• Title/Summary/Keyword: Clinical investigation

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A study on the practical measures of the corporate crime investigation -Focusing on white color crime-

  • Nam, SeonMo
    • International Journal of Advanced Culture Technology
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    • v.8 no.2
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    • pp.96-100
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    • 2020
  • In this paper, I try to help the business operation so that they could continue the desirable operation despite the unfavorable conditions. It is important to reinforce for corporate growth various support measures to generate profits. However, if they are involved in criminal activities such as slush fund creation, they will have to deal with them separately. As a result, To raise awareness helps to keep the company running. Recently, the companies are in a poor condition due to overseas migration. If a company does not create profits by doing business, it is a burden to continue operating and it will eventually be hard to support and destroy. The corporate crime and white-collar crime are mostly similar types, mainly because they occur in the industry. The corporate crime proceeds throughout the company and ultimately translates into corporate profits. The white-collar crime, on the other hand, is a profitable part of the individual. In the process of generating profits, the purpose and management method of slush funds is an important issue in judging whether illegal immorality of business is intended or not. In addition, in the case of the corporate crime, it seems necessary to identify the types of slush fund raising activities in addition to the investigations of the accomplices and clinical investigations, and to apply efficient investigation methods on a case-by-case basis. At present, many companies frequently migrate overseas due to the influence of domestic regulations. In this process, if it is involved in crime such as a borrowing accounts or the purpose of slush fund creation should be treated separately.

The Bioequivalence of Plunazol Tablet (Fluconazole 150 mg) to Three capsules of Diflucan 50 mg (디푸루칸 캡슐 50 mg (3 캡슐, 플루코나졸 150mg)에 대한 푸루나졸 정 150mg의 생물학적 동등성)

  • Chang, Hee-Chul;Lee, Min-Suk;Ryu, Chong-Hyon;Lyu, Seung-Hyo;Cho, Sang-Heon;Choi, Yeon-Jin;Hwang, Ae-Kyung;Kim, Yun-Ah;Park, Si-Hyun;Yoon, Ji-Won;Bae, Kyun-Seop
    • Journal of Pharmaceutical Investigation
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    • v.39 no.3
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    • pp.207-216
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    • 2009
  • Fluconazole is used as an orally administrated antifungal drug for the treatment of tinea corporis, candidiasis including skin mycotic pneumonia infections. The dosage of fluconazole varies with indication ranging from 50 mg/day to 400 mg/day. The fluconazole capsule 50 mg (3 capsules daily) is already available in Korean market. To improve the patient compliance, a fluconazole tablet 150 mg (once a day administration) was developed recently. The purpose of this study was to evaluate the bioequivalence of three doses of fluconazole capsule 50 mg (Diflucan 50 mg, Pfizer Korea Inc., as a reference drug) and a single dose of fluconazole tablet 150 mg (Plunazol 150 mg, Daewoong Pharm. Co., Korea) according to the guidelines of the Korea Food and Drug Administration (KFDA). The bioequivalence for three capsules of Diflucan 50 mg and a single tablet of Plunazol 150 mg was investigated in twenty-four healthy male volunteers under a randomized 2${\times}$2 crossover trial design. The average age of twenty-four volunteers was 24.78${\pm}$3.27 year-old, average height was 175.56${\pm}$5.45 cm and average weight was 67.24${\pm}$6.86 kg. After three capsules of Diflucan 50 mg or a single tablet of Plunazol 150 mg were orally administered, blood was taken at predetermined time intervals and the plasma concentrations of fluconazole in plasma were determined using LC-MS-MS. The 90% confidence intervals for the main parameters of statistical results after logarithmic transformation were AUCt 0.9272-1.0084 and Cmax 0.8423-0.9544 respectively, which are in the range of log 0.8 to log 1.25 and the statistical results of additional parameters (AUClast, t1/2 and MRT) were also in the 90% confidence interval that is in the range of log 0.8 to log 1.25. Therefore, the results of this study confirm the bioequivalence of three capsules of Diflucan 50 mg to one tablet of Plunazol 150 mg.

A Study of Perception and Practice on Family Nursing of Clinical Nurse (임상간호사의 가족간호에 대한 인식 및 수행정도에 관한 연구)

