고신대학교 의과대학 학술지 (Kosin Medical Journal)

  • 제33권3호
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  • Pages.380-385
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  • 2018
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  • 2005-9531(pISSN)
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  • 2586-7024(eISSN)
고신대학교 의과대학 (Kosin University College of Medicine)
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Comparative observational study of aminophylline with prophylactic and therapeutic uses for clinical outcomes in preterm infants

  • Bae, Mi Hye (Department of Pediatrics, Pusan National University Hospital) ;
  • Lee, Na Rae (Department of Pediatrics, Pusan National University Hospital) ;
  • Han, Young Mi (Department of Pediatrics, Pusan National University Hospital) ;
  • Byun, Shin Yun (Department of Pediatrics, Pusan National University Hospital) ;
  • Park, Kyung Hee (Department of Pediatrics, Pusan National University Hospital)
  • Received : 2018.03.27
  • Accepted : 2018.05.30
  • Published : 2018.12.31
⟨ 이전 논문 다음 논문 ⟩

Abstract

Objectives: Aminophylline has been used for prevention or treatment of apnea in preterm infants with idiopathic apnea of prematurity. The aim of this study was to assess the clinical usefulness of prophylactic in comparison with therapeutic aminophylline therapy. Methods: This retrospective observational study included infants born with a birth weight of < 2,500 g or at < 36 weeks of gestation. Infants born between August 2013 and July 2014 who received aminophylline therapy within 24 hr after birth were assigned to the prophylactic group, while infants born between August 2014 and July 2015 who received aminophylline therapy after obvious apnea were assigned to the therapeutic group. We compared clinical characteristics, including days of ventilator and oxygen therapy and bronchopulmonary dysplasia (BPD) between both groups. Results: Sixty-four patients and 25 infants were identified in the prophylactic and therapeutic groups, respectively. The mean gestational age and birth weight were $32.57{\pm}1.96weeks$ and $1765{\pm}205g$, respectively, in the prophylactic group and $32.46{\pm}1.82weeks$ and $1770{\pm}250g$, respectively, in the therapeutic group. No significant differences in clinical characteristics were found between the two groups. Similar clinical outcomes, including days of ventilator and oxygen therapy, intraventricular hemorrhage (IVH), periventricular leukomalacia, and BPD, were observed between the two groups. Conclusions: The present study showed that the prophylactic use of aminophylline does not improve the clinical outcomes, including BPD, IVH, and ventilator dependency as compared with therapeutic use. In other words, routine prophylactic use of aminophylline is unnecessary.

Keywords

Acknowledgement

Supported by : Pusan National University Hospital

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