• 한국응용약물학회:학술대회논문집
• /
• 한국응용약물학회 2003년도 Annual Meeting of KSAP : International Symposium on Pharmaceutical and Biomedical Sciences on Obesity
• /
• pp.29-34
• /
• 2003

Visceral fat accumulation is known to be an evident clinical index for the insulin resistance related with obesity. Patients with excessive accumulation of visceral fat frequently suffered from metabolic disorder, such as hyperlipidemia, hypertension, and glucose intolerance. However, molecular mechanism for the pathogenesis of obesity-accompanied metabolic disorders has not been fully elucidated. It has been clarified that adipocytes in visceral fat area have different functions from subcutaneous fat area, and these differences might contribute the pathological significance of excessive accumulation of visceral fat for the accompanied insulin resistance and hyperinsulinemia.

• Journal of Ginseng Research
• /
• 제7권2호
• /
• pp.125-132
• /
• 1983

It was attempted in the present study to determind the effect of Korean ginseng on acute viral(B type) hepatitis by double blind test clinically and the results were as follows. 1. The double blind test of 4 week period showed no statistical significance of the effect of ginseng on the disease. 2. The double blind test of 2 week period, however, showed a significant effect in such clinical symptoms as appetite, stomach ache, headache, chillness dizziness, nausea and vomitting, stool habit change and jaundice. Improvement of the blood serum level of transaminases, bilirubin. alkaline phosphatase and cholesterol Chillness feeding period was observed.

• 한국수의병리학회:학술대회논문집
• /
• 한국수의병리학회 2003년도 추계학술대회초록집
• /
• pp.35-38
• /
• 2003

The parathyroid gland is probably the simplest endocrine organ in the body. The only cells of clinical significance are the parathyroid or chief cells. The primary signal that these cells listen to is calcium. Primary hyperparathyroidism is due to a parathyroid adenoma. The most common cause of hypercalcemia in veterinary medicine is hypercalcemia of malignancy associated with variety of neoplasms. Secondary hyperparathyroidism is due to a disease process, most commonly associated with renal and nutritional hyperparathyroidism. Primary and secondary hyperparathyroidism are markedly different in their clinical, laboratory, and pathogenic mechanism.

• 의료법학
• /
• 제22권4호
• /
• pp.159-184
• /
• 2021

첨단재생바이오법의 제정 의의는 본질적으로 '이식'이라는 의료행위인 재생의료를 약사법 규제에서 벗어나 의료기술적 접근으로 환자치료기회를 확대하는 데 있다. 그러나, 법이 시행된 지 1년여가 지난 상황에서 식약처가 승인하는 고위험연구는 1건도 승인되지 않고 있는 등 임상연구가 활성화되지 않고 있다. 그 이유는 환자치료기회 확대를 위한 법률 취지에도 불구하고 법률적 근거가 미흡함에도 임상연구 승인을 위한 자료요건을 의약품 개발과 연결하여 정하고 있어 많은 연구자들이 자료요건을 맞추기가 어려운 실정이다. 법 제정 이전 약사법 체계 내의 세포치료제 임상연구를 위한 제출자료는 품질 및 비임상시험 자료가 상당히 면제되었지만, 첨단재생바이오법이 시행되면서 임상연구 계획 승인신청 시 품질 및 비임상시험자료를 의약품에 준해 요구하고 있다. 이를 바로잡으려면 치료기회 확대를 위한 첨단재생의료 임상연구의 정체성을 고려할 때 의약품 개발과 연결하는 데는 제한점이 있음을 인식하고 첨단재생의료 임상연구의 정체성을 지키고, 한편으로 품목허가 시 임상연구 결과를 활용할 수 있도록 하면서 활용요건을 구체화하여 시장의 힘으로, 임상연구자의 자발적인 동기로 임상연구 승인을 위한 기본요건보다 필요한 자료를 스스로 준비할 수 있도록 해야 한다.

• 기본간호학회지
• /
• 제16권4호
• /
• pp.459-471
• /
• 2009

Introduction: Critical thinking involves identifying problem(s), assessing resources, and generating possible solutions and allows clinical nurses to decide which solution is the most reasonable under the given circumstances, taking into consideration the "hat ifs" and how they will affect the end result. This research was conducted to further understanding and identification of subjective factors in critical thinking in clinical nurses. Methods: The research design was a Q-Methodological Approach. Q-population was formulated from a non-structured questionnaire and interviews from 17 experienced clinical nurses. Thirty selected Q-statements were sorted by 30 experienced clinical nurses. Results: Four factors for critical thinking were identified: (1) Deductive reasoning based on causal relation, (2) Construction of an effective model based on patients' responses, (3) Formulating categories based on priorities for effective interventions, and (4) Judging validity of the situational significance on clinical performances. Conclusion: Critical thinking is an attitude and reasoning process. From this study, the frame of reference for clinical nurses in formulating critical thinking within the context of clinical settings is identified and indicates the way nurses utilize thinking skills when they care for patients and areas that need further exploration as nurses and faculty develop education systems to advance clinical performance competency.