  • Oh, Moon-Sook
    • Journal of Korean Academy of Nursing Administration
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    • v.4 no.2
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    • pp.439-455
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    • 1998
  • This is the descriptive investigation study intended to provide basic informations to develop concrete method of nurse arbitration which can improve the quality of nursing care on family by investigating and analyzing the perception and practice on family nursing of clinical nurse. 332 nurses working in 4 university hospitals in Seoul have been the object and the collection of data have been conducted by visiting cooperated by the department of nursing in university hospital from April 4th through April 17th 1998. The measuring instrument of the perception and the practice on family nursing which was written by the researcher was used based on the family nursing arbitration by recently amending Calgary Family Arbitration of the Model of Wright & Leahey. Cronbach's a value of this instrument was .9288 in the perception and .9168 in the practice the collected data have been analyzed by frequency percentage, averaged value. t-test, F-test(ANOVA), Duncan's Multiple Range, Pearson's Correlation Coefficient, and the results are as the follows: 1. The perception on patient's family nursing of clinical nurse showed comparatively high by 3.22 in average(maximum 3.52, minimum 2.82) on the basis of 4 point but the practice showed low by average 2.47(maximum 3.02, minimum 2.11), By providing the patients and their family with "The information about the health problem of the which is the role of giving explanation and information about the disease. the nurse presents the method of their helping patient and in case that the family lack of knowledge about the health problem and crisis of the patient which is the role of education about the method of solving the crisis and change. the nurse educates about the necessity and method of taking care of the crisis and the changes. The third question that the relation of recognizing the difficuly of family and cooperating with them in supporting the patient for mutual function is to be formed showed high in the degree of perception and practice of the necessity. 2. General characteristics of perception about patient's family nursing of the object showed no significant difference except the concerns about the family usually(F=5.472. p<.001) and general characteristics which showed significant difference in the degree of practice were educational background (F=3.177, p<.05), clinical experience (F=2.462, p<.05) and position(F=7.029. p<.001), and attention about patient's family(F=10.603, p<.001), 3. The relation between perception and practice about the nursing on patient's family showed pure correlation but the degree was very low(r=.188, p<.05). The above results showed that the clinical nurses has been high understanding about the necessity of patient's family nursing but the degree of practice has been very low due to the lack of education about the family nursing, having no ways of nurse arbitration for practical duty and lack of political administrative support. Therefore concrete and systematic family situation and arbitration method to be applied clinically are required to be developed and also the education about patient's family nursing and the development of the course for clinical practice are required and political and administrative support for clinical practice about patient's family nursing is required as well.

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An Investigation on the Effects of Wet Cupping on Wisu (BL21) for Non-acute Low Back Pain: A Pilot Randomized Controlled Trial (비급성 요통에 대한 위수혈 자락관법의 효과 탐색: 예비 무작위 대조군 시험)

  • Kim, Hyungsuk;Cho, Jae-Heung;Kim, Koh-Woon;Chung, Won-Seok;Park, Jae-Hyun;Shin, Woo-Chul;Chung, Seok-Hee
    • Journal of Korean Medicine Rehabilitation
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    • v.28 no.4
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    • pp.21-32
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    • 2018
  • Objectives This study was designed to investigate the effects of wet cupping on Wisu (BL12) in non-acute low back pain patients. Methods We recruited 30 participants for this study. Fifteen patients were randomly assigned to the Wisu (BL21) treatment group (WT group) and 15 were assigned to the non-acupoint treatment group (NT group). Both groups were treated with the pricking-cupping bloodletting method three times. Values at baseline and follow-up were analyzed by Wilcoxon signed rank test and the differences between the two groups were determined by Wilcoxon rank sum test. p-values less than 0.05 were considered significant. The primary outcome was the visual analogue scale (VAS), and secondary outcomes were the Oswestry disability index (ODI), Rolland-Morris disability questionnaire (RMDQ), Euroqol-5 dimension questionnaire (EQ-5D) and finger-to-ground distance (FTGD). These outcomes were measured on the day of first treatment before the procedure and on follow-up 7 days after the last treatment. Results Significant changes were identified in the VAS for pain and ODI in each group after wet cupping treatment on Wisu (p<0.05). However, no significant changes were found between groups. Meanwhile, RMDQ and EQ-5D were significantly decreased only in the NT group (p<0.05) without any differences between groups. FTGD was decreased in both groups, but not significantly. Conclusions Wet cupping with both Wisu treatment and non-acupoint had significant effects on non-acute low back pain, although there were no differences between the two groups. A large-scale study is needed to identify the effect of wet cupping on Wisu.

A Clinical and Mycological Investigation on Tinea versicolor (전풍(?風)의 임상적(臨床的) 및 균학적(菌學的) 연구(硏究))

