• BMB Reports
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• 제41권2호
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• pp.102-107
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• 2008

Extracellular proteases play an important role in a wide range of host physiological events, such as food digestion, extracellular matrix degradation, coagulation and immunity. Among the large extracellular protease family, serine proteases that contain a "paper clip"-like domain and are therefore referred to as CLIP-domain serine protease (clip-SP), have been found to be involved in unique biological processes, such as immunity and development. Despite the increasing amount of biochemical information available regarding the structure and function of clip-SPs, their in vivo physiological significance is not well known due to a lack of genetic studies. Recently, Drosophila has been shown to be a powerful genetic model system for the dissection of biological functions of the clip-SPs at the organism level. Here, the current knowledge regarding Drosophila clip-SPs has been summarized and future research directions to evaluate the role that clip-SPs play in Drosophila immunity are discussed.

• 대한치과의사협회지
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• 제54권12호
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• pp.1024-1034
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• 2016

Purpose. The purpose of this study was to compare the type and frequency of prosthetic complications associated with attachment types for implant overdenture. Material and methods. In this retrospective study, 38 patients (mean age, 63.5 years) have been treated with implant overdentures from 2007 to 2014. Ten patients received a bar-clip attachment. Eleven patients had received a milled bar with Locator attachment. Seventeen patients had received a Locator attachment. The mean follow-up period was 36.9 months (range, 15-83 months). The type and frequency of prosthetic complications was recorded. The frequency was analyzed to determine the statistical difference among the 3 different attachments by using one-way ANOVA (${\alpha}=.05$) and Bonferroni post hoc method at a 5% level of significance. Results. The total number of prosthetic complications was higher in the bar-clip attachment (55 events) than in the milled bar with Locator attachment (39 events) and the Locator attachment (34 events). There were no statistically significant differences, and the most common prosthetic complication was the loss of retention. In the bar-clip attachment group, the average frequency of prosthetic complications was 3.0 events per prosthesis during the first year. In the milled bar with Locator attachment and Locator attachment groups, the average frequencies were 1.45 events and 2.35 events, respectively. Statistically significant differences were observed in the frequency of the complication. (p = .043) Conclusions. Compared to the bar-clip attachment, implant overdentures that use milled bars with the Locator attachment have a significantly lower incidence of prosthetic complications in the first year of follow-up after placement.

• 감성과학
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• 제13권4호
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• pp.621-634
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• 2010

본 연구는 영상차원(2D vs. 3D), 영상 시청순서(2D ${\to}$ 3D vs. 3D ${\to}$ 2D), 그리고 설험참가자의 성차에 따라 영상 시청에 따른 주관적 피로감, 재인기억, 그리고 각성 수준에서 어떠한 차이가 있는지 살펴보기 위해 수행되었다. 본 연구의 결과를 요약하면 다음과 같다. 첫째, 주관적 시각피로도는 2D 영상차원에 비해 3D 영상차원에 대해 전반적으로 높게 보고되었고, 특히 3D ${\to}$ 2D의 시청순서 집단에 비해 2D ${\to}$ 3D의 시청순서 집단에서 이러한 차이가 더 뚜렷하였다. 둘째 영상 내용에 대한 정확재인률은 3D ${\to}$ 2D의 시청순서 집단에서만 2D 영상차원에 대한 3D 영상차원의 우세성이 관찰되었고, 특히 시청순서 조건을 통합할 경우 2D 영상차원 조건에서는 여성이, 반면 3D 영상차원 조건에서 남성이 상대적으로 더 높은 정확재인률을 보였다. 셋째, 3D영상이 전반적으로 시청자의 각성 수준을 높이기는 하지만, 이러한 경향은 영상차원 자체보다는 3D 영상과 대비되는 2D 영상에 대한 이전의 시청 경험이 더 유의한 영향을 주는 것으로 관찰되었다.

