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In Vivo Immunotoxicities of Butylated Hydroxyanisole (BHA) and Butylated Hydroxytoluene (BHT) in Male Mice

  • Moon, Chang-Kiu;Lee, Soo-Hwan;Park, Kwang-Sik;Hwang, Gwi-Seo;Mock, Myung-Soo;Chung, Dong-Seok;Kim, Dae-Dok;Min, Seok-Ki
    • Archives of Pharmacal Research
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    • v.10 no.4
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    • pp.223-227
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    • 1987
  • The effects of butylated hydroxyanisole and butylated hydroxytoluene on the immune status in normal male were evaluated. They exhibited significant decrease in the circulating leukocyte counts. Relative spleen and thymus weights were slightly decreased, but not stratistically significant. These were, however, significant liver hypertrophies in theier exposed mice. Splenic IgM PFCs per one million cells in 1/20 LD50 BHA and BHT exposed mice were significantly reduced IgM PFCs per spleen were similar tothose of control, except in 1/20 LD50 BHA exposed mice, where they were significantly suppressed. The precise nature of the inhibition is not clear. Direct cytotoxicity is not responsible for the depressed antibody response, even following relatively high doses of them, because the changes in spleen cellularity are not significant. Both substances, however, did not show any effects on the arthus reaction and delayed hypersensitivity reaction induced by heat aggreagted bovine serum albumin, and in vivo phagocytosis of colloidal carbon. In the light of the present results, in vivo antibody response as well as in vitro, may be sensitive to BHA of the present results, in vivo antibody response as well as in vitro, amy be sensitie to BHA and BHT. Further elucidation of the precise nature of antibody suppression in their exposed mice, is warranted.

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Book research into acupuncture treatement for dry eye (건성안(乾性眼)에 대한 침료법(鍼療法)의 문헌적(文獻的) 고찰(考察))

  • Kwon, Do-Hee;Kim, Yong-Suk;Choi, Do-Yong
    • Journal of Acupuncture Research
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    • v.17 no.3
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    • pp.10-24
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    • 2000
  • 1. Objectives : Millions of people throuout the world are affected by some form of dry eye disorder. I made researches for more effective treatments for dry eye. 2. Methodes : I refered to occidental and oriental medical records. 3. The results were as follows : Common symptoms of dry eye are dryness, burning, irritation, grittiness, itching, fatigue of eye, photophobia, congestion, mattering and tear. Treatments of dry eye are to clear away heat and fire, remove dampness, replenish Um and promote production of body fluid, tonify the blood and replenish Ki. Acupunctre and moxibustion therapy of dry eye are as follows: Very busy points of traditional regular acupuncture are Sangsong, Chanjuk, Sajukkong, Chongmyong, Sabaek, Tongjaryo, Taeyang, Pungji, Tuimup, Paekoe, Un-gyo, Chonjong, Hapkok, Yangbaek, Kansu, Yanggye, Imup, Chok-samni, Taechung, Kwangmyong, Yang-gok, Uihui, Chohae, Haenggan. Less busy points of it are Oyo, Kuhu, Sungup, Konmyong, Konmyongl, Konmyong2, Sangmyong, SanghaChongmyong, Shinmyong, Osang, Shinjong, Yonghyang, Yaemyong, Chon-yu, Chon-ju, Kwallye, Naebi, Noeho, Tuyu, Mokchang, Ponshin, Shinhoe, Yepung, Okchim, Pungbu, Kokchon, Kollyun, Nae-gwan, Tae-nung, Samumgyo, Sokolkong, Shinsu, Um-gyo, Igan, Chongok, Choktaek, Kyonjungsu, Kokchi, Kongchoe, Kyuum, Kihae, Taekolkong, Taedon, Pino, Pisu, Sabong, Samgan, Kokchi, Shinmun, Shinmaek, Shimsu, Yangno, Aengmun, Yolgyol, Oegwan, Wijung, Chang-gan, Chungjo, Chungdo, Chigu, Chium, Chollyo, Tongni, Pungmun, Haryom. Very busy points of ear-acupuncture are Kan, Bi, Shin, An, Less busy points of it are Shim, Pye, Naebunbe, Mok1, Mok2, Shinmun, Ichom. Useful points of bleeding by needle are Taeyang meridian, Yangmyong meridian, Chono, Chonjong, Paekoe, Sangsong, Chanjuk, Sajukkong, nasal cavity. Useful points of moxibustion are Inchung, Huaryo, Shinchu, Pungmun, Kansu, Shimsu, Kokchi, Kongchoe, Sohae.

