• 한국지능시스템학회논문지
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• 제14권4호
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• pp.402-410
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• 2004

본 논문에서는 복잡하고 비선형적인 시스템을 위하여 최적 면역 알고리즘의 개선된 클론선택에 기반을 둔 최적FNN 설계방법을 제안한다. FNN은 퍼지추론의 간략 추론과 학습방법으로는 오류역전파 알고리즘을 하였고 멤버쉽함수의 파라미터, 학습률 및 모멘텀 계수들을 선정하기 위하여 개선된 클론 선택을 사용하는 방법을 도입하였다. 제안한 알고리즘은 생체의 면역반응에 기초를 둔 면역알고리즘의 클론선택을 기본으로 분화율을 조절하여 성능을 개선하였다. 그 과정을 통하여 다양한 항체들을 생성하고 목적함수나 제한조건과 같은 항원들에 대하여 가장 높은 친화도를 가지는 항체를 최적 항체로 선택하였다. 제안된 알고리즘의 성능을 평가하기 위하여 가스로공정과 교통경로선택 공정을 사용한다.

• 한국산림과학회지
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• 제83권2호
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• pp.239-245
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• 1994

전국 4개소에 식재된 사시나무 25개 클론중 18개 클론의 평균치에 대하여 광의(廣義)의 수고유전력(樹高遺傳力)(반복력(反復力))을 구한 결과 $H^2_{CM}=0.883$로 상당히 높은 것으로 추정되었다. 이에 따라 18클론중에서 최우수 l클론(5%), 즉 백담 15호를 선발하는 경우 35.3%의 개량효과(1.02m의 실질적 수고개량)가 있으며, 최우수클론 2클론, 즉 백담(百潭) 15호(號)와 선녀(仙女) 4호(號)를 선발(選拔)하면(10%) 25.6%의 개량효과 (0.74m의 실질적 수고개량)를 얻을 수 있을 것이다. 또한 최종 선발수령(選拔樹齡)에 가면 수고유전력(樹高遺傳力)이 더욱 높아질 것으로 기대되며, 따라서 더욱 높은 개량효과를 얻을 수 있을 것으로 기대된다.

• 제어로봇시스템학회논문지
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• 제6권12호
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• pp.1079-1085
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• 2000

In this paper, we propose a method of cooperative control (T-cell modeling) and selection of group behavior strategy (B-cell modeling) based on immune system in distributed autonomous robotic system (DARS). An immune system is the living bodys self-protection and self-maintenance system. these features can be applied to decision making of the optimal swarm behavior in a dynamically changing environment. For applying immune system to DARS, a robot is regarded as a B-cell, each environmental condition as an antigen, a behavior strategy as an antibody, and control parameter as a T-cell, respectively. When the environmental condition (antigen) changes, a robot selects an appropriate behavior strategy (antibody). And its behavior strategy is stimulated and suppressed by other robots using communication (immune network). Finally, much stimulated strategy is adopted as a swarm behavior strategy. This control scheme is based on clonal selection and immune network hypothesis, and it is used for decision making of the optimal swarm strategy. Adaptation ability of the robot is enhanced by adding T-cell model as a control parameter in dynamic environments.

• 대한수의학회지
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• 제39권6호
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• pp.1112-1118
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• 1999

Galectin-3 plays an important role in cell development, differentiation and cancer metastasis, including cell-cell/extracellular matrix (ECM) interactions and is supposed to have an effect of apoptosis on T-cells in thymic clonal selection. In this study, to know the effect of galectin-3 on thymocyte development, we used recombinant human galectin-3 (rHgal-3) from Escherichia coli, JM105, which was inserted with human gal-3 gene-transformed plasmid vector (prGal-3) to express human galectin-3. Expressed rHgal-3 was confirmed by western blot using the culture supernant of hybridoma (M3/38) producing monoclonal antibody to human galectin-3. Sepharose gel affinity chromatography was used to purify the expressed rHgal-3. Thymocytes and hepatocytes from 6-week-old male BALB/c mice were incubated with rHgal-3 and showed marked increase of apoptotic population on analysis using flow cytometry with 7-AAD in a dosedependent manner. However, rHgal-3 failed to induce apoptosis on hepatocytes. Interestingly, this apoptotic effect was not inhibited by lactose, a specific lectin domain inhibitor. From these results, we concluded that extrinsic -3 induces apoptosis on mouse thymocytes, and galectin-3 may have an apoptotic effect on T-cells in thymic clonal selection.