• The Korean Journal of Physiology and Pharmacology
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• 제5권3호
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• pp.253-258
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• 2001

The present study was aimed to examine whether the expression of renin is associated with that of cyclooxygenase-2 (COX-2) in the kidney. Male Sprague-Dawley rats were made two-kidney, one clip (2K1C) or deoxycorticosterone acetate (DOCA)-salt hypertensive, to stimulate or to inhibit the endogenous renin-angiotensin system, respectively. The expression of renin and COX-2 mRNA was determined in the cortex of the kidney by reverse transcription-polymerase chain reaction. 2K1C hypertensive rats showed an increased expression of renin as well as of COX-2 in the clipped kidney. The expression of renin was decreased in parallel with that of COX-2 in the contralateral non-clipped kidney. Removal of the renal arterial clip reversed the expression of both genes, along with the blood pressure, to the control level. On the other hand, DOCA-salt hypertension was associated with parallel decreases of renin and COX-2 expression. These results indicate that renin and COX-2 genes are coordinately expressed in the kidney.

• The Korean Journal of Physiology and Pharmacology
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• 제4권2호
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• pp.143-147
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• 2000

The present study was aimed at investigating whether there are changes in the expression of nitric oxide synthase (NOS) in relation with the unclipping-induced fall of blood pressure in two-kidney, one clip (2K1C) hypertension. Male Sprague-Dawley rats were made 2K1C hypertensive by clipping the left renal artery for four weeks. Sham-clipped rats served as control. The expression of endothelial constitutive (ec) NOS proteins and tissue levels of NO metabolites were determined in the kidney. Systolic blood pressure was significantly increased in clipped rats compared with that in the control. The development of hypertension was associated with decreases in the expression of ecNOS proteins and tissue levels of NO metabolites in the clipped kidney. The blood pressure at twenty-four hours after removal of the renal arterial clip fell to the control level. Accordingly, in the unclipped kidney, the expression of ecNOS proteins and tissue contents of NO metabolites were increased to the control level. The contralateral kidney was not affected by the development or reversal of hypertension. It is suggested that an enhanced expression of ecNOS in the unclipped kidney is an important component in the reversal of renovascular hypertension.

• 정보처리학회논문지B
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• 제11B권1호
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• pp.35-44
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• 2004

작은 화면을 가진 이동 단말기에서 데스크탑 화면에 맞추어 제작된 웹 컨텐츠들을 브라우징 하는 것은 많은 어려움을 갖는다. 웹 페이지에는 이동 단말기용 브라우저의 제한된 기능으로 인해 표시할 수 없는 객체가 일부 포함되어 있는 경우도 있고, 브라우저에서 호환되지 않는 마크업 표준을 사용하여 브라우징 자체가 불가능할 수도 있다. 본 논문에서는 웹 페이지를 이동 단말기에 최적화된 형태로 변환할 수 있는 웹 클리핑 방식의 새로운 이동 인터넷 컨텐츠 적응 방법을 소개한다. 이 방법에서는 컨텐츠 제공자가 클립 편집기를 이용하여 설정한 클립 명세에 따라 원본 웹 문서가 자동으로 클리핑 되고 변환된다. 클립 편집기는 컨텐츠 제공자가 단일 클립, 그룹 클립, 다중 레벨 클립, 동적 클립을 설정하고, 문서의 레이아웃을 수정할 수 있도록 한다. 이렇게 설정된 클립 명세에 따라 원본 문서로부터 추출된 각 클립들은 먼저 중간 언어 형태의 문서로 변환되고, 이는 다시 이동 단말기를 위한 최종 마크업 문서로 변환된다. 또한 다양한 이미지 타입에 대한 변환기능을 제공한다.

• 한국철도학회논문집
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• 제5권1호
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• pp.48-54
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• 2002

This research estimated decreased vibration level as quantitative according to change of track system on Seoul Subway Line No. 1 from existing ballasted track system(Pandrol type clip) to concrete track system(Youbgdan type isolation rubber clip). Following change to concrete system, vibration level at tunnel floor decreased between 4-8dB(V). Vibration equations suggested in this paper consider the velocity of train and can estimate quantitative vibration response. These are divided by ultimate limit state($\beta$=0), serviceability limit state($\beta$=1.28) and safety state($\beta$=3), respectively. The reliability index, $\beta$=0, means 50％ data line obtained by least squares best-fit line. The reliability index $\beta$=1.28 and 3 represent boundaries below 90％ and 99.9％ respectively.