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Study on Solid-liquid Mixture Flow in Inclined Annulus (경사 환형관내 고-액 혼합 유동특성에 관한 연구)

  • Kim, Young-Ju;Kim, Young-Hun;Woo, Nam-Sub
    • Journal of Ocean Engineering and Technology
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    • v.25 no.5
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    • pp.15-20
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    • 2011
  • This study carried out a series of experiments involving impact tests (Drop Weight type & Charpy type with a standard specimen and newly designed I-type specimen), hardness tests, and fracture surface observations of French-made roll shell steel (F), abnormal roll shell steel (M), reheated roll shell steel (R), and S25C steel under heat treatment conditiAn experimental study was carried out to study the solid-liquid mixture upward hydraulic transport of solid particles in vertical and inclined annuli with a rotating inner cylinder. The lift forces acting on a fluidized particle play a central role in many important applications such as the removal of drill cuttings in horizontal drill holes, sand transport in fractured reservoirs, sediment transport, the cleaning of particles from surfaces, etc. In this study a clear acrylic pipe was used to observe the movement of solid particles. Annular velocities varied from 0.4 to 1.2 m/s. The effect of the annulus inclination and drill pipe rotation on the carrying capacity of a drilling fluid, particle rising velocity, and pressure drop in a slim hole annulus were measured for fully-developed flows of water and aqueous solutions of CMC (sodium carboxymethyl cellulose) and bentonite. The rotation of the inner cylinder was efficient at carrying particles to some degree. For a higher particle volume concentration, the hydraulic pressure loss of the mixture flow increased because of the friction between the wall and solids or between solids.

Energy Performance Evaluation of a Double-skin Facade with a Venetian Blind in Residential Buildings (주거건물용 이중외피 시스템의 블라인드 조절에 따른 에너지 성능평가에 관한 연구)

  • Lee, So-Yeun;Kang, Jae-Sik;Kim, Kang-Soo
    • Journal of the Korean Solar Energy Society
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    • v.30 no.6
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    • pp.1-9
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    • 2010
  • Apartment balcony has been remodeled since the government permitted remodeling in January 2006.But extended balcony has great impact on building heat gain and loss. Therefore It has problems such as increase of heating and cooling energy. So $\underline{t}echnical$ solutions about window solar gain in summer is an urgent matter. The Purpose of this study is to evaluate energy performance of a blind in a double-skin facade in residential buildings by using EnergyPlus program. The results show that slat angles of $90^{\circ}$ is best in energy performance if we do not consider daylight. Poorly daylighted living room needs electric light and it also causes high cooling load. On the other hand, the results show that the application of blinds controlled automatically is best for energy performance when we consider daylight. Blind slat angles of $50\sim60^{\circ}$ have best performance when blinds are controlled in this angle throughout the day on a clear day in August. Blind slat angles of $0\sim30^{\circ}$ have best performance when blinds $\underline{are\;controlled}$ in this angle throughout the day on a cloudy day (more than 7 of total sky cover) in August.

Inhibition of entry of Toxoplasma gonldii into MDCK cells by fetal bovine serum (Tomplasma gondii의 숙주세포 침투를 억제하는 우태아혈청 성분)

  • 남호우;김동진
    • Parasites, Hosts and Diseases
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    • v.31 no.4
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    • pp.379-381
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    • 1993
  • We experienced the partial Inhibition of entry of Taxoplasma gondii Into MDCK cells when the FBS was depleted from media. MDCK cells and Toxoplasma (RH strains) were co-cultured, the penetration was inhibited up to 60-80% with concentration-dependence of FBS. Inhibitory effect was clear when the conc. of FBS was over 1% (v/v) with 50% inhibition comic. of 5%. When ToxopLosma was pre-incubated with FBS and then applied to MDCK cells, there were no inhibitory effect, but when FBS was added to Toxoplasma- MDCK co-culture, the time of adding was c10cal with rapid inhibition. And when FBS was further treated with heat ($95^{\circ}C$, 10 min), the Inhibitory effect was decreased slightiy in both raw and inactivated FBS. The FBS factor(s) might participate to neutralize secreted materials which enhancing penetration or Intervene between receptor-ligand blnding at the moment of entry through sterically rather than functionally.

