• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.21 no.1
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• pp.1-11
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• 2018

The emergence of mucosal healing as a treatment goal that could modify the natural course of Crohn's disease and the accumulating evidence showing that biologics are most effective in achieving mucosal healing, along with the success of early treatment regimens for rheumatoid arthritis, have led to the identification of early Crohn's disease and development of the concept of catching the therapeutic window during the early disease course. Thus, an increasing number of pediatric gastroenterologists are adopting an early biologic treatment strategy with or without an immunomodulator. Although early biologic treatment is effective, cost and overtreatment are issues that limit its early use. Currently, there are insufficient data on who will benefit most from early biologics, as well as on who will not need early or even any biologics. For now, top-down biologics should be considered for patients with currently known high-risk factors of poor outcomes. For other patients, close, objective monitoring and accelerating the step-up process by means of a treat-to-target approach seems the best way to catch the therapeutic window in early pediatric Crohn's disease. The individual benefits of immunomodulator addition during early biologic treatment should be weighed against its risks and decision on early combination treatment should be made after comprehensive discussion with each patient and guardian.

• THE INTERNATIONAL COMMERCE & LAW REVIEW
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• v.48
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• pp.57-76
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• 2010

This study reviews maritime transport policy regarding liner conference and the changes in the liner market over the decades. Liner shipping industry has long been protected from competition by block exemption. To prevent excessive competition in punctual operation and its inelastic market structure, liner shipping companies formed conferences that are protected to fix the prices under the law. In the US, deregulation in transport sector began from 80's and continuing with OSRA 1998, conferences were dissolving. On the other hand, the EU with close conference system, Regulation 4056/86 contained block exemption remained in force for unlimited time without review clause. However, in Oct 2008, the EU has announced its removal, and conferences were no longer permitted to fix the price nor exchange information. Although OSRA 1998 has already broken up conferences by allowing individual service contracts, but the repeal of the immunity for price fixing will alter significantly the rule on cooperation in the industry since it is a unilateral move by the EU, especially in transatlantic lane. There are rapid changes in shipping market getting much more complicated, and with removal of 4056/86 allowing the market to be more competitive, opening up the industry with far more diverse strategic options. Hence this paper reviews on liner shipping industry and its changes of policies over the years from protected market to open competition market of today.

• Journal of Power Electronics
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• v.18 no.2
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• pp.343-355
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• 2018

A wide-voltage-conversion range bidirectional DC-DC converter is proposed in this paper. The topology is comprised of one typical LC energy storage component and a special common grounded asymmetric H-bridge with four active power switches/anti-parallel diodes. The narrow output PWM voltage is generated from the voltage difference between two normal (wider) output PWM voltages from the asymmetric H-bridge with duty cycles close to 0.5. The equivalent switching frequency of the output PWM voltage is double the actual switching frequency, and a wide step-down/step-up ratio range is achieved. A 300W prototype has been constructed to validate the feasibility and effectiveness of the proposed bidirectional converter between the variable low voltage side (24V~48V) and the constant high voltage side (200V). The slave active power switches allow ZVS turn-on and turn-off without requiring any extra hardware. The maximum conversion efficiency is 94.7% in the step-down mode and 93.5% in the step-up mode. Therefore, the proposed bidirectional topology with a common ground is suitable for energy storage systems such as renewable power generation systems and electric vehicles with a hybrid energy source.

• Bulletin of the Korean Chemical Society
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• v.35 no.6
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• pp.1817-1824
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• 2014

The adsorption characteristics of chromium (VI) and phosphate on calcined Mg-Al-$CO_3$ layered double hydroxides (CLDH) were investigated in single and binary systems. A series of batch experiments were performed to study the influence of various experimental parameters. In this study, CLDH exhibited a high adsorption capacity for Cr (VI) and P in a single system. The experimental data were close to the theoretical adsorption capacity given by the Langmuir isotherm, the calculating adsorption capacities of Cr (VI) and P were up to 70.42 mg/g and 97.09 mg/g, respectively. It was found that the initial pH was approximately 6 and it took 24 h to reach equilibrium when P and Cr (VI) were added simultaneously. The experimental data were best fitted by a pseudo-second-order kinetics model. Competitive adsorption between Cr (VI) and P existed in the binary system. The presence of Cr (VI) had no significant influence on P adsorption. However, the suppression of Cr (VI) adsorption was obvious when the initial concentration of P was up to 10 mg/L with a concentration of 0.5 g/L of CLDH.