• 성인간호학회지
• /
• 제23권1호
• /
• pp.1-9
• /
• 2011

Purpose: To evaluate undergraduate nursing students' ability in clinical competence, critical thinking, and problem solving following enrollment in a clinical reasoning course. Methods: A clinical reasoning course utilizing a human patient simulator and scenarios was offered to 22 senior students at a College of Nursing in Seoul. Students' clinical competence was measured with a checklist of 15 items by analyzing students' performance recorded on video tapes for eight scenarios. Critical thinking disposition and problem solving were measured by a self-administered questionnaire before and after the course. Data were analyzed using descriptive statistics and Wilcoxon signed-rank test. Results: The high scored items of clinical competence were: 'obtain relevant subjective/objective data', 'interpret vital signs', 'communicate with healthcare providers', and 'utilize standard precautions including handwashing.' Students' critical thinking and problem solving scores following the course were increased with statistical significance. Conclusion: A clinical reasoning course utilizing a human patient simulator creates a realistic clinical environment for nursing students and provides the opportunity to obtain clinical competence, critical thinking, and problem solving skills.

• 동서간호학연구지
• /
• 제20권2호
• /
• pp.129-135
• /
• 2014

Purpose: The purpose of this study was to identify changes in image of nurses of nursing students before and after their first clinical practice. Methods: The survey was performed to 60 nursing students in one university in Goseong-gun, Gangwon-do. All participants had their first clinical practice for 8 weeks at four general hospitals in Seoul. The data were collected by questionnaires and were analyzed with frequency, independent t-test, one-way ANOVA using SPSS 19.0. Results: After the first clinical practice, the mean score ($4.05{\pm}0.85$) of the image of nurse was slightly higher than that of the image ($4.03{\pm}0.93$) before the clinical practice. However, there was no statistical significance in the scores between before and after the clinical practice (t=-0.55, p=.589). In four subcategories, before the first clinical practice, professional image was the highest followed by traditional, personal, and social image in order but after the clinical practice, professional image was the highest followed by traditional, social, and personal image in the mean scores of the image of nurse. Conclusion: The findings of the study may be a basis for expanding nursing practice and education related to image of nurse.

• 대한치과기공학회지
• /
• 제29권2호
• /
• pp.65-77
• /
• 2007

This study is for the purpose of studying the validity of the construction of items and grading of the evaluation table at clinical practice used as the method of evaluation when clinical practice of Dept. of Dental Technology. 205 dental technicians in 4 cities were questioned to analyze the relation between items of the evaluation table at clinical practice and its grading. The collected materials were inspected by SAS V8 for Windows. The results are as follows: 1. Making up all the items and grading seem to be appropriate because they had the marks more than midium(more than 3.28). 2. Making up detailed items and grading seem to be trusted because they had the marks more than 3.30. 3.The significance level of the relation between items of the evaluation at clinical practice and its grading by t-inspection is p<0.0001 and so it appears to be meaningful. 4. It proved to be meaningful in result of regression analysis of the influence on the construction of the evaluation at clinical practice and its grading. With this result, further study is needed for the better methods of the evaluation in its adjustment and graduated grading among the items.

• 동의신경정신과학회지
• /
• 제19권2호
• /
• pp.195-207
• /
• 2008

Objective: The purpose of this study was to compare satisfaction of practice and clinical skill in different participation learning and observation learning, and to offer the basic data to promote quality of nursing education. Method: The study used a quasi-experimental, nonequivalent control group post-test design. The subjects were 62 nursing students of K college in Jeonbuk, and the period of data gathering was limited from 19 Nov. 2006 to 30 Nov. 2006. Experience group was taught by hand-on education and control group was taught by conventional education. The instrument tools included self-efficacy, satisfaction of practice and clinical skill. The collected data were analyzed by SPSS-PC programme. Result: The results of this study were as follows: There was statistically a significance difference between the two group about satisfaction of practice(t=2.011 p=.043), and clinical skill(t=11.997, p=.000). Self-efficacy showed a significantly positive correlation with satisfaction of practice(r=.476, p=.000) and clinical skill(r=.178, p=.014). Also, satisfaction of practice showed a significantly positive correlation with clinical skill(r=.l82, p=.000). Conclusion: In conclusion, this study suggests that hand-on education is an effective learning method to nursing students. By utilizing hand-on education, makes nursing students plan self-directed nursing performance and improve their clinical skills.

• 대한심미치과학회지
• /
• 제12권2호
• /
• pp.31-38
• /
• 2003

Amelogenesis imperfecta patients suffered common clinical problems of poor esthetics, teeth sensitivity, and loss of occlusal vertical dimension. Amelogenesis imperfecta is a group of inherited disorders primarily affecting dental enamel. Variants of amelogenesis imperfecta generally classified hypoplastic, hypocalcified, or hypomaturation types based on the primary enamel defects. The mildest problems were found in the pitted hypoplastic type whereas the most severe problems were encountered in the hypocalcified type amelogenesis imperfecta. Management stragies include composite resin veneer and jacket crowns for anterior teeth as well as steel crowns for posterior teeth. Knowledge of the clinical features and dental complications of each variants if amelogenesis impecta helps in the diagnosis of the condition and allows institution of early preventive measures. The objective of this paper is to provide a review of the current concepts of the wide spectrum of etiological factors involved in the pathogenesis of this significance clinical entity in the primary dentition.