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Biodegradation and Removal of PAHs by Bacillus velezensis Isolated from Fermented Food

  • Sultana, Omme Fatema;Lee, Saebim;Seo, Hoonhee;Al Mahmud, Hafij;Kim, Sukyung;Seo, Ahyoung;Kim, Mijung;Song, Ho-Yeon
    • Journal of Microbiology and Biotechnology
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    • v.31 no.7
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    • pp.999-1010
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    • 2021
  • Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the environment. They are highly toxigenic and carcinogenic. Probiotic bacteria isolated from fermented foods were tested to check their ability to degrade and/or detoxify PAHs. Five probiotic bacteria with distinct morphologies were isolated from a mixture of 26 fermented foods co-cultured with benzo(a)pyrene (BaP) containing Bushnell Haas minimal broth. Among them, B. velezensis (PMC10) significantly reduced the abundance of BaP in the broth. PMC10 completely degraded BaP presented at a lower concentration in broth culture. B. velezensis also showed a clear zone of degradation on a BaP-coated Bushnell Haas agar plate. Gene expression profiling showed significant increases of PAH ring-hydroxylating dioxygenases and 4-hydroxybenzoate 3-monooxygenase genes in B. velezensis in response to BaP treatment. In addtion, both live and heat-killed B. velezensis removed BaP and naphthalene (Nap) from phosphate buffer solution. Live B. velezensis did not show any cytotoxicity to macrophage or human dermal fibroblast cells. Live-cell and cell-free supernatant of B. velezensis showed potential anti-inflammatory effects. Cell-free supernatant and extract of B. velezensis also showed free radical scavenging effects. These results highlight the prospective ability of B. velezensis to biodegrade and remove toxic PAHs from the human body and suggest that the biodegradation of BaP might be regulated by ring-hydroxylating dioxygenase-initiated metabolic pathway.

Lysimetric Analysis for Transpiration and Carbon Accumulation of Cnidium officinale Makino in Hot Weather Conditions (고온조건에서 라이시미터를 이용한 천궁의 증산 및 탄소축적량 분석)

  • Seo, Young Jin;Kim, Kwang Seop;Kim, Dong Chun;Nam, Hyo Hoon;Kim, Jun Hyung;Lee, Bu Yong
    • Korean Journal of Medicinal Crop Science
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    • v.28 no.6
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    • pp.463-470
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    • 2020
  • Background: Evaluation of transpiration is required for agricultural and environmental management applications, as crop yields and plant growth are primarily water limited. This study aimed to determine the transpiration and carbon accumulation of Cnidium officinale. Methods and Results: The transpiration of C. officinale was evaluated using weighing lysimeter. The relationship between transpiration and factors such as solar radiation, air temperature, and leaf area was assessed. Transpiration increased as the leaf area increased with the growth stage. Furthermore, daily transpiration per unit leaf area was 0.69 ± 0.16 g·cm-2·day-1 and there were no significant differences in daily transpiration during the cultivation period. The maximum transpiration was 620.6 g m-2·h-1 and diurnal changes in transpiration were highly correlated with solar radiation although the maximum transpiration was observed at the air temperatures of 20℃ - 26℃. The ratio of carbon accumulation to transpiration was 0.12%. Conclusions: Our results indicated that the transpiration of C. officinale is primarily regulated by solar radiation energy on clear days and that 97% of the water is discharged through transpiration for heat dissipation. Therefore, weighing lysimeters can measure transpiration accurately and may be useful in interpreting plant growth.