• 한국육종학회지
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• 제40권3호
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• pp.263-268
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• 2008

잣나무 채종원의 유전간벌을 위하여 재적생장에 대한 개량 효과와 유효클론수를 이용한 유전다양성을 평가하였다. 유전 간벌은 클론의 일반조합능력으로 나타나는 육종가(breeding value), 암꽃과 수꽃 개화량을 이용한 종자생산 기여도, 클론별 ramet수 등를 이용한 클론별 변이를 기초로 하였다. 차대 검정 결과에 의하여 산출된 재적생장에 대한 클론별 일반조합능력(genetic value) 및 1991년부터 2003년까지 조사된 개화량 성적을 이용하여 잣나무 채종원(1981년 조성) 179클론에 대하여 간벌 강도에 따른 유전다양성 및 개량효과를 분석하였다. 이때 채종원 외부로부터의 화분오염율은 30%(gene migration = 15%)로 설정하였다. 그 결과 재적생장에 대한 개량효과는 간벌율이 10%에서 60%까지 높아짐에 따라서 점차 증가하였다. 하지만 이보다 더 높은 간벌 강도에서 현저한 개량효과 증가는 나타나지 않았다. 유효클론수는 간벌강도 10%에서 60% 사이에서는 40클론으로 나타났으며, 70% 간벌율 이상에서는 증가하거나 감소하는 변동을 나타냈다. 따라서 본 잣나무 채종원에 대해서는 50%에서 60% 수준의 간벌 강도가 적당한 것으로 판단된다.

• Fisheries and Aquatic Sciences
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• 제18권3호
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• pp.287-296
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• 2015

Although rotifers have been considered the best feeding option for several species of fishes in aquaculture, they are sometimes larger than appropriate for the early larval stage of some marine fishes. Thus, we aimed to determine whether size-based selection of the parents could affect the average body size of their progeny in two clonal populations of the rotifer Brachionus rotundiformis. From each of the clones, 20 individuals were bi-directionally selected toward both smaller and larger sizes and each individual-based selection was conducted for 10 consecutive generations. The results showed that although there were sometimes differences in mean body size between parents and their progeny, no directional trend was observed in all selected lines of both clones. We demonstrated that artificial selection in a rotifer stock cannot lead to an expected size range although they appear to exhibit a large degree of body size polymorphism.

• 한국지능정보시스템학회:학술대회논문집
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• 한국지능정보시스템학회 2001년도 The Pacific Aisan Confrence On Intelligent Systems 2001
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• pp.298-309
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• 2001

This research aims to unravel the significant features of the human immune system, which would be successfully employed for a novel network intrusion detection model. Several salient features of the human immune system, which detects intruding pathogens, are carefully studied and the possibility and the advantages of adopting these features for network intrusion detection are reviewed and assessed.