  • Kim, Hong-Sik;Suh, Myung-Soo
    • The Korean Journal of Mycology
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    • v.9 no.4
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    • pp.199-207
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    • 1981
  • This investigation was undertaken to establish more accurately the clinical features of the desease as seen in Korea, and to investigate susceptibility factors and to study the ecology of P. orbiculare in this condition. All of 50 new patients with Tinea versicolor attending the Ewha University Hospital, during a period of 6 months were studied personally. 1. Clinical feature: The sex ratio of the whole series was 32 males to 18 females. Twenty of 50 patients (40%) were between the age of 20 to 29 years. The duration of disease was more than 4 months in 37 of 50 patients (74%). The cases of first onset in June, July and August were 33 of 50 patients (66%). Whereas, the developed in December, January and February were only 3 of 50 patients (6%). Seasonal fluctuation was remarkable in 16 of 25 patients (66.7%) who had the duration of more than 1 year. The course of disease was rapid in 33 of 50 patients (66%) and slow in 9 of 50 patients (18%). Thirty-three of 50 patients (66%) had not any subjective symptoms. Thirteen patients (26%) had mild itching sensation and 4 patients (8%) had severe itching. The frequency of the first affected were neck (27.4%), axilla (19.2%) anterior chest (15.0%) and groin (11.0%). 7) Hyperpigmented lesions were observed in 35 of 50 patients (70%) and hypopigmented lesions were observed in 11 of 50 patients (22%). Skin lesions were noticed mainly in the anterior chest, neck, back and axilla, and more severe in the anterior chest, back and abdomen than other areas. Tinea versicolor was particularly prevalent in those persons who had occupations of mental work and who perspired every day or every 2 or 3 days. A positive family history of Tinea versicolor was obtained in 7 of 50 patients (14%). Fourteen of 50 patients (28%) had association with superficial fungal infections. 2. Mycological features: Typical appearance of M. furfur was observed in all scrapings from 25 lesions and only 3 scrapings from 20 clinically skin of the patients. P. orbiculare was seen on direct examination of scrapings from 24 of 25 skin lesions, from 19 of 20. clinically normal skin of patients and from 18 of 29 control normal skin. The quantity of P. orbiculare was greater in skin lesions and clinically normal skin area than in control normal skin surfaces.

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A Statistical Study on the Contents of Theses of Oriental Medicine (한의학(韓醫學) 학위논문(學位論文)의 내용(內容)에 대(對)한 조사연구(調査硏究))

  • Park, Jong-Woon;Park, Chan-Guk
    • Journal of Korean Medical classics
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    • v.7
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    • pp.161-197
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    • 1994
  • I hereby have gained the following results by investigation and classification according to the contents of Masterial theses of 1015 volumes and Doctorial theses of 288 volumes, which have collected at their central libriaries, of theses which have published, until 1991, at Oriental Medical College of Kyunghee Univ., Kyungsan Univ., Dongguk Univ. and Taejon Univ. 1. The laboratory theses are more plentiful in number than those of literatural or clinical ones, especially more outstanding trends in the case of doctors. 2. In clinical theses, clinical obserbation was high frequnt in master and accupunture in doctor. 3. In laboratory theses, the usage of pharmacy was more frequnt than that of accupuntures or moxibutions. 4. In laboratory theses, it was more plentiful the case of being taken ill before experiment. 5. In experimental method, the drugs were more used complexed or complexed extract, in the case of accupunture, the methods were more adopted by general accup. and aqureaccupunture. 6. In laboritory theses, theses was abundant of no description of normal, control and laboratory groop. 7. It was the great number wi thin a day in the laboratory terms, the rats were most adopted as the objects of lab., in the number of lab method, doctor's was more plentiful than master's. 8. In literatural theses, there was expressed high frequnt trends of study of china, in era, Chosun dynasty in korea and Jin-Han in china. 9. The theory and books were mainly adopted as objects of theses study in the field of literature. 10. In another theses, there was many investigation of contents and drug and sign of illness were main object of study. 11. Laboratory theses had totally more reference and quotation than those of other theses. According to the above results, the number of laboratory theses are superior than clincal and literature theses, other study or statistical theses. But unfortunately they were not enough the transmission of meaning of theses and contribution of learning, beacuse how to do theses was not uni form and description was not evident. So afterward I think it is needed more careful attention and study in the method of theses works.

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Clinical investigation studies on 10 cases of patient with Bell' palsy using Trigger point treatment (Trigger point를 이용(利用)한 구안와사 환자(患者) 10례(例)에 대한 임상적(臨床的) 고찰(考察))

  • Jung, Young-don;Lee, Jun-gu;Kim, Young-il;Park, Tae-gyun;Shin, Young-il;Hwang, Jae-yeon;Lee, Hyen;Lee, Byung-ryul
    • Journal of Haehwa Medicine
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    • v.10 no.2
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    • pp.155-165
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    • 2002
  • From July 1th 2001 to October 31th 2001, the Clinical investigation studies were carried out 10 cases of patient with Bell' palsy using Trigger point treatment group, who had been treated in Han-seung Oriental Medical Clinic. The results were like below: 1. The distribution of sex : Male were 4cases. female were 6case and the female to male ratio was 1.5 : 1. 2. The distribution of contributing factor : Unknown reason was most predominant 4 cases, and then were revealed to labor too hard. mental stress(3 cases), trauma common cold(1 case) in turn. 3. The distribution of perid to fall ill : Under a week was the most number 6cases, and then were revealed a week under two weeks(3 cases), over two weeks(1 case) in turn. 4. About period of treatment : The Trigger Point treatment group is shorter than the Acupuncture treatment group. 5. The distribution of grade on admission in descending order : Gr I was the most number and then GrII, GrIII in turn. 6. The distribution of clinical symptoms on admission : Mastoid pain was the most number 9 cases and then lacrimal gland disorder 8 cases, dysgeusia 4cases, hyperacusis 2 cases, the others 2 cases in turn. 7. About effect of treatment : The Trigger point treatment group is more excellent than the Acupuncture treatment group. 8. The more patient age is young, the more effect of treatment was excellent, had nothing to do with both groups. 9. The more perid to fall ill is short, the more effect of treatment was excellent. had nothing to do with both groups. 10. About period of improved frontal belly : The Trigger point treatment group is more excellent than the Acupuncture treatment group.

