• The Transactions of The Korean Institute of Electrical Engineers
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• v.57 no.6
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• pp.1058-1062
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• 2008

In clinical decision support system(CDSS), unlike rule-based expert method, appropriate data-driven machine learning method can easily provide the information of individual feature(clinical test) for disease classification. However, currently developed methods focus on the improvement of the classification accuracy for diagnosis. With the analysis of feature importance in classification, one may infer the novel clinical test sets which highly differentiate the specific diseases or disease states. In this background, we introduce a novel CDSS that integrate a classifier and feature selection module together. Random forest algorithm is applied for the classifier and the feature importance measure. The system selects the significant clinical tests discriminating the diseases by examining the classification error during backward elimination of the features. The superior performance of random forest algorithm in clinical classification was assessed against artificial neural network and decision tree algorithm by using breast cancer, diabetes and heart disease data in UCI Machine Learning Repository. The test with the same data sets shows that the proposed system can successfully select the significant clinical test set for each disease.

• Proceedings of the Korean Information Science Society Conference
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• 2003.04c
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• pp.175-177
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• 2003

This paper addresses a problem of classifying human breast cancer into its subtypes. A main ingredient in our approach is kernel machines such as support vector machine (SVM). kernel principal component analysis (KPCA). and kernel partial least squares (KPLS). In the task of breast cancer classification, we employ both SVM and KPLS and compare their results. In addition to this classification. we also analyze the patterns of clinical outcomes in the feature space. In order to visualize the clinical outcomes in low-dimensional space, both KPCA and KPLS are used. It turns out that these methods are useful to identify correlations between clinical outcomes and the nonlinearly protected expression profiles in low-dimensional feature space.

• Phonetics and Speech Sciences
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• v.2 no.4
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• pp.239-244
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• 2010

The purpose of this study is to investigate two phonological error patterns on coronal feature of children with functional articulation disorders and to compare them with those of general children. We tested 120 children with functional articulation disorders and 100 general children from 2~4 years of age with 'Assessment of Phonology & Articulation for Chidren(APAC)'. The results were as follows: (1) 37 disordered children substituted [+coronal] consonants for [-coronal] consonants (fronting of velars) and 9 disordered children substituted [-coronal] consonants for [+coronal] consonants (backing to velars). (2) Theses two phonological patterns were affected by the articulatory place of following phoneme. (3) The fronting pattern of children with articulation disorders was similar with that of general children, but their backing pattern was different with that of general children. These results show the clinical usefulness of coronal feature in phonological pattern analysis, the need of articulatory assessment with various phonetic context, and the importance of error contexts in clinical judgment.

• Journal of Sasang Constitutional Medicine
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• v.24 no.4
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• pp.17-27
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• 2012

Objectives : This study proposes developing Sasang Medical Diagnosis Program using Facial form for increase in Sasang Constitution Diagnosis objectivity and putting the Diagnosis Program into practical use. The author presents a review of extant research on Sasang constitution diagnosis utilizing facial feature analysis and suggests an agenda for further research. Methods : For this thesis, a collection of dissertations on the subject of 'Usage of facial form for constitution diagnosis' published until September of 2012 such as RISS4U, OASIS, KISTI, Korean TK were reviewed. The final 33 dissertations were classified into two categories, basic or clinical research and then analyzed. Results : 9 out of 33 dissertations were of basic research and 24 were of clinical research. 1) As result of review of references, a uniform tendency was found in facial form according to Sasang Constitution. 2) In the grade of practical use, facial element is repeatedly used and the facial element of important use has constitutional differences. 3) Standard faces per Sasang Constitution were derived as result of 2-dimensional research. 4) 3-dimensional research focused on improvement of accuracy and reliability of 3D-AFRA, and there has been an attempt to develop a prototype for identification. Conclusions : For practical use of facial feature in Sasang Constitution Diagnosis, 1) Standardization of diagnosis through establishing Sasang Medical Diagnosis clinical protocol must be preceded. After the standardization, practical purpose and direction of facial form in general may be decided. 2) Information on high quality facial form of constitutional and conditional patients must be collected to form extensive database. 3) Subdivided symptomatology, as well as Sasang Constitution must be considered for diagnosis in order for diagnosis technique to acquire clinical practicality.

• Speech Sciences
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• v.11 no.1
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• pp.65-72
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• 2004

The force of articulation is different between voiced and voiceless consonants in the binary opposition system. However, the Korean voiceless stop consonants have a triple opposition system: lenis, aspirated, and glottalized. The aim of this study is to find the primary distinctive feature between the force of articulation and the aspiration for the three different types of Korean stops. Two native speakers of the Seoul dialect participated to this study. The corpus was composed of less than eight syllabic words containing consonants in word-initial position and intervocalic position. Radiocinematography and Mingography were used to analyze the articulatory tension and acoustic characteristics. Korean stops have independent features of articulatory tension and aspiration, in which the indices are different according to position. However, in this system which does not have the opposition of sonority, the force of articulation is the primary distinctive feature and the feature of aspiration is subsidiary.