• 한국초등수학교육학회지
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• 제18권2호
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• pp.357-377
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• 2014

본 연구는 클립형 콘텐츠를 활용한 수학 수업이 학업성취도 및 태도에 미치는 영향을 분석하는데 목적이 있다. 이를 위해 서울특별시 관악구에 소재한 S초등학교의 4학년 2개 반을 실험집단과 비교집단으로 나누어 실험 수업을 실시한 후 사전 사후 학업성취도 및 검사를 실시한 후 통계적으로 유의미한 변화가 있는지 살펴보았다. 또한 클립형 콘텐츠를 수학 수업에 적용하였을 때 학생들의 반응을 분석하기 위해서 질적 관찰을 실시하였다. 본 연구의 결과 클립형 콘텐츠를 활용한 수학 수업은 학업성취도에 긍정적인 영향을 주었다. 또한 클립형 콘텐츠를 활용한 수학 수업은 수학적 태도에도 긍정적인 영향을 주었는데, 특히 '교과에 대한 자아개념', '교과에 대한 태도' 영역에 긍정적인 영향을 주었다. 마지막으로 클립형 콘텐츠를 적용한 수학 수업에 대한 질적 관찰 결과, 클립형 콘텐츠를 활용한 수학 수업은 문제 해결력 향상, 수학적 의사소통 능력 신장, 수학 학습 동기 유발, 효과적인 발문 유도, 다양한 교육 내용 활용, 학습 공간의 확장에 긍정적인 영향을 주었다.

• Molecules and Cells
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• 제39권5호
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• pp.375-381
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• 2016

MicroRNAs (miRNAs) are small non-coding RNAs (~22 nucleotides) regulating gene expression at the post-transcriptional level. By directing the RNA-induced silencing complex (RISC) to bind specific target mRNAs, miRNA can repress target genes and affect various biological phenotypes. Functional miRNA target recognition is known to majorly attribute specificity to consecutive pairing with seed region (position 2-8) of miRNA. Recent advances in a transcriptome-wide method of mapping miRNA binding sites (Ago HITS-CLIP) elucidated that a large portion of miRNA-target interactions in vivo are mediated not only through the canonical "seed sites" but also via non-canonical sites (~15-80%), setting the stage to expand and determine their properties. Here we focus on recent findings from transcriptome-wide non-canonical miRNA-target interactions, specifically regarding "nucleation bulges" and "seed-like motifs". We also discuss insights from Ago HITS-CLIP data alongside structural and biochemical studies, which highlight putative mechanisms of miRNA target recognition, and the biological significance of these non-canonical sites mediating marginal repression.

• Structural Engineering and Mechanics
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• 제58권1호
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• pp.121-142
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• 2016

The national standard being used in Turkey for suspended ceiling systems (SCS) regulates material and dimensional properties but does not contain regulations regarding installation instructions which cause substandard applications of SCSs in practice. The lack of installation instructions would potentially affect the dynamic performance of these systems. Also, the vast majority of these systems are manufactured using substandard low-quality materials, and this will inevitably increase SCS related damages during earthquakes. The experimental work presented here focuses on the issue of dynamic performance of SCSs with different types of carrier systems (lay-on and clip-in systems), different weight conditions, and material-workmanship qualities. Moreover, the effects of auxiliary fastening elements, so called seismic perimeter clips, in improving the dynamic performance of SCSs were experimentally investigated. Results show that clip-in ceiling system performs better than lay-on system regardless of material and workmanship qualities. On the other hand, the quality aspect becomes the most important parameter in affecting the dynamic performance of lay-on type systems as opposed to tile weights and usage of perimeter clips. When high quality system is used, tile weight does not change the performance of lay-on system, however in poor quality system, tile weight becomes an important factor where heavier tiles considerably decrease the performance level. Perimeter clips marginally increase the dynamic performance of lay-on ceiling system, but it has no effect on the clip-in ceiling system under the shaking levels considered.