Preparation and Characterization of Nanocrystalline Spinel Ferrites by Chemical Co-precipitation (화학적 공침법을 이용한 침상형 페라이트 합성)

  • Shen, Jiao-Wen;Lim, Yun-Hui;Jo, Young-Min
    • Applied Chemistry for Engineering
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    • v.22 no.2
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    • pp.185-189
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    • 2011
  • In this work, nano-sized M-ferrites (M=Co, Ni, Cu, Zn) for the decomposition of carbon dioxide were synthesized by the chemical co-precipitation. From the thermogravimetric analysis, it was clear that the maximum weight loss of each sample took place below $350^{\circ}C$. High temperature calcination resulted in more systematic crystallines, smaller specific surface area and larger particle size. An analysis by FTIR in the range of $375{\sim}406cm^{-1}$ revealed the presence of chelates at the octahedral site, which implies the formation of spinel structure in the ferrites. The current work showed that a $500^{\circ}C$ is the optimum heat treatment temperature of metal ferrites for $CO_2$ decomposition reaction.

Analysis of Pattern Identification and Related Symptoms on Idiopathic Short Stature -Focusing on Traditional Chinese Medicine Literature- (특발성 저신장의 변증 유형 및 변증별 증상 분석 -중의학 논문을 중심으로-)

  • Lee, Boram;Kwon, Chan-Young;Jang, Soobin
    • The Journal of Pediatrics of Korean Medicine
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    • v.35 no.1
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    • pp.1-17
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    • 2021
  • Objectives We aimed to analyze traditional Chinese medicine (TCM) literatures in regards to the pattern identification and related symptoms of idiopathic short stature (ISS). Methods We searched relevant literatures published up to September 29, 2020 through three Chinese electronic databases. We performed frequency analysis of the selected studies by extracting information on pattern identification, clinical symptoms, and TCM treatments presenting pattern identification of ISS. Results Sixteen studies were included. Spleen deficiency, kidney deficiency, dual deficiency of spleen-kidney, and liver-kidney yin deficiency were frequently reported. Clinical symptoms of the spleen deficiency include sallow complexion, body constituent weakness, anorexia, lack of qi and no desire to speak, and loose stools. Herbal medicines (HMs) such as Sijunzi-tang were frequently reported. Clinical symptoms of the kidney deficiency include cold limb and fear of cold, soreness and weakness of waist and knees, and clear and long urine. HMs such as Bishendihuang-wan were frequently reported. Clinical symptoms of the dual deficiency of spleen-kidney include body constituent weakness, spirit lassitude and lack of strength, anorexia, soreness and weakness of waist and knees, and cold limb and fear of cold. HMs such as Sijunzi-tang plus Bishendihuang-wan were frequently reported. Clinical symptoms of the liver-kidney yin deficiency include tidal fever and night sweating, heat in the palms and soles, dizziness, and dry throat. HMs such as Liuweidihuang-wan were frequently reported. Conclusions This was the first study to analyze the frequency of pattern identification and related symptoms on ISS. In the future, a standardized Korean medicine pattern identification system should be established.

Comparison of EU-DEMO React & Wind Nb3Sn TF CICC current sharing temperature against Wind & React Nb3Sn CICCs

  • Kwon, Soun P.
    • Progress in Superconductivity and Cryogenics
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    • v.24 no.2
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    • pp.7-18
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    • 2022
  • European efforts to design superconducting conductors for a future tokamak have involved Nb3Sn cable-in-conduit conductor (CICC). Nb3Sn coils which undergo heat treatment to activate the Nb3Sn material are mostly produced through the wind-then-react route. However, some Nb3Sn coils have been proposed with CICCs of the react-then-wind route. The latter CICCs are physically constrained due to handling limitations which if not adhered to will result in irrecoverable damage to the Nb3Sn cable inside, nullifying any performance advantage. A group at the Swiss Plasma Center has proposed such CICC designs, constructing samples and testing them for performance. The characteristics and performance of these react & wind (R&W) CICCs are compared with the more common wind & react (W&R) CICCs, and it is found that the R&W designs show more extreme characteristics than typical W&R Nb3Sn CICCs for some parameters that are known to influence CICC performance. Where the R&W CICCs extend the range of those parameters, they also continue trends formed by the W&R CICCs with the parameters. The main observation, however, is that although the current sharing temperature performances of the R&W samples are above the average of the W&R samples they were compared to, they are not the highest. A similar observation applies to a cost comparison of the superconducting material where the R&W CICCs are found to be relatively cheap but not the cheapest. Given these results, clear practical advantages to the R&W CICC design is not evident.