• Annals of Clinical Neurophysiology
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• v.3 no.1
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• pp.40-42
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• 2001

Anorexia nervosa(AN) is a disorder characterized by disturbance of body image, fear of gaining weight, severe weight loss and, in female, amenorrhea. Compared with normal persons, patients with AN have neuropathic symptoms more frequently. But electrophysiologic abnormalities have rarely been reported. We experienced a case with recurrent neuropathic symptoms after severe weight loss. Further evaluation revealed AN. Electrophysiologic study showed sensorimotor polyneuropathy and focal neuropathy with conduction block. As far as we know, this feature of neuropathy in AN has not been described. We describe unusual feature of neuropathy in our patient with literature review.

• Journal of Haehwa Medicine
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• v.24 no.1
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• pp.37-46
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• 2015

Objective : This study aimed to explore the clinical feature of patients with dyspepsia who were treated by an Oriental internal medicine. Methods : We analyzed 130 patients who visited an Korean Medicine Hospital for their dyspepsia-related symptoms, from March 1, 2014 until to February 28, 2015 Results : The sex composition was consisted of 31.5% man and 68.5% woman, and 85.6% of outpatient and 14.4% of inpatient. The 39.2% of patients showed chronic complain (>6 months), and the main causes included stress and fatigue for 46.2% and 31.5% respectively. The accompanied symptoms were mainly fatigue (40.0%), insomnia (36.9%), abnormal stool (34.6%), upper back pain (31.5%), and headache (28.5%). The improvement rate was 68.5% while other (31.5%) showed no change of dysplasia. Conclusion : This study created an important information of patients with dysplasia, which will be critically helpful for development of Korean Medicine-based therapeutics in the future.

• Korean Journal of Clinical Laboratory Science
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• v.42 no.3
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• pp.111-115
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• 2010

A 15-year-old female with primary amenorrhea and Tuner's syndrome feature was referred for a chromosome analysis. The karyotype of the patient was 45,X/46,X,der(Y) mosaicism under initial GTG-banding analysis. Fluorescence in situ hybridization (FISH) analysis with probe for CEP X probes and SRY probe (Vysis, Inc. Downers Grove, IL 60515, USA) was carried out. This probe is direct labeled with SpectrumOrange (SRY, Yp11.3) and is available as a single probe or mixed with the CEP X SpectrumGreen probe. SRY SpectrumOrange/CEP X SpectrumGreen hybridized to a specimen obtained from an two isodicentric Y chromosomes. The karyotype of the patient was ish Xcen(DXZ1x1)/Xcen(DXZ1x1), Yp11.3(SRYx2) by using FISH. This karyotype was considered a variant of Tuner syndrome with mixed gonadal dysgenesis (MGD), male pseudohermaphroitism (MPH) and apparently normal male.

• Journal of Korean Neurosurgical Society
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• v.66 no.3
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• pp.247-257
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• 2023

Recently, the survival of the high-risk population of preterm infants has steadily improved, and the severity of prematurity is a growing threat of gestational-age-related fatal conditions. Posthemorrhagic hydrocephalus (PHH) is the most common but serious neurological complication in premature infants, which can have life-threatening consequences during the acute phase in the neonatal period and life-long psychomotor and cognitive sequelae in their later life. Although neonatologists, pediatric neurologists, and pediatric neurosurgeons have investigated a diversified strategy for several decades, a consensus on the best management of PHH in premature infants still must be reached. Several approaches have tried to reduce the incidence of intraventricular hemorrhage (IVH) and mitigate the effect of IVH-related hydrocephalus. This paper reviews and discusses the clinical feature of PHH in premature infants, general/nonsurgical management of prematurity for IVH prevention, and posthemorrhagic management, and how and when to intervene.

• Journal of Periodontal and Implant Science
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• v.35 no.3
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• pp.761-776
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• 2005

The purpose of the present study was to examine the relationship between the form of the clinical crowns in the maxillary anterior segment and the clinical feature of gingiva such as morphological characteristics and the gingival thickness. Fifty periodontally healthy subjects were clinically examined regarding the probing depth, the thickness of the free gingiva, and the width of the keratinized gingiva. From study models of the maxillary anterior region, the width at cervical third(CW) and the length(CL) of the clinical crown, the papillary height, and the gingival angle of the 6 anterior teeth were measured. Each tooth was classified into 4 groups (longnarrow, NL; narrow, N; wide, W; short-wide, WS) according to CW/CL ratio and all the data were compared between groups NL and WS using independent t-test. Stepwise multiple regression analysis was performed for each tooth region with the gingival thickness at the level of sulcus bottom, the width of keratinized gingiva, and gingival angle as the dependent variables. As the results, the NL group of the upper anterior teeth displayed, higher papilla height, and narrower keratinized gingiva, more acute gingival angle resulting in pronounced "scalloped" contour of the gingival margin, compared to the WS group. There was no significant difference between groups NL and WS with respect to probing depth and the gingival thickness. The regression analyses demonstrated that the gingival thickness in central incisors was significantly associated to the mesio-distal width and bucco-lingual width of the crown, and labial probing depth. The width of keratinized gingiva was significantly associated with labial probing depth in central incisors and with proximal probing depth and gingival angle in lateral incisors, and with labial and proximal probing depth, and gingival angle in canines. The gingival angle was significantly associated with papillary height and CW/CL ratio and additionally with proximal probing depth in central incisors, with the width of keratinized gingiva in lateral incisors, and with labial probing depth and the width of keratinized gingiva in canines. These results indicate that the form of clinical crown in upper anterior region could influence the clinical feature of gingiva and the influencing factors might be different according to the tooth region.