• Journal of the Korean Society for Precision Engineering
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• v.27 no.9
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• pp.94-102
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• 2010

The spindle is the main component in machine tools. To develop high speed machine tools, a lot of studies have been carried out for high speed spindle. Bearing is very important part in spindle. The bearing clearance is influenced by shrink fit and thermal expansion during operation. The designer must take into account the reduction of shrink fits. The aims of this study are to grasp the shrink fits and behavior of a bearing which is a deeply connected with fatigue life of bearing and performance of spindle through FEM(Finite Element Method). This paper proposed optimum value of shrink fit considering deformation of spindle and stress of fitting area using design of experiments. Thus, the proposed formula can be used to obtain bearing internal clearance.

• Journal of the Korean Society for Precision Engineering
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• v.26 no.5
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• pp.135-141
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• 2009

The bearing clearance is influenced by shrink fit and thermal expansion during operation. The designer must take into account the reduction of clearance after installation to the interference fits, and thermal expansion must be considered. The purpose of this study is to grasp the internal clearance variation and behavior of a bearing which is a deep connected with fatigue life of bearing and performance of spindle through FEM(Finite Element Method). Finite element analysis is performed by using commercial code ANSYS according to variation of thermal condition and rotational speeds. This paper presents correct negative internal clearance according to temperature during operation. Furthermore, interrelation between thermal expansion and contraction are presented to maintain adequate contact force for three type of spindle system (HSK-A60, HSK-40E, HSK-32E). The influence of the centrifugal force and Internal clearance variation of bearing is studied to operating rotational speed.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2009.10a
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• pp.575-576
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• 2009

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2011.06a
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• pp.571-572
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• 2011

• Journal of Mechanical Science and Technology
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• v.18 no.10
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• pp.1849-1858
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• 2004

For examining friction-factor characteristics of round-hole pattern surfaces which are usually applied on damper seals, flat plate test apparatus is designed and fabricated. The measurement method of leakage and pressure distribution along round-hole pattern specimen with different hole area is described and a method for determining the Fanning friction factor is discussed. Results show that the round-hole pattern surfaces provide a much larger friction factor than smooth surface, and the friction factor vs. clearance behavior yields that the friction factor generally decreases as the clearance increases unlike the results of Nava's flat plate test. As the hole depth is decreased, the friction factor is increased, and maximum friction factor is obtained for 50% of hole area. Since the present experimental friction factor results show coincident characteristics with Moody's friction factor model, empirical friction factors for round-hole pattern surfaces are obtained by using the Moody's formula based on curve-fit of the experimental data. Results of Villasmil's 2D CFD simulation support the present experimental test result.

• Journal of The Korean Society of Integrative Medicine
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• v.11 no.4
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• pp.61-71
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• 2023

Purpose : Energy bars are increasingly popular among active individuals, yet their timing and nutrient combinations' impact on exercise adaptation remains unclear. This study aims to address this knowledge gap by investigating whether the combination of pre- and post-workout supplementation can synergistically enhance fitness and alleviate fatigue in trained CrossFit participants. Investigate if combining pre- and post-workout supplements can enhance fitness and blood lactate management in trained CrossFit participants, potentially improving exercise performance for this group. Methods : In a randomized crossover study, 20 trained CrossFit individuals (11 males, 9 females) completed thrice-weekly 60-minute CrossFit sessions for 3 weeks, with a one-week washout period. Participants were randomly assigned to either a chocolate bar group (CH, 45 g, 225 kcal) or an energy bar group (ES, 48 g, 238 kcal, with protein, caffeine, taurine, and BCAAs). For one week, participants consumed two bars of their assigned supplement five minutes before and after workouts. After a washout period, they switched supplements. Blood lactate levels and a visual analog scale (VAS) were assessed before, immediately after, and 30 minutes post-workout. Fitness tests (hand grip, broad jump, sit-ups) were conducted at baseline and 30 minutes post-final workout. Data were analyzed using two-way repeated measures ANOVA (p<.05), 95 % confidence intervals, and magnitude inferences. Results : Hand grip strength (t=-5.60, p=.000), broad jump (t=-3.43, p=.003) and sit up (t=-3.94, p=.001) were significantly increased in the ES group. Compared to CH group, there was a significant time and group interactions for blood lactate level (F=5.51, p=.008) and VAS(F=31.67, p=.000) in the ES group. Conclusion : Pre- and post-workout energy bar supplementation may have a beneficial effect on blood lactate clearance and fitness in trained CrossFit individual. The combination of proprietary supplements taken may provide benefits for removing the blood lactate during high-intensity functional exercise.

