: Forty adults aged 65 years or older (twenty participants without cognitive decline, 20 participants with cognitive decline) were recruited. The COP progression velocity was measured using an F-scan pressure-sensitive insole system. The stance phase was divided into four sub-stages. (loading response, mid-stance, terminal stance, and pre-swing). Gait speed, double support phase, and cadence were also measured. Correlations and multiple regression analyses were performed. RESULTS: Gait speed was associated with the COP progression velocity in midstance (r = .719, p < .05), cadence (r = .719, p < .05) and the COP progression velocity in loading response velocity (r = .515, p < .05) in older adults with cognitive decline. However, no correlation was found in older adults without cognitive decline. In multiple regression analysis using gait speed as a dependent variable, the COP progression velocity in midstance and cadence were significant predictors of gait speed, with the COP progression velocity being the most significant predictor. CONCLUSION: The COP progression velocity is an important factor for predicting gait speed in older adults with cognitive decline, suggesting that the cognitive function influences gait speed and the velocity of COP progression.

• 한국학교ㆍ지역보건교육학회지
• /
• 제22권3호
• /
• pp.83-96
• /
• 2021

Background & objectives: Cognitive function decline is a main factor influencing the overall life of the elderly and places a burden of society. The aime of this study was to investigate the risk factors of cognitive function decline of elderly living alone and living with a spouse. Methods: This study used the Korean Longitudinal Study of Ageing from 2014 to 2018. 243 older adults who lived alone and 1,155 lived with a spouse with the Korean version of Mini Mental State Examination scores in normal range at the time of 2014 were included in the analysis. Logistic regression analysis was conducted to determine the difference of risk factors affecting cognitive function decline between in elderly living alone and elderly living with a spouse. Results: Cognitive function decline incidence rate of elderly living alone was 30.5% and the elderly living with a spouse showed 23.0%. According to the results of logistic regression analysis, the risk factors of cognitive function decline in the elderly living alone was age and residential area, while in the elderly living with a spouse were age, education level, social networks, and depression. Conclusions: The factors that affect the cognitive function decline of the elderly living alone and the elderly living with a spouse were different. Accordingly, other measures to prevent cognitive decline are necessary.

• 한국학교ㆍ지역보건교육학회지
• /
• 제24권4호
• /
• pp.27-37
• /
• 2023

Objectives: The purpose of this study was to investigate the effect of handgrip strength level on cognitive impairment in hypertensive patients. Methods: This study used the first to eighth year data of the Korean Longitudinal Study of Aging (KLoSA). Of the 10,254 respondents who participated in the basic survey, respondents were included that they were diagnosed with high blood pressure and had no cognitive impairment. The handgrip strength was based on the highest value of handgrip strength for both hands. Cognitive function using MMSE results and 23 points or less were defined as cognitive impairment. Cox models were conducted to estimate the hazard ratios (HRs) of cognitive impairment in relation to handgrip strength adjusting for covariates. Results: In the case of hypertension patients, the probability of cognitive decline decreased by 3.0% every time the maximum handgrip strength increased by 1 unit. In the analysis by age, under the age of 64 had a 1.8% decrease in the probability of cognitive decline whenever the maximum handgrip strength increased by 1 unit, and a 3.6% decrease in those over the age of 65. In the gender analysis, male had a 3.2% decrease in the probability of cognitive decline for every 1 unit increase in the maximum handgrip strength, and female had a 2.6% decrease. Conclusions: The results of this study are expected to be used as basic data for the development of interventions to prevent cognitive decline in hypertensive patients by identifying the effect of handgrip strength level on cognitive decline. It is also expected to be used as basic data for health education on the necessity of increasing muscle strength for hypertension patients in the community.

• Journal of Yeungnam Medical Science
• /
• 제40권3호
• /
• pp.225-232
• /
• 2023

Cognitive dysfunction is relatively less considered a complication of hypertension. However, there is sufficient evidence to show that high blood pressure in middle age increases the risk of cognitive decline and dementia in old age. The greatest impact on cognitive function in those with hypertension is on executive or frontal lobe function, similar to the area most damaged in vascular dementia. Possible cognitive disorders associated with hypertension are vascular dementia, Alzheimer disease, and Lewy body dementia, listed in decreasing strength of association. The pathophysiology of cognitive dysfunction in individuals with hypertension includes brain atrophy, microinfarcts, microbleeds, neuronal loss, white matter lesions, network disruption, neurovascular unit damage, reduced cerebral blood flow, blood-brain barrier damage, enlarged perivascular damage, and proteinopathy. Antihypertensive drugs may reduce the risk of cognitive decline and dementia. Given the high prevalence of dementia and its impact on quality of life, treatment of hypertension to reduce cognitive decline may be a clinically relevant intervention.