• 한국발생생물학회지:발생과생식
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• 제4권2호
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• pp.147-152
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• 2000

본 연구는 은어의 clone을 생산하여 생리적 형질에 대한 유전적 특성을 조사하고 또 clone의 유전율을 추정했다. 성숙한 완전 동형접합형 자성발생 2배체(난할형 2배체)에서 채란한 후 자성발생을 반복하여 4계통의 clone을 생산하였으며 부화 전부터 같은 수조에 혼합하여 사육하였다. 10개월간 사육한 후 사육수조의 수심을 낮추었을 때의 스트레스가 clone의 혈액성상과 유전율에 미치는 영향에 대해서 조사했다. 생산된 각 계통의 clone은 실험에 사용하기 전에 DNA fingerprint법을 이용하여 유전적 균질성을 확인한 후 스트레스어와 비스트레스어의 hematocrit 값, hemoglobin량, 적혈구수 및 평균적 혈구용적 (MCV)을 측정하였다. 비스트레스어에서 측정한 hematocrit값과 MCV에서 각 clone간에 유의차가 인정되었다. 실험어는 모두 같은 환경에서 사육하였기 때문에 이러한 유의차는 주로 각 clone의 유전적인 차이를 반영한 것으로 생각한다. 스트레스 반응률 (SRR)은 기대값보다 낮았으며 유전율 (h$^2$)은 비스트레스 group에서는 평균 0.238로 높았으나 스트레스 group에서는 매우 낮거나 거의 0에 가까웠다. 따라서 혼합 사육한 clone 계통은 생리적 형질의 유전적 특성을 조사하는데 좋은 수단이 된다. 또한 선발 육종의 선발형질로서도 유용하다.

• Journal of Veterinary Science
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• 제21권1호
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• pp.2.1-2.14
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• 2020

The emergence of livestock-associated (LA)-methicillin-resistant Staphylococcus aureus (MRSA) in livestock animal has become a significant zoonotic concern. In the present study, we investigated nationwide prevalence of LA-MRSA across pork production chain including pig farms, slaughterhouses, and retail markets. A total of 40 MRSA strains were isolated during the investigation and the overall prevalence of MRSA was 3.4% (n = 37), 0.6% (n = 2), and 0.4% (n = 1) in pig farms, slaughterhouses, and retail markets, respectively. Multilocus sequence typing analyses revealed that the 2 most significant clonal lineages in pork production chain in Korea were ST398 (n = 25) and ST541 (n = 6). All of the 40 MRSA isolates were further characterized to investigate key genotypic and phenotypic correlates associated with the emergence and spread of clonal complex 398 (CC398; ST398, and ST541) LA-MRSA. Although the prevalence of swine-associated MRSA was still relatively low and mostly restricted to pig farms, multidrug-resistant CC398 LA-MRSA isolates with new spa types (t18102 and t18103) were identified as a major clonal lineage. The CC398 LA-MRSA strains tended to exhibit increased levels of multiple drug resistance (MDR) phenotype compared with non-CC398 MRSA strains. Of note, in comparison with non-CC398 MRSA isolates, CC398 LA-MRSA isolates exhibited significantly enhanced tetracycline (TET) and zinc resistance. These findings suggested that co-selection pressure associated with MDR phenotype, especially TET resistance, and zinc resistance may have played a significant role in the emergence and persistence of CC398 LA-MRSA in pig farms in Korea.

• 한국지능시스템학회:학술대회논문집
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• 한국퍼지및지능시스템학회 1998년도 춘계학술대회 학술발표 논문집
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• pp.127-130
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• 1998

In this paper, we propose a method of cooperative control(T-cell modeling) and selection of group behavior strategy(B-cell modeling) based on immune system in distributed autonomous robotic system(DARS). Immune system is living body's self-protection and self-maintenance system. Thus these features can be applied to decision making of optimal swarm behavior in dynamically changing environment. For the purpose of applying immune system to DARS, a robot is regarded as a B cell, each environmental condition as an antigen, a behavior strategy as an antibody and control parameter as a T-call respectively. The executing process of proposed method is as follows. When the environmental condition changes, a robot selects an appropriate behavior strategy. And its behavior strategy is stimulated and suppressed by other robot using communication. Finally much stimulated strategy is adopted as a swarm behavior strategy. This control scheme is based of clonal selection and idiotopic network hypothesis. And it is used for decision making of optimal swarm strategy. By T-cell modeling, adaptation ability of robot is enhanced in dynamic environments.