• Korean Journal of Clinical Pharmacy
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• v.26 no.4
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• pp.312-317
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• 2016

Objective: Midazolam is mainly metabolized by cytochrome P450 (CYP) 3A. Inhibition or induction of CYP3A can affect the pharmacological activity of midazolam. The aims of this study were to develop a population pharmacokinetic (PK) model and evaluate the effect of CYP3A-mediated interactions among ketoconazole, rifampicin, and midazolam. Methods: Three-treatment, three-period, crossover study was conducted in 24 healthy male subjects. Each subject received 1 mg midazolam (control), 1 mg midazolam after pretreatment with 400 mg ketoconazole once daily for 4 days (CYP3A inhibition phase), and 2.5 mg midazolam after pretreatment with 600 mg rifampicin once daily for 10 days (CYP3A induction phase). The population PK analysis was performed using a nonlinear mixed effect model ($NONMEM^{(R)}$ 7.2) based on plasma midazolam concentrations. The PK model was developed, and the first-order conditional estimation with interaction was applied for the model run. A three-compartment model with first-order elimination described the PK. The influence of ketoconazole and rifampicin, CYP3A5 genotype, and demographic characteristics on PK parameters was examined. Goodness-of-fit (GOF) diagnostics and visual predictive checks, as well as bootstrap were used to evaluate the adequacy of the model fit and predictions. Results: Twenty-four subjects contributed to 900 midazolam concentrations. The final parameter estimates (% relative standard error, RSE) were as follows; clearance (CL), 31.8 L/h (6.0%); inter-compartmental clearance (Q) 2, 36.4 L/h (9.7%); Q3, 7.37 L/h (12.0%), volume of distribution (V) 1, 70.7 L (3.6%), V2, 32.9 L (8.8%); and V3, 44.4 L (6.7%). The midazolam CL decreased and increased to 32.5 and 199.9% in the inhibition and induction phases, respectively, compared to that in control phase. Conclusion: A PK model for midazolam co-treatment with ketoconazole and rifampicin was developed using data of healthy volunteers, and the subject's CYP3A status influenced the midazolam PK parameters. Therefore, a population PK model with enzyme-mediated drug interactions may be useful for quantitatively predicting PK alterations.

• Biomolecules & Therapeutics
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• v.25 no.6
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• pp.648-658
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• 2017

7-O-Succinyl macrolactin A (SMA) exerts several pharmacological effects including anti-bacterial, anti-inflammation, and anti-cancer activities. Recently, SMA has been extensively evaluated as an anti-cancer drug. Thus, the objectives of the present study were to characterise the pharmacokinetics of SMA via both non-compartmental and compartmental analysis in mice, rats, and dogs, and to derive an appropriate first-in-man dose based on allometric scaling of the animal data. The time courses of plasma SMA concentrations after intravenous administration to rats and dogs were analysed retrospectively, as were data collected after intraperitoneal SMA injection in mice. Pharmacokinetic parameters were estimated via both noncompartmental and compartmental analysis, and were correlated with body weight and/or the potential maximum life-span. The clearance and distribution volume of SMA in humans were predicted, and a first-in-man dose proposed. A two-compartment model best described the time courses of SMA plasma concentrations after a saturation elimination process was applied to fit the dataset obtained from rats. Incorporation of the maximum potential life-span during allometric scaling was required to improve the estimation of human clearance. The SMA clearance and the distribution volume in the steady state, in a 70-kg adult male, were estimated to be 30.6 L/h and 19.5 L, respectively. To meet the area under the curve (AUC) required for anti-tumour activity, a dose of 100 mg (~1.5 mg/kg) was finally proposed as the first dose for a 70-kg human. Although toxicological profiles derived from non-clinical studies must be considered before any final decision is made, our work will facilitate clinical studies on SMA.

• The Korean Journal of Nuclear Medicine
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• v.28 no.3
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• pp.338-342
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• 1994

Pulmonary clearance of Tc-99m-DTPA(PCD) has been used for the measurement of polmonary epithelial permeability. It has been reported to be increased not only in variety of polmonary diseases including ARDS, interstitial fibrosis, and smokers, but also in normal subjects on positive end expiratory pressure respirator, or after exercise. It was also noted that decrease of pulmonary blood flow due to pulmonary arterial obstruction results in delayed PCD. Normal range of PCD varies with institutes. We prospectively measured PCD in 17 normals (5 males and 12 females) consisted of staffs and trainees in the department of radiology of Kangnam St. Mary's hospital using original Bark Nebulizer (India). Age ranged from 32 to 43 years. 370 MBq of Tc-99m-DTPA was inhaled in supine position and supine posterior images were subsequently obtained with 1 min/frame, $64{\times}64$ matrix and word mode for 30min. Regions of interest were set on each lung, whole lungs, and upper, middle and lower thirds of right lung, respectively. Best fit regression curve was obtained by least square method from initial 7min after peak activity on each curve and time for half clearance of maximum activity (t1/2) was calculated. Mean t1/2 was $51{\pm}11.2min$ for whole lung. There was no significant difference between t1/ 2 of right and left lungs. Initial uptake was higher in the lower third and t1/2 was shorter in the lower third than in the upper third(P<0.05). We reviewed several reports on PCD and compared our data with the others. In this study, faster clearance in the lower third may be due to the position imaged with or the environment the subjects belong to, and further investigation is under way.

• Journal of the Korean Society for Precision Engineering
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• v.10 no.1
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• pp.114-125
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• 1993

Thermoelastoplastic analysis of a typical device consisting of fixed tube and movable case having an inital clearance in between, which is subjected to pressure and thermal load, has been carried out to examine the cause of malfunction mainly at high temperature condition, and to improve the design. Stresses, deformed shape, interface state and their effects on normal function of case are discussed by using finite element method. The extraction energy can be remarkably reduced by changing the configuration of tube from the present design (Parallel type) to the improved design (Tapered type). This effect has been proved by sustained cyclic function test.