• Korean Journal of Clinical Pharmacy
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• v.21 no.3
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• pp.228-236
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• 2011

배경: 약물로 인한 Clostridium difficile-associated diarrhea (CDAD)는 널리 알려져 있으며 우리나라에서 항생제와 프로톤 펌프 억제제 소모량을 고려할 때 질환 치료과정에서의 CDAD 발생빈도 및 CDAD 유발 이전에 투여한 약물의 사용빈도와 CDAD의 치료방법을 조사할 필요성이 있다. 방법: 경상대학교 병원에서 2011년 1월부터 6월까지의 입원환자를 대상으로 대변 독소 검사에 의해 CDAD로 판명된 환자의 성별, 연령분포, 질환명, 입원병동, 재발률을 조사하였으며 CDAD 판명이전에 투여한 약제 및 CDAD 판명후 치료약제를 조사하였다. 결과: 연구기간 동안 CDAD 대변 독소 검사 의뢰된 환자수는 1,500명이었으며 CDAD 양성은 111명(9.3%)이었고, 재발은 29명(26.1%)이었다. CDAD를 주소로 입원한 환자는 17명 (15.3%)이었고, 나머지는 입원기간 중에 발생하였다. CDAD 양성인 환자의 연령대는 60대에서 32.4% (36/111명) 이었고, 내과병동에서 34.2%를 나타내었고, 재발률은 외과계 병동에서 41.4%로 가장 높게 나타났다. CDAD 환자의 17% (19/111명)은 항암제 투여 동안 발생하였으며 CDAD 발생 전 사용약물로는 세팔로스포린계 항생제가 162회로 가장 빈번하게 사용 되었으며, 히스타민2 수용체길항제 107회, 스테로이드 82회, 비 스테로이드 항염제 79회, 프로톤 펌프 억제제 77회, 하제 59회, 항암제가 33회 처방되었다. CDAD 치료약제로는 8종의 약제가 241회 처방 되었으며 metronidazole이 99회로 가장 빈번하게 사용되었고, vancomycin이 37회로 나타났다. 결론: 입원환자에 있어서 CDAD양성은 특히 고령의 암환자가 많아 항암제 투여 시에는 CDAD 발생에 주의해야 할것으로 보인다. CDAD의 치료약제로는 metronidazole이 vancomycin 보다 많이 사용되는 것으로 나타났다.

• Clinical and Experimental Pediatrics
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• v.55 no.3
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• pp.77-82
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• 2012

Human astrovirus (HAstV) is a major cause of acute diarrhea among children, resulting in outbreaks of diarrhea and occasionally hospitalization. Improved surveillance and application of sensitive molecular diagnostics have further defined the impact of HAstV infections in children. These studies have shown that HAstV infections are clinically milder (diarrhea, vomiting, fever) than infections with other enteric agents. Among the 8 serotypes of HAstV identified, serotype 1 is the predominant strain worldwide. In addition to serotype 1, the detection rate of HAstV types 2 to 8 has increased by using newly developed assays. HAstV is less common compared with other major gastroenteritis viruses, including norovirus and rotavirus; however, it is a potentially important viral etiological agent with a significant role in acute gastroenteritis. A better understanding of the molecular epidemiology and characteristics of HAstV strains may be valuable to develop specific prevention strategies.

• Journal of Sasang Constitutional Medicine
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• v.24 no.2
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• pp.61-70
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• 2012

1. Objectives : The aim of this study was to report significant improvement of chronic diarrhea and hematochezia after treatment with Dojeokgangki-tang in a Soyangin Patient with Crohn's Disease. 2. Methods : The patient's subjective and objective symptoms were observed daily throughout the hospitalization period, and the Crohn's disease activity index(CDAI) was calculated to gauge the progress or lack of progress. 3. Results : The symptoms of diarrhea and hematochezia disappeared by the end of the hospitalization period without recurrence, and the CDAI score dropped from 92.5 to 47. 4. Conclusions : A patient with Crohn's disease, who was in the state of repetitive relapse and remission after long term clinical courses was treated with Dojeokgangki-tang in a short period and the the symptoms of diarrhea and hematochezia disappeared without recurrence. Then the patient could stop taking corticosteriods and taper off immune-suppressing drugs.