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A Study on the Perception and Attitude of Korean Medical Students toward Career Choice as a Korean Medicine Doctor (1개 한의대 학생의 진로선택에 대한 인식과 태도 조사)

  • Kim, Ji-Young;Lee, Jae-Hyok
    • Journal of Society of Preventive Korean Medicine
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    • v.19 no.1
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    • pp.1-10
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    • 2015
  • Objective : The purpose of this research is to investigate the perception and attitude of Korean medical students toward career choice as a Korean medicine doctor. Method : The subject were 89 Korean medical students. Question investigation was applied. The questionnaire in this study contained 20 questions to investigate the perception toward career choice as a Korean medicine doctor. Results : Korean medical students showed higher interest in clinical practice, most of students(80.9%) answered they have planning for life's work as practicing Korean medicine doctor. First ranking as career they want is the pay doctor(36.2%), second is the intern(27.0%) as Korean medicine doctor within one year. The average age of students who answered that they hope to be intern is lower than who did not. Female students who hope to be intern preferred internal medicine, gynecology and pediatrics. But male students who hope to be intern preferred department of acupuncture & moxibustion, ophthalmology, otolaryngology & dermatology and rehabilitation. Conclusion : The result suggests that Korean medical students have an affirmative perception toward clinical doctor, but they are not interested in the other career.

A Study on the Factors Affecting the Length of Hospital Stay in Teaching Hospitals (수련병원의 평균재원일수에 영향을 주는 요인에 관한 연구)

  • Seo, Sun Won;Park, Eal Whan
    • Quality Improvement in Health Care
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    • v.1 no.2
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    • pp.34-43
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    • 1994
  • Background: The average hospital stay in most Korean teaching hospitals is longer than that of hospitals in developed countries. The investigation of average hospital stay of teaching hospitals is considered as an important measure to evaluate the effectiveness of hospital management. In this article authors analyzed the relationship of several variables (hospital ownership, number of beds, location of hospitals, number of physician) to length of hospital stay in each clinical department. Methods: The average hospital stay of each clinical department of 184 teaching hospitals was investigated. Authors reviewed the papers of teaching hospitals, that was reported to the Korean Association of Hospitals. Results: The means of hospital stay day of hospitals were not significantly different according to the number of hospital beds and location of hospitals. Only the difference of hospital stay according to ownerships was significant. The length of stay was the highest in public hospitals and the lowest in juridical hospitals. Conclusions: The number of beds and location of hospitals were not associated with the average hospital stay. But ownerships affected the average hospital stay. The national or public hospitals had the longest length of hospital stay. Number of specialists and number of all physicians were closely related to the average hospital stay.

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Investigation of Clinical Research of Acupuncture Treatment on Urinary Incontinence in Medline (MEDLINE과 SCOPUS 검색을 통한 요실금에 대한 침구치료의 국외 연구 동향 분석)

  • Kim, Eun-Gyung;Hwang, Deok-Sang;Lee, Jin-Moo;Lee, Chang-Hoon;Jang, Jun-Bok;Lee, Kyung-Sub
    • The Journal of Korean Obstetrics and Gynecology
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    • v.26 no.2
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    • pp.166-177
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    • 2013
  • Purpose: The purpose of this study is to examine acupuncture and moxibustion treatment suggested on the papers of urinary incontinence(UI) in medicine journals and to establish the future direction. Methods: The papers which were associated with acupuncture and HG published between 1992 and 2012 in Medline and Scopus were searched. Results: 14 studies met the condition. They were 3 randomized controlled trials(RCTs) and 5 clinical studies. 8 studies revealed that acupuncture and moxibustion have efficacies in UI. Conclusions: From the paper research, acupuncture and moxibustion treatment seem to be effective on UI. However, due to the lack sufficient research of UI, it would be necessary to fulfill further study about the period of acupuncture and moxibustion treatment on UI and the selection of acupoint through well-designed study and establish standard of evidence of them.