• 한국인터넷방송통신학회논문지
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• 제19권1호
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• pp.187-195
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• 2019

최근 빅데이터 관련 기술들이 발전함에 따라 다양한 분야에서 생성되는 데이터들을 수집하여 저장하고 처리 및 분석할 수 있게 되었다. 이러한 빅데이터 기술들을 임상 결과 분석에 활용하고, 임상시험 설계 최적화를 통해 보건의료분야에 투입되는 막대한 비용을 절감할 수 있을 것으로 전망된다. 따라서 본 논문에서는 임상 결과를 분석하여 임상시험 기간과 비용 등을 줄일 수 있는 가이드 정보를 제시하고자 한다. 먼저 Sqoop을 사용하여 임상 결과 데이터가 저장된 관계형 데이터 베이스로부터 HDFS에 수집하여 저장하고, 하둡을 기반으로 동작하는 처리 도구인 Hive를 이용하여 데이터를 처리한다. 공공분야, 기업 등 각 분야에서 많이 활용되고 있는 빅데이터 분석 도구인 R을 이용하여 연관성 분석을 한다.

• 고신대학교 의과대학 학술지
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• 제33권3호
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• pp.380-385
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• 2018

Objectives: Aminophylline has been used for prevention or treatment of apnea in preterm infants with idiopathic apnea of prematurity. The aim of this study was to assess the clinical usefulness of prophylactic in comparison with therapeutic aminophylline therapy. Methods: This retrospective observational study included infants born with a birth weight of < 2,500 g or at < 36 weeks of gestation. Infants born between August 2013 and July 2014 who received aminophylline therapy within 24 hr after birth were assigned to the prophylactic group, while infants born between August 2014 and July 2015 who received aminophylline therapy after obvious apnea were assigned to the therapeutic group. We compared clinical characteristics, including days of ventilator and oxygen therapy and bronchopulmonary dysplasia (BPD) between both groups. Results: Sixty-four patients and 25 infants were identified in the prophylactic and therapeutic groups, respectively. The mean gestational age and birth weight were $32.57{\pm}1.96weeks$ and $1765{\pm}205g$, respectively, in the prophylactic group and $32.46{\pm}1.82weeks$ and $1770{\pm}250g$, respectively, in the therapeutic group. No significant differences in clinical characteristics were found between the two groups. Similar clinical outcomes, including days of ventilator and oxygen therapy, intraventricular hemorrhage (IVH), periventricular leukomalacia, and BPD, were observed between the two groups. Conclusions: The present study showed that the prophylactic use of aminophylline does not improve the clinical outcomes, including BPD, IVH, and ventilator dependency as compared with therapeutic use. In other words, routine prophylactic use of aminophylline is unnecessary.

• 대한한방부인과학회지
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• 제36권2호
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• pp.36-54
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• 2023

Objectives: This study was aimed to develop a Korean Medicine (KM) clinical practice guideline (CPG) of Nausea and Vomiting of Pregnancy (NVP). Methods: We conducted a questionnaire survey targeting KM doctors belonging to the Association of Korean Medicine by e-mail. We received 1,023 responds, and analyzed the answers. Results: 1. 83.0% of respondents knew the concepts and contents of CPG, and 98.1% had practical use plan. 2. 82.1% of respondents used pattern identification diagnosis for NVP patients, and the most commonly diagnosed pattern was spleen-stomach weakness (脾胃虛弱) with 41.3%. 3. The most frequently used treatment for NVP patients was KM combined treatment (46.7%). Herbal medicine+acupuncture (46.8%) was most used among KM combined treatments, and herbal medicine (37.1%) was most used among KM single treatments. 4. Among the contents of CPG for NVP, the fields of interest were selected in the order of KM treatment, KM-Western medicine cooperative treatment, KM diagnosis, prevention and regimen management. In the 'diagnosis part', the use of the symptom evaluation scale questionnaire was 41.8%, higher than the KM pattern diagnosis (34.4%). In the 'treatment part', herbal medicine accounted for 33.8%, higher than that of acupuncture (including electro-acupuncture) at 23.7%. 5. As for the expected development effects, opinions on evidence-based, safety, clinical use, and standardization were the most common. Conclusions: We figured out KM doctors' recognition of KM clinical practice guideline, clinical diagnosis, treatment on NVP to make the contents of the CPG reflecting the clinical situation.

• 한국콘텐츠학회논문지
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• 제12권12호
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• pp.714-720
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• 2012

임상 연구에서 가장 중요한 것은 임상 자료를 정확하게 수집하는 것이다. 이를 위해, 최근 많은 제약회사들과 임상 연구기관에서는 전자 증례기록지(electronic Case Report Form, eCRF)를 도입하려고 노력하고 있다. eCRF는 임상연구에서 임상 자료를 수집하고 관리하기 위해 디자인된 컴퓨터 시스템이다. 하지만, 임상연구에서 eCRF의 중요성을 인식하고 있지만, eCRF 도입 초기에 많은 노력과 비용이 소요되기 때문에 널리 사용되고 있지는 못한다. 본 연구에서는 한의학연구원에서 임상연구를 위해 개발된 eCRF의 사용현황을 실증적 자료를 바탕으로 조사했다. 특히, eCRF에 자료를 입력하는데 걸리는 시간, 사용 시간, 쿼리 수 등을 시간적 흐름에 따른 변화에 중점을 두었다.