• 성인간호학회지
• /
• 제28권2호
• /
• pp.202-212
• /
• 2016

Purpose: The purpose of this study was to assess the relationship between cognitive function impairment and quality of life (QoL) among patients with breast cancer. Specifically, the intention was to verify the mediating effects for promoting behaviors leading to better health and QoL. Methods: A purposive sample of 152 patients undergoing chemotherapy was recruited. A cross-sectional survey design was used. Data were collected using four instruments: Everyday Cognition Scale, Korean Mini-Mental State Examination, Functional Assessment of Cancer Therapy-Breast Cancer Version 4, and Health Promoting Lifestyle Profile. Results: The mean score for subjective cognitive decline was 65.84; the health promotion behavior was 95.89, and 83.34 for QoL. Health promotion behavior was directly affected by cognitive decline ($R^2=6.0%$) as was QoL ($R^2=43%$). Subjective cognitive decline (${\beta}=-.57$ p<.001) and health promotion behavior (${\beta}=.37$, p<.001) were seen as predicting factors in QoL and explained 56% ($R^2=56%$). Health promotion behavior had a partial mediating effect in the relationship between self-reported cognitive decline and QoL (Sobel test: Z=-3.37, p<.001). Conclusion: Based on the findings of this study, nursing intervention programs focusing on managing cognitive decline and promoting health promotion behavior are highly recommended to improve QoL in cancer patients.

• 디지털융복합연구
• /
• 제18권12호
• /
• pp.343-351
• /
• 2020

본 연구는 노인을 대상으로 인지기능에 관한 교육과 함께 주의, 기억, 실행기능, 기억책략 등을 다루는 인지과제를 수행하는 인지훈련을 실시하여 훈련 이전의 인지기능 수준은 어떤 개인적 특성과 관련이 있는지, 주관적 인지감퇴는 실제적인 인지감퇴를 반영하는지, 인지훈련의 효과는 어떤 개인 특성과 관련이 있는지를 알아보기 위해 수행되었다. 연구 참가자는 건강한 노인 20명으로 14회기의 인지훈련을 주 1회, 회기당 2시간씩 진행하였으며 사전 및 사후로 검사를 실시하였다. 연구 결과, 인지기능은 연령과 자아존중감, 성격 특질 중 외향성과 개방성이 관련이 있는 것으로 나타났으며, 주관적인 인지감퇴는 객관적인 인지기능보다는 우울, 불안, 성격, 자기효능감, 자아존중감, 주관적 연령과의 상관이 유의하였다. 또한 인지훈련을 통해 전반적인 인지기능을 측정하는 정신상태, 기억, 전두엽기능 검사 점수가 향상되었으며 인지훈련의 효과는 연령, 주관적 인지감퇴, 불안, 자기효능감, 자아존중감, 주관적 연령, 성격과 관련이 있는 것으로 나타났다. 이러한 결과는 어떤 특성의 노인이 인지노화에 취약한지 알려주며, 인지훈련의 효과를 높이기 위해 교육 참가자의 특성을 고려해야 한다는 것을 시사한다.

• 한국융합학회논문지
• /
• 제11권8호
• /
• pp.229-236
• /
• 2020

본 연구는 한국고용정보원에서 실시한 제 6차 고령화연구패널조사를 이용하여 신체활동, 생활습관, 사회활동 참여로 구성된 고령자의 융합적 라이프스타일이 인지저하 위험도에 미치는 영향력을 탐색하고, 참여하는 사회활동 유형이 인지저하 위험도에 미치는 영향력을 파악하고자 실시하였다. 분석대상자로 65세 이상 노인 4,298명을 연구에 포함하였다. 연구 결과, 고령자의 라이프스타일 구성요소 모두 인지저하에 유의한 영향을 미쳤으며, 특히 참여하는 사회활동수가 1단위 증가할수록 인지저하 위험도가 약 2배씩 감소하는 것으로 나타났다. 또한, 사회활동 유형 중 종교활동, 표현적집단 활동, 연고집단 활동은 인지저하 위험도를 감소시키는 유의한 변수로 도출되었다. 따라서, 고령자의 융합적 라이프스타일 향상을 위한 지역사회 및 정책적 차원의 적극적인 지지와 실천적 방안이 필요하며, 지역 특수성을 고려하여 여가복지시설을 중심으로 사회활동의 양적 확충 및 질적 향상의 필요성을 시사한다.