• BMB Reports
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• v.41 no.2
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• pp.102-107
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• 2008

Extracellular proteases play an important role in a wide range of host physiological events, such as food digestion, extracellular matrix degradation, coagulation and immunity. Among the large extracellular protease family, serine proteases that contain a "paper clip"-like domain and are therefore referred to as CLIP-domain serine protease (clip-SP), have been found to be involved in unique biological processes, such as immunity and development. Despite the increasing amount of biochemical information available regarding the structure and function of clip-SPs, their in vivo physiological significance is not well known due to a lack of genetic studies. Recently, Drosophila has been shown to be a powerful genetic model system for the dissection of biological functions of the clip-SPs at the organism level. Here, the current knowledge regarding Drosophila clip-SPs has been summarized and future research directions to evaluate the role that clip-SPs play in Drosophila immunity are discussed.

• The Journal of the Korean dental association
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• v.54 no.12
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• pp.1024-1034
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• 2016

Purpose. The purpose of this study was to compare the type and frequency of prosthetic complications associated with attachment types for implant overdenture. Material and methods. In this retrospective study, 38 patients (mean age, 63.5 years) have been treated with implant overdentures from 2007 to 2014. Ten patients received a bar-clip attachment. Eleven patients had received a milled bar with Locator attachment. Seventeen patients had received a Locator attachment. The mean follow-up period was 36.9 months (range, 15-83 months). The type and frequency of prosthetic complications was recorded. The frequency was analyzed to determine the statistical difference among the 3 different attachments by using one-way ANOVA (${\alpha}=.05$) and Bonferroni post hoc method at a 5% level of significance. Results. The total number of prosthetic complications was higher in the bar-clip attachment (55 events) than in the milled bar with Locator attachment (39 events) and the Locator attachment (34 events). There were no statistically significant differences, and the most common prosthetic complication was the loss of retention. In the bar-clip attachment group, the average frequency of prosthetic complications was 3.0 events per prosthesis during the first year. In the milled bar with Locator attachment and Locator attachment groups, the average frequencies were 1.45 events and 2.35 events, respectively. Statistically significant differences were observed in the frequency of the complication. (p = .043) Conclusions. Compared to the bar-clip attachment, implant overdentures that use milled bars with the Locator attachment have a significantly lower incidence of prosthetic complications in the first year of follow-up after placement.

• Science of Emotion and Sensibility
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• v.13 no.4
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• pp.621-634
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• 2010

This study aimed to investigate the effects of dimensions of movie clip (2D vs. 3D), viewing orders (2D ${\to}$ 3D vs. 3D ${\to}$ 2D), and gender difference on participants' subjective fatigue, recognition for the elements in the clips, and arousal level. The results can be summarized as followings. First, subjective fatigue level was higher in the 3D condition than 2D condition, but this tendency was more clear in the 2D ${\to}$ 3D condition than in the 3D ${\to}$ 2D condition. Second, correct recognition rates were significantly higher for 3D than 2D only in the 3D ${\to}$ 2D condition. In particular, male participants showed higher correct recognition rates than female participants in the 3D clip condition, whereas female participants showed higher correct recognition rates than male participants in the 2D clip condition. Third, although 3D clips tended to induce higher level of arousal, this tendency was showed only in the 2D ${\to}$ 3D condition, which implied previous exposure to 2D clip increased the arousal level in following 3D clip than vice versa.

• The Korean Journal of Physiology and Pharmacology
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• v.5 no.3
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• pp.253-258
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• 2001

The present study was aimed to examine whether the expression of renin is associated with that of cyclooxygenase-2 (COX-2) in the kidney. Male Sprague-Dawley rats were made two-kidney, one clip (2K1C) or deoxycorticosterone acetate (DOCA)-salt hypertensive, to stimulate or to inhibit the endogenous renin-angiotensin system, respectively. The expression of renin and COX-2 mRNA was determined in the cortex of the kidney by reverse transcription-polymerase chain reaction. 2K1C hypertensive rats showed an increased expression of renin as well as of COX-2 in the clipped kidney. The expression of renin was decreased in parallel with that of COX-2 in the contralateral non-clipped kidney. Removal of the renal arterial clip reversed the expression of both genes, along with the blood pressure, to the control level. On the other hand, DOCA-salt hypertension was associated with parallel decreases of renin and COX-2 expression. These results indicate that renin and COX-2 genes are coordinately expressed in the kidney.

• The Korean Journal of Physiology and Pharmacology
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• v.4 no.2
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• pp.143-147
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• 2000

The present study was aimed at investigating whether there are changes in the expression of nitric oxide synthase (NOS) in relation with the unclipping-induced fall of blood pressure in two-kidney, one clip (2K1C) hypertension. Male Sprague-Dawley rats were made 2K1C hypertensive by clipping the left renal artery for four weeks. Sham-clipped rats served as control. The expression of endothelial constitutive (ec) NOS proteins and tissue levels of NO metabolites were determined in the kidney. Systolic blood pressure was significantly increased in clipped rats compared with that in the control. The development of hypertension was associated with decreases in the expression of ecNOS proteins and tissue levels of NO metabolites in the clipped kidney. The blood pressure at twenty-four hours after removal of the renal arterial clip fell to the control level. Accordingly, in the unclipped kidney, the expression of ecNOS proteins and tissue contents of NO metabolites were increased to the control level. The contralateral kidney was not affected by the development or reversal of hypertension. It is suggested that an enhanced expression of ecNOS in the unclipped kidney is an important component in the reversal of renovascular hypertension.

