• 재활복지
• /
• v.14 no.3
• /
• pp.225-256
• /
• 2010

This study aims to provide the basic data of the rehabilitation program for the schoolchild with intellectual disability by designing new framework of the features of postural control for the schoolchild with intellectual disability. For this, the study investigated what sensations the schoolchild are using to maintain posture by selectively or synthetically applying vision, vestibular sensation and somato-sensation, and how the coordinative sensory system of the schoolchild is responding to any sway referenced sensory stimulus. The study intended to prove the limitation of motor system in estimating the postural stability by providing the cognitive motor task, and provided the features of postural control of the schoolchild with intellectual disability by measuring the onset times and orders of muscle contraction of neuron-muscle when there is a postural control taking place due to the exterior disturbance. Furthermore, by comparatively analyzing the difference between the normal schoolchild and the intellectually disabled schoolchild, this study provided an optimal direction for treatment planning when the rehabilitation program is applied in the postural control ability training program for the schoolchild with intellectual disability. Taking gender and age into consideration, 52 schoolchild including 26 normal schoolchild and 26 intellectually disabled schoolchild were selected. To measure the features of postural control, CTSIB test, and postural control strategy test were conducted. The result of experiment is as followed. First, the schoolchild with intellectual disability showed different feature in using sensory system to control posture. The normal schoolchild tended to depend on somato-sensory or vision, and showed a stable postural control toward a sway referenced stimulus on somato-sensory system. The schoolchild with intellectual disability tended to use somato-sensory or vision, and showed a very instable postural control toward a sway referenced vision or a sway referenced stimulus on somato-sensory system. In sensory analysis, the schoolchild with intellectual disability showed lower level of proficiency in somato-sensation percentile, vision percentile and vestibular sensation percentile compare to the normal schoolchild. Second, as for the onset times and orders of muscle contraction for strategies of postural control when there is an exterior physical stimulus, the schoolchild with intellectual disability showed a relatively delayed onset time of muscle control, and it was specially greater when the perturbation is from backward. As for the onset orders of muscle contraction, it started from muscles near coax then moved to the muscles near ankle joint, and the numbers and kinds of muscles involved were greater than the normal schoolchild. The normal schoolchild showed a fast muscle contracting reaction from every direction after the perturbation stimulus, and the contraction started from the muscles near the ankle joint and expanded to the muscles near coax. From the results of the experiments, the special feature of the postural control of the schoolchild with intellectual disability is that they have a higher dependence on vision in sensory system, and there was no appropriate integration of swayed sensation observed in upper level of central nerve system. In the motor system, the onset time of muscle contraction for postural control was delayed, and it proceeded in reversed order of the normal schoolchild. Therefore, when use the clinical physical therapy to improve the postural control ability, various sensations should be provided and should train the schoolchild to efficiently use the provided sensations and use the sensory experience recorded in upper level of central nerve system to improve postural control ability. At the same time, a treatment program that can improve the processing ability of central nerve system through meaningful activities with organizing and planning adapting reaction should be provided. Also, a proprioceptive motor control training program that can induce faster muscle contraction reaction and more efficient onset orders from muscularskeletal system is need to be provided as well.

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.4
• /
• pp.2185-2190
• /
• 2013

Gallbladder carcinoma, the most frequent malignant neoplasm of the biliary tract system, has always been considered to feature late clinical presentation and diagnosis, limited treatment options and an extremely poor prognosis. In recent years, while the incidence of gallbladder cancer has appeared to be on the increase, the available treatment methods have not greatly improved survival of the affected patients. Thus, exploring new therapeutic targets for this devastating disease is an urgent matter at present. Epidemical studies have demonstrated that the incidence of gallbladder carcinoma exhibits a distinct gender bias, affecting females two to three times more than males, pointing to crucial roles of estrogen. It is well known that estrogen acts on target tissues by binding to estrogen receptors (ERs), which are mainly divided into three subtypes, $ER{\alpha}$, $ER{\beta}$ and $ER{\gamma}$. $ER{\alpha}$ and $ER{\beta}$ appear to have overlapping but also unique even opposite biological effects. As important pathogenic mediators, ERs have been considered to relate to several kinds of tumors. In gallbladder carcinoma tissue, ERs have been shown to be positively expressed, and ERs expression levels are associated with differentiation and prognosis of this cancer. Nevertheless, the exact mechanisms of estrogen inducing growth of gallbladder carcinoma remain poorly understood. On the base of the current investigations, we deduce that estrogen participates in promotion of gallbladder carcinoma by influencing the formation of gallstones, stimulating angiogenesis, and promoting abnormal proliferation. Since ERs mediate the carcinogenic actions of estrogen in gallbladder, and therapy targeting ERs may provide new directions for gallbladder carcinoma. Therefore, it should be stressed that ERs are potential therapeutic targets for gallbladder carcinoma.

• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.2
• /
• pp.559-562
• /
• 2012

Serum alpha-fetoprotein (AFP) is a significant marker for clinical diagnosis and prognosis evaluation in hepatocellular carcinoma (HCC) patients. However, some proportion of liver cancer patients are AFP-negative (AFP ${\leq}$20ng/ml). In order to study the differences between clinicopathological factors and prognosis of alpha-fetoprotein negative and positive patients, a total of 114 cases (41 AFP-negative and 73 AFP-positive) were selected for our research. By systematically statistical analysis, the results demonstrated that compared with AFP-negative patients, AFP-positive examples were more likely to feature cirrhosis nodules, non-complete neoplasm capsules, and a poor Edmondson-steiner grade. Furthermore, AFP-negative patients demonstrated a favorable long-term prognosis. By univariate analysis and multivariate analysis with Cox's proportional hazards model, multiple tumors were found to be independent risk factors for worse survival of AFP negative patients; however, less tumor-free margins, multiple tumors and Edmondson-steiner grades III/IV, proved to be independent risk factors leading to a poor prognosis of AFP positive cases. Finally, we can infer that high levels of AFP signify a highly malignant tumor and unfavorable prognosis.

• Journal of the Institute of Electronics and Information Engineers
• /
• v.53 no.11
• /
• pp.114-122
• /
• 2016

EIS (Electro interstitial scan) is a non-invasive and simple method to find the physio-pathological information inferred by electric current response with respect to low direct current applied between remote sites of the body. Although a few EIS-based devices for diagnosing diabetes were commercialized, they were not successful in offering clinical validity nor in confirming diagnostic principle. In this study, we measured the voltage responses of diabetic patients and normal subjects with a commercialized EIS device to test the usefulness of EIS in screening diabetes. For this purpose, voltage was measured between pairs of electrodes contacted at both palm, both soles of the feet and left and right forehead above both eyes. After feature extraction of voltage signals, the AUC (area under the curve) between the two groups was calculated and we found that seven variables were appropriately shown above 60% of accuracy. In addition, we applied the k-NN (k-nearest neighbors) method and found that the accuracy of classification between the two groups reached the accuracy of 76.2%. This result implies that the voltage response analysis based on EIS has potential as a diabetics screening method.

• Tuberculosis and Respiratory Diseases
• /
• v.62 no.5
• /
• pp.421-426
• /
• 2007

Portopulmonary hypertension (PPHTN) is a clinically and pathophysiologically distinct complication of advanced liver disease. PPHTN is characterized by the development of pulmonary arterial hypertension in association with advanced hepatic disease-related portal hypertension. A characteristic feature of PPHTN is an obstruction to the pulmonary artery flow caused by vasoconstriction, the proliferation of the endothelium and smooth muscle components of the vascular wall, as well as in situ thrombosis. This disorder is commonly underdiagnosed but the clinical implications are significant because it has substantial effects on survival and requires special treatment. We report a case of portopulmonary hypertension in a 53-year-old woman with primary biliary cirrhosis who presented with exertional dyspnea.

• Journal of radiological science and technology
• /
• v.26 no.1
• /
• pp.71-82
• /
• 2003

In this paper, I proposed a classifier of liver cirrhotic step using T1-weighted MRI(magnetic resonance imaging) and hierarchical neural network. The data sets for classification of each stage, which were normal, 1type, 2type and 3type, were obtained in Pusan National University Hospital from June 2001 to december 2001. And the number of data was 46. We extracted liver region and nodule region from T1-weighted MR liver image. Then objective interpretation classifier of liver cirrhotic steps in T1-weighted MR liver images. Liver cirrhosis classifier implemented using hierarchical neural network which gray-level analysis and texture feature descriptors to distinguish normal liver and 3 types of liver cirrhosis. Then proposed Neural network classifier teamed through error back-propagation algorithm. A classifying result shows that recognition rate of normal is 100%, 1type is 82.3%, 2type is 86.7%, 3type is 83.7%. The recognition ratio very high, when compared between the result of obtained quantified data to that of doctors decision data and neural network classifier value. If enough data is offered and other parameter is considered, this paper according to we expected that neural network as well as human experts and could be useful as clinical decision support tool for liver cirrhosis patients.

• Journal of the korean academy of Pediatric Dentistry
• /
• v.26 no.2
• /
• pp.275-283
• /
• 1999

Authors evaluated 152 patients at the department of Pediatric Dentistry in Seoul National University Hospital through clinical records and radiographs. And the following features were studied ; age, sex distribution, number of mesiodens per patients, location, status of eruption, shape and orientation of crown, and complication. From the above results, the relationship between features of mesiodens and complications were evaluated using chi-square analysis. 1. Complications due to the presence of mesiodens did not occur in 31.6%, delayed eruption of adjacent teeth was observed in 33.6%, midline diastema in 22.4%, rotation in 8.6%, displacement in 3.3%, and crowding in 0.7% of all evaluated patients. 2. As compared with the above 8.5 year group, in the under 8.5 year group, the frequency of complications was significantly higher(P<0.05). As compared with those positioned lingually, in mesiodens labially or within the arch the frequency of complications was significantly higher(P<0.01). Also, the frequency of complications was significantly higher when the mesiodens was tuberculate in form(P<0.05). 3. Of the 104 patients with complications, the frequency of delayed eruption was significant higher in the under 8.5 year group, and in above 8.5 year group, the frequency of malocclusion was significantly higher(P<0.05). When mesiodens were located in the midline region, the frequency of malocclusion was significant higher, while in case with laterally positioned mesiodens the frequency of delayed eruption was significantly higher(P<0.01).