• Korean Journal of Veterinary Research
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• v.34 no.4
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• pp.805-813
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• 1994

Immunohistochemical study on the intestinal tissues obtained from the 21 pigs of the 14 terms in Korea in which the clinical and epidemiological features had indicated the possible outbreaks of porcine epidemic diarrhea(PED) was performed using the indirect immunofluorescence test and/or the immunoperoxidase method in order to detect PED viral antigens in the infected cells of the intestines, and histopathological features were described as well. By immunohistochemical analysis, PED viral antigens were detected in the epithelial cells covering the small intestinal villi and recognized slightly in the cells lining the colonic surface epithelium as well. Occasional fluorescence was also seen in a few intestinal crypt epithelium. On light microscopy, the piglets with PED showed marked villous atrophy and fusion, and severe enterocyte degeneration and desquamation. On the other hand, the older pigs more than 4 week old age was mild villous atrophy and fusion, severe villous epithelial cell proliferation, and moderate mononuclear cell infiltration.

• Journal of Sasang Constitutional Medicine
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• v.31 no.4
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• pp.65-73
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• 2019

Objectives The purpose of this case study is to investigate the effects of Kwakhyangjeonggi-san on Diarrhea after Chemotherapy in a 64-year-old male patient with glioblastoma. Methods A 64-year-old Korean male patient diagnosed with glioblastoma was treated with Kwakhyangjeonggi-san. The treatment was executed two times everyday from August 3rd to September 27th of 2019. Clinical improvement was evaluated with Bristol Stool Form Scale and the number of defecations per day. Results After the treatment, the patient showed improvement in Bristol Stool Form Scale type. The number of defecations per day did not improve much. Conclusion The results suggest that Kwakhyangjeonggi-san may be an effective additional treatment for diarrhea after chemotherapy in a patient with glioblastoma.

• Journal of Veterinary Clinics
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• v.24 no.4
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• pp.529-536
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• 2007

The purpose of this study was to elucidate the effect of Oldenlandiae herba and Houttuyniae cordata on calf diarrhea in farms. We examined the antibacterial and antiviral effect of Oldenlandiae herba and Houttuyniae cordata extracts in vitro. And we divided diarrheal calves into three roups in farm; Oldenlandiae herba administration group(10 calves), Oldenlandiae herba and Houttuyniae cordata administration group(10 calves) and control group(7 calves). We estimated the therapeutic effect of the calf diarrhea by using clinical signs, CBC, AST, BUN, creatinine, and measurement of lymphocyte distribution in whole blood. Oldenlandiae herba and Houttuyniae cordata extracts by ethanol(98%) had antibacterial and antiviral effect. In the condition of diarrhea, the fecal condition of Oldenlandiae herba and Houttuyniae cordata group was relieved more than that of others group during experimental period. PCV and fibrinogen concentrations were high in control group. AST and BUN were within normal range in all groups. Administration of Oldenlandiae herba and Houttuyniae cordata was not toxic to the liver and kidney. And Oldenlandiae herba and Houttuyniae cordata extracts also affected the lymphocytes distribution in blood. From these results, we suggested that administration of Oldenlandiae herba and Houttuyniae cordata should be effective on the dairy calf diarrhea in farms.

• Journal of Veterinary Clinics
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• v.27 no.6
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• pp.635-639
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• 2010

The prevalence of bovine viral diarrhea virus (BVDV) in Korean indigenous calves with diarrhea in Gyeongbuk province was investigated. Seventy-five cases were identified as BVDV positive in the diarrhea stools. Phylogenetic analysis revealed that all our cases were classified as BVDV-2a. Most of the present BVDV-2a cases were isolated from calves showing clinical signs of watery diarrhea. Our observations indicate that not all BVDV-2 infections cause clinically severe disease. This study shows the high incidence of BVDV-2 infection in Gyeongbuk province. Therefore, the results suggest that a vaccine development and immunization strategies are required for the effective control of BVDV infection in the Republic of Korea.

• Korean Journal of Veterinary Service
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• v.14 no.2
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• pp.159-174
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• 1991