• The KIPS Transactions:PartB
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• v.11B no.1
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• pp.35-44
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• 2004

Web contents created for desktop screens give rise to problems when they are to be displayed on the small screens of mobile terminals. While in some cases some of the objects of a page may not be displayable due to the lack of browser capability, the entire page may not be displayable due to the incompatibility with the browser in other cases. In this paper, we introduce a new mobile content adaptation approach based on web clipping, which transforms an original page into one that is optimally displayed on a mobile terminal. In this method, a source page is automatically clipped and transformed according to the clip specification made by the content provider using a clip editing tool. The clip editing tool allows the user to specify group clips, multi-level cups and dynamic clips as well as simple clips, and the presentation layout through a graphic user interface. Based on the clip specifications, each clip is transformed into an intermediate meta-language document, which in turn is transformed into a presentation page in the target markup language. Transcoding of image objects in major image file formats is also supported.

• Journal of the Korean Society for Railway
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• v.5 no.1
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• pp.48-54
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• 2002

This research estimated decreased vibration level as quantitative according to change of track system on Seoul Subway Line No. 1 from existing ballasted track system(Pandrol type clip) to concrete track system(Youbgdan type isolation rubber clip). Following change to concrete system, vibration level at tunnel floor decreased between 4-8dB(V). Vibration equations suggested in this paper consider the velocity of train and can estimate quantitative vibration response. These are divided by ultimate limit state($\beta$=0), serviceability limit state($\beta$=1.28) and safety state($\beta$=3), respectively. The reliability index, $\beta$=0, means 50％ data line obtained by least squares best-fit line. The reliability index $\beta$=1.28 and 3 represent boundaries below 90％ and 99.9％ respectively.

• Journal of Elementary Mathematics Education in Korea
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• v.18 no.2
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• pp.357-377
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• 2014

The purpose of this study is to identify whether math class with clip-type contents has a significant impacts on the academic achievement and attitude of students. To answer the questions, two classes of 4th graders at Sinlim Elementary School in Gwanak-gu, Seoul were selected as subjects; they were divided into experimental group and comparative group. They were confirmed as a homogeneous group at the significance level of 0.05 during a pre-test. The findings are as follows. First, math class with clip-type contents had positive influence on the academic achievement. Second, math class with clip-type contents had positive influence on the attitude towards learning. Furthermore, proper clip-type contents for class boost their understanding and enhance their mathematical thinking with multiple views. It led to their self-confidence in learning math, developing a positive attitude towards math. The benefits of the present research can be summarized as follows. First, the math class with clip-type contents benefited both teachers and students. For teachers, it helped them boost the quality of their teaching. For students, it helped them understand the class better, improving their academic achievement. Second, the diverse, interesting contents had a positive impact on the following of the students: self-concept of math; attitude towards math; learning habits.

• Molecules and Cells
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• v.39 no.5
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• pp.375-381
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• 2016

MicroRNAs (miRNAs) are small non-coding RNAs (~22 nucleotides) regulating gene expression at the post-transcriptional level. By directing the RNA-induced silencing complex (RISC) to bind specific target mRNAs, miRNA can repress target genes and affect various biological phenotypes. Functional miRNA target recognition is known to majorly attribute specificity to consecutive pairing with seed region (position 2-8) of miRNA. Recent advances in a transcriptome-wide method of mapping miRNA binding sites (Ago HITS-CLIP) elucidated that a large portion of miRNA-target interactions in vivo are mediated not only through the canonical "seed sites" but also via non-canonical sites (~15-80%), setting the stage to expand and determine their properties. Here we focus on recent findings from transcriptome-wide non-canonical miRNA-target interactions, specifically regarding "nucleation bulges" and "seed-like motifs". We also discuss insights from Ago HITS-CLIP data alongside structural and biochemical studies, which highlight putative mechanisms of miRNA target recognition, and the biological significance of these non-canonical sites mediating marginal repression.

• Structural Engineering and Mechanics
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• v.58 no.1
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• pp.121-142
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• 2016

The national standard being used in Turkey for suspended ceiling systems (SCS) regulates material and dimensional properties but does not contain regulations regarding installation instructions which cause substandard applications of SCSs in practice. The lack of installation instructions would potentially affect the dynamic performance of these systems. Also, the vast majority of these systems are manufactured using substandard low-quality materials, and this will inevitably increase SCS related damages during earthquakes. The experimental work presented here focuses on the issue of dynamic performance of SCSs with different types of carrier systems (lay-on and clip-in systems), different weight conditions, and material-workmanship qualities. Moreover, the effects of auxiliary fastening elements, so called seismic perimeter clips, in improving the dynamic performance of SCSs were experimentally investigated. Results show that clip-in ceiling system performs better than lay-on system regardless of material and workmanship qualities. On the other hand, the quality aspect becomes the most important parameter in affecting the dynamic performance of lay-on type systems as opposed to tile weights and usage of perimeter clips. When high quality system is used, tile weight does not change the performance of lay-on system, however in poor quality system, tile weight becomes an important factor where heavier tiles considerably decrease the performance level. Perimeter clips marginally increase the dynamic performance of lay-on ceiling system, but it has no effect on the clip-in ceiling system under the shaking levels considered.