• 문화기술의 융합
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• 제4권4호
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• pp.387-392
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• 2018

새로운 의료기기 개발이나 신약 개발에 있어서 임상시험은 중요한 부분을 차지하고 있다. 하지만 임상시험을 진행하는데 시간과 비용이 많이 소요 된다. 이런 부분을 해결하기 위해서 해외 주요 국가들뿐만 아니라 우리나라에서도 임상시험에서 수집되는 데이터들의 표준 형식을 정의하고 있다. 한의학에서도 새로운 의료기기 개발을 위해서 임상시험을 진행하고 있다. 임상시험에서 수집하는 데이터들의 표준을 정의한다면 이를 활용할 수 있는 방법은 다양할 것으로 보인다. 다양한 임상시험 데이터를 하나의 표준화된 데이터로 수집 및 관리를 한다면 다양한 결과를 도출할 수 있을 것이다. 이런 내용을 바탕으로 임상시험 통합 데이터 수집 및 관리 체계를 구축하였다. 그리고 그 활용 방안에 대해서 모색하고자 한다.

• 한국간호교육학회지
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• 제25권3호
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• pp.378-387
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• 2019

Purpose: This article is a comprehensive review for concept clarification of critical thinking, clinical reasoning, and clinical judgment, which still lack a consensus and are of mixed use. Methods: Norris's method of concept clarification was used to review concepts that have no clear definition or conceptualization yet. Results: This review summarized literature from various disciplines, classified each concept based on similarities and differences, and provided hypothetic conceptual schema. Conclusion: Clinical reasoning and clinical judgment are clinical situation specific concepts, while critical thinking is a concept applied in general situations. Critical thinking is a broader concept and serves as a foundation for clinical reasoning and clinical judgment. Clinical reasoning precedes clinical judgment. Clinical judgement implies the end point or conclusion of clinical reasoning. Each of critical thinking, clinical reasoning, and clinical judgment is a cognitive and affective process not a psychomotor process. The concept of clinical competency involves action taken after the cognitive processes of clinical reasoning and clinical judgment.

• Clinical and Experimental Pediatrics
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• 제51권10호
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• pp.1042-1046
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• 2008

The fluoroquinolones are an important group of antibiotics widely used in the treatment of various infectious diseases in adults, as a result of an excellent spectrum of activity, good tissue penetration and convenient ways of administration. In recent decades, there has been extensive development, clinical investigation, licensure and use of fluoroquinolone antibiotics. However, the use of fluoroquinolones in children has been limited because of their potential to induce arthropathy in juvenile animals. Despite class label warnings against use in children, prescriptions for quinolone antibiotics to treat infections in children have become increasingly prevalent. The main use of fluoroquinolones in pediatrics should be, understandably, in serious life-threatening infections for which other antibiotics therapies are not effective or available. While most of the published studies failed to detect an increased rate of articular adverse effects in children treated with fluoroquinolones, an increase in the use of these compounds, particularly in community-acquired lower respiratory infections, could accelerate the emergence of multidrug-resistant (including fluoroquinolone) pneumococcal strains. This review will discus the main issues related to the use of fluoroquinolones in children, the major problems of resistance developing among these compounds, with special emphasis on the potential side effects and skilled use of these alternative potent drugs in pediatric infection.

• 생물정신의학
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• 제6권1호
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• pp.34-40
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• 1999

New antidepressants have become available for clinical use in the 1990s. Before this decade, the drugs available to treat depression consisted essentially of monoamine oxidase inhibitors, tricyclic antidepressants, and lithium. Following the introduction of SSRIs, the options have expanded and now include SSRIs, nefazodone, venlafaxine, mirtazapine, reboxetine, tianeptine. Newer antidepressants possess a variety of pharmacological characteristics that are relevant to the choice of an antidepressant for clinical use. This review summarizes some of the major pharmacological characteristics among the drugs.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.429.2-430
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• 2002

Complications of diabetes increase morbidity and motality and decrease quality of life. Recently. UKPDS has been reported that strict regulation of blood glucose. hypertension and hyperlipidemia could decrease complications of type 2 diabetes. This study evaluated use of hypoglycemic agents, control of blood glucose. frequency of complications and preventive management at a local 2ndary hospital in Korea. (omitted)

• Korean Journal of Acupuncture
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• 제28권4호
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• pp.113-118
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• 2011

Objectives : The purpose of this study is to review the principal of Sacred tortoise method (Younggupalbub) and to investigate the usefulness of it. Methods : The authors reviewed several literatures related with the Sacred tortoise method (Younggupalbub). We investigated the clinical usefulness as well found some problems in utilizing it. Results and Conclusions : Sacred tortoise method (Younggupalbub) is an acupuncture treatment used according to the time and it may cause many problems for the patients and oriental medical doctors in the clinical use.