A field trial of norfloxacin on bovine 206, swine 222 and poultry 205 with respiratory diseases and diarrhea was conducted from Sept 1, 1990 to Jan 30, 1991 in Inchon and Kyonggi-do. The results are as follows. 1. Guinea pigs and rabbits were dosages 10 and 20 times normal. Ten days of observation saw no side effect. 2. Oral treatment on bovine, swine and poultry showed a curing rate of 82.00∼89.06%(Mean 86.00%), compared with 87.27∼96.36%(Mean 92.24%) by Injection. 3. The curing rate was 81.92% by the fourth treatment. 4. The curing rate with and without the use of adjuvant was 80.00∼100% and 83.60∼93. 10%, respectively, for swine, and 81.82∼100% and 82.00∼97.14% for bovine. 5. The curing rate was more dependent on seriousness of illness, environment and time than age. 6. The main disease causing bacteria of bovine respiratory diseases： Haemolytic Sta 27.62%, Haemolytic Str 33.33%, sum of this bacteria is 60.95%, diarrhea: Haemolytic coliform 80.20%, swine respiratory diseases； Haemophilus Spp 20.95%, Haemolytic Sta 72%, Haemolytic Str 21.90%, Sum of these bacteria is 68.57％, diarrhea; Haemolytic coliform 57.26%, poultry respiratory diseases； mycoplasma Spp 29.52%, Haemolytic Sta 13.33％, Sum of this bacteria is 42.85%, diarrhea； Haemolytic coliform 53.00%. 7. The curing rate of norfloxacin by species of strain, the unidentified bacteria on bovine respiratory diseases was the lowest with 77.78％, the others ranged from 84.21％ to 100％ with most of them over 90%. 8. The loss of clinical sign on bovine and swine was the highest when after 2∼4 application. 9. In terms of antibiotic sensitivity test, norfloxacin was the highest with 84.62∼100％ (mean 90.09％) among eight bacterias, only 5 of 15 antibiotics had a sensitivity of over 56.25%, showing a high degree of tolerance.

• Korean Journal of Veterinary Service
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• v.45 no.4
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• pp.293-304
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• 2022

Among several diseases of calves, diarrhea is the most prevalent disease and has been a major cause of economic loss to the cattle industry. The main etiologic agents of diarrhea in calves are bacteria, viruses, and protozoa, but non-infectious factors including foreign bodies obstruction in the digestive system also focused as the cause of calf diarrhea in the recent days. Because there is still limited information for foreign body-related diarrhea in calves, especially in Hanwoo, the present retrospective study reviewed the medical records for diarrheic calves with foreign body in the digestive system (n=32). The morbidity was determined as 3.03% and more than half of them presented the acidosis, hyponatremia, and azotemia. The mortality in laparotomy-operated calves to remove foreign bodies or in non-operated ones was 28% or 85.7%, respectively, implied the importance of aggressive decision for laparotomy when the foreign bodies were determined in the digestive system in diarrheic calves. During laparotomy, trichobezoars (hair balls) and hays were the main foreign bodies and prevalently placed in the abomasum. In the trials to predict prognosis by several clinical factors, the time for laparotomy over 2 days after first diagnosis, acidosis, and foreign body in the abomasum were highly associated with mortality. Therefore, we believe that prompt surgical procedure (laparotomy) is necessary upon obstruction in the digestive system by foreign bodies is tentatively diagnosed in the diarrheic calf. In addition, when differential diagnosis list is made, foreign body-related diarrhea is necessary to be included in case of diarrheic calf.

• Journal of Veterinary Clinics
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• v.41 no.1
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• pp.30-36
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• 2024

A 3-year-old, 20.6 kg, neutered male German Shepherd dog was referred to Kyungpook National University Veterinary Medicine Teaching Hospital. Clinical examination revealed chronic diarrhea for 6 weeks and a non-tender, distended abdomen without lethargy, anorexia, and vomiting. Diarrhea was watery and had a waxing and waning course despite symptomatic treatment. A complete blood count identified mild leukocytosis and mild anemia. Serum biochemistry analysis showed elevated alanine aminotransferase and aspartate aminotransferase levels, and mild hypoalbuminemia. Abdominal ultrasound examination revealed mixed echogenicity with absent blood flow at the caudate process of the caudate liver lobe and a small amount of ascites. Computed tomography revealed torsion of the caudate process of the caudate liver lobe and spleen and gas dilatation of the intestine. After establishing a diagnosis of organ torsion on imaging, we deemed the condition an emergency and immediately performed surgery. Given that laparotomy confirmed organ torsion, liver lobectomy, total splenectomy, and prophylactic gastropexy were conducted. The patient was discharged 11 days after surgery without complications. In general, liver lobe torsion and splenic torsion are uncommon in dogs and present with nonspecific clinical signs, such as abdominal pain, lethargy, anorexia, and vomiting. In the current case, torsion of the caudate liver lobe and spleen occurred without other clinical signs except for a distended abdomen. Moreover, no reports in dogs have demonstrated the simultaneous occurrence of both diseases.