• Advances in pediatric surgery
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• v.13 no.1
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• pp.1-12
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• 2007

Biliary atresia (BA) is the result of fibrosing destructive inflammatory process affecting intrahepatic and extrahepatic bile ducts, which lead to cirrhosis and portal hypertension. Kasai portoenterostomy has been the standard operative procedure in biliary atresia. Recently, there has been remarkable increase in the survival rate in cases of BA. However, long-term survivors are not clearly evaluated in Korea. To define long-term prognosis factors of patients who underwent surgery for BA, a retrospective study was undertaken of 10 (37 %) patients surviving more than 10 years among 27 patients who underwent one of Kasai procedures between 1981 and 1995. Hepatomegaly was present in 4 and splenomegaly in 7 patients. Serum bilirubin was normalized at 1 year after operation. Aspartate aminotransferase (AST, GOT), Alanine aminotransferase(ALT, GPT) were normalized at 12 years and alkaline phosphatase(ALP) was normalized at 13.5 years. Cholangitis developed mainly within 5 years after operation so close follow up is needed. Life long follow-up is needed because of progressive deterioration of liver function even after 10 years.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.45 no.2
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• pp.44-48
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• 2008

According to increment of stage, the speed of changeable stage Carry-increment adder can be close to $O(\sqrt{2n})$ because the word length which is computed in stage can be lengthened by 1 bit. But the number of stage bits is increased, fan-out of carry which is inputted in stage is increased. So tile speed can be slow. This paper presents a new carry-increment adder design method to fix the number of fan-outs regardless of the number of stages. By layout simulation of 37-bit adder, the area can be Increased up to 40%, but speed improvement up to 75% can be achieved, by the proposed method, compared with a conventional method.

• Journal of Advanced Marine Engineering and Technology
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• v.38 no.10
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• pp.1257-1262
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• 2014

The variances of atomization characteristics with the misalignment of injectors defined as the fraction of skewness for various angles of impingement and pressure conditions were studied using the doublet impinging injectors with a like-on-like arrangement. Water was used as simulant and the spray characteristics along with the changes in the skewness were analyzed using the methods of spray image photography. Experiment was carried for the impinging nozzles of orifice diameter of 1.2 mm within Reynolds numbers ranging from $9{\times}10^3-4.5{\times}10^4$ and the fraction of skewness considered for the experiment ranges from 0.0 to 0.9 at ambient temperature condition. Flat sheet with a distinct rim produced perpendicular to the plane of impinging jets goes ondisappear and sheet appears comparatively shorterwith the increase in fraction of skewness resulting the atomization of fluid droplet very close to impingement point with decrease in breakup length and increase in spray angle up to certain extent. The maximum allowable skewness was found as the result. The skewness up to the certain extent can be considered as the parameter to control the atomization characteristics of simulant inside the combustion chamberproviding the high economic performance of fuel and time.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.20 no.4
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• pp.379-382
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• 1998

The 44 years old man was consulted to our department due to restriction of mouth opening. On radiograph, we found bony expansive lesion at right mandibular ramus and temporal bone that it was suspected malignant tumor. So we had performed incisional bone biopsy at right ramus through skin incision. The result of biopsy was osteosarcoma. Then, he had experienced radiation therapy for the protection of recurrence after several times surgery of nasopharyngeal angiofibroma, 28 years ago. So, we concluded radiation induced osteosarcoma from his radiation therapy history. He had referred to the department of hematooncology because of severe expansion to skull base and was received 4 times chemotherapy with cisplatin and adriamycin, but he was expired just after 4th chemotherapy. Such radiation induced osteosarcoma have relative good prognosis due to rare metastasis from other reports. So if it will early detect from close follow up after radiation therapy, survival rate will rise up. But we missed early detection of our case. So, we report a case of rare radiation induced osteosarcoma. Ly detection of our case.

• Journal of Chest Surgery
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• v.45 no.2
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• pp.116-119
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• 2012

A 61-year-old female patient was diagnosed with dilated cardiomyopathy with severe left ventricle dysfunction. Two days after admission, continuous renal replacement therapy was performed due to oliguria and lactic acidosis. On the fifth day, an intra-aortic balloon pump was inserted due to low cardiac output syndrome. Beginning 4 days after admission, she was supported for 15 days thereafter with an extracorporeal left ventricular assist device (LVAD) because of heart failure with multi-organ failure. A heart transplant was performed while the patient was stabilized with the LVAD. She developed several complications after the surgery, such as cytomegalovirus pneumonia, pulmonary tuberculosis, wound dehiscence, and H1N1 infection. On postoperative day 19, she was discharged from the hospital with close follow-up and treatment for infection. She received follow-up care for 10 months without any immune rejection reaction.

• Fashion & Textile Research Journal
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• v.10 no.6
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• pp.836-847
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• 2008

Maximalism in modern fashion has emerged as an anti-conception against Minimaslism which dominated the trend of 21st century. Contrary to the traits of Minimalism which are oriented to constraint and editing, Maximalism expresses human sensitivity, concern to tradition and other culture, and instinctive desire for decoration. The trend of Maximalism is reflected in various areas of fashion and shoes design, and its influence is still enlarging. This idea for designing shoes come from analyzing the related documentaries, fashion magazines and internet sites since 2005, when the maximalism was main concepts in worldwide fashion trends. The traits of Maxmalistic trend expressed in shoes are decentralizing, pluralisml, sensitivity, etc. The molding constituents, such as form, material, color, accessary decoration, have been expressed as diversified and differentiated traits of shoes design through molding modes such as exaggeration and concentration, distortion and modification, removal and mixing-up. This study takes advantage of this opportunity to grasp the diversified and colorful trend and molding traits of Maximalim expressed in shoes design, close up the molding value of shoes design, and finally enlarge the realm of aesthetic expression of shoes design.