• The Journal of the Korea institute of electronic communication sciences
• /
• v.13 no.3
• /
• pp.661-668
• /
• 2018

Biomedical signals using skin resistance have different characteristics according to stress diseases. Biological diagnostic devices for diagnosing stress diseases have been developed by using these characteristics, and devices have been developed so that the signals measured by the skin storage meter can be easily analyzed. Experts in the field will look directly at the output signal to determine the likelihood of any stress disorder. However, it is very difficult for a person to accurately determine whether a person to be measured has a stress disorder by analyzing a bio-signal measured by each person to be measured, and the result of the judgment is very likely to be wrong. In order to solve these problems, we implemented the function of determining the signal of a stress disorder by using the machine learning technique. SVM was used as a classification method in consideration of low computing ability of measurement equipment. Training data and test data were randomly generated for each disease using error range 5 based on 13 diseases. Simulation results showed more than 90% decision accuracy. In the future, if the measurement equipment is actually applied to the patients, we can retrain the classifier with the newly generated data.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.22 no.4
• /
• pp.709-717
• /
• 2008

$Ch\acute{e}n\;Xiuyu\acute{a}n$(陳修園) was a famous doctor and educator of the late Tang Dynasty. He was well known both for his books for beginners, and for his unique medical theories based on his profound research of <$Sh\bar{a}ngh\acute{a}nl\grave{u}n$(傷寒論)> and <$J\bar{i}nku\grave{i}y\grave{a}ol\ddot{u}e$>. He wrote <$Y\bar{i}xues\bar{a}nz\grave{i}j\bar{i}ng$(醫學三字經)> to establish the basic textbook for the beginners to set up right principles in pursuing their medical career. <$Y\bar{i}xues\bar{a}nz\grave{i}j\bar{i}ng$> was written in rhyme form, so that it can be easily memorized and used in future practices. There are quite many medical books in rhyme form, but this book is very unique as $Ch\acute{e}n\;Xiuyu\acute{a}n$ annotated his own notes, which is rare in this form of books. This feature makes <$Y\bar{i}xues\bar{a}nz\grave{i}j\bar{i}ng$> very outstanding, also with the fact that $Ch\acute{e}n\;Xiuyu\acute{a}n$ was the one with profound understanding and original theories based on medical bibles such as <$N\grave{e}ij\bar{i}ng$(內經)> and <$Sh\bar{a}ngh\acute{a}nl\grave{u}n$(傷寒論)>. We have translated this precious educational material into korean, hoping that this work could be of any help to students of korean medicine. And while doing this work, we have found followings: <$Y\bar{i}xues\bar{a}nz\grave{i}j\bar{i}ng$> covers the entire fields of medicine from theoretical discussions to practical clinical information. Nevertheless, as this is written in rhyme form, there are few phrases that are not easily understood for the sake of rhyme. Beginners probably may have difficulties in reading this book. To make this difficulty alleviated, and to develop our own educational material, we need to study further on the notes that $Ch\acute{e}n\;Xiuyu\acute{a}n$ annotated himself.

• Journal of The Korean Society of Clinical Toxicology
• /
• v.5 no.1
• /
• pp.1-7
• /
• 2007

Purpose: The aim of this study was to evaluate the characteristics and the prognostic factors of carbamate poisoned patients who visited emergency departments. Methods: From August 2005 to July 2006, we investigated the demographic feature, dose of exposure, time of exposure, alcohol intake, route of exposure, reason of exposure, site of exposure, pre-existing medical condition, time from exposure to emergency department (ED), transfer from other hospitals, vital sign at ED arrival, symptom or sign at ED arrival, and result of care of the patients who visited the ED of thirty-eight hospitals in Korea. According to the result of care, we divided the patients into two groups, the survival and the dead. To evaluated the prognostic factors, we calculated the odds ratio of each factor for the survival. Results: Among the sixty-eight patients, fifty-five patients (80.9%) were survival and thirteen patients (19.1%) were dead. The patients in the dead were older than the patients in the survival. The Glasgow coma scale (GCS) of the patients in the dead was lower than the GCS in the survival. The odds ratio of the GCS at ED arrival for the survival was 1.58 (95% CI; 1.23-2.05). Other factors showed no statistical significances. Conclusion: The GCS at emergency department arrival was the prognosis factor of the carbamate poisoned patients who visited emergency departments. If the carbamate poisoned patients showed altered mentalities, they should be provided intensive care, immediately.